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NPS

Previous and Unofficial Names
GPR154
VRR1
GPRA
Structural Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Name Reference
Human 7 371 7p14.3 NPSR1 2-5
Rat 7 371 8q13 Npsr1
Mouse 7 371 9 A4 Npsr1 1
Contents:
Previous and Unofficial Names
Structural Information
Database Links
Agonists
Transduction Mechanisms
Tissue Distribution
Physiological Functions
Biologically Significant Variants
Receptor Comments
Database Links
ChEMBL Target 100871 (Mm)
Ensembl ENSG00000187258 (Hs), ENSMUSG00000043659 (Mm), ENSRNOG00000015863 (Rn)
Entrez Gene 387129 (Hs), 319239 (Mm)
GeneCards NPSR1 (Hs)
HomoloGene 45515 (Hs)
OMIM 608595 (Hs)
PharmGKB Gene PA134951416 (Hs)
Protein Ontology (PRO) PRO:000001491 (Hs)
RefSeq Nucleotide NM_207172 (Hs), NM_175678 (Mm)
RefSeq Protein NP_997055 (Hs), NP_783609 (Mm)
UniGene Hs. 453723 (Hs)
UniProt Q56H78 (Hs), Q8BZP8 (Mm), P0COL6 (Rn)
Wikipedia NPS
Search for 3D structures on the PDB
Search using keywords: Neuropeptide S receptor NPS Search using accession numbers: P0COL6 || Q56H78 || Q8BZP8
Agonists
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Affinity Units Reference
[125I]Tyr10NPS (human) Hs Full agonist 9.5 pKd 2
NPS (mouse) Hs Full agonist 8.5 pEC50 2
NPS (rat) Hs Full agonist 8.5 pEC50 2
NPS (human) Hs Full agonist 8.0 pEC50 2
Agonist Comments
[125I]-Tyr10-hNPS = [125I]-Tyr10 Neuropeptide S (human).
Primary Transduction Mechanisms
Transducer Effector/Response
Gq/G11 family Phospholipase C stimulation
References:  2
Secondary Transduction Mechanisms
Transducer Effector/Response
Gs family Adenylate cyclase stimulation
References:  4
Tissue Distribution
Brain: anterior olfactory nucleus, dorsal and ventral endopiriform nucleus, amygdala, precommissural nucleus, paraventricular thalamic nucleus, subiculum, motor cortex 2, retrosplenial agranular cortex, somatosensory cortex, hypothalamus, midbrain.
Species:  Rat
Technique:  in situ hybridisation.
References:  2
Isoform A (371 amino acids) is found in bronchial smooth muscle cells, basally in colon epithelium and in occasional basal keratinocytes in skin.
Species:  Human
Technique:  immunocytochemistry.
References:  3
Isoform B (377 amino acids) is found in apical epithelial cells in the bronchus and gut and in all layers of the epidermis.
Species:  Human
Technique:  immunocytochemistry.
References:  3
Brain: Hypothalamus > midbrain, forebrain > cortex, brainstem >hippocampus.
Species:  Rat
Technique:  RT-PCR.
References:  2
Brain > salivary gland > thyroid, mammary gland > testis.
Species:  Rat
Technique:  RT-PCR
References:  2
Physiological Functions
When injected centrally, NPS produces a long-lasting arousal, increasing locomotor activity.
Species:  Mouse
Tissue:  In vivo
References:  2
When injected centrally, NPS promotes wakefulness and decreases both REM sleep and slow wave sleep.
Species:  Rat
Tissue:  In vivo
References:  2
Reduces anxiety-like behaviour when injected centrally.
Species:  Mouse
Tissue:  In vivo
References:  2
Biologically Significant Variants
An Asn107->Ile mutation is significantly up-regulated in a mouse model of ovalbumen-induced lung inflammation supporting a role in the pathogenesis of asthma.
Type:  Single nucleotide polymorphism.
Species:  Human
References:  3
A splice variant (isoform B) with an alternative 3' exon, encodes a protein of 377 amino acids.
Type:  Splice variants.
Species:  Human
References:  3
Receptor Comments
NPS precursor mRNA is highly expressed in a cluster of neurons located adjacent to the Locus coeruleus[2]

To cite this receptor data page, please use the following:

Olivier Civelli, Dr. Rainer K. Reinscheid.
Neuropeptide S receptor: NPS. Last modified on 2010-06-30. Accessed on 2010-09-10. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=302.


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