image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation. 

GAL2 receptor

Family: Galanin receptors

Contents:
Gene and Protein Information
Previous and Unofficial Names
Database Links
Agonists
Antagonists
Expression Datasets
Phenotypes, Alleles and Disease Models
References
Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 387 17q25.3 GALR2 galanin receptor 2
Mouse 7 371 11 E2 Galr2 galanin receptor 2
Rat 7 372 10q32.3 Galr2 galanin receptor 2
Previous and Unofficial Names
Galanin-2 receptor
GALR2
GALNR2
GAL2-R
GALR-2
galanin receptor 2
galanin receptor type 2
mGalR
Database Links
ChEMBL Target 11498 (Hs), 101237 (Rn)
Ensembl ENSG00000182687 (Hs), ENSMUSG00000020793 (Mm), ENSRNOG00000009407 (Rn)
Entrez Gene 8811 (Hs), 14428 (Mm), 29234 (Rn)
GeneCards GALR2 (Hs)
GenitoUrinary Development Molecular Anatomy Project Galr2 (Mm)
HomoloGene 2863 (Hs)
Human Protein Reference Database 04735 (Hs)
InterPro O43603 (Hs), O88854 (Mm), O08726 (Rn)
KEGG Gene hsa:8811 (Hs), mmu:14428 (Mm), rno:29234 (Rn)
OMIM 603691 (Hs)
PharmGKB Gene PA28546 (Hs)
PhosphoSitePlus O43603 (Hs), O88854 (Mm), O08726 (Rn)
Protein Ontology (PRO) PRO:000001586 (Hs)
RefSeq Nucleotide NM_003857 (Hs), NM_010254 (Mm), NM_019172 (Rn)
RefSeq Protein NP_003848 (Hs), NP_034384 (Mm), NP_062045 (Rn)
TreeFam ENSG00000182687 (Hs), ENSMUSG00000020793 (Mm), ENSRNOG00000009407 (Rn)
UniGene Hs. 158351 (Hs)
UniProt O43603 (Hs), O88854 (Mm), O08726 (Rn)
Wikipedia GAL2 receptor
Galanin receptors
Search for 3D structures on the PDB
Search by keyword: Galanin receptors GAL2 receptor Search by accession number: O08726, O43603, O88854
Natural/Endogenous Ligand(s)
galanin {Sp: Human} , galanin {Sp: Mouse, Rat}
galanin-like peptide {Sp: Human} , galanin-like peptide {Sp: Mouse} , galanin-like peptide {Sp: Rat}
Rank order of potency (Human)
galanin-like peptide ≥ galanin  [1]
Agonists
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Affinity Units Reference
galanin-(2–29) (rat) Rn Full agonist 8.46 pKi 4
[D-Trp2]galanin-(1–29) Rn Full agonist 8.15 pKi 2
Antagonists
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Affinity Units Reference
M871 Hs Antagonist 7.9 pKi 3
Expression Datasets

Click here to show/hide data

Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

There should be a chart of expression data here, you may need to enable JavaScript!
Phenotypes, Alleles and Disease Models Mouse data from MGI

Click here to show/hide data

Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Galr2tm1Dgen Galr2tm1Dgen/Galr2tm1Dgen
B6.129-Galr2		 MGI:1337018  MP:0001022 abnormal L5 dorsal root ganglion morphology PMID: 16487144 
Galr2Gt(OST105469)Lex Galr2Gt(OST105469)Lex/Galr2Gt(OST105469)Lex
involves: 129S5/SvEvBrd * C57BL/6J		 MGI:1337018  MP:0005017 decreased B cell number
Galr2Gt(OST105469)Lex Galr2Gt(OST105469)Lex/Galr2Gt(OST105469)Lex
involves: 129S5/SvEvBrd * C57BL/6J		 MGI:1337018  MP:0002757 decreased vertical activity
Galr2Gt(OST105469)Lex Galr2Gt(OST105469)Lex/Galr2Gt(OST105469)Lex
involves: 129S5/SvEvBrd * C57BL/6J		 MGI:1337018  MP:0005015 increased T cell number
Galr2tm1Dgen Galr2tm1Dgen/Galr2tm1Dgen
B6.129-Galr2		 MGI:1337018  MP:0001973 increased thermal nociceptive threshold PMID: 16487144 

REFERENCES

Show »

1. Ohtaki, T; Kumano, S; Ishibashi, Y; Ogi, K; Matsui, H; Harada, M; Kitada, C; Kurokawa, T; Onda, H; Fujino, M. (1999) Isolation and cDNA cloning of a novel galanin-like peptide (GALP) from porcine hypothalamus. J. Biol. Chem., 274 (52): 37041-5. [PMID:10601261]

2. Smith, KE; Forray, C; Walker, MW; Jones, KA; Tamm, JA; Bard, J; Branchek, TA; Linemeyer, DL; Gerald, C. (1997) Expression cloning of a rat hypothalamic galanin receptor coupled to phosphoinositide turnover. J. Biol. Chem., 272 (39): 24612-6. [PMID:9305929]

3. Sollenberg, U.E., Lundstrom, L., Barfa, T., Langel, U. (2006) M871- A Novel Peptide Antagonist Selectively Recognising the Galanin Receptor Type 2. International Journal of Peptide Research and Therapeutics, 12 (2): 115-119.

4. Wang, S; Hashemi, T; He, C; Strader, C; Bayne, M. (1997) Molecular cloning and pharmacological characterization of a new galanin receptor subtype. Mol. Pharmacol., 52 (3): 337-43. [PMID:9281594]

To cite this database page, please use the following:

Galanin receptors: GAL2 receptor. Last modified on 28/01/2013. Accessed on 20/05/2013. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=244.


Contact us | Print | Back to top | Help