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GAL1 receptor

Family: Galanin receptors

Contents:
Gene and Protein Information
Previous and Unofficial Names
Database Links
Antagonists
Expression Datasets
Phenotypes, Alleles and Disease Models
References
Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 349 18q23 GALR1 galanin receptor 1
Mouse 7 348 18 E3-E4 Galr1 galanin receptor 1
Rat 7 346 18q12.3 Galr1 galanin receptor 1
Previous and Unofficial Names
Galanin-1 receptor
GALR1
GALNR1
GALNR
GAL1-R
GALR-1
galanin receptor type 1
Database Links
ChEMBL Target 10190 (Hs), 100998 (Rn)
Ensembl ENSG00000166573 (Hs), ENSMUSG00000024553 (Mm), ENSRNOG00000016654 (Rn)
Entrez Gene 2587 (Hs), 14427 (Mm), 50577 (Rn)
GeneCards GALR1 (Hs)
GenitoUrinary Development Molecular Anatomy Project Galr1 (Mm)
HomoloGene 74396 (Hs)
Human Protein Reference Database 02657 (Hs)
InterPro P47211 (Hs), P56479 (Mm), Q62805 (Rn)
KEGG Gene hsa:2587 (Hs), mmu:14427 (Mm), rno:50577 (Rn)
OMIM 600377 (Hs)
PharmGKB Gene PA28545 (Hs)
PhosphoSitePlus P47211 (Hs), P56479 (Mm), Q62805 (Rn)
Protein Ontology (PRO) PRO:000001585 (Hs)
RefSeq Nucleotide NM_001480 (Hs), NM_008082 (Mm), NM_012958 (Rn)
RefSeq Protein NP_001471 (Hs), NP_032108 (Mm), NP_037090 (Rn)
TreeFam ENSG00000166573 (Hs), ENSMUSG00000024553 (Mm), ENSRNOG00000016654 (Rn)
UniGene Hs. 272191 (Hs)
UniProt P47211 (Hs), P56479 (Mm), Q62805 (Rn)
Wikipedia GAL1 receptor
Galanin receptors
Search for 3D structures on the PDB
Search by keyword: Galanin receptors GAL1 receptor Search by accession number: Q62805, P47211, P56479
Natural/Endogenous Ligand(s)
galanin {Sp: Human} , galanin {Sp: Mouse, Rat}
galanin-like peptide {Sp: Human} , galanin-like peptide {Sp: Mouse} , galanin-like peptide {Sp: Rat}
Comments: Galanin is more potent than galanin-like peptide
Rank order of potency (Human)
galanin > galanin-like peptide  [1]
Antagonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
2,3-dihydro-1,4-dithiin-1,1,4,4-tetroxide Hs Antagonist 5.57 pIC50 2
Expression Datasets

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Phenotypes, Alleles and Disease Models Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Galr1tm1Dgen Galr1tm1Dgen/Galr1tm1Dgen
involves: 129P2/OlaHsd * C57BL/6		 MGI:1096364  MP:0002169 no abnormal phenotype detected

REFERENCES

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1. Ohtaki, T; Kumano, S; Ishibashi, Y; Ogi, K; Matsui, H; Harada, M; Kitada, C; Kurokawa, T; Onda, H; Fujino, M. (1999) Isolation and cDNA cloning of a novel galanin-like peptide (GALP) from porcine hypothalamus. J. Biol. Chem., 274 (52): 37041-5. [PMID:10601261]

2. Scott, MK; Ross, TM; Lee, DH; Wang, HY; Shank, RP; Wild, KD; Davis, CB; Crooke, JJ; Potocki, AC; Reitz, AB. (2000) 2,3-Dihydro-dithiin and -dithiepine-1,1,4,4-tetroxides: small molecule non-peptide antagonists of the human galanin hGAL-1 receptor. Bioorg. Med. Chem., 8 (6): 1383-91. [PMID:10896115]

To cite this database page, please use the following:

Galanin receptors: GAL1 receptor. Last modified on 28/01/2013. Accessed on 23/05/2013. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=243.


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