Nomenclature: S1P2 receptor

Family: Lysophospholipid (S1P) receptors

Annotation status:  image of an orange circle Annotated and awaiting review. Please contact us if you can help with reviewing. 

Contents

Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 353 19p13.2 S1PR2 sphingosine-1-phosphate receptor 2
Mouse 7 352 9 A3 S1pr2 sphingosine-1-phosphate receptor 2
Rat 7 352 8q13 S1pr2 sphingosine-1-phosphate receptor 2
Previous and Unofficial Names
edg5
AGR16
H218
lpB2
Gpcr13
endothelial differentiation, sphingolipid G-protein-coupled receptor, 5
GPCR18
snGPCR18
G-protein coupled receptor 13
G-protein coupled receptor H218
S1P receptor 2
S1P receptor Edg-5
S1P2
endothelial differentiation G-protein coupled receptor 5
sphingosine 1-phosphate receptor 2
sphingosine 1-phosphate receptor Edg-5
sphingosine-1-phosphate receptor 2
LPb2
1100001A16Rik
Database Links
ChEMBL Target
Ensembl Gene
Entrez Gene
GPCRDB
GeneCards
GenitoUrinary Development Molecular Anatomy Project
HomoloGene
Human Protein Reference Database
InterPro
KEGG Gene
OMIM
PharmGKB Gene
PhosphoSitePlus
Protein Ontology (PRO)
RefSeq Nucleotide
RefSeq Protein
TreeFam
UniGene Hs.
UniProtKB
Wikipedia
Natural/Endogenous Ligands
sphingosine 1-phosphate
sphingosylphosphorylcholine
Comments: sphingosine 1-phosphate exhibits greater potency than sphingosylphosphorylcholine
Rank order of potency
sphingosine 1-phosphate > dihydrosp​hingosine​-1-phosph​ate > sphingosylphosphorylcholine  [2,21]
Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
sphingosine 1-phosphate Hs Agonist 7.57 – 7.69 pKd 14,27
pKd 7.57 – 7.69 (Kd 2.04x10-8 – 2.7x10-8 M) [14,27]
sphingosine 1-phosphate Mm Agonist 8.7 pEC50 24
pEC50 8.7 (EC50 2x10-9 M) [24]
sphingosine 1-phosphate Hs Agonist 8.05 – 8.54 pEC50 9,23
pEC50 8.05 – 8.54 [9,23]
AUY954 Mm Agonist 4.7 – 5.0 pEC50 23
pEC50 4.7 – 5.0 [23]
View species-specific agonist tables
Antagonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
JTE-013 Hs Antagonist 7.77 pIC50 22
pIC50 7.77 (IC50 1.7x10-8 M) [22]
JTE-013 Rn Antagonist 7.66 – 7.77 pIC50 8,22
pIC50 7.66 – 7.77 (IC50 1.7x10-8 – 2.2x10-8 M) [8,22]
View species-specific antagonist tables
Primary Transduction Mechanisms
Transducer Effector/Response
Gs family
Gq/G11 family
G12/G13 family
Adenylate cyclase stimulation
Phospholipase C stimulation
Calcium channel
Comments:  Activation of Rho, MAPK, and phosphorylation of MLC [5].
References:  5,12
Tissue Distribution
Embryonic brain
Expression level:  High
Species:  Mouse
Technique:  RT-PCR, Northern hybridization analysis
References:  18-19,29
Adult heart, lung
Expression level:  High
Species:  Mouse
Technique:  Northern blot analysis
References:  28
Heart, lung, kidney, liver, and thymus
Species:  Mouse
Technique:  Northern blot
References:  29
Expression Datasets

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Functional Assays
Cell proliferation and survival
Species:  Human
Tissue:  HTC4 hepatoma cells stably transfected with human S1P2
Response measured: 
References:  1
Negative regulation of cell motility
Species:  Mouse
Tissue:  B16 melanoma cell
Response measured: 
References:  3
Negative regulation of endothelial morphogenesis and angiogenesis
Species:  Mouse
Tissue:  Vascular endothelial cells
Response measured: 
References:  10
Physiological Consequences of Altering Gene Expression
Deafness and stria vascularis defects
Species:  Mouse
Tissue: 
Technique:  Gene knockout
References:  6,15,17
No gross anatomical abnormalities, but spontaneous seizures (3 – 7 weeks of age) and neuronal hyperexcitability
Species:  Mouse
Tissue: 
Technique:  Gene targeting (replacement vector with LacZ marker gene, deletion of entire ORF)
References:  19
Slightly reduced viability; normal development and fertility
Species:  Mouse
Tissue: 
Technique:  Gene knockout
References:  11
Suppression of pathologic neovascularization in knockout mice
Species:  Mouse
Tissue: 
Technique:  Gene knockout
References:  25
Severe vascular phenotype in S1P2/S1P3 double and S1P1/S1P2/S1P3 triple knockout mice
Species:  Mouse
Tissue: 
Technique:  Gene knockout
References:  16
Eyelid closure during embryonic development in S1P2/S1P3 double knockout mice
Species:  Mouse
Tissue: 
Technique:  Gene knockout
References:  7
Loss of phagocytic activity in receptor knockout macrophages
Species:  Mouse
Tissue: 
Technique:  Gene knockout
References:  20
Suppression of vasoconstriction in knockout mice
Species:  Mouse
Tissue: 
Technique:  Gene knockout
References:  26
Development of clonal B-cell lymphomas with age in knockout mice
Species:  Mouse
Tissue: 
Technique:  Gene knockout
References:  4
Phenotypes, Alleles and Disease Models Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
S1pr2tm1Ajml S1pr2tm1Ajml/S1pr2tm1Ajml
involves: 129S5/SvEvBrd * C57BL/6
MGI:99569  MP:0005402 abnormal action potential PMID: 11553273 
S1pr1tm1Rlp|S1pr2tm1Rlp S1pr1tm1Rlp/S1pr1tm1Rlp,S1pr2tm1Rlp/S1pr2tm1Rlp
involves: 129S6/SvEvTac * C57BL/6
MGI:1096355  MGI:99569  MP:0000260 abnormal angiogenesis PMID: 15138255 
S1pr1tm1Rlp|S1pr2tm1Rlp|S1pr3tm1Rlp S1pr1tm1Rlp/S1pr1tm1Rlp,S1pr3tm1Rlp/S1pr3tm1Rlp,S1pr2tm1Rlp/S1pr2tm1Rlp
involves: 129S6/SvEvTac * C57BL/6
MGI:1096355  MGI:1339365  MGI:99569  MP:0000260 abnormal angiogenesis PMID: 15138255 
S1pr2tm1Ajml S1pr2tm1Ajml/S1pr2tm1Ajml
involves: 129S5/SvEvBrd * C57BL/6
MGI:99569  MP:0004994 abnormal brain wave pattern PMID: 11553273 
S1pr2tm1Ajml S1pr2tm1Ajml/S1pr2tm1Ajml
involves: 129S5/SvEvBrd * C57BL/6
MGI:99569  MP:0002206 abnormal CNS synaptic transmission PMID: 11553273 
S1pr2tm1Ajml S1pr2tm1Ajml/S1pr2tm1Ajml
involves: 129S5/SvEvBrd * C57BL/6
MGI:99569  MP:0002910 abnormal excitatory postsynaptic currents PMID: 11553273 
S1pr2tm1Jch|S1pr3tm1Jch S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
MGI:1339365  MGI:99569  MP:0001386 abnormal maternal nurturing PMID: 12006579 
S1pr2tm1Ajml S1pr2tm1Ajml/S1pr2tm1Ajml
involves: 129S5/SvEvBrd * C57BL/6
MGI:99569  MP:0002272 abnormal nervous system electrophysiology PMID: 11553273 
S1pr2tm1Jch|S1pr3tm1Jch S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
MGI:1339365  MGI:99569  MP:0001504 abnormal posture PMID: 17287522 
S1pr2tm1Ajml S1pr2tm1Ajml/S1pr2tm1Ajml
either: (involves: 129S5/SvEvBrd) or (involves: 129S5/SvEvBrd * C57BL/6)
MGI:99569  MP:0004305 abnormal Rosenthal canal morphology PMID: 16945494 
S1pr2tm1Rlp|S1pr3tm1Rlp S1pr3tm1Rlp/S1pr3tm1Rlp,S1pr2tm1Rlp/S1pr2tm1Rlp
involves: 129S6/SvEvTac * C57BL/6
MGI:1339365  MGI:99569  MP:0004244 abnormal spontaneous abortion rate PMID: 15138255 
S1pr2tm1Rlp S1pr2tm1Rlp/S1pr2tm1Rlp
involves: 129S6/SvEvTac * C57BL/6
MGI:99569  MP:0004365 abnormal strial basal cells PMID: 17284444 
S1pr2tm1Rlp S1pr2tm1Rlp/S1pr2tm1Rlp
involves: 129S6/SvEvTac * C57BL/6
MGI:99569  MP:0004367 abnormal strial intermediate cells PMID: 17284444 
S1pr2tm1Rlp S1pr2tm1Rlp/S1pr2tm1Rlp
involves: 129S6/SvEvTac * C57BL/6
MGI:99569  MP:0004366 abnormal strial marginal cells PMID: 17284444 
S1pr2tm1Rlp S1pr2tm1Rlp/S1pr2tm1Rlp
involves: 129S6/SvEvTac * C57BL/6
MGI:99569  MP:0000048 abnormal stria vascularis PMID: 17284444 
S1pr2tm1Rlp S1pr2tm1Rlp/S1pr2tm1Rlp
involves: 129S6/SvEvTac * C57BL/6
MGI:99569  MP:0004368 abnormal stria vascularis vasculature morphology PMID: 17284444 
S1pr2tm1Ajml S1pr2tm1Ajml/S1pr2tm1Ajml
either: (involves: 129S5/SvEvBrd) or (involves: 129S5/SvEvBrd * C57BL/6)
MGI:99569  MP:0003149 abnormal tectorial membrane morphology PMID: 16945494 
S1pr2tm1Rlp|S1pr3tm1Rlp S1pr3tm1Rlp/S1pr3tm1Rlp,S1pr2tm1Rlp/S1pr2tm1Rlp
involves: 129S6/SvEvTac * C57BL/6
MGI:1339365  MGI:99569  MP:0006055 abnormal vascular endothelial cell morphology PMID: 15138255 
S1pr2tm1Rlp S1pr2tm1Rlp/S1pr2tm1Rlp
involves: 129S6/SvEvTac * C57BL/6
MGI:99569  MP:0004427 abnormal vestibular labyrinth PMID: 17284444 
S1pr2tm1Jch|S1pr3tm1Jch S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
MGI:1339365  MGI:99569  MP:0004742 abnormal vestibular system physiology PMID: 17287522 
S1pr2tm1Ajml S1pr2tm1Ajml/S1pr2tm1Ajml
either: (involves: 129S5/SvEvBrd) or (involves: 129S5/SvEvBrd * C57BL/6)
MGI:99569  MP:0004742 abnormal vestibular system physiology PMID: 16945494 
S1pr2tm1Jch|S1pr3tm1Jch S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
MGI:1339365  MGI:99569  MP:0000034 abnormal vestibule morphology PMID: 17287522 
S1pr2tm1Rlp S1pr2tm1Rlp/S1pr2tm1Rlp
involves: 129S6/SvEvTac * C57BL/6
MGI:99569  MP:0004763 absent brainstem auditory evoked potential PMID: 17284444 
S1pr2tm1Ajml S1pr2tm1Ajml/S1pr2tm1Ajml
either: (involves: 129S5/SvEvBrd) or (involves: 129S5/SvEvBrd * C57BL/6)
MGI:99569  MP:0004763 absent brainstem auditory evoked potential PMID: 16945494 
S1pr2tm1Rlp S1pr2tm1Rlp/S1pr2tm1Rlp
involves: 129S6/SvEvTac * C57BL/6
MGI:99569  MP:0004737 absent distortion product otoacoustic emissions PMID: 17284444 
S1pr2tm1Jch S1pr2tm1Jch/S1pr2tm1Jch
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
MGI:99569  MP:0006359 absent startle reflex PMID: 17287522 
S1pr2tm1Jch|S1pr3tm1Jch S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
MGI:1339365  MGI:99569  MP:0006359 absent startle reflex PMID: 17287522 
S1pr2tm1Jch|S1pr3+|S1pr3tm1Jch S1pr3tm1Jch/S1pr3+,S1pr2tm1Jch/S1pr2tm1Jch
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
MGI:1339365  MGI:99569  MP:0006359 absent startle reflex PMID: 17287522 
S1pr2tm1Jch|S1pr3tm1Jch S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
MGI:1339365  MGI:99569  MP:0004518 absent vestibular hair cell stereocilia PMID: 17287522 
S1pr2tm1Rlp|S1pr3tm1Rlp S1pr3tm1Rlp/S1pr3tm1Rlp,S1pr2tm1Rlp/S1pr2tm1Rlp
involves: 129S6/SvEvTac * C57BL/6
MGI:1339365  MGI:99569  MP:0002857 cochlear ganglion degeneration PMID: 17284444 
S1pr2tm1Rlp S1pr2tm1Rlp/S1pr2tm1Rlp
involves: 129S6/SvEvTac * C57BL/6
MGI:99569  MP:0002857 cochlear ganglion degeneration PMID: 17284444 
S1pr2tm1Jch|S1pr3tm1Jch S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
MGI:1339365  MGI:99569  MP:0002857 cochlear ganglion degeneration PMID: 17287522 
S1pr2tm1Rlp S1pr2tm1Rlp/S1pr2tm1Rlp
involves: 129S6/SvEvTac * C57BL/6
MGI:99569  MP:0004362 cochlear hair cell degeneration PMID: 17284444 
S1pr2tm1Jch|S1pr3tm1Jch S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
MGI:1339365  MGI:99569  MP:0004398 cochlear inner hair cell degeneration PMID: 17287522 
S1pr2tm1Jch|S1pr3tm1Jch S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
MGI:1339365  MGI:99569  MP:0004404 cochlear outer hair cell degeneration PMID: 17287522 
S1pr2tm1Ajml S1pr2tm1Ajml/S1pr2tm1Ajml
either: (involves: 129S5/SvEvBrd) or (involves: 129S5/SvEvBrd * C57BL/6)
MGI:99569  MP:0004404 cochlear outer hair cell degeneration PMID: 16945494 
S1pr2tm1Rlp S1pr2tm1Rlp/S1pr2tm1Rlp
involves: 129S6/SvEvTac * C57BL/6
MGI:99569  MP:0001967 deafness PMID: 17284444 
S1pr2tm1Ajml S1pr2tm1Ajml/S1pr2tm1Ajml
either: (involves: 129S5/SvEvBrd) or (involves: 129S5/SvEvBrd * C57BL/6)
MGI:99569  MP:0001967 deafness PMID: 16945494 
S1pr2tm1Jch S1pr2tm1Jch/S1pr2tm1Jch
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
MGI:99569  MP:0001935 decreased litter size PMID: 12006579 
S1pr2tm1Jch|S1pr3tm1Jch S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
MGI:1339365  MGI:99569  MP:0001935 decreased litter size PMID: 12006579 
S1pr2tm1Rlp S1pr2tm1Rlp/S1pr2tm1Rlp
involves: 129S6/SvEvTac * C57BL/6
MGI:99569  MP:0003144 decreased otolith number PMID: 17284444 
S1pr2tm1Ajml S1pr2tm1Ajml/S1pr2tm1Ajml
either: (involves: 129S5/SvEvBrd) or (involves: 129S5/SvEvBrd * C57BL/6)
MGI:99569  MP:0003144 decreased otolith number PMID: 16945494 
S1pr2tm1Jch|S1pr3tm1Jch S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
MGI:1339365  MGI:99569  MP:0002757 decreased vertical activity PMID: 17287522 
S1pr2tm1Jch|S1pr3tm1Jch S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
MGI:1339365  MGI:99569  MP:0004465 degeneration of organ of Corti supporting cells PMID: 17287522 
S1pr2tm1Ajml S1pr2tm1Ajml/S1pr2tm1Ajml
either: (involves: 129S5/SvEvBrd) or (involves: 129S5/SvEvBrd * C57BL/6)
MGI:99569  MP:0006023 detached Reissner membrane PMID: 16945494 
S1pr1tm1Rlp|S1pr2tm1Rlp S1pr1tm1Rlp/S1pr1tm1Rlp,S1pr2tm1Rlp/S1pr2tm1Rlp
involves: 129S6/SvEvTac * C57BL/6
MGI:1096355  MGI:99569  MP:0006207 embryonic lethality during organogenesis PMID: 15138255 
S1pr1tm1Rlp|S1pr2tm1Rlp|S1pr3tm1Rlp S1pr1tm1Rlp/S1pr1tm1Rlp,S1pr3tm1Rlp/S1pr3tm1Rlp,S1pr2tm1Rlp/S1pr2tm1Rlp
involves: 129S6/SvEvTac * C57BL/6
MGI:1096355  MGI:1339365  MGI:99569  MP:0006207 embryonic lethality during organogenesis PMID: 15138255 
S1pr2tm1Rlp S1pr2tm1Rlp/S1pr2tm1Rlp
involves: 129S6/SvEvTac * C57BL/6
MGI:99569  MP:0003143 enlarged otoliths PMID: 17284444 
S1pr2tm1Rlp|S1pr3tm1Rlp S1pr3tm1Rlp/S1pr3tm1Rlp,S1pr2tm1Rlp/S1pr2tm1Rlp
involves: 129S6/SvEvTac * C57BL/6
MGI:1339365  MGI:99569  MP:0005191 head tilt PMID: 17284444 
S1pr2tm1Rlp S1pr2tm1Rlp/S1pr2tm1Rlp
involves: 129S6/SvEvTac * C57BL/6
MGI:99569  MP:0005191 head tilt PMID: 17284444 
S1pr2tm1Jch|S1pr3tm1Jch S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
MGI:1339365  MGI:99569  MP:0005191 head tilt PMID: 17287522 
S1pr2tm1Ajml S1pr2tm1Ajml/S1pr2tm1Ajml
either: (involves: 129S5/SvEvBrd) or (involves: 129S5/SvEvBrd * C57BL/6)
MGI:99569  MP:0005191 head tilt PMID: 16945494 
S1pr2tm1Rlp|S1pr3tm1Rlp S1pr3tm1Rlp/S1pr3tm1Rlp,S1pr2tm1Rlp/S1pr2tm1Rlp
involves: 129S6/SvEvTac * C57BL/6
MGI:1339365  MGI:99569  MP:0001914 hemorrhage PMID: 15138255 
S1pr1tm1Rlp|S1pr2tm1Rlp S1pr1tm1Rlp/S1pr1tm1Rlp,S1pr2tm1Rlp/S1pr2tm1Rlp
involves: 129S6/SvEvTac * C57BL/6
MGI:1096355  MGI:99569  MP:0001914 hemorrhage PMID: 15138255 
S1pr1tm1Rlp|S1pr2tm1Rlp|S1pr3tm1Rlp S1pr1tm1Rlp/S1pr1tm1Rlp,S1pr3tm1Rlp/S1pr3tm1Rlp,S1pr2tm1Rlp/S1pr2tm1Rlp
involves: 129S6/SvEvTac * C57BL/6
MGI:1096355  MGI:1339365  MGI:99569  MP:0001914 hemorrhage PMID: 15138255 
S1pr2tm1Jch|S1pr3tm1Jch S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
MGI:1339365  MGI:99569  MP:0001523 impaired righting response PMID: 17287522 
S1pr2tm1Jch|S1pr3tm1Jch S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
MGI:1339365  MGI:99569  MP:0001522 impaired swimming PMID: 17287522 
S1pr2tm1Ajml S1pr2tm1Ajml/S1pr2tm1Ajml
either: (involves: 129S5/SvEvBrd) or (involves: 129S5/SvEvBrd * C57BL/6)
MGI:99569  MP:0001522 impaired swimming PMID: 16945494 
S1pr2tm1Jch|S1pr3tm1Jch S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
MGI:1339365  MGI:99569  MP:0001513 limb grasping PMID: 17287522 
S1pr2tm1Rlp S1pr2tm1Rlp/S1pr2tm1Rlp
involves: 129S6/SvEvTac * C57BL/6
MGI:99569  MP:0000043 organ of Corti degeneration PMID: 17284444 
S1pr2tm1Jch|S1pr3tm1Jch S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
MGI:1339365  MGI:99569  MP:0000043 organ of Corti degeneration PMID: 17287522 
S1pr2tm1Ajml S1pr2tm1Ajml/S1pr2tm1Ajml
either: (involves: 129S5/SvEvBrd) or (involves: 129S5/SvEvBrd * C57BL/6)
MGI:99569  MP:0000043 organ of Corti degeneration PMID: 16945494 
S1pr2tm1Ajml S1pr2tm1Ajml/S1pr2tm1Ajml
either: (involves: 129S5/SvEvBrd) or (involves: 129S5/SvEvBrd * C57BL/6)
MGI:99569  MP:0004897 otosclerosis PMID: 16945494 
S1pr2tm1Jch|S1pr3tm1Jch S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
MGI:1339365  MGI:99569  MP:0002081 perinatal lethality PMID: 12006579 
S1pr2tm1Ajml S1pr2tm1Ajml/S1pr2tm1Ajml
either: (involves: 129S5/SvEvBrd) or (involves: 129S5/SvEvBrd * C57BL/6)
MGI:99569  MP:0002083 premature death PMID: 16945494 
S1pr2tm1Rlp|S1pr3tm1Rlp S1pr3tm1Rlp/S1pr3tm1Rlp,S1pr2tm1Rlp/S1pr2tm1Rlp
involves: 129S6/SvEvTac * C57BL/6
MGI:1339365  MGI:99569  MP:0002080 prenatal lethality PMID: 15138255  17284444 
S1pr2tm1Rlp|S1pr3tm1Rlp S1pr3tm1Rlp/S1pr3tm1Rlp,S1pr2tm1Rlp/S1pr2tm1Rlp
involves: 129S6/SvEvTac * C57BL/6
MGI:1339365  MGI:99569  MP:0001921 reduced fertility PMID: 15138255 
S1pr2tm1Ajml S1pr2tm1Ajml/S1pr2tm1Ajml
either: (involves: 129S5/SvEvBrd) or (involves: 129S5/SvEvBrd * C57BL/6)
MGI:99569  MP:0004329 saccular degeneration PMID: 16945494 
S1pr2tm1Jch|S1pr3tm1Jch S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
MGI:1339365  MGI:99569  MP:0004331 saccular macula degeneration PMID: 17287522 
S1pr2tm1Ajml S1pr2tm1Ajml/S1pr2tm1Ajml
involves: 129S5/SvEvBrd * C57BL/6
MGI:99569  MP:0002064 seizures PMID: 11553273 
S1pr2tm1Ajml S1pr2tm1Ajml/S1pr2tm1Ajml
either: (involves: 129S5/SvEvBrd) or (involves: 129S5/SvEvBrd * C57BL/6)
MGI:99569  MP:0002064 seizures PMID: 16945494 
S1pr2tm1Rlp|S1pr3tm1Rlp S1pr3tm1Rlp/S1pr3tm1Rlp,S1pr2tm1Rlp/S1pr2tm1Rlp
involves: 129S6/SvEvTac * C57BL/6
MGI:1339365  MGI:99569  MP:0001786 skin edema PMID: 15138255 
S1pr2tm1Ajml S1pr2tm1Ajml/S1pr2tm1Ajml
either: (involves: 129S5/SvEvBrd) or (involves: 129S5/SvEvBrd * C57BL/6)
MGI:99569  MP:0008308 small scala media PMID: 16945494 
S1pr2tm1Ajml S1pr2tm1Ajml/S1pr2tm1Ajml
either: (involves: 129S5/SvEvBrd) or (involves: 129S5/SvEvBrd * C57BL/6)
MGI:99569  MP:0004364 thin stria vascularis PMID: 16945494 
S1pr2tm1Ajml S1pr2tm1Ajml/S1pr2tm1Ajml
involves: 129S5/SvEvBrd * C57BL/6
MGI:99569  MP:0003997 tonic-clonic seizures PMID: 11553273 
S1pr2tm1Jch|S1pr3tm1Jch S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
MGI:1339365  MGI:99569  MP:0004334 utricular macular degeneration PMID: 17287522 
S1pr2tm1Jch|S1pr3tm1Jch S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
MGI:1339365  MGI:99569  MP:0004324 vestibular hair cell degeneration PMID: 17287522 
General Comments
S1P2 receptor has been shown to be a specific receptor for the central nervous system membrane protein Nogo-A-Δ20 [13].
Available Assays
DiscoveRx PathHunter® CHO-K1 EDG5 β-Arrestin Cell Line (Cat no. 93-0256C2)
PathHunter® eXpress EDG5 CHO-K1 β-Arrestin GPCR Assay (Cat no. 93-0256E2CP0M)
more info

REFERENCES

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To cite this database page, please use the following:

Jerold Chun, Yasuyuki Kihara, Chido Mpamhanga.
Lysophospholipid (S1P) receptors: S1P2 receptor. Last modified on 05/02/2014. Accessed on 01/11/2014. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=276.

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