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α1B-adrenoceptor

Family: Adrenoceptors

Contents:
Gene and Protein Information
Previous and Unofficial Names
Database Links
Agonists
Antagonists
Allosteric Regulators
Transduction Mechanisms
Tissue Distribution
Expression Datasets
Functional Assays
Physiological Functions
Physiological Consequences of Altering Gene Expression
Phenotypes, Alleles and Disease Models
References
Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 519 5q23-q32 ADRA1B adrenoceptor alpha 1B 23
Mouse 7 515 11 B1.1 Adra1b adrenergic receptor, alpha 1b 16
Rat 7 514 10q21 Adra1b adrenoceptor alpha 1B 2
Previous and Unofficial Names
α1b
adrenergic, alpha-1B-, receptor
Adrenergic alpha 1B- receptor
adrenergic alpha 1B receptor
adrenergic receptor, alpha 1b
adrenergic, alpha 1B, receptor
alpha 1B-adrenoceptor
alpha 1B-adrenoreceptor
alpha-1B adrenergic receptor
alpha-1B adrenoceptor
alpha-1B adrenoreceptor
alpha1B-adrenergic receptor
Database Links
ChEMBL Target 128 (Hs), 10652 (Mm), 12474 (Rn)
DrugBank Target 632 (Hs)
Ensembl ENSG00000170214 (Hs), ENSMUSG00000050541 (Mm)
Entrez Gene 147 (Hs), 11548 (Mm), 24173 (Rn)
GeneCards ADRA1B (Hs)
GenitoUrinary Development Molecular Anatomy Project Adra1b (Mm)
HomoloGene 55477 (Hs)
Human Protein Reference Database 00080 (Hs)
InterPro P35368 (Hs), P15823 (Mm), P97717 (Rn)
KEGG Gene hsa:147 (Hs), mmu:11548 (Mm), rno:24173 (Rn)
OMIM 104220 (Hs)
PharmGKB Gene PA33 (Hs)
PhosphoSitePlus P35368 (Hs), P97717 (Mm), P15823 (Rn)
Protein Ontology (PRO) PRO:000001184 (Hs)
RefSeq Nucleotide NM_000679 (Hs), NM_007416 (Mm), NM_016991 (Rn)
RefSeq Protein NP_000670 (Hs), NP_031442 (Mm), NP_058687 (Rn)
TreeFam ENSG00000170214 (Hs), ENSMUSG00000050541 (Mm)
UniGene Hs. 368632 (Hs)
UniProt P35368 (Hs), P15823 (Mm), P97717 (Rn)
Wikipedia α1B-adrenoceptor
Adrenoceptors
Search for 3D structures on the PDB
Search by keyword: Adrenoceptors α1B-adrenoceptor Search by accession number: P97717, P35368, P15823
Natural/Endogenous Ligand(s)
(-)-adrenaline
(-)-noradrenaline
Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
[125I]HEAT Hs Full agonist 10.2 pKd 25
(-)-adrenaline Hs Full agonist 6.5 pKi 25
oxymetazoline Hs Full agonist 6.5 pKi 19,25
(-)-noradrenaline Hs Full agonist 6.2 pKi 25
(+)-adrenaline Hs Full agonist 5.1 pKi 25
NS-49 Hs Partial agonist 5.1 pKi 19
methoxamine Hs Full agonist 4.0 pKi 25
phenylephrine Hs Full agonist 6.3 – 7.5 pIC50 12,18
Agonist Comments
Non catecholamine agonists, such as methoxamine and amidephrine, have both low affinity and low intrinsic activity at the α1B- adrenoceptor [18]. Much data has been generated using the hamster α1B-adrenoceptor, since this was the first α1B- homolog to be cloned. There is no evidence for any significant species differences in agonist and antagonist affinity between hamster, rat and human receptors.
Antagonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
[125I]BE-2254 Hs Inverse agonist 9.9 pKd 17,24
(+)-cyclazosin Hs Inverse agonist 9.9 pKi 13
prazosin Hs Inverse agonist 9.6 – 9.9 pKi 12,25,27
tamsulosin Hs Inverse agonist 9.6 – 9.7 pKi 12,27
tamsulosin Hs Antagonist 9.5 pKi 25
NAN 190 Hs Antagonist 9.2 pKi 28
spiperone Hs Inverse agonist 9.2 pKi 28
WB 4101 Hs Antagonist 8.5 – 9.0 pKi 12,25
rho-TIA Hs Antagonist 8.4 pKi 7
A-119637 Hs Antagonist 8.3 pKi 4
L-765314 Rn Antagonist 8.3 pKi 20
clozapine Hs Antagonist 8.2 pKi 28
ketanserin Hs Antagonist 8.2 pKi 28
A-123189 Hs Antagonist 8.0 pKi 4
risperidone Hs Antagonist 8.0 pKi 28
ritanserin Hs Antagonist 8.0 pKi 28
Rec 15/2739 Hs Antagonist 7.8 pKi 12
L-765314 Hs Antagonist 7.7 pKi 20
silodosin Hs Antagonist 7.7 pKi 25
cyproheptadine Hs Antagonist 7.6 pKi 28
spiroxatrine Hs Antagonist 7.6 pKi 28
phentolamine Hs Antagonist 7.5 pKi 25
5-methylurapidil Hs Antagonist 7.2 – 7.7 pKi 12,25,28
indoramin Hs Antagonist 7.4 pKi 12
mianserin Hs Antagonist 7.4 pKi 28
BMY-7378 Hs Antagonist 7.0 – 7.5 pKi 4,28
(+)-niguldipine Hs Antagonist 6.7 – 7.7 pKi 12,25
Ro-70-0004 Hs Antagonist 7.1 pKi 27
View species-specific antagonist tables
Antagonist Comments
(+) Cyclazosin shows α1B- selectivity in radioligand binding assays with recombinant receptors; however, a lack of functional selectivity in isolated tissue preparations has been reported [26]. A 19 amino acid peptide, rho-TIA, has been reported to produce non-competitive blockade of α1B-adrenoceptor mediated inositol phosphate formation at concentrations having little effect on this response in cells expressing the other α1 subtypes. Higher concentrations produce nearly complete blockade of the α1B- response, and competitive inhibition of the α1A- and α1D- mediated response [7].
Allosteric Regulator Comments
While no allosteric regulation of the α1B- adrenoceptor has been proven, the conopeptide sigma-TIA displaced radioligand binding to recombinant α1B- adrenoceptors in a non-competitive manner [7,15].

Explore drug-target interactions for this set of compounds using iPHACE

Primary Transduction Mechanisms
Transducer Effector/Response
Gq/G11 family Phospholipase C stimulation
Calcium channel
Other - See Comments
Comments:  The α1B-adrenoceptor is coupled to calcium release and inositol phosphate production less efficiently than the α1A but more efficiently than the α1D.
References:  15,17
Secondary Transduction Mechanisms
Transducer Effector/Response
Phospholipase D stimulation
Other - See Comments
Comments:  α1- adrenoceptors (all subtypes) can also activate protein Kinase C, mitogen activated protein kinases.
References:  15,17
Tissue Distribution
α1B-adrenoceptors are either absent or scarce on human prostatic stromal smooth muscle, proximal urethra or corpus cavernosa. α1B-adrenoceptors are found in the human spleen and kidney, and with other subtypes in human somatic arteries and veins.
Species:  Human
Technique:  RT-PCR, RNase protection assay.
References:  17,22
In the rat brain, highest levels of α1B- adrenoceptor protein are found in regions involved in stress and neuroendocrine function. Intense labeling was found in hypothalamic paraventricular nuclei, supraoptic nucleus, median eminence and arcuate nucleus. Immunoreactivity was also found in layer V of the frontal cortex, thalamus, hippocampus, diagonal band of Broca and caudate-putamen. Some midbrain and hindbrain regions important for motor function were also immunoreactive.
Species:  Rat
Technique:  Immunohistochemistry.
References:  1,9
High expression levels of α1B-adrenoceptor was found in the medial layer of the aorta and caudal, femoral, iliac, renal, superior mesenteric and mesenteric resistance arteries.
Species:  Rat
Technique:  Immunohistochemistry.
References:  21
Expression Datasets

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Functional Assays
Isolated first order venules.
Species:  Human
Tissue:  Vasculature
Response measured:  Vasculature
References:  14
Isolated longitudinal strip of rat spleen.
Species:  Rat
Tissue:  Spleen
Response measured:  Contraction
References:  26
Physiological Functions
Contraction of mesenteric resistance arteries.
Species:  Rat
Tissue:  Vasculature.
References:  21
α1B-adrenoceptors appear to be involved in the regulation of cardiac growth and contractile function.
Species:  Mouse
Tissue:  Heart.
References:  6
Contraction of mammary artery and saphenous vein (with α1A).
Species:  Human
Tissue:  Vasculature
References:  14
Adrenaline induced stimulation of hydroxyl radical formation in isolated hepatocytes.
Species:  Rat
Tissue:  Liver.
References:  5
CNS Stimulation by d-amphetamine, cocaine and morphine.
Species:  Mouse
Tissue:  Brain.
References:  10
Growth of vascular adventitia following balloon injury.
Species:  Rat
Tissue:  Aorta.
References:  29
Contraction of umbilical vein.
Species:  Human
Tissue:  Vasculature.
References:  11
Physiological Consequences of Altering Gene Expression
α1B- knockout mice are protected against methamphetamine induced degeneration of the nigro-striatal neuronal pathway in CNS. α1B- knockout mice show an enhanced reactivity to new situations.
Species:  Mouse
Tissue: 
Technique:  Transgenesis.
References:  3
α1B- knockout mice have elevated glycogen stores in both fed and fasted state and are hyperinsulinemic when fasted. They are more sensitive to obesity induced by a high fat diet.
Species:  Mouse
Tissue: 
Technique:  Transgenesis.
References:  8
Phenotypes, Alleles and Disease Models Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd		 MGI:104774  MP:0004184 abnormal baroreceptor physiology PMID: 15466664 
Adra1atm1Pcs|Adra1btm1Cta Adra1atm1Pcs/Adra1atm1Pcs,Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N		 MGI:104773  MGI:104774  MP:0002972 abnormal cardiac muscle contractility PMID: 14519431 
Adra1atm1Pcs|Adra1btm1Cta Adra1atm1Pcs/Adra1atm1Pcs,Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N		 MGI:104773  MGI:104774  MP:0000304 abnormal cardiac stroke volume PMID: 12782680 
Adra1atm1Pcs|Adra1btm1Cta Adra1atm1Pcs/Adra1atm1Pcs,Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N		 MGI:104773  MGI:104774  MP:0001544 abnormal cardiovascular system physiology PMID: 12782680 
Adra1atm1Pcs|Adra1btm1Cta Adra1atm1Pcs/Adra1atm1Pcs,Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N		 MGI:104773  MGI:104774  MP:0002332 abnormal exercise endurance PMID: 12782680 
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd * C57BL/6J		 MGI:104774  MP:0002078 abnormal glucose homeostasis PMID: 14581480 
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd		 MGI:104774  MP:0003921 abnormal heart left ventricle morphology PMID: 15466664 
Adra1atm1Pcs|Adra1btm1Cta Adra1atm1Pcs/Adra1atm1Pcs,Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N		 MGI:104773  MGI:104774  MP:0005406 abnormal heart size PMID: 12782680 
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd * C57BL/6J		 MGI:104774  MP:0001449 abnormal learning/ memory PMID: 11222061 
Adra1atm1Pcs|Adra1btm1Cta Adra1atm1Pcs/Adra1atm1Pcs,Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N		 MGI:104773  MGI:104774  MP:0004215 abnormal myocardial fiber physiology PMID: 14519431 
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd * C57BL/6J		 MGI:104774  MP:0003562 abnormal pancreatic beta cell physiology PMID: 14581480 
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd * C57BL/6J		 MGI:104774  MP:0003461 abnormal response to novel object PMID: 11222061 
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129/Sv * C57BL/6J		 MGI:104774  MP:0002216 abnormal seminiferous tubule morphology PMID: 17951539 
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129/Sv * C57BL/6J		 MGI:104774  MP:0002784 abnormal Sertoli cell morphology PMID: 17951539 
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd * C57BL/6J		 MGI:104774  MP:0001463 abnormal spatial learning PMID: 11222061 
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd		 MGI:104774  MP:0000230 abnormal systemic arterial blood pressure PMID: 9326654 
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129/Sv * C57BL/6J		 MGI:104774  MP:0002782 abnormal testicular secretion PMID: 17951539 
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129/Sv * C57BL/6J		 MGI:104774  MP:0001155 arrest of spermatogenesis PMID: 17951539 
Adra1atm1Pcs|Adra1btm1Cta Adra1atm1Pcs/Adra1atm1Pcs,Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N		 MGI:104773  MGI:104774  MP:0006138 congestive heart failure PMID: 12782680 
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd		 MGI:104774  MP:0005140 decreased cardiac muscle contractility PMID: 15466664  9326654 
Adra1atm1Pcs|Adra1btm1Cta Adra1atm1Pcs/Adra1atm1Pcs,Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N		 MGI:104773  MGI:104774  MP:0003393 decreased cardiac output PMID: 12782680 
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd * C57BL/6J		 MGI:104774  MP:0002702 decreased circulating free fatty acid level PMID: 14581480 
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129/Sv * C57BL/6J		 MGI:104774  MP:0002780 decreased circulating testosterone level PMID: 17951539 
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd		 MGI:104774  MP:0001417 decreased exploration in new environment PMID: 11115730 
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd * C57BL/6J		 MGI:104774  MP:0005439 decreased glycogen level PMID: 14581480 
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd		 MGI:104774  MP:0005333 decreased heart rate PMID: 15466664 
Adra1atm1Pcs|Adra1btm1Cta Adra1atm1Pcs/Adra1atm1Pcs,Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N		 MGI:104773  MGI:104774  MP:0005333 decreased heart rate PMID: 12782680 
Adra1atm1Pcs|Adra1btm1Cta Adra1atm1Pcs/Adra1atm1Pcs,Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N		 MGI:104773  MGI:104774  MP:0002834 decreased heart weight PMID: 12782680 
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129/Sv * C57BL/6J		 MGI:104774  MP:0001935 decreased litter size PMID: 17951539 
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129/Sv * C57BL/6J		 MGI:104774  MP:0004901 decreased male germ cell number PMID: 17951539 
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd		 MGI:104774  MP:0002843 decreased systemic arterial blood pressure PMID: 15466664 
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd		 MGI:104774  MP:0006264 decreased systemic arterial systolic blood pressure PMID: 15466664 
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129/Sv * C57BL/6J		 MGI:104774  MP:0004852 decreased testis weight PMID: 17951539 
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd		 MGI:104774  MP:0003026 decreased vasoconstriction PMID: 15466664 
Adra1atm1Pcs|Adra1btm1Cta Adra1atm1Pcs/Adra1atm1Pcs,Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N		 MGI:104773  MGI:104774  MP:0003068 enlarged kidney PMID: 12782680 
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd * C57BL/6J		 MGI:104774  MP:0001559 hyperglycemia PMID: 14581480 
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd * C57BL/6J		 MGI:104774  MP:0009750 impaired behavioral response to addictive substance PMID: 11923452 
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd * C57BL/6J		 MGI:104774  MP:0009712 impaired conditioned place preference behavior PMID: 11923452 
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd * C57BL/6J		 MGI:104774  MP:0005293 impaired glucose tolerance PMID: 14581480 
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd		 MGI:104774  MP:0004000 impaired passive avoidance behavior PMID: 11115730 
Adra1atm1Pcs|Adra1btm1Cta Adra1atm1Pcs/Adra1atm1Pcs,Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N		 MGI:104773  MGI:104774  MP:0005599 increased cardiac muscle contractility PMID: 12782680 
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd * C57BL/6J		 MGI:104774  MP:0002079 increased circulating insulin level PMID: 14581480 
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd * C57BL/6J		 MGI:104774  MP:0005669 increased circulating leptin level PMID: 14581480 
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129/Sv * C57BL/6J		 MGI:104774  MP:0001751 increased circulating luteinizing hormone level PMID: 17951539 
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd * C57BL/6J		 MGI:104774  MP:0001415 increased exploration in new environment PMID: 11222061 
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd * C57BL/6J		 MGI:104774  MP:0005440 increased glycogen level PMID: 14581480 
Adra1atm1Pcs|Adra1btm1Cta Adra1atm1Pcs/Adra1atm1Pcs,Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N		 MGI:104773  MGI:104774  MP:0003823 increased left ventricular developed pressure PMID: 14519431 
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd * C57BL/6J		 MGI:104774  MP:0005458 increased percent body fat PMID: 14581480 
Adra1atm1Pcs|Adra1btm1Cta Adra1atm1Pcs/Adra1atm1Pcs,Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N		 MGI:104773  MGI:104774  MP:0004485 increased response of heart to induced stress PMID: 12782680 
Adra1atm1Pcs|Adra1btm1Cta Adra1atm1Pcs/Adra1atm1Pcs,Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N		 MGI:104773  MGI:104774  MP:0009763 increased sensitivity to induced morbidity/mortality PMID: 12782680 
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd * C57BL/6J		 MGI:104774  MP:0005658 increased susceptibility to diet-induced obesity PMID: 14581480 
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd * C57BL/6J		 MGI:104774  MP:0005331 insulin resistance PMID: 14581480 
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129/Sv * C57BL/6J		 MGI:104774  MP:0008280 male germ cell apoptosis PMID: 17951539 
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129/Sv * C57BL/6J		 MGI:104774  MP:0001925 male infertility PMID: 17951539 
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129/Sv * C57BL/6J		 MGI:104774  MP:0001922 reduced male fertility PMID: 17951539 
Adra1atm1Pcs|Adra1btm1Cta Adra1atm1Pcs/Adra1atm1Pcs,Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N		 MGI:104773  MGI:104774  MP:0002188 small heart PMID: 12782680 
Adra1atm1Pcs|Adra1btm1Cta Adra1atm1Pcs/Adra1atm1Pcs,Adra1btm1Cta/Adra1btm1Cta
B6.129-Adra1b Adra1a		 MGI:104773  MGI:104774  MP:0002188 small heart PMID: 12782680 
Adra1atm1Pcs|Adra1btm1Cta Adra1atm1Pcs/Adra1atm1Pcs,Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N		 MGI:104773  MGI:104774  MP:0004565 small myocardial fiber PMID: 12782680 
Adra1atm1Pcs|Adra1btm1Cta Adra1atm1Pcs/Adra1atm1Pcs,Adra1btm1Cta/Adra1btm1Cta
B6.129-Adra1b Adra1a		 MGI:104773  MGI:104774  MP:0004565 small myocardial fiber PMID: 12782680 
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129/Sv * C57BL/6J		 MGI:104774  MP:0001157 small seminal vesicle PMID: 17951539 
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129/Sv * C57BL/6J		 MGI:104774  MP:0001153 small seminiferous tubules PMID: 17951539 
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129/Sv * C57BL/6J		 MGI:104774  MP:0001147 small testis PMID: 17951539 

REFERENCES

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To cite this database page, please use the following:

Richard A. Bond, David B. Bylund, Douglas C. Eikenburg, J. Paul Hieble, Rebecca Hills, Kenneth P. Minneman, Sergio Parra.
Adrenoceptors: α1B-adrenoceptor. Last modified on 25/10/2012. Accessed on 19/05/2013. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=23.


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