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Y4 receptor

Family: Neuropeptide Y receptors

Contents:
Gene and Protein Information
Previous and Unofficial Names
Database Links
Agonists
Antagonists
Transduction Mechanisms
Tissue Distribution
Expression Datasets
Functional Assays
Physiological Functions
Physiological Consequences of Altering Gene Expression
Phenotypes, Alleles and Disease Models
General Comments
References
Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 375 10q11.2 PPYR1 pancreatic polypeptide receptor 1 9,20,32
Mouse 7 375 14 B Ppyr1 pancreatic polypeptide receptor 1 9,15
Rat 7 375 16p16 Ppyr1 pancreatic polypeptide receptor 1 21,30,32
Previous and Unofficial Names
PP1
PP1
NPY4R
Y4
NPY4-R
neuropeptide Y receptor type 4
pancreatic polypeptide receptor 1
NYYR-D
Database Links
ChEMBL Target
Ensembl
Entrez Gene
GeneCards
GenitoUrinary Development Molecular Anatomy Project
HomoloGene
Human Protein Reference Database
InterPro
KEGG Gene
OMIM
PharmGKB Gene
PhosphoSitePlus
Protein Ontology (PRO)
RefSeq Nucleotide
RefSeq Protein
TreeFam
UniGene Hs.
UniProt
Wikipedia
Search for 3D structures on the PDB
Search by keyword: Neuropeptide Y receptors Y4 receptor
Natural/Endogenous Ligand(s)
neuropeptide Y {Sp: Human, Mouse, Rat}
pancreatic polypeptide {Sp: Human} , pancreatic polypeptide {Sp: Rat} , pancreatic polypeptide {Sp: Mouse}
Rank order of potency (Human)
Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
[125I]PYY (pig) Hs Full agonist 9.8 pKd 20
[125I]GR231118 Rn Full agonist 9.6 pKd 10
pancreatic polypeptide {Sp: Human} Rn Full agonist 10.5 – 10.9 pKi 13,30
pancreatic polypeptide {Sp: Rat} Mm Full agonist 10.7 pKi 28
pancreatic polypeptide {Sp: Human} Mm Full agonist 10.6 pKi 28
pancreatic polypeptide {Sp: Rat} Rn Full agonist 10.3 – 10.8 pKi 13,21,30
pancreatic polypeptide {Sp: Bovine} Rn Full agonist 10.2 – 10.7 pKi 13,30
PP-(2-36) (human) Rn Full agonist 10.4 pKi 30
[Leu31,Pro34]PYY (human) Rn Full agonist 10.2 pKi 13
pancreatic polypeptide {Sp: Rat} Hs Full agonist 10.0 pKi 28
GR231118 Hs Full agonist 9.8 pKi 28
GR231118 Mm Full agonist 9.8 pKi 28
pancreatic polypeptide {Sp: Human} Hs Full agonist 8.7 – 10.9 pKi 3,20,28,32
[Leu31,Pro34]NPY Rn Full agonist 8.3 – 10.7 pKi 13,21,30
[Pro34]PYY (human) Mm Full agonist 9.5 pKi 28
[Ile31,Gln34]PP (human) Rn Full agonist 9.2 pKi 30
PP-(13-36) (human) Rn Full agonist 9.0 pKi 30
[Pro34]PYY (human) Hs Full agonist 8.9 pKi 28
peptide YY {Sp: Human} Hs Full agonist 8.8 pKi 20
NPY {Sp: Pig} Rn Full agonist 8.7 pKi 13
[Pro34]PYY (human) Rn Full agonist 8.6 pKi 30
[Leu31,Pro34]NPY Rn Full agonist 8.3 pKi 30
PP-(20-36) (human) Rn Full agonist 8.1 pKi 30
neuropeptide Y {Sp: Human, Mouse, Rat} Hs Full agonist 8.0 pKi 20
NPY-(2-36) Rn Full agonist 7.9 pKi 13
[Leu31,Pro34]NPY Hs Full agonist 7.7 pKi 20
NPY-(3-36) (pig) Rn Full agonist 7.7 pKi 13
neuropeptide Y {Sp: Human, Mouse, Rat} Rn Full agonist 6.4 – 8.8 pKi 13,30
PYY-(3-36) {Sp: Human} Rn Full agonist 7.6 pKi 13
PYY-(13-36) (mouse, rat, pig) Rn Full agonist 7.5 pKi 13
NPY-(2-36) (pig) Hs Full agonist 7.4 pKi 20
peptide YY {Sp: Mouse, Rat, Pig} Rn Full agonist 6.3 – 8.5 pKi 13,30
NPY-(13-36) (pig) Rn Full agonist 6.3 – 8.2 pKi 13,30
NPY-(13-36) (pig) Hs Full agonist 6.9 pKi 20
neuropeptide Y {Sp: Human, Mouse, Rat} Rn Full agonist 6.4 pKi 30
peptide YY {Sp: Human} Rn Full agonist 6.4 pKi 30
peptide YY {Sp: Mouse, Rat, Pig} Rn Full agonist 6.3 pKi 30
PYY-(13-36) (mouse, rat, pig) Rn Full agonist 6.2 pKi 30
PYY-(3-36) {Sp: Mouse, Rat} Rn Full agonist 6.2 pKi 30
GR231118 Rn Full agonist 9.5 pIC50 10
[Leu31,Pro34]NPY Mm Full agonist 8.4 – 9.5 pIC50 15
pancreatic polypeptide {Sp: Bovine} Hs Full agonist 8.6 pIC50 32
[Leu31,Pro34]NPY (pig) Rn Full agonist 8.4 pIC50 10
[Leu31,Pro34]PYY (pig) Rn Full agonist 8.0 pIC50 10
peptide YY {Sp: Mouse, Rat, Pig} Mm Full agonist 6.3 – 8.5 pIC50 15
10-OBn-7α-F-gingkolide B Mm Full agonist 6.1 – 8.5 pIC50 15
NPY-(2-36) Mm Full agonist 5.6 – 7.1 pIC50 15
[Ala31,Aib32]NPY (pig) Hs Full agonist 6.0 pIC50 6
View species-specific agonist tables
Antagonists
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Affinity Units Reference
GR231118 Rn Antagonist 10.8 pKi 13

Explore drug-target interactions for this set of compounds using iPHACE

Primary Transduction Mechanisms
Transducer Effector/Response
Gi/Go family Adenylate cyclase inhibition
References:  22,29-30
Secondary Transduction Mechanisms
Transducer Effector/Response
Gq/G11 family Phospholipase C stimulation
References:  22
Tissue Distribution
Colon, small intestine, pancreas, prostate.
Species:  Human
Technique:  Northern blotting.
References:  20
Brain: hypothalamus, hippocampus, brainstem.
Species:  Rat
Technique:  in situ hybridisation.
References:  23
CNS: dorsal vagal complex.
Species:  Rat
Technique:  in situ hybridisation.
References:  18
Aorta, tail artery, hypothalamus, femoral artery, pulmonary artery, renal artery.
Species:  Rat
Technique:  RT-PCR.
References:  4
Proximal and distal colon.
Species:  Rat
Technique:  RT-PCR.
References:  11
Large and small intestine (epithelial and nonepithelial tissue).
Species:  Rat
Technique:  RT-PCR.
References:  14
Expression Datasets

Click here to show/hide data

Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Functional Assays
Measurement of cAMP levels in LMTK- cells transfected with the human Y4 receptor.
Species:  Human
Tissue:  LMTK- cells.
Response measured:  Inhibition of cAMP accumulation.
References:  3,30
Measurement of Ca2+ levels in LMTK- cells transfected with the human Y4 reeptor.
Species:  Human
Tissue:  LMTK- cells.
Response measured:  Stimulation of Ca2+ accumulation.
References:  3
Measurement of cAMP levels in HEK 293 cells transfected with the human Y4 receptor.
Species:  Human
Tissue:  HEK 293 cells.
Response measured:  Inhibition of cAMP accumulation.
References:  29
Measurement of cAMP levels in CHO cells transfected with the human Y4 receptor.
Species:  Human
Tissue:  CHO cells.
Response measured:  Inhibition of cAMP accumulation.
References:  20
Physiological Functions
Modulation of food intake.
Species:  Mouse
Tissue:  In vivo.
References:  1
Contraction.
Species:  Rat
Tissue:  Colon.
References:  12,24
Stimulation of LH release.
Species:  Rat
Tissue:  In vivo.
References:  16-17,25
Inhibition of arterial neurogenic vasoconstriction.
Species:  Rat
Tissue:  Tail artery, renal artery, femoral artery.
References:  4
Inhibition of electrogenic ion transport.
Species:  Human
Tissue:  Isolated descending colon.
References:  7
Inhibition of electrogenic ion transport.
Species:  Mouse
Tissue:  Colonic mucosal preparaions.
References:  8,28
Reduced appetite and food intake.
Species:  Human
Tissue:  In vivo.
References:  5
Physiological Consequences of Altering Gene Expression
Y4 receptor knockout mice exhibit an increase in water consumption during the dark phase.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  31
Y4 receptor knockout ob/ob mice exhibit increased fertility compared to ob/ob mice.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  26
Y4 receptor knockout mice exhibit reduced vasoconstrictor and vagal inhibitory activity.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  27
Y4 receptor knockout mice do not exhibit agonist-induced inhibition of food intake, as seen in wild-type mice.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  2
Colonic mucosa from Y4 receptor knockout mice does not exhibit the agonist-induced decrease in ion transport as seen in wild-type tissues.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  28
Phenotypes, Alleles and Disease Models Mouse data from MGI

Click here to show/hide data

Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Lepob|Ppyr1tm1.1Hhz Lepob/Lepob,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * C57BL/6
MGI:104663  MGI:105374  MP:0005452 abnormal adipose tissue amount PMID: 12000791 
Npy2rtm1.1Hhz|Ppyr1tm1.1Hhz Npy2rtm1.1Hhz/Npy2rtm1.1Hhz,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * BALB/cJ * C57BL/6
MGI:105374  MGI:108418  MP:0002896 abnormal bone mineralization PMID: 12861009 
Npy2rtm1.1Hhz|Ppyr1tm1.1Hhz Npy2rtm1.1Hhz/Npy2rtm1.1Hhz,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * BALB/cJ * C57BL/6
MGI:105374  MGI:108418  MP:0003795 abnormal bone structure PMID: 12861009 
Lepob|Ppyr1tm1.1Hhz Lepob/Lepob,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * C57BL/6
MGI:104663  MGI:105374  MP:0000662 abnormal branching of the mammary ductal tree PMID: 12000791 
Npy2rtm1.1Hhz|Ppyr1tm1.1Hhz Npy2rtm1.1Hhz/Npy2rtm1.1Hhz,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * BALB/cJ * C57BL/6
MGI:105374  MGI:108418  MP:0000130 abnormal cancellous bone morphology PMID: 12861009 
Ppyr1tm1.1Hhz Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * C57BL/6
MGI:105374  MP:0008459 abnormal circulating pancreatic peptide level PMID: 12000791 
Npy2rtm1.1Hhz|Ppyr1tm1.1Hhz Npy2rtm1.1Hhz/Npy2rtm1.1Hhz,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * BALB/cJ * C57BL/6
MGI:105374  MGI:108418  MP:0008459 abnormal circulating pancreatic peptide level PMID: 12861009 
Ppyr1tm1.1Hhz Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * BALB/cJ * C57BL/6
MGI:105374  MP:0008459 abnormal circulating pancreatic peptide level PMID: 12861009 
Lepob|Ppyr1tm1.1Hhz Lepob/Lepob,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * C57BL/6
MGI:104663  MGI:105374  MP:0005180 abnormal circulating testosterone level PMID: 12000791 
Ppyr1tm1.1Hhz Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * C57BL/6
MGI:105374  MP:0001422 abnormal drinking behavior PMID: 16364461 
Lepob|Ppyr1tm1.1Hhz Lepob/Lepob,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * C57BL/6
MGI:104663  MGI:105374  MP:0001927 abnormal estrous cycle PMID: 12000791 
Ppyr1tm1.1Hhz Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * C57BL/6
MGI:105374  MP:0005334 abnormal fat pad morphology PMID: 12000791 
Lepob|Ppyr1tm1.1Hhz Lepob/Lepob,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * C57BL/6
MGI:104663  MGI:105374  MP:0002161 abnormal fertility/fecundity PMID: 12000791 
Ppyr1tm1.1Hhz Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * C57BL/6
MGI:105374  MP:0005449 abnormal food intake PMID: 12000791 
Npy2rtm1.1Hhz|Ppyr1tm1.1Hhz Npy2rtm1.1Hhz/Npy2rtm1.1Hhz,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * C57BL/6
MGI:105374  MGI:108418  MP:0003953 abnormal hormone level PMID: 17272395 
Lepob|Ppyr1tm1.1Hhz Lepob/Lepob,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * C57BL/6
MGI:104663  MGI:105374  MP:0002786 abnormal Leydig cell morphology PMID: 12000791 
Ppyr1tm1.1Hhz Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * C57BL/6
MGI:105374  MP:0006269 abnormal mammary gland growth during pregnancy PMID: 12000791 
Npy2rtm1.1Hhz|Ppyr1tm1.1Hhz Npy2rtm1.1Hhz/Npy2rtm1.1Hhz,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * BALB/cJ * C57BL/6
MGI:105374  MGI:108418  MP:0005006 abnormal osteoblast physiology PMID: 12861009 
Npy2rtm1.1Hhz|Ppyr1tm1.1Hhz Npy2rtm1.1Hhz/Npy2rtm1.1Hhz,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * BALB/cJ * C57BL/6
MGI:105374  MGI:108418  MP:0000057 abnormal osteogenesis PMID: 12861009 
Lepob|Ppyr1tm1.1Hhz Lepob/Lepob,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * C57BL/6
MGI:104663  MGI:105374  MP:0001131 abnormal ovarian follicle morphology PMID: 12000791 
Lepob|Ppyr1tm1.1Hhz Lepob/Lepob,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * C57BL/6
MGI:104663  MGI:105374  MP:0002673 abnormal sperm number PMID: 12000791 
Lepob|Ppyr1tm1.1Hhz Lepob/Lepob,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * C57BL/6
MGI:104663  MGI:105374  MP:0001142 abnormal vagina opening PMID: 12000791 
Ppyr1tm1.1Hhz Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * C57BL/6
MGI:105374  MP:0001262 decreased body weight PMID: 12000791 
Npy2rtm1.1Hhz|Ppyr1tm1.1Hhz Npy2rtm1.1Hhz/Npy2rtm1.1Hhz,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * BALB/cJ * C57BL/6
MGI:105374  MGI:108418  MP:0001262 decreased body weight PMID: 12861009 
Ppyr1tm1.1Hhz Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * BALB/cJ * C57BL/6
MGI:105374  MP:0001262 decreased body weight PMID: 12861009 
Npy2rtm1.1Hhz|Ppyr1tm1.1Hhz Npy2rtm1.1Hhz/Npy2rtm1.1Hhz,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * BALB/cJ * C57BL/6
MGI:105374  MGI:108418  MP:0001780 decreased brown adipose tissue amount PMID: 12861009 
Npy2rtm1.1Hhz|Ppyr1tm1.1Hhz Npy2rtm1.1Hhz/Npy2rtm1.1Hhz,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * BALB/cJ * C57BL/6
MGI:105374  MGI:108418  MP:0002727 decreased circulating insulin level PMID: 12861009 
Npy2rtm1.1Hhz|Ppyr1tm1.1Hhz Npy2rtm1.1Hhz/Npy2rtm1.1Hhz,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * BALB/cJ * C57BL/6
MGI:105374  MGI:108418  MP:0005668 decreased circulating leptin level PMID: 12861009 
Npy2rtm1.1Hhz|Ppyr1tm1.1Hhz Npy2rtm1.1Hhz/Npy2rtm1.1Hhz,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * BALB/cJ * C57BL/6
MGI:105374  MGI:108418  MP:0000135 decreased cortical bone thickness PMID: 12861009 
Ppyr1tm1.1Hhz Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * BALB/cJ * C57BL/6
MGI:105374  MP:0003910 decreased eating behavior PMID: 12861009 
Ppyr1tm1.1Hhz Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * BALB/cJ * C57BL/6
MGI:105374  MP:0004989 decreased osteoblast cell number PMID: 12861009 
Ppyr1tm1.1Hhz Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * C57BL/6
MGI:105374  MP:0001783 decreased white adipose tissue amount PMID: 12000791 
Npy2rtm1.1Hhz|Ppyr1tm1.1Hhz Npy2rtm1.1Hhz/Npy2rtm1.1Hhz,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * BALB/cJ * C57BL/6
MGI:105374  MGI:108418  MP:0001783 decreased white adipose tissue amount PMID: 12861009 
Ppyr1tm1.1Hhz Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * BALB/cJ * C57BL/6
MGI:105374  MP:0001783 decreased white adipose tissue amount PMID: 12861009 
Ppyr1tm1.1Hhz Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * C57BL/6
MGI:105374  MP:0001353 increased aggression towards mice PMID: 12000791 
Lep+|Lepob|Ppyr1tm1.1Hhz Lepob/Lep+,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * C57BL/6
MGI:104663  MGI:105374  MP:0001260 increased body weight PMID: 12000791 
Npy2rtm1.1Hhz|Ppyr1tm1.1Hhz Npy2rtm1.1Hhz/Npy2rtm1.1Hhz,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * BALB/cJ * C57BL/6
MGI:105374  MGI:108418  MP:0009347 increased cancellous bone thickness PMID: 12861009 
Lepob|Ppyr1tm1.1Hhz Lepob/Lepob,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * C57BL/6
MGI:104663  MGI:105374  MP:0001745 increased circulating corticosterone level PMID: 12000791 
Npy2rtm1.1Hhz|Ppyr1tm1.1Hhz Npy2rtm1.1Hhz/Npy2rtm1.1Hhz,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * C57BL/6
MGI:105374  MGI:108418  MP:0004702 increased circulating insulin-like growth factor I level PMID: 17272395 
Ppyr1tm1.1Hhz Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * C57BL/6
MGI:105374  MP:0003911 increased drinking behavior PMID: 16364461 
Npy2rtm1.1Hhz|Ppyr1tm1.1Hhz Npy2rtm1.1Hhz/Npy2rtm1.1Hhz,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * BALB/cJ * C57BL/6
MGI:105374  MGI:108418  MP:0003909 increased eating behavior PMID: 12861009 
Npy2rtm1.1Hhz|Ppyr1tm1.1Hhz Npy2rtm1.1Hhz/Npy2rtm1.1Hhz,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * C57BL/6
MGI:105374  MGI:108418  MP:0005137 increased growth hormone level PMID: 17272395 
Lepob|Ppyr1tm1.1Hhz Lepob/Lepob,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * C57BL/6
MGI:104663  MGI:105374  MP:0004909 increased seminal vesicle weight PMID: 12000791 
Lepob|Ppyr1tm1.1Hhz Lepob/Lepob,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * C57BL/6
MGI:104663  MGI:105374  MP:0005455 increased susceptibility to weight gain PMID: 12000791 
Lep+|Lepob|Ppyr1tm1.1Hhz Lepob/Lep+,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * C57BL/6
MGI:104663  MGI:105374  MP:0000008 increased white adipose tissue amount PMID: 12000791 
Ppyr1tm1Hhz Ppyr1tm1Hhz/Ppyr1tm1Hhz
involves: 129X1/SvJ * C57BL/6
MGI:105374  MP:0002169 no abnormal phenotype detected PMID: 19121371 
General Comments
For a review on NPY receptor knockout mice see [19].

REFERENCES

To cite this database page, please use the following:

Annette Beck-Sickinger, William F. Colmers, Helen M. Cox, Henri N. Doods, Herbert Herzog, Dan Larhammar, Martin C. Michel, Remi Quirion, Thue Schwartz, Thomas Westfall.
Neuropeptide Y receptors: Y4 receptor. Last modified on 19/11/2012. Accessed on 23/05/2013. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=307.


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