1. Audinot, V., Lahaye, C., Suply, T., Beauverger, P., Rodriguez, M., Galizzi, J. P., Fauchere, J. L. and Boutin, J. A. (2001) [125I]-S36057: a new and highly potent radioligand for the melanin-concentrating hormone receptor.
Br J Pharmacol, 133: 371-378.
[PMID:11375253]
2. Audinot, V; Zuana, OD; Fabry, N; Ouvry, C; Nosjean, O; Henlin, JM; Fauchère, JL; Boutin, JA. (2009) S38151 [p-guanidinobenzoyl-[Des-Gly(10)]-MCH(7-17)] is a potent and selective antagonist at the MCH(1) receptor and has anti-feeding properties in vivo.
Peptides, 30 (11): 1997-2007.
[PMID:19619599]
3. Bednarek, M. A., Hreniuk, D. L., Tan, C., Palyha, O. C., MacNeil, D. J., Van der Ploeg, L. H., Howard, A. D. and Feighner, S. D. (2002) Synthesis and biological evaluation in vitro of selective, high affinity peptide antagonists of human melanin-concentrating hormone action at human melanin-concentrating hormone receptor 1.
Biochemistry, 41: 6383-6390.
[PMID:12009900]
4. Borowsky, B., Durkin, M. M., Ogozalek, K., Marzabadi, M. R., DeLeon, J., Lagu, B., Heurich, R., Lichtblau, H., Shaposhnik, Z., Daniewska, I., Blackburn, T. P., Branchek, T. A., Gerald, C., Vaysse, P. J. and Forray, C. (2002) Antidepressant, anxiolytic and anorectic effects of a melanin-concentrating hormone-1 receptor antagonist.
Nat Med, 8: 825-830.
[PMID:12118247]
5. Burgaud, JL; Poosti, R; Fehrentz, JA; Martinez, J; Nahon, JL. (1997) Melanin-concentrating hormone binding sites in human SVK14 keratinocytes.
Biochem. Biophys. Res. Commun., 241 (3): 622-9.
[PMID:9434758]
6. Bächner, D., Kreienkamp, H., Weise, C., Buck, F. and Richter, D. (1999) Identification of melanin concentrating hormone (MCH) as the natural ligand for the orphan somatostatin-like receptor 1 (SLC-1).
FEBS Lett, 457: 522-524.
[PMID:10471841]
7. Chaki, S., Funakoshi, T., Hirota-Okuno, S., Nishiguchi, M., Shimazaki, T., Iijima, M., Grottick, A. J., Kanuma, K., Omodera, K., Sekiguchi, Y., Okuyama, S., Tran, T. A., Semple, G. and Thomsen, W. (2005) Anxiolytic- and antidepressant-like profile of ATC0065 and ATC0175: nonpeptidic and orally active melanin-concentrating hormone receptor 1 antagonists.
J Pharmacol Exp Ther, 313: 831-839.
[PMID:15677346]
8. Chambers, J., Ames, R. S., Bergsma, D., Muir, A., Fitzgerald, L. R., Hervieu, G., Dytko, G. M., Foley, J. J., Martin, J., Liu, W. S., Park, J., Ellis, C., Ganguly, S., Konchar, S., Cluderay, J., Leslie, R., Wilson, S. and Sarau, H. M. (1999) Melanin-concentrating hormone is the cognate ligand for the orphan G-protein-coupled receptor SLC-1.
Nature, 400: 261-265.
[PMID:10421367]
9. Chen, Y., Hu, C., Hsu, C. K., Zhang, Q., Bi, C., Asnicar, M., Hsiung, H. M., Fox, N., Slieker, L. J., Yang, D. D., Heiman, M. L. and Shi, Y. (2002) Targeted disruption of the melanin-concentrating hormone receptor-1 results in hyperphagia and resistance to diet-induced obesity.
Endocrinology, 143: 2469-2477.
[PMID:12072376]
10. David, D. J., Klemenhagen, K. C., Holick, K. A., Saxe, M. D., Mendez, I., Santarelli, L., Craig, D., Zong, H., Swanson, C., Hegde, L. G., Ping, X. I., Dong, D., Marzabadi, M. R., Gerald, C. and Hen, R. (2007) Efficacy of the MCHR1 antagonist N-[3-(1-{[4-(3,4-difluorophenoxy)phenyl]methyl}(4-piperidyl))-4-methylphenyl]-2-methylpropanamide (SNAP 94847) in mouse models of anxiety and depression following acute and chronic administration is independent of hippocampal neurogenesis.
J Pharmacol Exp Ther, : -.
[PMID:17237257]
11. Duncan, E. A., Rider, T. R., Jandacek, R. J., Clegg, D. J., Benoit, S. C., Tso, P. and Woods, S. C. (2006) The regulation of alcohol intake by melanin-concentrating hormone in rats.
Pharmacol Biochem Behav, 85: 728-735.
[PMID:17188345]
12. Frezzotti, R. and Caporossi, A. (1990) Pathogenesis of posterior capsular opacification. Part I. Epidemiological and clinico-statistical data.
J Cataract Refract Surg, 16: 347-352.
[PMID:2355323]
13. Georgescu, D., Sears, R. M., Hommel, J. D., Barrot, M., Bolaños, C. A., Marsh, D. J., Bednarek, M. A., Bibb, J. A., Maratos-Flier, E., Nestler, E. J. and DiLeone, R. J. (2005) The hypothalamic neuropeptide melanin-concentrating hormone acts in the nucleus accumbens to modulate feeding behavior and forced-swim performance.
J Neurosci, 25: 2933-2940.
[PMID:15772353]
14. Guo, T., Gu, H., Hobbs, D. W., Busler, D. E. and Rokosz, L. L. (2007) Discovery of tetralin ureas as potent melanin concentrating hormone 1 receptor antagonists.
Bioorg Med Chem Lett, 17: 1718-1721.
[PMID:17251014]
15. Hawes, B. E., Kil, E., Green, B., O'Neill, K., Fried, S. and Graziano, M. P. (2000) The melanin-concentrating hormone receptor couples to multiple G proteins to activate diverse intracellular signaling pathways.
Endocrinology, 141: 4524-4532.
[PMID:11108264]
16. Hertzog, DL; Al-Barazanji, KA; Bigham, EC; Bishop, MJ; Britt, CS; Carlton, DL; Cooper, JP; Daniels, AJ; Garrido, DM; Goetz, AS; et al.. (2006) The discovery and optimization of pyrimidinone-containing MCH R1 antagonists.
Bioorg. Med. Chem. Lett., 16 (18): 4723-7.
[PMID:16870432]
17. Hervieu, G. J., Cluderay, J. E., Harrison, D., Meakin, J., Maycox, P., Nasir, S. and Leslie, R. A. (2000) The distribution of the mRNA and protein products of the melanin-concentrating hormone (MCH) receptor gene, slc-1, in the central nervous system of the rat.
Eur J Neurosci, 12: 1194-1216.
[PMID:10762350]
18. Hill, J., Duckworth, M., Murdock, P., Rennie, G., Sabido-David, C., Ames, R. S., Szekeres, P., Wilson, S., Bergsma, D. J., Gloger, I. S., Levy, D. S., Chambers, J. K. and Muir, A. I. (2001) Molecular cloning and functional characterization of MCH2, a novel human MCH receptor.
J Biol Chem, 276: 20125-20129.
[PMID:11274220]
19. Kokkotou, E. G., Tritos, N. A., Mastaitis, J. W., Slieker, L. and Maratos-Flier, E. (2001) Melanin-concentrating hormone receptor is a target of leptin action in the mouse brain.
Endocrinology, 142: 680-686.
[PMID:11159839]
20. Kolakowski, L. F., Jung, B. P., Nguyen, T., Johnson, M. P., Lynch, K. R., Cheng, R., Heng, H. H., George, S. R. and O'Dowd, B. F. (1996) Characterization of a human gene related to genes encoding somatostatin receptors.
FEBS Lett, 398: 253-258.
[PMID:8977118]
21. Kowalski, T. J., Farley, C., Cohen-Williams, M. E., Varty, G. and Spar, B. D. (2004) Melanin-concentrating hormone-1 receptor antagonism decreases feeding by reducing meal size.
Eur J Pharmacol, 497: 41-47.
[PMID:15321733]
22. Lakaye, B., Minet, A., Zorzi, W. and Grisar, T. (1998) Cloning of the rat brain cDNA encoding for the SLC-1 G protein-coupled receptor reveals the presence of an intron in the gene.
Biochim Biophys Acta, 1401: 216-220.
[PMID:9531978]
23. Lalonde, R. and Qian, S. (2007) Exploratory activity, motor coordination, and spatial learning in Mchr1 knockout mice.
Behav Brain Res, 178: 293-304.
[PMID:17270288]
24. Lembo, P. M., Grazzini, E., Cao, J., Hubatsch, D. A., Pelletier, M., Hoffert, C., St-Onge, S., Pou, C., Labrecque, J., Groblewski, T., O'Donnell, D., Payza, K., Ahmad, S. and Walker, P. (1999) The receptor for the orexigenic peptide melanin-concentrating hormone is a G-protein-coupled receptor.
Nat Cell Biol, 1: 267-271.
[PMID:10559938]
25. Lynch, J. K., Freeman, J. C., Judd, A. S., Iyengar, R., Mulhern, M., Zhao, G., Napier, J. J., Wodka, D., Brodjian, S., Dayton, B. D., Falls, D., Ogiela, C., Reilly, R. M., Campbell, T. J., Polakowski, J. S., Hernandez, L., Marsh, K. C., Shapiro, R., Knourek-Segel, V., Droz, B., Bush, E., Brune, M., Preusser, L. C., Fryer, R. M., Reinhart, G. A., Houseman, K., Diaz, G., Mikhail, A., Limberis, J. T., Sham, H. L., Collins, C. A. and Kym, P. R. (2006) Optimization of chromone-2-carboxamide melanin concentrating hormone receptor 1 antagonists: assessment of potency, efficacy, and cardiovascular safety.
J Med Chem, 49: 6569-6584.
[PMID:17064075]
26. Marsh, D. J., Weingarth, D. T., Novi, D. E., Chen, H. Y., Trumbauer, M. E., Chen, A. S., Guan, X. M., Jiang, M. M., Feng, Y., Camacho, R. E., Shen, Z., Frazier, E. G., Yu, H., Metzger, J. M., Kuca, S. J., Shearman, L. P., Gopal-Truter, S., MacNeil, D. J., Strack, A. M., MacIntyre, D. E., Van der Ploeg, L. H. and Qian, S. (2002) Melanin-concentrating hormone 1 receptor-deficient mice are lean, hyperactive, and hyperphagic and have altered metabolism.
Proc Natl Acad Sci U S A, 99: 3240-3245.
[PMID:11867747]
27. Mori, M., Harada, M., Terao, Y., Sugo, T., Watanabe, T., Shimomura, Y., Abe, M., Shintani, Y., Onda, H., Nishimura, O. and Fujino, M. (2001) Cloning of a novel G protein-coupled receptor, SLT, a subtype of the melanin-concentrating hormone receptor.
Biochem Biophys Res Commun, 283: 1013-1018.
[PMID:11355873]
28. Nagasaki, H., Chung, S., Dooley, C. T., Wang, Z., Li, C., Saito, Y., Clark, S. D., Houghten, R. A. and Civelli, O. (2009) The pharmacological properties of a novel MCH1 receptor antagonist isolated from combinatorial libraries.
Eur. J. Pharmacol., 602: 194-202.
[PMID:19041642]
29. Pissios P., Ozcan U. (2007) Melanin concentrating hormone is a novel regulator of islet function and growth.
Diabetes, 56: 311-319.
[PMID:17259374]
30. Pissios, P., Trombly, D. J., Tzameli, I. and Maratos-Flier, E. (2003) Melanin-concentrating hormone receptor 1 activates extracellular signal-regulated kinase and synergizes with G(s)-coupled pathways.
Endocrinology, 144: 3514-3523.
[PMID:12865333]
31. Qu, D., Ludwig, D. S., Gammeltoft, S., Piper, M., Pelleymounter, M. A., Cullen, M. J., Mathes, W. F., Przypek, R., Kanarek, R. and Maratos-Flier, E. (1996) A role for melanin-concentrating hormone in the central regulation of feeding behaviour.
Nature, 380: 243-247.
[PMID:8637571]
32. Rossi, M., Choi, S. J., O'Shea, D., Miyoshi, T., Ghatei, M. A. and Bloom, S. R. (1997) Melanin-concentrating hormone acutely stimulates feeding, but chronic administration has no effect on body weight.
Endocrinology, 138: 351-355.
[PMID:8977423]
33. Sailer, A. W., Sano, H., Zeng, Z., McDonald, T. P., Pan, J., Pong, S. S., Feighner, S. D., Tan, C. P., Fukami, T., Iwaasa, H., Hreniuk, D. L., Morin, N. R., Sadowski, S. J., Ito, M., Ito, M., Bansal, A., Ky, B., Figueroa, D. J., Jiang, Q., Austin, C. P., MacNeil, D. J., Ishihara, A., Ihara, M., Kanatani, A., Van der Ploeg, L. H., Howard, A. D. and Liu, Q. (2001) Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R.
Proc Natl Acad Sci U S A, 98: 7564-7569.
[PMID:11404457]
34. Saito, Y., Cheng, M., Leslie, F. M. and Civelli, O. (2001) Expression of the melanin-concentrating hormone (MCH) receptor mRNA in the rat brain.
J Comp Neurol, 435: 26-40.
[PMID:11370009]
35. Saito, Y., Nothacker, H. P., Wang, Z., Lin, S. H., Leslie, F. and Civelli, O. (1999) Molecular characterization of the melanin-concentrating-hormone receptor.
Nature, 400: 265-269.
[PMID:10421368]
36. Saito, Y., Wang, Z., Hagino-Yamagishi, K., Civelli, O., Kawashima, S. and Maruyama, K. (2001) Endogenous melanin-concentrating hormone receptor SLC-1 in human melanoma SK-MEL-37 cells.
Biochem Biophys Res Commun, 289: 44-50.
[PMID:11708774]
37. Shearman, L. P., Camacho, R. E., Sloan Stribling, D., Zhou, D., Bednarek, M. A., Hreniuk, D. L., Feighner, S. D., Tan, C. P., Howard, A. D., Van der Ploeg, L. H., MacIntyre, D. E., Hickey, G. J. and Strack, A. M. (2003) Chronic MCH-1 receptor modulation alters appetite, body weight and adiposity in rats.
Eur J Pharmacol, 475: 37-47.
[PMID:12954357]
38. Shimomura, Y., Mori, M., Sugo, T., Ishibashi, Y., Abe, M., Kurokawa, T., Onda, H., Nishimura, O., Sumino, Y. and Fujino, M. (1999) Isolation and identification of melanin-concentrating hormone as the endogenous ligand of the SLC-1 receptor.
Biochem Biophys Res Commun, 261: 622-626.
[PMID:10441476]
39. Smith, D. G., Davis, R. J., Rorick-Kehn, L., Morin, M., Witkin, J. M., McKinzie, D. L., Nomikos, G. G. and Gehlert, D. R. (2006) Melanin-concentrating hormone-1 receptor modulates neuroendocrine, behavioral, and corticolimbic neurochemical stress responses in mice.
Neuropsychopharmacology, 31: 1135-1145.
[PMID:16205780]
40. Suply, T., Della Zuana, O., Audinot, V., Rodriguez, M., Beauverger, P., Duhault, J., Canet, E., Galizzi, J. P., Nahon, J. L., Levens, N. and Boutin, J. A. (2001) SLC-1 receptor mediates effect of melanin-concentrating hormone on feeding behavior in rat: a structure-activity study.
J Pharmacol Exp Ther, 299: 137-146.
[PMID:11561073]
41. Takekawa, S., Asami, A., Ishihara, Y., Terauchi, J., Kato, K., Shimomura, Y., Mori, M., Murakoshi, H., Kato, K., Suzuki, N., Nishimura, O. and Fujino, M. (2002) T-226296: a novel, orally active and selective melanin-concentrating hormone receptor antagonist.
Eur J Pharmacol, 438: 129-135.
[PMID:11909603]
42. Tavares, F. X., Al-Barazanji, K. A., Bishop, M. J., Britt, C. S., Carlton, D. L., Cooper, J. P., Feldman, P. L., Garrido, D. M., Goetz, A. S., Grizzle, M. K., Hertzog, D. L., Ignar, D. M., Lang, D. G., McIntyre, M. S., Ott, R. J., Peat, A. J. and Zhou, H. Q. (2006) 6-(4-chlorophenyl)-3-substituted-thieno[3,2-d]pyrimidin-4(3H)-one-based melanin-concentrating hormone receptor 1 antagonist.
J Med Chem, 49: 7108-7118.
[PMID:17125263]
43. Verlaet, M., Adamantidis, A., Coumans, B., Chanas, G., Zorzi, W., Heinen, E., Grisar, T. and Lakaye, B. (2002) Human immune cells express ppMCH mRNA and functional MCHR1 receptor.
FEBS Lett, 527: 205-210.
[PMID:12220661]
44. Wang, S., Behan, J., O'Neill, K., Weig, B., Fried, S., Laz, T., Bayne, M., Gustafson, E. and Hawes, B. E. (2001) Identification and pharmacological characterization of a novel human melanin-concentrating hormone receptor, mch-r2.
J Biol Chem, 276: 34664-34670.
[PMID:11459838]
45. Witty, D. R., Bateson, J., Hervieu, G. J., Al Barazanji, K., Jeffrey, P., Hamprecht, D., Haynes, A., Johnson, C. N., Muir, A. I., O'Hanlon, P. J., Stemp, G., Stevens, A. J., Thewlis, K. and Winborn, K. Y. (2006) Discovery of potent and stable conformationally constrained analogues of the MCH R1 antagonist SB-568849.
Bioorg. Med. Chem., 16: 4872-4878.
[PMID:16839763]
Annotated and expert reviewed. Please contact us if you can help with updates.
