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S1P4 receptor

Family: Lysophospholipid (S1P) receptors

Contents:
Gene and Protein Information
Previous and Unofficial Names
Database Links
Agonists
Transduction Mechanisms
Expression Datasets
Phenotypes, Alleles and Disease Models
References
Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 384 19p13.3 S1PR4 sphingosine-1-phosphate receptor 4
Mouse 7 386 10 C1 S1pr4 sphingosine-1-phosphate receptor 4
Rat 7 - 7q11 S1pr4 sphingosine-1-phosphate receptor 4
Previous and Unofficial Names
edg6
lpC1
endothelial differentiation, G-protein-coupled receptor 6
endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 6
lpC1
S1P4
Edg6_predicted
LOC314649
endothelial differentiation, G-protein-coupled receptor 6 (predicted)
endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor 6
endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor 6 (predicted)
sphingosine 1-phosphate receptor 4
sphingosine-1-phosphate receptor 4
AI790342
Database Links
ChEMBL Target 10809 (Hs)
Ensembl ENSG00000125910 (Hs), ENSMUSG00000044199 (Mm), ENSRNOG00000005370 (Rn)
Entrez Gene 8698 (Hs), 13611 (Mm), 314649 (Rn)
GeneCards S1PR4 (Hs)
GenitoUrinary Development Molecular Anatomy Project S1pr4 (Mm)
HomoloGene 2799 (Hs)
Human Protein Reference Database 04779 (Hs)
InterPro O95977 (Hs), Q9Z0L1 (Mm)
KEGG Gene hsa:8698 (Hs), mmu:13611 (Mm), rno:314649 (Rn)
OMIM 603751 (Hs)
PharmGKB Gene PA162402371 (Hs)
PhosphoSitePlus O95977 (Hs), Q9Z0L1 (Mm)
Protein Ontology (PRO) PRO:000001709 (Hs)
RefSeq Nucleotide NM_003775 (Hs), NM_010102 (Mm), NM_001108075 (Rn)
RefSeq Protein NP_003766 (Hs), NP_034232 (Mm), NP_001101545 (Rn)
TreeFam ENSG00000125910 (Hs), ENSMUSG00000044199 (Mm), ENSRNOG00000005370 (Rn)
UniGene Hs. 515061 (Hs)
UniProt O95977 (Hs), Q9Z0L1 (Mm)
Wikipedia S1P4 receptor
Lysophospholipid (S1P) receptors
Search for 3D structures on the PDB
Search by keyword: Lysophospholipid (S1P) receptors S1P4 receptor Search by accession number: O95977, Q9Z0L1
Natural/Endogenous Ligand(s)
sphingosine 1-phosphate
sphingosyl phosphorylcholine
Comments: sphingosine 1-phosphate exhibits greater potency than sphingosyl phosphorylcholine
Rank order of potency
sphingosine 1-phosphate > dihydrosp​hingosine​-1-phosph​ate > sphingosyl phosphorylcholine  [6]
Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
AFD(R) Hs Agonist 8.4 pEC50 1
KRP 203-phosphate Mm Agonist 8.0 pEC50 5
sphingosine 1-phosphate Hs Agonist 7.9 pEC50 2
FTY720-phosphate Mm Agonist 7.15 pEC50 1,5
AUY954 Mm Agonist 5.0 – 6.0 pEC50 4
phytosphingosine 1-phosphate Hs Agonist 8.8 pIC50 2
dihydrosp​hingosine​-1-phosph​ate Hs Agonist 8.0 pIC50 2
analogue26_3,5-diphenyl-1,2,4-oxadiazole Hs Agonist 7.15 pIC50 3
sphingosine 1-phosphate Hs Agonist 6.1 – 7.0 pIC50 1-2
View species-specific agonist tables
Agonist Comments
The EC50 was determined by physiometer functional characterization of the human S1P4 receptor expressed CHO cells
Primary Transduction Mechanisms
Transducer Effector/Response
Gi/Go family
G12/G13 family
References: 
Expression Datasets

Click here to show/hide data

Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Phenotypes, Alleles and Disease Models Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
S1pr4+|S1pr4tm1Dgen S1pr4tm1Dgen/S1pr4+
involves: 129P2/OlaHsd * C57BL/6		 MGI:1333809  MP:0009142 decreased prepulse inhibition
S1pr4tm1Dgen S1pr4tm1Dgen/S1pr4tm1Dgen
involves: 129P2/OlaHsd * C57BL/6		 MGI:1333809  MP:0006207 embryonic lethality during organogenesis

REFERENCES

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1. Brinkmann, V; Davis, MD; Heise, CE; Albert, R; Cottens, S; Hof, R; Bruns, C; Prieschl, E; Baumruker, T; Hiestand, P; et al.. (2002) The immune modulator FTY720 targets sphingosine 1-phosphate receptors. J. Biol. Chem., 277 (24): 21453-7. [PMID:11967257]

2. Candelore, MR; Wright, MJ; Tota, LM; Milligan, J; Shei, GJ; Bergstrom, JD; Mandala, SM. (2002) Phytosphingosine 1-phosphate: a high affinity ligand for the S1P(4)/Edg-6 receptor. Biochem. Biophys. Res. Commun., 297 (3): 600-6. [PMID:12270137]

3. Li, Z; Chen, W; Hale, JJ; Lynch, CL; Mills, SG; Hajdu, R; Keohane, CA; Rosenbach, MJ; Milligan, JA; Shei, GJ; et al.. (2005) Discovery of potent 3,5-diphenyl-1,2,4-oxadiazole sphingosine-1-phosphate-1 (S1P1) receptor agonists with exceptional selectivity against S1P2 and S1P3. J. Med. Chem., 48 (20): 6169-73. [PMID:16190743]

4. Pan, S; Mi, Y; Pally, C; Beerli, C; Chen, A; Guerini, D; Hinterding, K; Nuesslein-Hildesheim, B; Tuntland, T; Lefebvre, S; et al.. (2006) A monoselective sphingosine-1-phosphate receptor-1 agonist prevents allograft rejection in a stringent rat heart transplantation model. Chem. Biol., 13 (11): 1227-34. [PMID:17114004]

5. Song, J; Matsuda, C; Kai, Y; Nishida, T; Nakajima, K; Mizushima, T; Kinoshita, M; Yasue, T; Sawa, Y; Ito, T. (2008) A novel sphingosine 1-phosphate receptor agonist, 2-amino-2-propanediol hydrochloride (KRP-203), regulates chronic colitis in interleukin-10 gene-deficient mice. J. Pharmacol. Exp. Ther., 324 (1): 276-83. [PMID:17898319]

6. Van Brocklyn, JR; Gräler, MH; Bernhardt, G; Hobson, JP; Lipp, M; Spiegel, S. (2000) Sphingosine-1-phosphate is a ligand for the G protein-coupled receptor EDG-6. Blood, 95 (8): 2624-9. [PMID:10753843]

To cite this database page, please use the following:

Chido Mpamhanga.
Lysophospholipid (S1P) receptors: S1P4 receptor. Last modified on 29/02/2012. Accessed on 19/05/2013. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=278.


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