Nomenclature: S1P3 receptor

Family: Lysophospholipid (S1P) receptors

Annotation status:  image of an orange circle Annotated and awaiting review. Please contact us if you can help with reviewing. 

Contents

Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 378 9q22.1-q22.2 S1PR3 sphingosine-1-phosphate receptor 3
Mouse 7 378 13 B1 S1pr3 sphingosine-1-phosphate receptor 3
Rat 7 379 17 p14 S1pr3 sphingosine-1-phosphate receptor 3
Previous and Unofficial Names
edg3
lpB3
EDG-3
endothelial differentiation, sphingolipid G-protein-coupled receptor, 3
sphingosine-1-phosphate receptor 3
LOC306792
sphingosine 1-phosphate receptor 3
LPb3
S1P3
AI132464
lysophospholipid receptor B3
endothelial differentiation G-protein coupled receptor 3
S1P receptor Edg-3
similar to Sphingosine 1-phosphate receptor Edg-3
Database Links
ChEMBL Target
Ensembl Gene
Entrez Gene
GPCRDB
GeneCards
GenitoUrinary Development Molecular Anatomy Project
HomoloGene
Human Protein Reference Database
InterPro
KEGG Gene
OMIM
PharmGKB Gene
PhosphoSitePlus
Protein Ontology (PRO)
RefSeq Nucleotide
RefSeq Protein
TreeFam
UniGene Hs.
UniProtKB
Wikipedia
Natural/Endogenous Ligands
sphingosine 1-phosphate
sphingosylphosphorylcholine
Comments: sphingosine 1-phosphate exhibits greater potency than sphingosylphosphorylcholine
Rank order of potency
sphingosine 1-phosphate > dihydrosp​hingosine​-1-phosph​ate > sphingosylphosphorylcholine  [22]
Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
sphingosine 1-phosphate Hs Agonist 7.58 – 9.64 pKd 9,17,27
pKd 7.58 – 9.64 (Kd 2.3x10-10 – 2.62x10-8 M) [9,17,27]
sphingosine 1-phosphate Hs Agonist 8.4 – 9.8 pEC50 7,14,24
pEC50 8.4 – 9.8 [7,14,24]
sphingosine 1-phosphate Mm Agonist 8.64 pEC50 25
pEC50 8.64 (EC50 2.3x10-9 M) [25]
AFD(R) Hs Agonist 7.8 – 9.4 pEC50 7
pEC50 7.8 – 9.4 [7]
FTY720-phosphate Hs Agonist 7.8 – 9.4 pEC50 7,11
pEC50 7.8 – 9.4 [7,11]
(S)-FTY720-phosphate Hs Agonist 8.51 pEC50 24
pEC50 8.51 (EC50 3.1x10-9 M) [24]
VPC12249 Hs Agonist 6.5 pEC50 12
pEC50 6.5 [12]
AUY954 Mm Agonist 5.9 – 5.96 pEC50 12,24
pEC50 5.9 – 5.96 [12,24]
FTY720-phosphate Hs Agonist 8.3 pIC50 11
pIC50 8.3 (IC50 5x10-9 M) [11]
compound 26 [PMID:16190743] Hs Agonist 4.9 pIC50 19
pIC50 4.9 [19]
View species-specific agonist tables
Antagonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
VPC03090-P Hs Antagonist 7.23 – 7.29 pKi 16
pKi 7.23 – 7.29 (Ki 5.1x10-8 – 5.87x10-8 M) [16]
VPC44116 Hs Antagonist 6.52 pKi 12
pKi 6.52 (Ki 3x10-7 M) [12]
Primary Transduction Mechanisms
Transducer Effector/Response
Gi/Go family
Gq/G11 family
G12/G13 family
Adenylate cyclase inhibition
Phospholipase C stimulation
Comments:  Activation of MAPK [23] and Akt [5-6].
References:  2,28
Tissue Distribution
Heart, lung, kidney, spleen, brain, thymus, muscle and testis
Species:  Mouse
Technique:  Northern blot
References:  29-30
Embryonic brain
Species:  Mouse
Technique:  in situ hybridisation
References:  15
Expression Datasets

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Functional Assays
Migration
Species:  Mouse
Tissue:  B cell, monocytes
Response measured: 
References:  3,8,10
Cell proliferation and survival
Species:  Human
Tissue:  HTC4 hepatoma cells stably transfected with human S1P3
Response measured: 
References:  1
Physiological Consequences of Altering Gene Expression
Protection from heart ischemia/reperfusion injury in knockout mice
Species:  Mouse
Tissue: 
Technique:  Gene knockouts
References:  20,26
Protection from kidney ischemia/reperfusion injury in knockout mice
Species:  Mouse
Tissue: 
Technique:  Gene knockouts
References:  4
Blockade of HDL-induced vasorelaxation in knockout mice
Species:  Mouse
Tissue: 
Technique:  Gene knockouts
References:  21
Eyelid closure during embryonic development in S1P2/S1P3 double knockout mice
Species:  Mouse
Tissue: 
Technique:  Gene knockouts
References:  13
No obvious phenotypic abnormalities, but severe vascular phenotype in S1P2/S1P3 double and S1P1/S1P2/S1P3 triple knockout mice
Species:  Mouse
Tissue: 
Technique:  Gene knockouts
References:  18
No obvious phenotypic abnormalities
Species:  Mouse
Tissue: 
Technique:  Gene knockouts
References:  15
B-cell migration and development
Species:  Mouse
Tissue: 
Technique:  Gene knockouts
References:  10
Migration deficit of anti-inflammatory monocytes in knockout mice
Species:  Mouse
Tissue: 
Technique:  Gene knockouts
References:  3
Phenotypes, Alleles and Disease Models Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
S1pr1tm1Rlp|S1pr2tm1Rlp|S1pr3tm1Rlp S1pr1tm1Rlp/S1pr1tm1Rlp,S1pr3tm1Rlp/S1pr3tm1Rlp,S1pr2tm1Rlp/S1pr2tm1Rlp
involves: 129S6/SvEvTac * C57BL/6
MGI:1096355  MGI:1339365  MGI:99569  MP:0000260 abnormal angiogenesis PMID: 15138255 
S1pr3tm1Rlp S1pr3tm1Rlp/S1pr3tm1Rlp
involves: 129S6/SvEvTac * C57BL/6
MGI:1339365  MP:0002459 abnormal B cell physiology PMID: 15184895 
S1pr3tm1Jch S1pr3tm1Jch/S1pr3tm1Jch
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
MGI:1339365  MP:0005621 abnormal cell physiology PMID: 11443127 
S1pr3tm1Jch S1pr3tm1Jch/S1pr3tm1Jch
involves: 129S1/Sv * 129X1/SvJ
MGI:1339365  MP:0008713 abnormal cytokine level PMID: 18305483 
S1pr1tm1Rlp|S1pr3tm1Rlp S1pr1tm1Rlp/S1pr1tm1Rlp,S1pr3tm1Rlp/S1pr3tm1Rlp
involves: 129S6/SvEvTac * C57BL/6
MGI:1096355  MGI:1339365  MP:0002109 abnormal limb morphology PMID: 15138255 
S1pr2tm1Jch|S1pr3tm1Jch S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
MGI:1339365  MGI:99569  MP:0001386 abnormal maternal nurturing PMID: 12006579 
S1pr2tm1Jch|S1pr3tm1Jch S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
MGI:1339365  MGI:99569  MP:0001504 abnormal posture PMID: 17287522 
S1pr3tm1Jch S1pr3tm1Jch/S1pr3tm1Jch
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
MGI:1339365  MP:0002273 abnormal respiratory alveolar epithelial cell morphology PMID: 15968000 
S1pr2tm1Rlp|S1pr3tm1Rlp S1pr3tm1Rlp/S1pr3tm1Rlp,S1pr2tm1Rlp/S1pr2tm1Rlp
involves: 129S6/SvEvTac * C57BL/6
MGI:1339365  MGI:99569  MP:0004244 abnormal spontaneous abortion rate PMID: 15138255 
S1pr2tm1Rlp|S1pr3tm1Rlp S1pr3tm1Rlp/S1pr3tm1Rlp,S1pr2tm1Rlp/S1pr2tm1Rlp
involves: 129S6/SvEvTac * C57BL/6
MGI:1339365  MGI:99569  MP:0006055 abnormal vascular endothelial cell morphology PMID: 15138255 
S1pr2tm1Jch|S1pr3tm1Jch S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
MGI:1339365  MGI:99569  MP:0004742 abnormal vestibular system physiology PMID: 17287522 
S1pr2tm1Jch|S1pr3tm1Jch S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
MGI:1339365  MGI:99569  MP:0000034 abnormal vestibule morphology PMID: 17287522 
S1pr2tm1Jch|S1pr3tm1Jch S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
MGI:1339365  MGI:99569  MP:0006359 absent startle reflex PMID: 17287522 
S1pr2tm1Jch|S1pr3+|S1pr3tm1Jch S1pr3tm1Jch/S1pr3+,S1pr2tm1Jch/S1pr2tm1Jch
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
MGI:1339365  MGI:99569  MP:0006359 absent startle reflex PMID: 17287522 
S1pr2tm1Jch|S1pr3tm1Jch S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
MGI:1339365  MGI:99569  MP:0004518 absent vestibular hair cell stereocilia PMID: 17287522 
S1pr2tm1Rlp|S1pr3tm1Rlp S1pr3tm1Rlp/S1pr3tm1Rlp,S1pr2tm1Rlp/S1pr2tm1Rlp
involves: 129S6/SvEvTac * C57BL/6
MGI:1339365  MGI:99569  MP:0002857 cochlear ganglion degeneration PMID: 17284444 
S1pr2tm1Jch|S1pr3tm1Jch S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
MGI:1339365  MGI:99569  MP:0002857 cochlear ganglion degeneration PMID: 17287522 
S1pr2tm1Jch|S1pr3tm1Jch S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
MGI:1339365  MGI:99569  MP:0004398 cochlear inner hair cell degeneration PMID: 17287522 
S1pr2tm1Jch|S1pr3tm1Jch S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
MGI:1339365  MGI:99569  MP:0004404 cochlear outer hair cell degeneration PMID: 17287522 
S1pr3tm1Jch S1pr3tm1Jch/S1pr3tm1Jch
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
MGI:1339365  MP:0001935 decreased litter size PMID: 11443127 
S1pr2tm1Jch|S1pr3tm1Jch S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
MGI:1339365  MGI:99569  MP:0001935 decreased litter size PMID: 12006579 
S1pr3tm1Jch S1pr3tm1Jch/S1pr3tm1Jch
involves: 129S1/Sv * 129X1/SvJ
MGI:1339365  MP:0009764 decreased sensitivity to induced morbidity/mortality PMID: 18305483 
S1pr3tm1Jch S1pr3tm1Jch/S1pr3tm1Jch
involves: 129S1/Sv * 129X1/SvJ
MGI:1339365  MP:0008734 decreased susceptibility to endotoxin shock PMID: 18305483 
S1pr2tm1Jch|S1pr3tm1Jch S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
MGI:1339365  MGI:99569  MP:0002757 decreased vertical activity PMID: 17287522 
S1pr2tm1Jch|S1pr3tm1Jch S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
MGI:1339365  MGI:99569  MP:0004465 degeneration of organ of Corti supporting cells PMID: 17287522 
S1pr1tm1Rlp|S1pr3tm1Rlp S1pr1tm1Rlp/S1pr1tm1Rlp,S1pr3tm1Rlp/S1pr3tm1Rlp
involves: 129S6/SvEvTac * C57BL/6
MGI:1096355  MGI:1339365  MP:0006207 embryonic lethality during organogenesis PMID: 15138255 
S1pr1tm1Rlp|S1pr2tm1Rlp|S1pr3tm1Rlp S1pr1tm1Rlp/S1pr1tm1Rlp,S1pr3tm1Rlp/S1pr3tm1Rlp,S1pr2tm1Rlp/S1pr2tm1Rlp
involves: 129S6/SvEvTac * C57BL/6
MGI:1096355  MGI:1339365  MGI:99569  MP:0006207 embryonic lethality during organogenesis PMID: 15138255 
S1pr3tm1Jch S1pr3tm1Jch/S1pr3tm1Jch
involves: 129S1/Sv * 129X1/SvJ
MGI:1339365  MP:0008466 enlarged mesenteric lymph nodes PMID: 18305483 
S1pr2tm1Rlp|S1pr3tm1Rlp S1pr3tm1Rlp/S1pr3tm1Rlp,S1pr2tm1Rlp/S1pr2tm1Rlp
involves: 129S6/SvEvTac * C57BL/6
MGI:1339365  MGI:99569  MP:0005191 head tilt PMID: 17284444 
S1pr2tm1Jch|S1pr3tm1Jch S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
MGI:1339365  MGI:99569  MP:0005191 head tilt PMID: 17287522 
S1pr2tm1Rlp|S1pr3tm1Rlp S1pr3tm1Rlp/S1pr3tm1Rlp,S1pr2tm1Rlp/S1pr2tm1Rlp
involves: 129S6/SvEvTac * C57BL/6
MGI:1339365  MGI:99569  MP:0001914 hemorrhage PMID: 15138255 
S1pr1tm1Rlp|S1pr3tm1Rlp S1pr1tm1Rlp/S1pr1tm1Rlp,S1pr3tm1Rlp/S1pr3tm1Rlp
involves: 129S6/SvEvTac * C57BL/6
MGI:1096355  MGI:1339365  MP:0001914 hemorrhage PMID: 15138255 
S1pr1tm1Rlp|S1pr2tm1Rlp|S1pr3tm1Rlp S1pr1tm1Rlp/S1pr1tm1Rlp,S1pr3tm1Rlp/S1pr3tm1Rlp,S1pr2tm1Rlp/S1pr2tm1Rlp
involves: 129S6/SvEvTac * C57BL/6
MGI:1096355  MGI:1339365  MGI:99569  MP:0001914 hemorrhage PMID: 15138255 
S1pr2tm1Jch|S1pr3tm1Jch S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
MGI:1339365  MGI:99569  MP:0001523 impaired righting response PMID: 17287522 
S1pr2tm1Jch|S1pr3tm1Jch S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
MGI:1339365  MGI:99569  MP:0001522 impaired swimming PMID: 17287522 
S1pr2tm1Jch|S1pr3tm1Jch S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
MGI:1339365  MGI:99569  MP:0001513 limb grasping PMID: 17287522 
S1pr2tm1Jch|S1pr3tm1Jch S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
MGI:1339365  MGI:99569  MP:0000043 organ of Corti degeneration PMID: 17287522 
S1pr2tm1Jch|S1pr3tm1Jch S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
MGI:1339365  MGI:99569  MP:0002081 perinatal lethality PMID: 12006579 
S1pr2tm1Rlp|S1pr3tm1Rlp S1pr3tm1Rlp/S1pr3tm1Rlp,S1pr2tm1Rlp/S1pr2tm1Rlp
involves: 129S6/SvEvTac * C57BL/6
MGI:1339365  MGI:99569  MP:0002080 prenatal lethality PMID: 15138255  17284444 
S1pr2tm1Rlp|S1pr3tm1Rlp S1pr3tm1Rlp/S1pr3tm1Rlp,S1pr2tm1Rlp/S1pr2tm1Rlp
involves: 129S6/SvEvTac * C57BL/6
MGI:1339365  MGI:99569  MP:0001921 reduced fertility PMID: 15138255 
S1pr2tm1Jch|S1pr3tm1Jch S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
MGI:1339365  MGI:99569  MP:0004331 saccular macula degeneration PMID: 17287522 
S1pr2tm1Rlp|S1pr3tm1Rlp S1pr3tm1Rlp/S1pr3tm1Rlp,S1pr2tm1Rlp/S1pr2tm1Rlp
involves: 129S6/SvEvTac * C57BL/6
MGI:1339365  MGI:99569  MP:0001786 skin edema PMID: 15138255 
S1pr2tm1Jch|S1pr3tm1Jch S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
MGI:1339365  MGI:99569  MP:0004334 utricular macular degeneration PMID: 17287522 
S1pr2tm1Jch|S1pr3tm1Jch S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
MGI:1339365  MGI:99569  MP:0004324 vestibular hair cell degeneration PMID: 17287522 
Available Assays
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PathHunter® HEK 293 EDG3 β-Arrestin Cell Line (Cat no. 93-0217C1)
more info

REFERENCES

1. An S, Zheng Y, Bleu T. (2000) Sphingosine 1-phosphate-induced cell proliferation, survival, and related signaling events mediated by G protein-coupled receptors Edg3 and Edg5. J. Biol. Chem.275 (1): 288-96. [PMID:10617617]

2. Ancellin N, Hla T. (1999) Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5. J. Biol. Chem.274 (27): 18997-9002. [PMID:10383399]

3. Awojoodu AO, Ogle ME, Sefcik LS, Bowers DT, Martin K, Brayman KL, Lynch KR, Peirce-Cottler SM, Botchwey E. (2013) Sphingosine 1-phosphate receptor 3 regulates recruitment of anti-inflammatory monocytes to microvessels during implant arteriogenesis. Proc. Natl. Acad. Sci. U.S.A.110 (34): 13785-90. [PMID:23918395]

4. Bajwa A, Huang L, Ye H, Dondeti K, Song S, Rosin DL, Lynch KR, Lobo PI, Li L, Okusa MD. (2012) Dendritic cell sphingosine 1-phosphate receptor-3 regulates Th1-Th2 polarity in kidney ischemia-reperfusion injury. J. Immunol.189 (5): 2584-96. [PMID:22855711]

5. Banno Y, Takuwa Y, Akao Y, Okamoto H, Osawa Y, Naganawa T, Nakashima S, Suh PG, Nozawa Y. (2001) Involvement of phospholipase D in sphingosine 1-phosphate-induced activation of phosphatidylinositol 3-kinase and Akt in Chinese hamster ovary cells overexpressing EDG3. J. Biol. Chem.276 (38): 35622-8. [PMID:11468290]

6. Baudhuin LM, Jiang Y, Zaslavsky A, Ishii I, Chun J, Xu Y. (2004) S1P3-mediated Akt activation and cross-talk with platelet-derived growth factor receptor (PDGFR). FASEB J.18 (2): 341-3. [PMID:14657000]

7. Brinkmann V, Davis MD, Heise CE, Albert R, Cottens S, Hof R, Bruns C, Prieschl E, Baumruker T, Hiestand P et al.. (2002) The immune modulator FTY720 targets sphingosine 1-phosphate receptors. J. Biol. Chem.277 (24): 21453-7. [PMID:11967257]

8. Cinamon G, Zachariah MA, Lam OM, Foss Jr FW, Cyster JG. (2008) Follicular shuttling of marginal zone B cells facilitates antigen transport. Nat. Immunol.9 (1): 54-62. [PMID:18037889]

9. Deng Q, Clemas JA, Chrebet G, Fischer P, Hale JJ, Li Z, Mills SG, Bergstrom J, Mandala S, Mosley R et al.. (2007) Identification of Leu276 of the S1P1 receptor and Phe263 of the S1P3 receptor in interaction with receptor specific agonists by molecular modeling, site-directed mutagenesis, and affinity studies. Mol. Pharmacol.71 (3): 724-35. [PMID:17170199]

10. Donovan EE, Pelanda R, Torres RM. (2010) S1P3 confers differential S1P-induced migration by autoreactive and non-autoreactive immature B cells and is required for normal B-cell development. Eur. J. Immunol.40 (3): 688-98. [PMID:20039302]

11. Forrest M, Sun SY, Hajdu R, Bergstrom J, Card D, Doherty G, Hale J, Keohane C, Meyers C, Milligan J et al.. (2004) Immune cell regulation and cardiovascular effects of sphingosine 1-phosphate receptor agonists in rodents are mediated via distinct receptor subtypes. J. Pharmacol. Exp. Ther.309 (2): 758-68. [PMID:14747617]

12. Foss FW, Snyder AH, Davis MD, Rouse M, Okusa MD, Lynch KR, Macdonald TL. (2007) Synthesis and biological evaluation of gamma-aminophosphonates as potent, subtype-selective sphingosine 1-phosphate receptor agonists and antagonists. Bioorg. Med. Chem.15 (2): 663-77. [PMID:17113298]

13. Herr DR, Lee CW, Wang W, Ware A, Rivera R, Chun J. (2013) Sphingosine 1-phosphate receptors are essential mediators of eyelid closure during embryonic development. J. Biol. Chem.288 (41): 29882-9. [PMID:24003216]

14. Im DS, Clemens J, Macdonald TL, Lynch KR. (2001) Characterization of the human and mouse sphingosine 1-phosphate receptor, S1P5 (Edg-8): structure-activity relationship of sphingosine1-phosphate receptors. Biochemistry40 (46): 14053-60. [PMID:11705398]

15. Ishii I, Friedman B, Ye X, Kawamura S, McGiffert C, Contos JJ, Kingsbury MA, Zhang G, Brown JH, Chun J. (2001) Selective loss of sphingosine 1-phosphate signaling with no obvious phenotypic abnormality in mice lacking its G protein-coupled receptor, LP(B3)/EDG-3. J. Biol. Chem.276 (36): 33697-704. [PMID:11443127]

16. Kennedy PC, Zhu R, Huang T, Tomsig JL, Mathews TP, David M, Peyruchaud O, Macdonald TL, Lynch KR. (2011) Characterization of a sphingosine 1-phosphate receptor antagonist prodrug. J. Pharmacol. Exp. Ther.338 (3): 879-89. [PMID:21632869]

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To cite this database page, please use the following:

Jerold Chun, Yasuyuki Kihara, Chido Mpamhanga.
Lysophospholipid (S1P) receptors: S1P3 receptor. Last modified on 28/01/2014. Accessed on 02/09/2014. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=277.

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