Nomenclature: Y4 receptor

Family: Neuropeptide Y receptors

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates. 

Contents

Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 375 10q11.2 NPY4R neuropeptide Y receptor Y4 9,20,32
Mouse 7 375 14 B Npy4r neuropeptide Y receptor Y4 9,15
Rat 7 375 16p16 Npy4r neuropeptide Y receptor Y4 21,30,32
Previous and Unofficial Names
PP1
PP1
NPY4R
Y4
NPY4-R
neuropeptide Y receptor type 4
pancreatic polypeptide receptor 1
NYYR-D
PPYR1
Ppyr1
Database Links
ChEMBL Target
Ensembl Gene
Entrez Gene
GPCRDB
GeneCards
GenitoUrinary Development Molecular Anatomy Project
HomoloGene
Human Protein Reference Database
InterPro
KEGG Gene
OMIM
PharmGKB Gene
PhosphoSitePlus
Protein Ontology (PRO)
RefSeq Nucleotide
RefSeq Protein
TreeFam
UniGene Hs.
UniProtKB
Wikipedia
Natural/Endogenous Ligands
neuropeptide Y {Sp: Human, Mouse, Rat}
pancreatic polypeptide {Sp: Human} , pancreatic polypeptide {Sp: Rat} , pancreatic polypeptide {Sp: Mouse}
Comments: peptide YY is the principal endogenous agonist
Rank order of potency (Human)
PP (PPY, P01298) > NPY (NPY, P01303) = PYY (PYY, P10082)
Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
[125I]PYY (pig) Hs Full agonist 9.8 pKd 20
pKd 9.8 [20]
[125I]GR231118 Rn Full agonist 9.6 pKd 10
pKd 9.6 [10]
pancreatic polypeptide {Sp: Rat} Mm Full agonist 10.7 pKi 28
pKi 10.7 [28]
pancreatic polypeptide {Sp: Human} Rn Full agonist 10.5 – 10.9 pKi 13,30
pKi 10.5 – 10.9 [13,30]
pancreatic polypeptide {Sp: Human} Mm Full agonist 10.6 pKi 28
pKi 10.6 [28]
pancreatic polypeptide {Sp: Rat} Rn Full agonist 10.3 – 10.8 pKi 13,21,30
pKi 10.3 – 10.8 [13,21,30]
pancreatic polypeptide {Sp: Bovine} Rn Full agonist 10.2 – 10.7 pKi 13,30
pKi 10.2 – 10.7 [13,30]
PP-(2-36) (human) Rn Full agonist 10.4 pKi 30
pKi 10.4 [30]
[Leu31,Pro34]PYY (human) Rn Full agonist 10.2 pKi 13
pKi 10.2 [13]
pancreatic polypeptide {Sp: Rat} Hs Full agonist 10.0 pKi 28
pKi 10.0 [28]
GR231118 Hs Full agonist 9.8 pKi 28
pKi 9.8 [28]
GR231118 Mm Full agonist 9.8 pKi 28
pKi 9.8 [28]
pancreatic polypeptide {Sp: Human} Hs Full agonist 8.7 – 10.9 pKi 3,20,28,32
pKi 8.7 – 10.9 [3,20,28,32]
[Leu31,Pro34]NPY Rn Full agonist 8.3 – 10.7 pKi 13,21,30
pKi 8.3 – 10.7 [13,21,30]
pKi 8.3 [30]
[Pro34]PYY (human) Mm Full agonist 9.5 pKi 28
pKi 9.5 [28]
[Ile31,Gln34]PP (human) Rn Full agonist 9.2 pKi 30
pKi 9.2 [30]
PP-(13-36) (human) Rn Full agonist 9.0 pKi 30
pKi 9.0 [30]
[Pro34]PYY (human) Hs Full agonist 8.9 pKi 28
pKi 8.9 [28]
peptide YY {Sp: Human} Hs Full agonist 8.8 pKi 20
pKi 8.8 [20]
NPY {Sp: Pig} Rn Full agonist 8.7 pKi 13
pKi 8.7 [13]
[Pro34]PYY (human) Rn Full agonist 8.6 pKi 30
pKi 8.6 [30]
PP-(20-36) (human) Rn Full agonist 8.1 pKi 30
pKi 8.1 [30]
neuropeptide Y {Sp: Human, Mouse, Rat} Hs Full agonist 8.0 pKi 20
pKi 8.0 [20]
NPY-(2-36) Rn Full agonist 7.9 pKi 13
pKi 7.9 [13]
[Leu31,Pro34]NPY Hs Full agonist 7.7 pKi 20
pKi 7.7 [20]
NPY-(3-36) (pig) Rn Full agonist 7.7 pKi 13
pKi 7.7 [13]
neuropeptide Y {Sp: Human, Mouse, Rat} Rn Full agonist 6.4 – 8.8 pKi 13,30
pKi 6.4 – 8.8 [13,30]
pKi 6.4 [30]
PYY-(3-36) {Sp: Human} Rn Full agonist 7.6 pKi 13
pKi 7.6 [13]
NPY-(2-36) (pig) Hs Full agonist 7.4 pKi 20
pKi 7.4 [20]
peptide YY {Sp: Mouse, Rat, Pig} Rn Full agonist 6.3 – 8.5 pKi 13,30
pKi 6.3 – 8.5 [13,30]
pKi 6.3 [30]
NPY-(13-36) (pig) Rn Full agonist 6.3 – 8.2 pKi 13,30
pKi 6.3 – 8.2 [13,30]
NPY-(13-36) (pig) Hs Full agonist 6.9 pKi 20
pKi 6.9 [20]
PYY-(13-36) (mouse, rat, pig) Rn Full agonist 6.2 – 7.5 pKi 13,30
pKi 7.5 [13]
pKi 6.2 [30]
peptide YY {Sp: Human} Rn Full agonist 6.4 pKi 30
pKi 6.4 [30]
PYY-(3-36) {Sp: Mouse, Rat} Rn Full agonist 6.2 pKi 30
pKi 6.2 [30]
GR231118 Rn Full agonist 9.5 pIC50 10
pIC50 9.5 [10]
[Leu31,Pro34]NPY Mm Full agonist 8.4 – 9.5 pIC50 15
pIC50 8.4 – 9.5 [15]
pancreatic polypeptide {Sp: Bovine} Hs Full agonist 8.6 pIC50 32
pIC50 8.6 [32]
[Leu31,Pro34]NPY (pig) Rn Full agonist 8.4 pIC50 10
pIC50 8.4 [10]
[Leu31,Pro34]PYY (pig) Rn Full agonist 8.0 pIC50 10
pIC50 8.0 [10]
peptide YY {Sp: Mouse, Rat, Pig} Mm Full agonist 6.3 – 8.5 pIC50 15
pIC50 6.3 – 8.5 [15]
NPY-(2-36) Mm Full agonist 5.6 – 7.1 pIC50 15
pIC50 5.6 – 7.1 [15]
[Ala31,Aib32]NPY (pig) Hs Full agonist 6.0 pIC50 6
pIC50 6.0 [6]
View species-specific agonist tables
Antagonists
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Affinity Units Reference
GR231118 Rn Antagonist 10.8 pKi 13
pKi 10.8 [13]
Primary Transduction Mechanisms
Transducer Effector/Response
Gi/Go family Adenylate cyclase inhibition
References:  22,29-30
Secondary Transduction Mechanisms
Transducer Effector/Response
Gq/G11 family Phospholipase C stimulation
References:  22
Tissue Distribution
Colon, small intestine, pancreas, prostate.
Species:  Human
Technique:  Northern blotting.
References:  20
Brain: hypothalamus, hippocampus, brainstem.
Species:  Rat
Technique:  in situ hybridisation.
References:  23
CNS: dorsal vagal complex.
Species:  Rat
Technique:  in situ hybridisation.
References:  18
Aorta, tail artery, hypothalamus, femoral artery, pulmonary artery, renal artery.
Species:  Rat
Technique:  RT-PCR.
References:  4
Proximal and distal colon.
Species:  Rat
Technique:  RT-PCR.
References:  11
Large and small intestine (epithelial and nonepithelial tissue).
Species:  Rat
Technique:  RT-PCR.
References:  14
Expression Datasets

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Functional Assays
Measurement of cAMP levels in CHO cells transfected with the human Y4 receptor.
Species:  Human
Tissue:  CHO cells.
Response measured:  Inhibition of cAMP accumulation.
References:  20
Measurement of cAMP levels in LMTK- cells transfected with the human Y4 receptor.
Species:  Human
Tissue:  LMTK- cells.
Response measured:  Inhibition of cAMP accumulation.
References:  3,30
Measurement of Ca2+ levels in LMTK- cells transfected with the human Y4 reeptor.
Species:  Human
Tissue:  LMTK- cells.
Response measured:  Stimulation of Ca2+ accumulation.
References:  3
Measurement of cAMP levels in HEK 293 cells transfected with the human Y4 receptor.
Species:  Human
Tissue:  HEK 293 cells.
Response measured:  Inhibition of cAMP accumulation.
References:  29
Physiological Functions
Modulation of food intake.
Species:  Mouse
Tissue:  In vivo.
References:  1
Contraction.
Species:  Rat
Tissue:  Colon.
References:  12,24
Stimulation of LH release.
Species:  Rat
Tissue:  In vivo.
References:  16-17,25
Inhibition of arterial neurogenic vasoconstriction.
Species:  Rat
Tissue:  Tail artery, renal artery, femoral artery.
References:  4
Inhibition of electrogenic ion transport.
Species:  Human
Tissue:  Isolated descending colon.
References:  8
Inhibition of electrogenic ion transport.
Species:  Mouse
Tissue:  Colonic mucosal preparaions.
References:  7,28
Reduced appetite and food intake.
Species:  Human
Tissue:  In vivo.
References:  5
Physiological Consequences of Altering Gene Expression
Y4 receptor knockout mice exhibit an increase in water consumption during the dark phase.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  31
Y4 receptor knockout ob/ob mice exhibit increased fertility compared to ob/ob mice.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  26
Y4 receptor knockout mice exhibit reduced vasoconstrictor and vagal inhibitory activity.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  27
Y4 receptor knockout mice do not exhibit agonist-induced inhibition of food intake, as seen in wild-type mice.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  2
Colonic mucosa from Y4 receptor knockout mice does not exhibit the agonist-induced decrease in ion transport as seen in wild-type tissues.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  28
Phenotypes, Alleles and Disease Models Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Lepob|Ppyr1tm1.1Hhz Lepob/Lepob,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * C57BL/6
MGI:104663  MGI:105374  MP:0005452 abnormal adipose tissue amount PMID: 12000791 
Npy2rtm1.1Hhz|Ppyr1tm1.1Hhz Npy2rtm1.1Hhz/Npy2rtm1.1Hhz,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * BALB/cJ * C57BL/6
MGI:105374  MGI:108418  MP:0002896 abnormal bone mineralization PMID: 12861009 
Npy2rtm1.1Hhz|Ppyr1tm1.1Hhz Npy2rtm1.1Hhz/Npy2rtm1.1Hhz,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * BALB/cJ * C57BL/6
MGI:105374  MGI:108418  MP:0003795 abnormal bone structure PMID: 12861009 
Lepob|Ppyr1tm1.1Hhz Lepob/Lepob,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * C57BL/6
MGI:104663  MGI:105374  MP:0000662 abnormal branching of the mammary ductal tree PMID: 12000791 
Npy2rtm1.1Hhz|Ppyr1tm1.1Hhz Npy2rtm1.1Hhz/Npy2rtm1.1Hhz,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * BALB/cJ * C57BL/6
MGI:105374  MGI:108418  MP:0000130 abnormal cancellous bone morphology PMID: 12861009 
Ppyr1tm1.1Hhz Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * C57BL/6
MGI:105374  MP:0008459 abnormal circulating pancreatic peptide level PMID: 12000791 
Npy2rtm1.1Hhz|Ppyr1tm1.1Hhz Npy2rtm1.1Hhz/Npy2rtm1.1Hhz,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * BALB/cJ * C57BL/6
MGI:105374  MGI:108418  MP:0008459 abnormal circulating pancreatic peptide level PMID: 12861009 
Ppyr1tm1.1Hhz Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * BALB/cJ * C57BL/6
MGI:105374  MP:0008459 abnormal circulating pancreatic peptide level PMID: 12861009 
Lepob|Ppyr1tm1.1Hhz Lepob/Lepob,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * C57BL/6
MGI:104663  MGI:105374  MP:0005180 abnormal circulating testosterone level PMID: 12000791 
Ppyr1tm1.1Hhz Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * C57BL/6
MGI:105374  MP:0001422 abnormal drinking behavior PMID: 16364461 
Lepob|Ppyr1tm1.1Hhz Lepob/Lepob,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * C57BL/6
MGI:104663  MGI:105374  MP:0001927 abnormal estrous cycle PMID: 12000791 
Ppyr1tm1.1Hhz Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * C57BL/6
MGI:105374  MP:0005334 abnormal fat pad morphology PMID: 12000791 
Lepob|Ppyr1tm1.1Hhz Lepob/Lepob,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * C57BL/6
MGI:104663  MGI:105374  MP:0002161 abnormal fertility/fecundity PMID: 12000791 
Ppyr1tm1.1Hhz Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * C57BL/6
MGI:105374  MP:0005449 abnormal food intake PMID: 12000791 
Npy2rtm1.1Hhz|Ppyr1tm1.1Hhz Npy2rtm1.1Hhz/Npy2rtm1.1Hhz,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * C57BL/6
MGI:105374  MGI:108418  MP:0003953 abnormal hormone level PMID: 17272395 
Lepob|Ppyr1tm1.1Hhz Lepob/Lepob,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * C57BL/6
MGI:104663  MGI:105374  MP:0002786 abnormal Leydig cell morphology PMID: 12000791 
Ppyr1tm1.1Hhz Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * C57BL/6
MGI:105374  MP:0006269 abnormal mammary gland growth during pregnancy PMID: 12000791 
Npy2rtm1.1Hhz|Ppyr1tm1.1Hhz Npy2rtm1.1Hhz/Npy2rtm1.1Hhz,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * BALB/cJ * C57BL/6
MGI:105374  MGI:108418  MP:0005006 abnormal osteoblast physiology PMID: 12861009 
Npy2rtm1.1Hhz|Ppyr1tm1.1Hhz Npy2rtm1.1Hhz/Npy2rtm1.1Hhz,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * BALB/cJ * C57BL/6
MGI:105374  MGI:108418  MP:0000057 abnormal osteogenesis PMID: 12861009 
Lepob|Ppyr1tm1.1Hhz Lepob/Lepob,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * C57BL/6
MGI:104663  MGI:105374  MP:0001131 abnormal ovarian follicle morphology PMID: 12000791 
Lepob|Ppyr1tm1.1Hhz Lepob/Lepob,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * C57BL/6
MGI:104663  MGI:105374  MP:0002673 abnormal sperm number PMID: 12000791 
Lepob|Ppyr1tm1.1Hhz Lepob/Lepob,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * C57BL/6
MGI:104663  MGI:105374  MP:0001142 abnormal vagina opening PMID: 12000791 
Ppyr1tm1.1Hhz Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * C57BL/6
MGI:105374  MP:0001262 decreased body weight PMID: 12000791 
Npy2rtm1.1Hhz|Ppyr1tm1.1Hhz Npy2rtm1.1Hhz/Npy2rtm1.1Hhz,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * BALB/cJ * C57BL/6
MGI:105374  MGI:108418  MP:0001262 decreased body weight PMID: 12861009 
Ppyr1tm1.1Hhz Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * BALB/cJ * C57BL/6
MGI:105374  MP:0001262 decreased body weight PMID: 12861009 
Npy2rtm1.1Hhz|Ppyr1tm1.1Hhz Npy2rtm1.1Hhz/Npy2rtm1.1Hhz,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * BALB/cJ * C57BL/6
MGI:105374  MGI:108418  MP:0001780 decreased brown adipose tissue amount PMID: 12861009 
Npy2rtm1.1Hhz|Ppyr1tm1.1Hhz Npy2rtm1.1Hhz/Npy2rtm1.1Hhz,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * BALB/cJ * C57BL/6
MGI:105374  MGI:108418  MP:0002727 decreased circulating insulin level PMID: 12861009 
Npy2rtm1.1Hhz|Ppyr1tm1.1Hhz Npy2rtm1.1Hhz/Npy2rtm1.1Hhz,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * BALB/cJ * C57BL/6
MGI:105374  MGI:108418  MP:0005668 decreased circulating leptin level PMID: 12861009 
Npy2rtm1.1Hhz|Ppyr1tm1.1Hhz Npy2rtm1.1Hhz/Npy2rtm1.1Hhz,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * BALB/cJ * C57BL/6
MGI:105374  MGI:108418  MP:0000135 decreased cortical bone thickness PMID: 12861009 
Ppyr1tm1.1Hhz Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * BALB/cJ * C57BL/6
MGI:105374  MP:0003910 decreased eating behavior PMID: 12861009 
Ppyr1tm1.1Hhz Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * BALB/cJ * C57BL/6
MGI:105374  MP:0004989 decreased osteoblast cell number PMID: 12861009 
Ppyr1tm1.1Hhz Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * C57BL/6
MGI:105374  MP:0001783 decreased white adipose tissue amount PMID: 12000791 
Npy2rtm1.1Hhz|Ppyr1tm1.1Hhz Npy2rtm1.1Hhz/Npy2rtm1.1Hhz,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * BALB/cJ * C57BL/6
MGI:105374  MGI:108418  MP:0001783 decreased white adipose tissue amount PMID: 12861009 
Ppyr1tm1.1Hhz Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * BALB/cJ * C57BL/6
MGI:105374  MP:0001783 decreased white adipose tissue amount PMID: 12861009 
Ppyr1tm1.1Hhz Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * C57BL/6
MGI:105374  MP:0001353 increased aggression towards mice PMID: 12000791 
Lep+|Lepob|Ppyr1tm1.1Hhz Lepob/Lep+,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * C57BL/6
MGI:104663  MGI:105374  MP:0001260 increased body weight PMID: 12000791 
Npy2rtm1.1Hhz|Ppyr1tm1.1Hhz Npy2rtm1.1Hhz/Npy2rtm1.1Hhz,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * BALB/cJ * C57BL/6
MGI:105374  MGI:108418  MP:0009347 increased cancellous bone thickness PMID: 12861009 
Lepob|Ppyr1tm1.1Hhz Lepob/Lepob,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * C57BL/6
MGI:104663  MGI:105374  MP:0001745 increased circulating corticosterone level PMID: 12000791 
Npy2rtm1.1Hhz|Ppyr1tm1.1Hhz Npy2rtm1.1Hhz/Npy2rtm1.1Hhz,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * C57BL/6
MGI:105374  MGI:108418  MP:0004702 increased circulating insulin-like growth factor I level PMID: 17272395 
Ppyr1tm1.1Hhz Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * C57BL/6
MGI:105374  MP:0003911 increased drinking behavior PMID: 16364461 
Npy2rtm1.1Hhz|Ppyr1tm1.1Hhz Npy2rtm1.1Hhz/Npy2rtm1.1Hhz,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * BALB/cJ * C57BL/6
MGI:105374  MGI:108418  MP:0003909 increased eating behavior PMID: 12861009 
Npy2rtm1.1Hhz|Ppyr1tm1.1Hhz Npy2rtm1.1Hhz/Npy2rtm1.1Hhz,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * C57BL/6
MGI:105374  MGI:108418  MP:0005137 increased growth hormone level PMID: 17272395 
Lepob|Ppyr1tm1.1Hhz Lepob/Lepob,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * C57BL/6
MGI:104663  MGI:105374  MP:0004909 increased seminal vesicle weight PMID: 12000791 
Lepob|Ppyr1tm1.1Hhz Lepob/Lepob,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * C57BL/6
MGI:104663  MGI:105374  MP:0005455 increased susceptibility to weight gain PMID: 12000791 
Lep+|Lepob|Ppyr1tm1.1Hhz Lepob/Lep+,Ppyr1tm1.1Hhz/Ppyr1tm1.1Hhz
involves: 129X1/SvJ * C57BL/6
MGI:104663  MGI:105374  MP:0000008 increased white adipose tissue amount PMID: 12000791 
Ppyr1tm1Hhz Ppyr1tm1Hhz/Ppyr1tm1Hhz
involves: 129X1/SvJ * C57BL/6
MGI:105374  MP:0002169 no abnormal phenotype detected PMID: 19121371 
General Comments
For a review on NPY receptor knockout mice see [19].
Available Assays
DiscoveRx PathHunter® CHO-K1 PPYR1 β-Arrestin Cell Line (Cat no. 93-0233C2)
PathHunter® eXpress PPYR1 CHO-K1 β-Arrestin GPCR Assay (Cat no. 93-0233E2CP0M)
more info

REFERENCES

1. Asakawa A, Inui A, Ueno N, Fujimiya M, Fujino MA, Kasuga M. (1999) Mouse pancreatic polypeptide modulates food intake, while not influencing anxiety in mice. Peptides20: 1445-1448. [PMID:10698120]

2. Balasubramaniam A, Mullins DE, Lin S, Zhai W, Tao Z, Dhawan VC, Guzzi M, Knittel JJ, Slack K, Herzog H, Parker EM. (2006) Neuropeptide Y (NPY) Y4 receptor selective agonists based on NPY(32-36): development of an anorectic Y4 receptor selective agonist with picomolar affinity. J Med Chem49: 2661-2665. [PMID:16610810]

3. Bard JA, Walker MW, Branchek TA, Weinshank RL. (1995) Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY. J Biol Chem270: 26762-26765. [PMID:7592911]

4. Barrios VE, Sun J, Douglass J, Toombs CF. (1999) Evidence of a specific pancreatic polypeptide receptor in rat arterial smooth muscle. Peptides20: 1107-1113. [PMID:10499429]

5. Batterham RL, Le Roux CW, Cohen MA, Park AJ, Ellis SM, Patterson M, Frost GS, Ghatei MA, Bloom SR. (2003) Pancreatic polypeptide reduces appetite and food intake in humans. J Clin Endocrinol Metab88: 3989-3992. [PMID:12915697]

6. Cabrele C, Wieland HA, Koglin N, Stidsen C, Beck-Sickinger AG. (2002) Ala31-Aib32: identification of the key motif for high affinity and selectivity of neuropeptide Y at the Y5-receptor. Biochemistry41: 8043-8049. [PMID:12069595]

7. Cox HM, Pollock EL, Tough IR, Herzog H. (2001) Multiple Y receptors mediate pancreatic polypeptide responses in mouse colon mucosa. Peptides22: 445-452. [PMID:11287100]

8. Cox HM, Tough IR. (2002) Neuropeptide Y, Y1, Y2 and Y4 receptors mediate Y agonist responses in isolated human colon mucosa. Br J Pharmacol135: 1505-1512. [PMID:11906964]

9. Darby K, Eyre HJ, Lapsys N, Copeland NG, Gilbert DJ, Couzens M, Antonova O, Sutherland GR, Jenkins NA, Herzog H. (1997) Assignment of the Y4 receptor gene (PPYR1) to human chromosome 10q11.2 and mouse chromosome 14. Genomics46: 513-515. [PMID:9441761]

10. Dumont Y, Quirion R. (2000) [(125)I]-GR231118: a high affinity radioligand to investigate neuropeptide Y Y(1) and Y(4) receptors. Br J Pharmacol129: 37-46. [PMID:10694200]

11. Ferrier L, Segain JP, Bonnet C, Cherbut C, Lehur PA, Jarry A, Galmiche JP, Blottiere HM. (2002) Functional mapping of NPY/PYY receptors in rat and human gastro-intestinal tract. Peptides23: 1765-1771. [PMID:12383864]

12. Félétou M, Rodriguez M, Beauverger P, Germain M, Imbert J, Dromaint S, Macia C, Bourrienne A, Henlin JM, Nicolas JP, Boutin JA, Galizzi JP, Fauchere JL, Canet E, Duhault J. (1998) NPY receptor subtypes involved in the contraction of the proximal colon of the rat. Regul Pept75-76: 221-229. [PMID:9802413]

13. Gehlert DR, Schober DA, Gackenheimer SL, Beavers L, Gadski R, Lundell I, Larhammar D. (1997) [125I]Leu31, Pro34-PYY is a high affinity radioligand for rat PP1/Y4 and Y1 receptors: evidence for heterogeneity in pancreatic polypeptide receptors. Peptides18: 397-401. [PMID:9145427]

14. Goumain M, Voisin T, Lorinet AM, Laburthe M. (1998) Identification and distribution of mRNA encoding the Y1, Y2, Y4, and Y5 receptors for peptides of the PP-fold family in the rat intestine and colon. Biochem Biophys Res Commun247: 52-56. [PMID:9636652]

15. Gregor P, Millham ML, Feng Y, DeCarr LB, McCaleb ML, Cornfield LJ. (1996) Cloning and characterization of a novel receptor to pancreatic polypeptide, a member of the neuropeptide Y receptor family. FEBS Lett381: 58-62. [PMID:8641440]

16. Horvath TL, Pu S, Dube MG, Diano S, Kalra SP. (2001) A GABA-neuropeptide Y (NPY) interplay in LH release. Peptides22: 473-481. [PMID:11287104]

17. Jain MR, Pu S, Kalra PS, Kalra SP. (1999) Evidence that stimulation of two modalities of pituitary luteinizing hormone release in ovarian steroid-primed ovariectomized rats may involve neuropeptide Y Y1 and Y4 receptors. Endocrinology140: 5171-5177. [PMID:10537146]

18. Larsen PJ, Kristensen P. (1997) The neuropeptide Y (Y4) receptor is highly expressed in neurones of the rat dorsal vagal complex. Brain Res Mol Brain Res48: 1-6. [PMID:9379829]

19. Lin S, Boey D, Herzog H. (2004) NPY and Y receptors: lessons from transgenic and knockout models. Neuropeptides38: 189-200. [PMID:15337371]

20. Lundell I, Blomqvist AG, Berglund MM, Schober DA, Johnson D, Statnick MA, Gadski RA, Gehlert DR, Larhammar D. (1995) Cloning of a human receptor of the NPY receptor family with high affinity for pancreatic polypeptide and peptide YY. J Biol Chem270: 29123-29128. [PMID:7493937]

21. Lundell I, Statnick MA, Johnson D, Schober DA, Starbäck P, Gehlert DR, Larhammar D. (1996) The cloned rat pancreatic polypeptide receptor exhibits profound differences to the orthologous receptor. Proc Natl Acad Sci U S A93: 5111-5115. [PMID:8643536]

22. Misra S, Murthy KS, Zhou H, Grider JR. (2004) Coexpression of Y1, Y2, and Y4 receptors in smooth muscle coupled to distinct signaling pathways. J Pharmacol Exp Ther311: 1154-1162. [PMID:15308651]

23. Parker RM, Herzog H. (1999) Regional distribution of Y-receptor subtype mRNAs in rat brain. Eur J Neurosci11: 1431-1448. [PMID:10103138]

24. Pheng LH, Perron A, Quirion R, Cadieux A, Fauchere JL, Dumont Y, Regoli D. (1999) Neuropeptide Y-induced contraction is mediated by neuropeptide Y Y2 and Y4 receptors in the rat colon. Eur J Pharmacol374: 85-91. [PMID:10422644]

25. Raposinho PD, Broqua P, Hayward A, Akinsanya K, Galyean R, Schteingart C, Junien J, Aubert ML. (2000) Stimulation of the gonadotropic axis by the neuropeptide Y receptor Y1 antagonist/Y4 agonist 1229U91 in the male rat. Neuroendocrinology71: 2-7. [PMID:10644893]

26. Sainsbury A, Schwarzer C, Couzens M, Jenkins A, Oakes SR, Ormandy CJ, Herzog H. (2002) Y4 receptor knockout rescues fertility in ob/ob mice. Genes Dev16: 1077-1088. [PMID:12000791]

27. Smith-White MA, Herzog H, Potter EK. (2002) Cardiac function in neuropeptide Y Y4 receptor-knockout mice. Regul Pept110: 47-54. [PMID:12468109]

28. Tough IR, Holliday ND, Cox HM. (2006) Y(4) receptors mediate the inhibitory responses of pancreatic polypeptide in human and mouse colon mucosa. J Pharmacol Exp Ther319: 20-30. [PMID:16807358]

29. Voisin T, Goumain M, Lorinet AM, Maoret JJ, Laburthe M. (2000) Functional and molecular properties of the human recombinant Y4 receptor: resistance to agonist-promoted desensitization. J Pharmacol Exp Ther292: 638-646. [PMID:10640301]

30. Walker MW, Smith KE, Bard J, Vaysse PJ, Gerald C, Daouti S, Weinshank RL, Branchek TA. (1997) A structure-activity analysis of the cloned rat and human Y4 receptors for pancreatic polypeptide. Peptides18: 609-612. [PMID:9210181]

31. Wultsch T, Painsipp E, Donner S, Sperk G, Herzog H, Peskar BA, Holzer P. (2006) Selective increase of dark phase water intake in neuropeptide-Y Y2 and Y4 receptor knockout mice. Behav Brain Res168: 255-260. [PMID:16364461]

32. Yan H, Yang J, Marasco J, Yamaguchi K, Brenner S, Collins F, Karbon W. (1996) Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors. Proc Natl Acad Sci U S A93: 4661-4665. [PMID:8643460]

To cite this database page, please use the following:

Annette Beck-Sickinger, William F. Colmers, Helen M. Cox, Henri N. Doods, Herbert Herzog, Dan Larhammar, Martin C. Michel, Remi Quirion, Thue Schwartz, Thomas Westfall.
Neuropeptide Y receptors: Y4 receptor. Last modified on 12/02/2014. Accessed on 20/08/2014. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=307.

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