image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates. 

α1D-adrenoceptor

Family: Adrenoceptors

Contents:
Gene and Protein Information
Previous and Unofficial Names
Database Links
Agonists
Antagonists
Allosteric Regulators
Transduction Mechanisms
Tissue Distribution
Expression Datasets
Functional Assays
Physiological Functions
Physiological Consequences of Altering Gene Expression
Phenotypes, Alleles and Disease Models
General Comments
References
Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 572 20p13 ADRA1D adrenoceptor alpha 1D 2
Mouse 7 562 2 F1 Adra1d adrenergic receptor, alpha 1d 1
Rat 7 561 3q36 Adra1d adrenoceptor alpha 1D 17
Previous and Unofficial Names
α1A-adrenoceptor
adrenergic receptor
α1a/d-adrenoceptor
α1A/D
α1a/d
ADRA1R
ADRA1A
ADRA1
adrenergic, alpha-1D-, receptor
Adrd1
RA42
adrenergic receptor delta1
adrenergic receptor, alpha 1d
adrenergic receptor, delta1
alpha 1D-adrenoceptor
alpha 1D-adrenoreceptor
alpha-1A adrenergic receptor
alpha-1D adrenergic receptor
alpha-1D adrenoceptor
alpha-1D adrenoreceptor
Gpcr8
Adra-1
alpha1D-AR
Database Links
ChEMBL Target 103 (Hs), 10646 (Mm), 12742 (Rn)
DrugBank Target 789 (Hs)
Ensembl ENSG00000171873 (Hs), ENSMUSG00000027335 (Mm), ENSRNOG00000021256 (Rn)
Entrez Gene 146 (Hs), 11550 (Mm), 29413 (Rn)
GeneCards ADRA1D (Hs)
GenitoUrinary Development Molecular Anatomy Project Adra1d (Mm)
Human Protein Reference Database 00079 (Hs)
InterPro P25100 (Hs), P97714 (Mm), P23944 (Rn)
KEGG Gene hsa:146 (Hs), mmu:11550 (Mm), rno:29413 (Rn)
OMIM 104219 (Hs)
PharmGKB Gene PA24597 (Hs)
PhosphoSitePlus P25100 (Hs), P97714 (Mm), P23944 (Rn)
Protein Ontology (PRO) PRO:000001185 (Hs)
RefSeq Nucleotide NM_000678 (Hs), NM_013460 (Mm), NM_024483 (Rn)
RefSeq Protein NP_000669 (Hs), NP_038488 (Mm), NP_077809 (Rn)
TreeFam ENSG00000171873 (Hs), ENSMUSG00000027335 (Mm), ENSRNOG00000021256 (Rn)
UniGene Hs. 557 (Hs)
UniProt P25100 (Hs), P97714 (Mm), P23944 (Rn)
Wikipedia α1D-adrenoceptor
Adrenoceptors
Search for 3D structures on the PDB
Search by keyword: Adrenoceptors α1D-adrenoceptor Search by accession number: P23944, P25100, P97714
Natural/Endogenous Ligand(s)
(-)-adrenaline
(-)-noradrenaline
Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
[125I]HEAT Hs Full agonist 9.5 pKd 28
(-)-noradrenaline Hs Full agonist 7.4 pKi 28
(-)-adrenaline Hs Full agonist 7.2 pKi 28
cirazoline Rn Full agonist 6.9 pKi 21
clonidine Rn Full agonist 6.9 pKi 21
St 587 Rn Full agonist 6.5 pKi 21
oxymetazoline Hs Partial agonist 6.4 pKi 24,28
(-)-adrenaline Rn Full agonist 6.3 pKi 21
(-)-noradrenaline Rn Full agonist 6.3 pKi 21
oxymetazoline Rn Partial agonist 6.2 pKi 21
SKF 89748 Rn Full agonist 6.1 pKi 21
6-fluoro-noradrenaline Rn Full agonist 6.0 pKi 21
(+)-adrenaline Hs Full agonist 6.0 pKi 28
xylometazoline Rn Full agonist 6.0 pKi 21
phenylephrine Rn Full agonist 5.9 pKi 21
α-methylnoradrenaline Hs Full agonist 5.6 pKi 21
Sgd 101/75 Rn Full agonist 5.5 pKi 21
NS-49 Hs Partial agonist 5.4 pKi 24
methoxamine Hs Full agonist 4.9 pKi 28
methoxamine Rn Full agonist 4.5 pKi 21
amidephrine Rn Full agonist 4.2 pKi 21
View species-specific agonist tables
Agonist Comments
Non catecholamine agonists, such as methoxamine and amidephrine, have both low affinity and low intrinsic activity at the α1D- adrenoceptor[21].
Antagonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
[125I]BE-2254 Hs Antagonist 9.9 pKd 27
tamsulosin Hs Antagonist 10.2 pKi 28
tamsulosin Hs Antagonist 9.8 – 10.1 pKi 7,33
prazosin Hs Inverse agonist 9.5 – 10.2 pKi 7,28,33
A-123189 Rn Antagonist 9.8 pKi 3
A-119637 Rn Antagonist 9.7 pKi 3
A-119637 Hs Antagonist 9.6 pKi 3
WB 4101 Hs Antagonist 9.6 pKi 7,28
A-123189 Hs Antagonist 9.5 pKi 3
NAN 190 Hs Antagonist 9.2 pKi 34
BMY-7378 Rn Antagonist 9.0 pKi 3
BMY-7378 Hs Antagonist 8.7 – 9.1 pKi 3,34
silodosin Hs Antagonist 8.7 pKi 28
(+)-cyclazosin Hs Inverse agonist 8.5 pKi 8
phentolamine Hs Inverse agonist 8.2 pKi 28
spiperone Hs Antagonist 8.1 pKi 34
RS-100329 Hs Antagonist 7.9 pKi 33
spiroxatrine Hs Antagonist 7.9 pKi 34
ketanserin Hs Antagonist 7.8 pKi 34
Rec 15/2739 Hs Antagonist 7.8 pKi 7
ritanserin Hs Antagonist 7.8 pKi 34
RS-17053 Hs Antagonist 7.8 pKi 7
clozapine Hs Antagonist 7.7 pKi 34
(+)-cyclazosin Rn Inverse agonist 7.6 pKi 8
5-methylurapidil Hs Antagonist 7.1 – 8.0 pKi 7,28,34
mianserin Hs Antagonist 7.5 pKi 34
(+)-niguldipine Hs Antagonist 7.4 pKi 7,28
risperidone Hs Antagonist 7.4 pKi 34
Ro-70-0004 Hs Antagonist 7.2 pKi 33
SKF 105854 Hs Antagonist 7.1 pKi 13
cyproheptadine Hs Antagonist 6.9 pKi 34
indoramin Hs Antagonist 6.7 pKi 7
View species-specific antagonist tables
Antagonist Comments
Although cyslazosin does not show selectivity in radioligand binding assays with recombinant α1-adrenoceptors, functional selectivity for the α1D-adrenoceptor is observed in functional assays using isolated tissue assays measuring affinity for native α1- subtypes [20].
Differentiation between neutral antagonists and inverse agonists at the α1D- adrenoceptor has not been studied extensively.
Allosteric Regulator Comments
Lorazepam and midazolam have been shown to increase the maximum response to phenylephrine in cells expressing the human α1D-adrenoceptor[32].

Explore drug-target interactions for this set of compounds using iPHACE

Primary Transduction Mechanisms
Transducer Effector/Response
Gq/G11 family Phospholipase C stimulation
Calcium channel
Other - See Comments
Comments:  The α1D-adrenoceptor is coupled to calcium release and inositol phosphate production less efficiently than either the α1A- or α1B-adrenoceptor.
References:  9,19
Secondary Transduction Mechanisms
Transducer Effector/Response
Phospholipase D stimulation
Other - See Comments
Comments:  α1-adrenoceptors (all subtypes) can also activate protein Kinase C, mitogen activated protein kinases.
References:  9,19
Tissue Distribution
The α1D-adrenoceptor was the predominant α1 subtype in the human aorta, but either had the lowest expression of the three subtypes, or was not detectable, in other arteries and veins. However, another report showed high expression of α1D-adrenoceptor in blood vessels of human prostate.
Species:  Human
Technique:  RNAse Protection, immunohistochemistry.
References:  25,31
α1D- adrenoceptor message and protein is predominant in human bladder.
Species:  Human
Technique:  RNase protection assay, RT-PCR.
References:  18
In the rat brain, highest levels of α1D-adrenoceptor message are found in the olfactory bulb, cerebral cortex, hippocampus, dentate gyrus, reticular thalamic nucleus, motor neurons and the inferior olivary complex. In the thalamus, the α1B and α1D-adrenoceptors have a complimentary distribution.
Species:  Rat
Technique:  in situ hybridisation.
References:  23
Expression Datasets

Click here to show/hide data

Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

There should be a chart of expression data here, you may need to enable JavaScript!
Functional Assays
Isolated rat aortic ring.
Species:  Rat
Tissue:  Vasculature.
Response measured:  Contraction.
References:  12
Skeletal muscle arteriole.
Species:  Rat
Tissue:  Vasculature.
Response measured:  Contraction.
References:  16
Physiological Functions
Contraction of mesenteric resistance arteries.
Species:  Rat
Tissue:  Vasculature.
References:  19
α1D-adrenoceptors mediate nerve stimulated contraction of corpus cavernosa.
Species:  Rat
Tissue:  Corpus Cavernosa.
References:  22
Coronary artery vasoconstriction.
Species:  Mouse
Tissue:  Vasculature.
References:  4
Femoral artery vasoconstriction.
Species:  Rat
Tissue:  Vasculature.
References:  14
Locomotor activity in response to environmental stimulation.
Species:  Mouse
Tissue:  Brain.
References:  26
Reflex evoked urethral contraction.
Species:  Rat
Tissue:  Urethra.
References:  5
Endothelium dependent vasodilation of mesenteric vascular bed.
Species:  Rat
Tissue:  Vasculature.
References:  6
Physiological Consequences of Altering Gene Expression
α1D knockout mice had delayed tail-flick and hindpaw-licking responses to thermal stimuli.
Species:  Mouse
Tissue: 
Technique:  Transgenesis.
References:  11
α1D knockout mice had hypotension, a decreased pressor and decreased coronary vasoconstrictor response to phenylephrine and resistance to salt induced hypertension.
Species:  Mouse
Tissue: 
Technique:  Transgenesis.
References:  4,29-30
Phenotypes, Alleles and Disease Models Mouse data from MGI

Click here to show/hide data

Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Adra1dtm1Gzt Adra1dtm1Gzt/Adra1dtm1Gzt
involves: 129/Sv * C57BL/6J		 MGI:106673  MP:0001544 abnormal cardiovascular system physiology PMID: 11901185 
Adra1dtm1Jabl Adra1dtm1Jabl/Adra1dtm1Jabl
involves: 129S6/SvEvTac		 MGI:106673  MP:0003313 abnormal locomotor activation PMID: 12874602 
Adra1dtm1Gzt Adra1dtm1Gzt/Adra1dtm1Gzt
involves: 129X1/SvJ * C57BL/6		 MGI:106673  MP:0004142 abnormal muscle tone PMID: 15196805 
Adra1dtm1Gzt Adra1dtm1Gzt/Adra1dtm1Gzt
involves: 129X1/SvJ * C57BL/6		 MGI:106673  MP:0003088 abnormal prepulse inhibition PMID: 15196805 
Adra1dtm1Gzt Adra1dtm1Gzt/Adra1dtm1Gzt
involves: 129X1/SvJ * C57BL/6		 MGI:106673  MP:0008428 abnormal spatial working memory PMID: 15196805 
Adra1dtm1Gzt Adra1dtm1Gzt/Adra1dtm1Gzt
involves: 129X1/SvJ * C57BL/6		 MGI:106673  MP:0001489 decreased startle reflex PMID: 15196805 
Adra1dtm1Gzt Adra1dtm1Gzt/Adra1dtm1Gzt
involves: 129/Sv * C57BL/6J		 MGI:106673  MP:0002843 decreased systemic arterial blood pressure PMID: 11901185 
Adra1dtm1Gzt Adra1dtm1Gzt/Adra1dtm1Gzt
involves: 129/Sv * C57BL/6J		 MGI:106673  MP:0006264 decreased systemic arterial systolic blood pressure PMID: 11901185 
Adra1dtm1Jabl Adra1dtm1Jabl/Adra1dtm1Jabl
involves: 129S6/SvEvTac		 MGI:106673  MP:0002757 decreased vertical activity PMID: 12874602 
Adra1dtm1Gzt Adra1dtm1Gzt/Adra1dtm1Gzt
involves: 129X1/SvJ * C57BL/6		 MGI:106673  MP:0003858 enhanced coordination PMID: 15196805 
Adra1dtm1Gzt Adra1dtm1Gzt/Adra1dtm1Gzt
involves: 129/Sv * C57BL/6J		 MGI:106673  MP:0001596 hypotension PMID: 11901185 
Adra1dtm1Jabl Adra1dtm1Jabl/Adra1dtm1Jabl
involves: 129S6/SvEvTac		 MGI:106673  MP:0009750 impaired behavioral response to addictive substance PMID: 12874602 
General Comments
α1D- adrenoceptor message and protein is predominant in human bladder [18]. In bladder tissue from normal rats, only 25% of α1- adrenoceptor message was of the α1D- subtype; however following bladder obstruction, this percentage increased to 75% [10].
When recombinant α1D- adrenoceptors are expressed in fibroblast cell lines, most of the expression is intracellular, as opposed to the cell surface expression of the other α1 subtypes [15].

REFERENCES

Show »

1. Alonso-Llamazares, A., Zamanillo, D., Casanova, E., Ovalle, S., Calvo, P. and Chinchetru, M. A. (1995) Molecular cloning of alpha 1d-adrenergic receptor and tissue distribution of three alpha 1-adrenergic receptor subtypes in mouse. J Neurochem, 65: 2387-2392. [PMID:7595531]

2. Bruno, J. F., Whittaker, J., Song, J. F. and Berelowitz, M. (1991) Molecular cloning and sequencing of a cDNA encoding a human alpha 1A adrenergic receptor. Biochem Biophys Res Commun, 179: 1485-1490. [PMID:1656955]

3. Carroll, W. A., Sippy, K. B., Esbenshade, T. A., Buckner, S. A., Hancock, A. A. and Meyer, M. D. (2001) Two novel and potent 3-[(o-methoxyphenyl)piperazinylethyl]-5-phenylthien. Bioorganic & Medicinal Chemistry Letters, 11: 1119-1121. [PMID:11354357]

4. Chalothorn, D., McCune, D. F., Edelmann, S. E., Tobita, K., Keller, B. B., Lasley, R. D., Perez, D. M., Tanoue, A., Tsujimoto, G., Post, G. R. and Piascik, M. T. (2003) Differential cardiovascular regulatory activities of the alpha 1B- and alpha 1D-adrenoceptor subtypes. Journal of Pharmacology & Experimental Therapeutics, 305: 1045-1053. [PMID:12649302]

5. Conley, R. K., Williams, T. J., Ford, A. P. and Ramage, A. G. (2001) The role of alpha(1)-adrenoceptors and 5-HT(1A) receptors in the control of the micturition reflex in male anaesthetized rats. British Journal of Pharmacology, 133: 61-72. [PMID:11325795]

6. Filippi, S., Parenti, A., Donnini, S., Granger, H. J., Fazzini, A. and Ledda, F. (2001) alpha(1D)-adrenoceptors cause endothelium-dependent vasodilatation in the rat mesenteric vascular bed. Journal of Pharmacology & Experimental Therapeutics, 296: 869-875. [PMID:11181918]

7. Ford, A. P. D. W., Daniels, D. V., Chang, D. J., Gever, J. R., Jasper, J. R., Lesnick, J. D. and Clarke, D. E. (1997) Pharmacological pleiotropism of the human recombinant α1A-adrenoceptor: implications for α1-adrenoceptor classification. Br. J. Pharmacol., 121: 1127-1135. [PMID:9249248]

8. Giardina, D., Crucianelli, M., Romanelli, R., Leonardi, A., Poggesi, E. and Melchiorre, C. (1996) Synthesis and biological profile of the enantiomers of [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-cis-octahydroquinoxalin-1-yl]furan-2-ylmethanone (cyclazosin) a potent competitive alpha-1B adrenoceptor antagonist. J Med Chem, 39: 4602-4607. [PMID:8917649]

9. Hague, C., Chen, Z., Uberti, M. and Minneman, K. P. (2003) alpha1- adrenergic receptor subtypes: non-identical triplets with different dancing partners. Life Sci, 74: 411-418. [PMID:14609720]

10. Hampel, C., Dolber, P. C., Smith, M. P., Savic, S. L., Throff, J. W., Thor, K. B. and Schwinn, D. A. (2002) Modulation of bladder alpha1-adrenergic receptor subtype expression by bladder outlet obstruction. Journal of Urology, 167: 1513-1521. [PMID:11832780]

11. Harasawa, I., Honda, K., Tanoue, A., Shinoura, H., Ishida, Y., Okamura, H., Murao, N., Tsujimoto, G., Higa, K., Kamiya, H. O. and Takano, Y. (2003) Responses to noxious stimuli in mice lacking alpha(1d)-adrenergic receptors. Neuroreport, 14: 1857-1860. [PMID:14534435]

12. Hieble, J. P. and Ruffolo, R. R. Jr. (1996) Subclassification and nomenclature of alpha-1 and alpha-2 adrenoceptors. Prog in Drug Res, 47: 81-130. [PMID:8961765]

13. Hieble, J. P., Bylund, D. B., Clarke, D. E., Eikenburg, D. C., Langer, S. Z., Lefkowitz, R. J., Minneman, K. P. and Ruffolo, R. R. Jr. (1995) International Union of Pharmacology. X. Recommendation for nomenclature of α1-adrenoceptors: Consensus update. Pharmacol. Rev., 47: 267-270. [PMID:7568329]

14. Hrometz, S. L., Edelmann, S. E., McCune, D. F., Olges, J. R., Hadley, R. W., Perez, D. M. and Piascik, M. T. (1999) Expression of multiple alpha1-adrenoceptors on vascular smooth muscle: correlation with the regulation of contraction. Journal of Pharmacology & Experimental Therapeutics, 290: 452-463. [PMID:10381812]

15. Koshimizu, T. A., Tanoue, A., Hirasawa, A., Yamauchi, J. and Tsujimoto, G. (2003) Recent advances in alpha1-adrenoceptor pharmacology. Pharmacology & Therapeutics, 98: 235-244. [PMID:12725871]

16. Leech, C. J. and Faber, J. E. (1996) Different alpha-adrenoceptor subtypes mediate constriction of arterioles and venules. American Journal of Physiology, 270: H710-H722. [PMID:8779849]

17. Lomasney, J. et al.. (1991) Molecular cloning and expression of the cDNA for the α1A-adrenergic receptor: the gene for which is located on human chromosome 5. J. Biol. Chem., 266: 6365-6369. [PMID:1706716]

18. Malloy, B. J., Price, D. T., Price, R. R., Bienstock, A. M., Dole, M. K., Funk, B. L., Rudner, X. L., Richardson, C. D., Donatucci, C. F. and Schwinn, D. A. (1998) Alpha1-adrenergic receptor subtypes in human detrusor. Journal of Urology, 160: 937-943. [PMID:9720591]

19. Michelotti, G. A., Price, D. T. and Schwinn, D. A. (2000) alpha-1 Adrenergic receptor regulation: basic science and clinical implications. Pharmacol & Ther, 88: 281-309. [PMID:11337028]

20. Minarini, A., Budriesi, R., Chiarini, A., Leonardi, A. and Melchiorre, C. (1998) Search for alpha 1-adrenoceptor subtypes selective antagonists: design, synthesis and biological activity of cystazosin, an alpha 1D-adrenoceptor antagonist. Bioorganic & Medicinal Chemistry Letters, 8: 1353-1358. [PMID:9871765]

21. Minneman, K. P., Theroux, T. L., Hollinger, S., Han, C. and Esbenshade, T. A. (1994) Selectivity of agonists for cloned α1-adrenergic receptor subtypes. Mol. Pharmacol., 46: 929-936. [PMID:7969082]

22. Mizusawa, H., Hedlund, P., Sjunnesson, J., Brioni, J. D., Sullivan, J. P. and Andersson, K. E. (2002) Enhancement of apomorphine-induced penile erection in the rat by a selective alpha(1D)-adrenoceptor antagonist. British Journal of Pharmacology, 136: 701-708. [PMID:12086979]

23. Nicholas, A. P., Hokfelt, T. and Pieribone, V. A. (1996) The distribution and significance of CNS adrenoceptors examined with in situ hybridization. Trends in Pharmacological Sciences, 17: 245-255. [PMID:8756183]

24. Obika, K., Shibata, K., Horie, K., Foglar, R., Kimura, K. and Tsujimoto, G. (1995) NS-49, a novel alpha-1a adrenoceptor selective agonist characterization using recombinant human alpha-1 adrenoceptors. Europ J Pharmacol, 291: 327-334. [PMID:8719417]

25. Rudner, X. L., Berkowitz, D. E., Booth, J. V., Funk, B. L., Cozart, K. L., D'Amico, E. B., El-Moalem, H., Page, S. O., Richardson, C. D., Winters, B., Marucci, L. and Schwinn, D. A. (1999) Subtype specific regulation of human vascular alpha(1)-adrenergic receptors by vessel bed and age. Circulation, 100: 2336-2343. [PMID:10587338]

26. Sadalge, A., Coughlin, L., Fu, H., Wang, B., Valladares, O., Valentino, R. and Blendy, J. A. (2003) alpha 1d Adrenoceptor signaling is required for stimulus induced locomotor activity. Molecular Psychiatry, 8: 664-672. [PMID:12874602]

27. Schwinn, D. A., Johnston, G. I., Page, S. O., Mosley, M. J., Wilson, K. H., Worman, N. P., Campbell, S., Fidock, M. D., Furness, L. M., Parry-Smith, D. J. et al.. (1995) Cloning and pharmacological characterization of human alpha-1 adrenergic receptors: sequence corrections and direct comparison with other species homologues. Journal of Pharmacology & Experimental Therapeutics, 272: 134-142. [PMID:7815325]

28. Shibata, K., Foglar, R., Horie, K., Obika, K., Sakamoto, A., Ogawa, S. and Tsujimoto, G. (1995) KMD-3213, a novel, potent, alpha 1a-adrenoceptor-selective antagonist: characterization using recombinant human alpha 1-adrenoceptors and native tissues. Mol. Pharmacol., 48: 250-258. [PMID:7651358]

29. Tanoue, A., Koba, M., Miyawaki, S., Koshimizu, T. A., Hosoda, C., Oshikawa, S. and Tsujimoto, G. (2002) Role of the alpha1D-adrenergic receptor in the development of salt-induced hypertension. Hypertension, 40: 101-106. [PMID:12105146]

30. Tanoue, A., Nasa, Y., Koshimizu, T., Shinoura, H., Oshikawa, S., Kawai, T., Sunada, S., Takeo, S. and Tsujimoto, G. (2002) The alpha(1D)-adrenergic receptor directly regulates arterial blood pressure via vasoconstriction. Journal of Clinical Investigation, 109: 765-775. [PMID:11901185]

31. Walden, P. D., Gerardi, C. and Lepor, H. (1999) Localization and expression of the alpha1A-1, alpha1B and alpha1D-adrenoceptors in hyperplastic and non-hyperplastic human prostate. Journal of Urology, 161: 635-640. [PMID:9915474]

32. Waugh, D. J., Gaivin, R. J., Damron, D. S., Murray, P. A. and Perez, D. M. (1999) Binding, partial agonism, and potentiation of alpha(1)-adrenergic receptor function by benzodiazepines: A potential site of allosteric modulation. Journal of Pharmacology & Experimental Therapeutics, 291: 1164-1171. [PMID:10565838]

33. Williams, T. J., Blue, D. R., Daniels, D. V., Davis, B., Elworthy, T., Gever, J. R., Kava, M. S., Morgans, D., Padilla, F., Tassa, S., Vimont, R. L., Chapple, C. R., Chess-Williams, R., Eglen, R. M., Clarke, D. E. and Ford, A. P. (1999) In vitroalpha1-adrenoceptor pharmacology of Ro 70-0004 and RS-100329, novel alpha1A-adrenoceptor selective antagonists. Br. J. Pharmacol., 127: 252-258. [PMID:10369480]

34. Yoshio, R., Taniguchi, T., Itoh, H. and Muramatsu, I. (2001) Affinity of serotonin receptor antagonists and agonists to recombinant and native alpha1-adrenoceptor subtypes. Jpn J Pharmacol, 86: 189-195. [PMID:11459121]

To cite this database page, please use the following:

Richard A. Bond, David B. Bylund, Douglas C. Eikenburg, J. Paul Hieble, Rebecca Hills, Kenneth P. Minneman, Sergio Parra.
Adrenoceptors: α1D-adrenoceptor. Last modified on 27/11/2012. Accessed on 21/05/2013. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=24.


Contact us | Print | Back to top | Help