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NMU2 receptor

Family: Neuromedin U receptors

Contents:
Gene and Protein Information
Previous and Unofficial Names
Database Links
Agonists
Antagonists
Transduction Mechanisms
Tissue Distribution
Expression Datasets
Functional Assays
Physiological Functions
Phenotypes, Alleles and Disease Models
References
Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 412 5q33.1 NMUR2 neuromedin U receptor 2 4,18,37,41
Mouse 7 395 11 B1.3 Nmur2 neuromedin U receptor 2 9
Rat 7 395 10q22 Nmur2 neuromedin U receptor 2 18
Structural Information Comments
For human NMU2, sequences encoding both 412 and 415 amino acids have been reported as a consequence of the presence of two potential translation initiation sites. It is unclear which form is expressed physiologically, although there is circumstantial evidence to favour the shorter form [4].
There is evidence for the existence of receptor haplotypes [3].
Previous and Unofficial Names
Names References
FM-4 18
FM4 46
SNORF72 37
G-protein coupled receptor TGR-1
G-protein-coupled receptor FM-4
neuromedin U receptor 2
NMU-R2 41
TGR-1 17
NMU2R
Database Links
Ensembl ENSG00000132911 (Hs), ENSMUSG00000037393 (Mm), ENSRNOG00000014081 (Rn)
Entrez Gene 56923 (Hs), 216749 (Mm), 64042 (Rn)
GeneCards NMUR2 (Hs)
GenitoUrinary Development Molecular Anatomy Project Nmur2 (Mm)
HomoloGene 49618 (Hs)
Human Protein Reference Database 12003 (Hs)
InterPro Q9GZQ4 (Hs), Q91Z76 (Mm), Q9JIB1 (Rn)
KEGG Gene hsa:56923 (Hs), mmu:216749 (Mm), rno:64042 (Rn)
OMIM 605108 (Hs)
PharmGKB Gene PA31664 (Hs)
PhosphoSitePlus Q9GZQ4 (Hs), Q8BZ39 (Mm), Q9ESQ4 (Rn)
Protein Ontology (PRO) PRO:000001619 (Hs)
RefSeq Nucleotide NM_020167 (Hs), NM_153079 (Mm), NM_022275 (Rn)
RefSeq Protein NP_064552 (Hs), NP_694719 (Mm), NP_071611 (Rn)
TreeFam ENSG00000132911 (Hs), ENSMUSG00000037393 (Mm), ENSRNOG00000014081 (Rn)
UniGene Hs. 283093 (Hs)
UniProt Q9GZQ4 (Hs), Q91Z76 (Mm), Q9JIB1 (Rn)
Wikipedia NMU2 receptor
Neuromedin U receptors
Search for 3D structures on the PDB
Search by keyword: Neuromedin U receptors NMU2 receptor Search by accession number: Q9JIB1, Q9GZQ4, Q91Z76
Natural/Endogenous Ligand(s)
neuromedin S-33 {Sp: Human}
neuromedin S-36 {Sp: Mouse} , neuromedin S-36 {Sp: Rat}
neuromedin U-23 {Sp: Rat}
neuromedin U-25 {Sp: Human}
Agonists
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Affinity Units Reference
[125I]neuromedin U-25 (human) Hs Agonist 9.8 pKd 1,5
[125I]neuromedin U-23 (rat) Hs Agonist 9.1 pKd 37
[125I]neuromedin U-8 (pig) Hs Agonist 9.1 pKd 37
neuromedin U-25 {Sp: Pig} Hs Agonist 9.9 pKi 1
neuromedin U-23 {Sp: Rat} Hs Agonist 9.7 pKi 1
neuromedin U-25 {Sp: Human} Hs Agonist 9.6 pKi 1
neuromedin U-8 {Sp: Pig} Hs Agonist 9.3 pKi 1
neuromedin U-8 {Sp: Dog} Hs Agonist 8.1 pKi 1
neuromedin S-33 {Sp: Human} Hs Full agonist 10.0 pEC50 28
neuromedin U-8 {Sp: Pig} Hs Full agonist 8.5 – 9.5 pEC50 1,18,37
neuromedin U-23 {Sp: Rat} Hs Full agonist 8.5 – 9.3 pEC50 1,18,37
neuromedin U-25 {Sp: Human} Hs Full agonist 8.4 – 9.4 pEC50 1,5,18,37
neuromedin U-25 {Sp: Pig} Hs Full agonist 8.6 – 9.0 pEC50 1,18,37
neuromedin S-33 {Sp: Human} Hs Agonist 9.2 pIC50 28
Agonist Comments
1) pIC50 for neuromedin S is determined against 50pM [125I-Tyr0]-neuromedin S
2) Agonism and pEC50 values are based on Ca2+ signaling by recombinant receptors expressed in cell lines.
Antagonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
R-PSOP Hs Antagonist 7.04 pKB 27
Primary Transduction Mechanisms
Transducer Effector/Response
Gq/G11 family Phospholipase C stimulation
Comments:  Coupling to Gi/G0 G proteins has been identified as evidenced by inhibition of forskolin-induced cAMP accumulation [1,5,17,19].
References:  1,5,37,41-42
Tissue Distribution
Peripherally: in testis and lung.
Centrally: in spinal cord, hippocampus, medulla oblongata, pontine reticular formation, thalamus and hypothalamus and cortex.
Also found to be overexpressed in pancreatic ductal adenocarcinoma and in metastatic tissues.
Species:  Human
Technique:  Northern blot, quantitative PCR, in situ hybridization
References:  18,24,37,41
A similar pattern to that of human:
Expression in medulla, spinal cord, hypothalamus, thalamus, midbrain, and pons. More specifically in the hypothalamus in the paraventricular nucleus (PVN), the wall of the third ventricle, arcuate nucleus in dispersed and punctuate manner, dorsal and lateral arcuate nucleus around the periphery of the ventromedial hypothalamus (VMH).
Species:  Mouse
Technique:  Northern blot, quantitative PCR, in situ hybridization
References:  9,11
A similar pattern to that of human:
Expression in hypothalamus, hippocampus and spinal cord. More specifically in the hypothalamus in the paraventricular nucleus (PVN), the wall of the third ventricle, the mediopostal region of the arcuate, and in the CA1 region of the hippocampus, medulla oblongata and striatum. Greatest expression in the uterus and ovary.
Species:  Rat
Technique:  Northern blot, in situ hybridization, quantitative PCR
References:  7,10-11,13,17-18
Expression Datasets

Click here to show/hide data

Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Functional Assays
Cells transfected with NMU2.
Species:  Human
Tissue:  HEK-293, CHO and COS-7 cells.
Response measured:  Increase in intracellular calcium, inositol phosphate generation, inhibition of forskolin-stimulated cAMP generation, ERK activation, G-protein activation.
References:  1,5,17-18,37,41
Cells transfected with NMU2.
Species:  Mouse
Tissue:  HEK-293 cells.
Response measured:  Increase in intracellular calcium.
References:  9
Physiological Functions Comments
Evidence across species (human, rat, mouse) for involvement in a range of patho-physiological aspects including:
Inhibition of food intake and increase energy expenditure [2,11,15-16,18,20,22-23,25-26,31,33,35,47,50].
Stimulation of stress response and hypothalamic-pituitary-adrenal axis [14,18,21,34,43,45,47,51].
Regulation of reproductive system hormones [8,32,34,36,39,46,48].
Pro-nociceptive effect [6,30,44,49-50].
Inhibition of bone formation and remodeling [38,40].
Regulation of circadian rhythm [12,28-30].
Pancreatic cancer [24].
Phenotypes, Alleles and Disease Models Mouse data from MGI

Click here to show/hide data

Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Nmur2m1Hzg Nmur2m1Hzg/Nmur2m1Hzg
involves: 129/Sv * 129S1/SvImJ * C57BL/6		 MGI:2441765  MP:0005449 abnormal food intake PMID: 17030627 
Nmur2m1Hzg Nmur2m1Hzg/Nmur2m1Hzg
involves: 129/Sv * 129S1/SvImJ * C57BL/6		 MGI:2441765  MP:0001970 abnormal pain threshold PMID: 17030627 
Nmur2tm1Dgen Nmur2tm1Dgen/Nmur2tm1Dgen
B6N.Cg-Nmur2		 MGI:2441765  MP:0003638 abnormal response/metabolism to endogenous compounds PMID: 19324999 
Nmur2tm1.1Eege Nmur2tm1.1Eege/Nmur2tm1.1Eege
involves: 129S1/Sv * 129X1/SvJ * C57BL/6		 MGI:2441765  MP:0003638 abnormal response/metabolism to endogenous compounds PMID: 19584200 
Nmur2tm1Dgen Nmur2tm1Dgen/Nmur2tm1Dgen
B6N.Cg-Nmur2		 MGI:2441765  MP:0001262 decreased body weight PMID: 19324999 
Nmur2tm1Dgen Nmur2tm1Dgen/Nmur2tm1Dgen
B6N.Cg-Nmur2		 MGI:2441765  MP:0005560 decreased circulating glucose level PMID: 19324999 
Nmur2tm1Dgen Nmur2tm1Dgen/Nmur2tm1Dgen
B6N.Cg-Nmur2		 MGI:2441765  MP:0005668 decreased circulating leptin level PMID: 19324999 
Nmur2m1Hzg Nmur2m1Hzg/Nmur2m1Hzg
involves: 129/Sv * 129S1/SvImJ * C57BL/6		 MGI:2441765  MP:0003910 decreased eating behavior PMID: 17030627 
Nmur2tm1Dgen Nmur2tm1Dgen/Nmur2tm1Dgen
B6N.Cg-Nmur2		 MGI:2441765  MP:0003910 decreased eating behavior PMID: 19324999 
Nmur2m1Hzg Nmur2m1Hzg/Nmur2m1Hzg
involves: 129/Sv * 129S1/SvImJ * C57BL/6		 MGI:2441765  MP:0001442 decreased grooming behavior PMID: 17030627 
Nmur2tm1Dgen Nmur2tm1Dgen/Nmur2tm1Dgen
B6N.Cg-Nmur2		 MGI:2441765  MP:0003961 decreased lean body mass PMID: 19324999 
Nmur2tm1Dgen Nmur2tm1Dgen/Nmur2tm1Dgen
B6N.Cg-Nmur2		 MGI:2441765  MP:0010025 decreased total body fat amount PMID: 19324999 
Nmur2tm1Rtor Nmur2tm1Rtor/Nmur2tm1Rtor
involves: 129S1/Sv * C57BL/6NTac		 MGI:2441765  MP:0008531 increased chemical nociceptive threshold PMID: 17379411 
Nmur2tm1Dgen Nmur2tm1Dgen/Nmur2tm1Dgen
B6N.Cg-Nmur2		 MGI:2441765  MP:0005659 increased resistance to diet-induced obesity PMID: 19324999 
Nmur2tm1.1Eege Nmur2tm1.1Eege/Nmur2tm1.1Eege
involves: 129S1/Sv * 129X1/SvJ * C57BL/6		 MGI:2441765  MP:0005658 increased susceptibility to diet-induced obesity PMID: 19584200 
Nmur2tm1.1Eege Nmur2tm1.1Eege/Nmur2tm1.1Eege
involves: 129S1/Sv * 129X1/SvJ * C57BL/6		 MGI:2441765  MP:0005455 increased susceptibility to weight gain PMID: 19584200 
Nmur2m1Hzg Nmur2m1Hzg/Nmur2m1Hzg
involves: 129/Sv * 129S1/SvImJ * C57BL/6		 MGI:2441765  MP:0001973 increased thermal nociceptive threshold PMID: 17030627 
Nmur1tm1Rtor|Nmur2tm1Rtor Nmur1tm1Rtor/Nmur1tm1Rtor,Nmur2tm1Rtor/Nmur2tm1Rtor
involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6NCr * C57BL/6NTac		 MGI:1341898  MGI:2441765  MP:0001973 increased thermal nociceptive threshold PMID: 17379411 
Nmur2tm1Rtor Nmur2tm1Rtor/Nmur2tm1Rtor
involves: 129S1/Sv * C57BL/6NTac		 MGI:2441765  MP:0001973 increased thermal nociceptive threshold PMID: 17379411 
Nmur2tm1.1Eege Nmur2tm1.1Eege/Nmur2tm1.1Eege
involves: 129S1/Sv * 129X1/SvJ * C57BL/6		 MGI:2441765  MP:0010024 increased total body fat amount PMID: 19584200 
Nmur2tm1Dgen Nmur2tm1Dgen/Nmur2tm1Dgen
B6N.Cg-Nmur2		 MGI:2441765  MP:0008489 postnatal slow weight gain PMID: 19324999 

REFERENCES

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36. Quan, H; Funabashi, T; Furuta, M; Kimura, F. (2003) Effects of neuromedin U on the pulsatile LH secretion in ovariectomized rats in association with feeding conditions. Biochem. Biophys. Res. Commun., 311 (3): 721-7. [PMID:14623332]

37. Raddatz, R., Wilson, A. E., Artymyshyn, R., Bonini, J. A., Borowsky, B., Boteju, L. W., Zhou, S., Kouranova, E. V., Nagorny, R., Guevarra, M. S., Dai, M., Lerman, G. S., Vaysse, P. J., Branchek, T. A., Gerald, C., Forray, C. and Adham, N. (2000) Identification and characterization of two neuromedin U receptors differentially expressed in peripheral tissues and the central nervous system. J. Biol. Chem., 275: 32452-32459. [PMID:10899166]

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To cite this database page, please use the following:

Gary B. Willars, Khaled Al-hosaini.
Neuromedin U receptors: NMU2 receptor. Last modified on 04/03/2013. Accessed on 19/05/2013. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=299.


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