Nomenclature: ETB receptor

Family: Endothelin receptors

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates. 

Contents

Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 442 13q22 EDNRB endothelin receptor type B 2,18,35,38,45
Mouse 7 442 14 E2.3 Ednrb endothelin receptor type B 25
Rat 7 442 15 Ednrb endothelin receptor type B 7,46
Previous and Unofficial Names
HSCR2
HSCR
ETB
Ednra
ET-B
ET-BR
endothelin B receptor
endothelin receptor
endothelin receptor non-selective type
endothelin receptor type B
endothelin-B receptor
Sox10m1
ETR-b
AU022549
s
Database Links
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
GPCRDB
GeneCards
GenitoUrinary Development Molecular Anatomy Project
HomoloGene
Human Protein Reference Database
InterPro
KEGG Gene
OMIM
Orphanet Gene
PharmGKB Gene
PhosphoSitePlus
Protein Ontology (PRO)
RefSeq Nucleotide
RefSeq Protein
TreeFam
UniGene Hs.
UniProtKB
Wikipedia
Natural/Endogenous Ligands
endothelin-1 {Sp: Human, Mouse, Rat}
endothelin-2 {Sp: Human}
endothelin-3 {Sp: Human, Mouse, Rat}
Family selective agonists (Human)
ET-1 (EDN1, P05305) = ET-2 (EDN2, P20800), ET-3 (EDN3, P14138)
Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
endothelin-3 {Sp: Human, Mouse, Rat} Hs Full agonist 9.8 – 11.5 pKd 10,27-28,44
pKd 9.8 – 11.5 [10,27-28,44]
sarafotoxin S6c Rn Full agonist 10.2 – 10.8 pKd 44,56
pKd 10.2 – 10.8 [44,56]
endothelin-3 {Sp: Human, Mouse, Rat} Rn Full agonist 9.9 – 10.6 pKd 44,56
pKd 9.9 – 10.6 [44,56]
[125I]IRL1620 Hs Full agonist 9.9 – 10.1 pKd 36
pKd 9.9 – 10.1 (Kd 7.9x10-11 – 1.26x10-10 M) [36]
[125I]IRL1620 Rn Full agonist 9.8 – 10.1 pKd 36
pKd 9.8 – 10.1 [36]
[125I][Ala1,3,11,15]ET-1 Hs Full agonist 9.7 pKd 31
pKd 9.7 (Kd 2x10-10 M) [31]
[125I]ET-1 Hs Full agonist 9.2 – 10.0 pKd 10,14,26-28,32
pKd 9.2 – 10.0 [10,14,26-28,32]
sarafotoxin S6c Hs Full agonist 8.8 – 9.8 pKd 29,44
pKd 8.8 – 9.8 [29,44]
[125I]BQ3020 Hs Full agonist 8.3 – 10.0 pKd 23,31,40
pKd 8.3 – 10.0 (Kd 1x10-10 – 5x10-9 M) [23,31,40]
[Ala1,3,11,15]ET-1 Hs Full agonist 8.7 – 9.2 pKd 31
pKd 8.7 – 9.2 (Kd 6.43x10-10 – 1.82x10-9 M) [31]
BQ 3020 Hs Full agonist 9.7 pKi 43
pKi 9.7 (Ki 1.8x10-10 M) [43]
IRL 1620 Hs Full agonist 8.7 pKi 54
pKi 8.7 (Ki 2.26x10-9 M) [54]
View species-specific agonist tables
Agonist Comments

In mammals, the endothelin (ET) family comprises three endogenous isoforms, ET-1, ET-2 and ET-3. ET-1 is the principal isoform in the human cardiovascular system and is one of the most ubiquitous, potent and unusually long lasting constrictor of human vessels. ET-2 has been less extensively studied than other ET peptides but the peptide is present in human cardiovascular tissues and ET-2 was as potent a vasoconstrictor as ET-1 in human arteries and veins. VIC (vasoactive intestinal contractor) is the murine isoform of ET-2. Endothelial cells do not synthesise ET-3 but the mature peptide is detectable in plasma and other tissues including heart and brain. ET-3 is unique in that it is the only endogenous isoform that distinguishes between the two endothelin receptors. It has the same affinity at the ETB receptor as ET-1 but, at physiological concentrations, has little or no affinity for the ETA.The only endogenous peptides with a high degree of sequence similarity to the ETs are the sarafotoxins (S6a, S6b, S6c, S6d). This family of 21aa peptides were originally discovered in the venom of a snake, Atractaspis engadensis [11].

ETB receptors are initially classfied according to the the rank order of potency of ET agonists with ET-1 being equipotent to ET-3, confirmed by using selective peptide antagonists (BQ788) or non-peptide antagonists (eg A192621 or RO4868443).
Antagonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
TAK 044 Rn Antagonist 8.4 pA2 55
pA2 8.4 [55]
bosentan Rn Antagonist 6.0 pA2 8
pA2 6.0 [8]
SB209670 Rn Antagonist 9.4 pKB 17
pKB 9.4 (KB 4x10-10 M) [17]
A192621 Hs Antagonist 8.1 pKd 53
pKd 8.1 [53]
BQ788 Hs Antagonist 7.9 – 8.0 pKd 44
pKd 7.9 – 8.0 [44]
BQ788 Rn Antagonist 7.5 pKd 44
pKd 7.5 [44]
IRL 2500 Hs Antagonist 7.2 pKd 44
pKd 7.2 [44]
bosentan Hs Antagonist 7.1 pKi 33
pKi 7.1 (Ki 8x10-8 M) [33]
RO4868443 Hs Antagonist 7.2 pIC50 6
pIC50 7.2 (IC50 6.9x10-8 M) [6]
macitentan Hs Antagonist 6.41 pIC50 4
pIC50 6.41 (IC50 3.91x10-7 M) [4]
ambrisentan Hs Antagonist 5.92 pIC50 5
pIC50 5.92 (IC50 1.19x10-6 M) [5]
View species-specific antagonist tables
Antagonist Comments

Antagonists are currently classified as either ETA-selective, ETB-selective or mixed antagonists that display similar affinity for both receptors. A limited number of peptide (e.g. BQ788) and non-peptide (e.g. A192621) ETB antagonists have been developed, reflecting the lack of clinical need for this type of compound. They are less potent than ETA antagonists and display lower selectivity (usually only 1-2 orders of magnitude) for the ETB receptor [11]. The approved drug, macitentan, is a dual endothelin receptor antagonist [4] with higher affinity for the ETA receptor than for the ETB receptor (IC50 0.5nM and 391nM respectively) [4].
Primary Transduction Mechanisms
Transducer Effector/Response
Gs family
Gi/Go family
Gq/G11 family
Phospholipase C stimulation
Phospholipase A2 stimulation
Phospholipase D stimulation
Comments:  Activation of ETB receptors to produce a range of biological actions in different tissues is thought to be mediated by a number of transduction systems coupled to various types of G-protein including Gq/G11, Gs, Gq/13 and Gi2. The major enzymes systems activated include phospholipase C, A2 and D. Increases of tyrosine phosphorylation of cellular proteins, stimulation of mitogen-activated protein kinase (MAPK), and DNA synthesis are mediated by ETB receptors in certain cell types such as astrocytes[16,41,48,50].
References:  16,41,48,50
Tissue Distribution
Endothelial cells lining wall of all blood vessels. High desities in the lung (particularly airway smooth muscle) and brain, lower densities in heart (especially atrioventricular conducting system).
Species:  Human
Technique:  Radioligand binding
References:  15
Expression Datasets

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Functional Assays
Initial depressor response in vivo in chronically instrumented animals by ETB agonists activating endothelial ETB.
Species:  Rat
Tissue:  Vascular beds.
Response measured:  Vasodilatation.
References:  20-21
Rings of isolated trachae, denuded of epithelium.
Species:  Rat
Tissue:  Trachae.
Response measured:  Sarafotoxin S6c (ETB selective agonist) constriction.
References:  6,24,37
Physiological Functions
Clearance receptor: removal of ET circulating in the plasma.
Species:  Rat
Tissue:  Lungs, kidney.
References:  19
Endothelium dependent vasodilatation.
Species:  Human
Tissue:  Vasculature.
References:  49
Broncoconstriction.
Species:  Human
Tissue:  Bronchi.
References:  1
Endothelium dependent vasodilatation.
Species:  Rat
Tissue:  Vasculature.
References:  20-21
Broncoconstriction.
Species:  Rat
Tissue:  Bronchi.
References:  52
Endothelium dependent vasodilatation.
Species:  Mouse
Tissue:  Vasculature.
References:  30
Broncoconstriction.
Species:  Mouse
Tissue:  Bronchi.
References:  34
Physiological Consequences of Altering Gene Expression
Targetted disruption of gene encoding ETB receptor in mice produces aganglioic megacolon (resembling Hirschsprung's disease), associated with coat colour spotting. Mice are also deficient in sensing inflammatory pain. Piebald-lethal (sl) mice exhibit a recessive phenotype identical to that of the EDNRB knockout mice.
Species:  Human
Tissue: 
Technique:  Transgenesis.
References:  22,25
Phenotypes, Alleles and Disease Models Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Ednratm1Ywa|Ednrbtm1Ywa Ednratm1Ywa/Ednratm1Ywa,Ednrbtm1Ywa/Ednrbtm1Ywa
involves: 129S/SvEv
MGI:102720  MGI:105923  MP:0002191 abnormal artery morphology PMID: 9449665 
Ednrbs|Ednrbtm1Ywa Ednrbtm1Ywa/Ednrbs
involves: 129S/SvEv
MGI:102720  MP:0002329 abnormal blood gas PMID: 10626068 
Ednrbtm1Yko|Tg(Tek-cre)1Ywa Ednrbtm1Yko/Ednrbtm1Yko,Tg(Tek-cre)1Ywa/0
involves: 129P2/OlaHsd * Bkl:BKW * C57BL/6 * SJL
MGI:102720  MGI:2450309  MP:0009642 abnormal blood homeostasis PMID: 16801484 
Ednrbs-36Pub Ednrbs-36Pub/Ednrbs-36Pub
B6.Cg-Ednrb
MGI:102720  MP:0008271 abnormal bone ossification PMID: 17693063 
Ednrbs-15DttMb Ednrbs-15DttMb/Ednrbs-15DttMb
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0002152 abnormal brain morphology PMID: 17901218 
Ednrb+|Ednrbs-24Pub|m128-7Tpo|m128-7Tpo+ Ednrbs-24Pub/Ednrb+,m128-7Tpo/m128-7Tpo+
involves: 101/Rl * C3H/Rl * C57BL/6J * SSL/LeJ
MGI:102720  MGI:3849690  MP:0002884 abnormal branchial arch morphology PMID: 19391113 
Ednrbs-36Pub Ednrbs-36Pub/Ednrbs-36Pub
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0000163 abnormal cartilage morphology
Ednrbtm1Myks Ednrbtm1Myks/Ednrbtm1Myks
involves: 129P2/OlaHsd
MGI:102720  MP:0003091 abnormal cell migration PMID: 12812796 
Ednrbtm1Ywa Ednrbtm1Ywa/Ednrbtm1Ywa
involves: 129S5/SvEvBrd
MGI:102720  MP:0005100 abnormal choroid pigmentation PMID: 8001159 
Ednrbtm1Ywa Ednrbtm1Ywa/Ednrbtm1Ywa
involves: 129S5/SvEvBrd
MGI:102720  MP:0002075 abnormal coat/hair pigmentation PMID: 8001159 
Ednrbs-l Ednrbs-l/Ednrbs-l
involves: C3H/HeJ * C57BL/6
MGI:102720  MP:0002075 abnormal coat/hair pigmentation PMID: 5917257 
EdnrbWS4 EdnrbWS4/EdnrbWS4
involves: BALB/c * MSM
MGI:102720  MP:0000031 abnormal cochlea morphology PMID: 11773966 
Ednrbs-1Acrg|Ednrbs-9ThW Ednrbs-1Acrg/Ednrbs-9ThW
involves: 101/Rl * C3H/Rl * C57BL/6J
MGI:102720  MP:0002279 abnormal diaphragm morphology PMID: 14729956 
Ednrbs-15DttMb Ednrbs-15DttMb/Ednrbs-15DttMb
involves: 101/Rl * C3H/Rl * C57BL/6J
MGI:102720  MP:0002279 abnormal diaphragm morphology PMID: 14729956 
Ednrb+|Ednrbs-24Pub|m128-7Tpo|m128-7Tpo+ Ednrbs-24Pub/Ednrb+,m128-7Tpo/m128-7Tpo+
involves: 101/Rl * C3H/Rl * C57BL/6J * SSL/LeJ
MGI:102720  MGI:3849690  MP:0004252 abnormal direction of looping morphogenesis PMID: 19391113 
Ednrbs-l Ednrbs-l/Ednrbs-l
involves: C3H/HeJ * C57BL/6
MGI:102720  MP:0001045 abnormal enteric ganglia morphology PMID: 5917257 
Ednrbtm2(rtTA)Tilg|Ednrbtm3(tetO)Tilg Ednrbtm2(rtTA)Tilg/Ednrbtm3(tetO)Tilg
involves: 129P2/OlaHsd * 129S1/Sv
MGI:102720  MP:0001046 abnormal enteric neuron morphology PMID: 10591209 
Ednrbtm1(tTA)Tilg|Ednrbtm3(tetO)Tilg Ednrbtm1(tTA)Tilg/Ednrbtm3(tetO)Tilg
involves: 129P2/OlaHsd * 129S1/Sv
MGI:102720  MP:0001046 abnormal enteric neuron morphology PMID: 10591209 
Ednrbs|Lystbg-slt Ednrbs/Ednrbs,Lystbg-slt/Lystbg-slt
involves: C57BL/10Ch * Y257/Ch
MGI:102720  MGI:107448  MP:0001324 abnormal eye pigmentation PMID: 13943454 
Ednrbs Ednrbs/Ednrbs
Not Specified
MGI:102720  MP:0009379 abnormal foot pigmentation
Ednrbtm1Ywa Ednrbtm1Ywa/Ednrbtm1Ywa
involves: 129S5/SvEvBrd
MGI:102720  MP:0004381 abnormal hair follicle melanocyte morphology PMID: 8001159 
Ednrb+|Ednrbs-24Pub|m128-7Tpo|m128-7Tpo+ Ednrbs-24Pub/Ednrb+,m128-7Tpo/m128-7Tpo+
involves: 101/Rl * C3H/Rl * C57BL/6J * SSL/LeJ
MGI:102720  MGI:3849690  MP:0000432 abnormal head morphology PMID: 19391113 
EdnrbWS4 EdnrbWS4/EdnrbWS4
involves: BALB/c * MSM
MGI:102720  MP:0001963 abnormal hearing physiology PMID: 11773966 
Ednrb+|Ednrbs-15DttMb|Mycbp2+|Mycbp2tm1.1Adia Ednrbs-15DttMb/Ednrb+,Mycbp2tm1.1Adia/Mycbp2+
involves: 101/Rl * C3H/Rl * C57BL/6 * FVB/N
MGI:102720  MGI:2179432  MP:0003632 abnormal nervous system morphology PMID: 17901218 
Ednrbs-15DttMb Ednrbs-15DttMb/Ednrbs-15DttMb
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0003632 abnormal nervous system morphology PMID: 17901218 
Ednrbs-36Pub Ednrbs-36Pub/Ednrbs-36Pub
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0003632 abnormal nervous system morphology
Ednrbtm1Nrd|Gt(ROSA)26Sor+|Gt(ROSA)26Sortm1(EYFP)Cos|Tg(Wnt1-cre)11Rth Ednrbtm1Nrd/Ednrbtm1Nrd,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Tg(Wnt1-cre)11Rth/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA/J
MGI:102720  MGI:104735  MGI:2447280  MP:0002950 abnormal neural crest cell migration PMID: 18693272 
Ednrbs-1Acrg|Ednrbs-9ThW Ednrbs-1Acrg/Ednrbs-9ThW
involves: 101/Rl * C3H/Rl * C57BL/6J
MGI:102720  MP:0001053 abnormal neuromuscular synapse morphology PMID: 14729956 
Ednrbtm1Yko|Tg(Tek-cre)1Ywa Ednrbtm1Yko/Ednrbtm1Yko,Tg(Tek-cre)1Ywa/0
involves: 129P2/OlaHsd * Bkl:BKW * C57BL/6 * SJL
MGI:102720  MGI:2450309  MP:0003957 abnormal nitric oxide homeostasis PMID: 16801484 
Ednrbs-36Pub Ednrbs-36Pub/Ednrbs-36Pub
B6.Cg-Ednrb
MGI:102720  MP:0000057 abnormal osteogenesis PMID: 17693063 
Ednrb+|Ednrbs-36Pub|Spry2+|Spry2tm1.1Mrt Ednrbs-36Pub/Ednrb+,Spry2tm1.1Mrt/Spry2+
involves: 101/Rl * 129P2/OlaHsd * C3H/Rl * C57BL/6J
MGI:102720  MGI:1345138  MP:0009652 abnormal palatal rugae PMID: 17693063 
Ednrbs-36Pub Ednrbs-36Pub/Ednrbs-36Pub
B6.Cg-Ednrb
MGI:102720  MP:0009652 abnormal palatal rugae PMID: 17693063 
Ednrbs-36Pub|Tg(Spry2)2Tpo Ednrbs-36Pub/Ednrbs-36Pub,Tg(Spry2)2Tpo/0
B6.Cg-Ednrb Tg(Spry2)2Tpo
MGI:102720  MGI:3759542  MP:0009891 abnormal palate bone morphology PMID: 17693063 
Ednrbs-36Pub|Tg(Spry2)69Tpo Ednrbs-36Pub/Ednrbs-36Pub,Tg(Spry2)69Tpo/0
B6.Cg-Ednrb Tg(Spry2)69Tpo
MGI:102720  MGI:3759543  MP:0009891 abnormal palate bone morphology PMID: 17693063 
Ednrbs-1Acrg|Ednrbs-9ThW Ednrbs-1Acrg/Ednrbs-9ThW
involves: 101/Rl * C3H/Rl * C57BL/6J
MGI:102720  MP:0001078 abnormal phrenic nerve morphology PMID: 14729956 
Ednrbs-15DttMb Ednrbs-15DttMb/Ednrbs-15DttMb
involves: 101/Rl * C3H/Rl * C57BL/6J
MGI:102720  MP:0001078 abnormal phrenic nerve morphology PMID: 14729956 
Ednrbs-36Pub Ednrbs-36Pub/Ednrbs-36Pub
B6.Cg-Ednrb
MGI:102720  MP:0009655 abnormal secondary palate development PMID: 17693063 
Ednrbs-15DttMb Ednrbs-15DttMb/Ednrbs-15DttMb
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0005508 abnormal skeleton morphology
Ednrbs-36Pub Ednrbs-36Pub/Ednrbs-36Pub
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0005508 abnormal skeleton morphology
Ednrbs-36Pub Ednrbs-36Pub/Ednrbs-36Pub
B6.Cg-Ednrb
MGI:102720  MP:0003154 abnormal soft palate PMID: 17693063 
EdnrbWS4 EdnrbWS4/EdnrbWS4
involves: BALB/c * MSM
MGI:102720  MP:0000048 abnormal stria vascularis PMID: 11773966 
Ednrbs Ednrbs/Ednrbs
Not Specified
MGI:102720  MP:0005174 abnormal tail pigmentation
Ednrbtm1Yko|Tg(AQP2-cre)2Dek Ednrbtm1Yko/Ednrbtm1Yko,Tg(AQP2-cre)2Dek/0
involves: C57BL/6 * CBA
MGI:102720  MGI:3054060  MP:0009643 abnormal urine homeostasis PMID: 16868309 
Ednrbtm1Yko|Tg(AQP2-cre)2Dek Ednrbtm1Yko/Ednrbtm1Yko,Tg(AQP2-cre)2Dek/0
involves: C57BL/6 * CBA
MGI:102720  MGI:3054060  MP:0006274 abnormal urine sodium level PMID: 16868309 
Ednrb+|Ednrbs-24Pub|m128-7Tpo|m128-7Tpo+ Ednrbs-24Pub/Ednrb+,m128-7Tpo/m128-7Tpo+
involves: 101/Rl * C3H/Rl * C57BL/6J * SSL/LeJ
MGI:102720  MGI:3849690  MP:0003229 abnormal vitelline vasculature morphology PMID: 19391113 
Ednrbs-l Ednrbs-l/Ednrbs-l
involves: C3H/HeJ * C57BL/6
MGI:102720  MP:0005171 absent coat pigmentation PMID: 5917257 
Ednrbtm2(rtTA)Tilg|Ednrbtm3(tetO)Tilg Ednrbtm2(rtTA)Tilg/Ednrbtm3(tetO)Tilg
involves: 129P2/OlaHsd * 129S1/Sv
MGI:102720  MP:0005171 absent coat pigmentation PMID: 10591209 
Ednrbtm1(tTA)Tilg|Ednrbtm3(tetO)Tilg Ednrbtm1(tTA)Tilg/Ednrbtm3(tetO)Tilg
involves: 129P2/OlaHsd * 129S1/Sv
MGI:102720  MP:0005171 absent coat pigmentation PMID: 10591209 
Ednrbtm1Myks Ednrbtm1Myks/Ednrbtm1Myks
involves: 129P2/OlaHsd
MGI:102720  MP:0005171 absent coat pigmentation PMID: 12812796 
Ednrbs-36Pub Ednrbs-36Pub/Ednrbs-36Pub
B6.Cg-Ednrb
MGI:102720  MP:0000431 absent palatine shelf PMID: 17693063 
EdnrbWS4 EdnrbWS4/EdnrbWS4
involves: BALB/c * MSM
MGI:102720  MP:0006010 absent strial intermediate cells PMID: 11773966 
Ednrbtm1Ywa Ednrbtm1Ywa/Ednrbtm1Ywa
involves: 129S5/SvEvBrd
MGI:102720  MP:0002926 aganglionic megacolon PMID: 8001159 
Ednrbtm1Nrd|Gt(ROSA)26Sor+|Gt(ROSA)26Sortm1(EYFP)Cos|Tg(Wnt1-cre)11Rth Ednrbtm1Nrd/Ednrbtm1Nrd,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Tg(Wnt1-cre)11Rth/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA/J
MGI:102720  MGI:104735  MGI:2447280  MP:0002926 aganglionic megacolon PMID: 18693272 
Ednrbtm1Ywa Ednrbtm1Ywa/Ednrbtm1Ywa
involves: 129S5/SvEvBrd
MGI:102720  MP:0005150 cachexia PMID: 8001159 
Ednrbs-36Pub Ednrbs-36Pub/Ednrbs-36Pub
B6.Cg-Ednrb
MGI:102720  MP:0005170 cleft lip PMID: 17693063 
Ednrb+|Ednrbs-36Pub|Spry2+|Spry2tm1.1Mrt Ednrbs-36Pub/Ednrb+,Spry2tm1.1Mrt/Spry2+
involves: 101/Rl * 129P2/OlaHsd * C3H/Rl * C57BL/6J
MGI:102720  MGI:1345138  MP:0009890 cleft secondary palate PMID: 17693063 
Ednrbs-36Pub Ednrbs-36Pub/Ednrbs-36Pub
B6.Cg-Ednrb
MGI:102720  MP:0009890 cleft secondary palate PMID: 17693063 
Ednrbs-36Pub|Tg(Spry2)2Tpo Ednrbs-36Pub/Ednrbs-36Pub,Tg(Spry2)2Tpo/0
B6.Cg-Ednrb Tg(Spry2)2Tpo
MGI:102720  MGI:3759542  MP:0009890 cleft secondary palate PMID: 17693063 
Ednrbs-36Pub|Tg(Spry2)69Tpo Ednrbs-36Pub/Ednrbs-36Pub,Tg(Spry2)69Tpo/0
B6.Cg-Ednrb Tg(Spry2)69Tpo
MGI:102720  MGI:3759543  MP:0009890 cleft secondary palate PMID: 17693063 
EdnrbWS4 EdnrbWS4/EdnrbWS4
involves: BALB/c * MSM
MGI:102720  MP:0004362 cochlear hair cell degeneration PMID: 11773966 
EdnrbWS4 EdnrbWS4/EdnrbWS4
involves: BALB/c * MSM
MGI:102720  MP:0001967 deafness PMID: 11773966 
Ednrbtm1Ywa Ednrbtm1Ywa/Ednrbtm1Ywa
involves: 129S5/SvEvBrd
MGI:102720  MP:0005087 decreased acute inflammation PMID: 10496965 
Ednrb+|Ednrbtm1Ywa Ednrbtm1Ywa/Ednrb+
involves: 129S/SvEvBrd
MGI:102720  MP:0005087 decreased acute inflammation PMID: 10496965 
Ednrb+|Ednrbs-13Pub Ednrbs-13Pub/Ednrb+
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0001265 decreased body size
Ednrbs-13Pub|Ednrbs Ednrbs/Ednrbs-13Pub
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0001265 decreased body size
Ednrb+|Ednrbs-17Pub Ednrbs-17Pub/Ednrb+
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0001265 decreased body size
Ednrbs-17Pub|Ednrbs Ednrbs/Ednrbs-17Pub
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0001265 decreased body size
Ednrb+|Ednrbs-1Acrg Ednrbs-1Acrg/Ednrb+
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0001265 decreased body size
Ednrbs-1Acrg|Ednrbs Ednrbs/Ednrbs-1Acrg
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0001265 decreased body size
Ednrb+|Ednrbs-1MLPf Ednrbs-1MLPf/Ednrb+
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0001265 decreased body size
Ednrbs-1MLPf|Ednrbs Ednrbs/Ednrbs-1MLPf
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0001265 decreased body size
Ednrb+|Ednrbs-1Pu Ednrbs-1Pu/Ednrb+
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0001265 decreased body size
Ednrbs-1Pu|Ednrbs Ednrbs/Ednrbs-1Pu
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0001265 decreased body size
Ednrb+|Ednrbs-1XMLP Ednrbs-1XMLP/Ednrb+
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0001265 decreased body size
Ednrbs-1XMLP|Ednrbs Ednrbs/Ednrbs-1XMLP
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0001265 decreased body size
Ednrb+|Ednrbs-1XMLPc Ednrbs-1XMLPc/Ednrb+
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0001265 decreased body size
Ednrbs-1XMLPc|Ednrbs Ednrbs/Ednrbs-1XMLPc
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0001265 decreased body size
Ednrb+|Ednrbs-24Pub Ednrbs-24Pub/Ednrb+
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0001265 decreased body size
Ednrbs-24Pub|Ednrbs Ednrbs/Ednrbs-24Pub
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0001265 decreased body size
Ednrb+|Ednrbs-27Pu Ednrbs-27Pu/Ednrb+
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0001265 decreased body size
Ednrbs-27Pu|Ednrbs Ednrbs/Ednrbs-27Pu
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0001265 decreased body size
Ednrb+|Ednrbs-29Pub Ednrbs-29Pub/Ednrb+
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0001265 decreased body size
Ednrbs-29Pub|Ednrbs Ednrbs/Ednrbs-29Pub
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0001265 decreased body size
Ednrb+|Ednrbs-2CHLd Ednrbs-2CHLd/Ednrb+
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0001265 decreased body size
Ednrbs-2CHLd|Ednrbs Ednrbs/Ednrbs-2CHLd
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0001265 decreased body size
Ednrbs-2Etopc|Ednrbs Ednrbs/Ednrbs-2Etopc
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0001265 decreased body size
Ednrb+|Ednrbs-2Etopc Ednrbs-2Etopc/Ednrb+
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0001265 decreased body size
Ednrbs-2MLPl|Ednrbs Ednrbs/Ednrbs-2MLPl
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0001265 decreased body size
Ednrb+|Ednrbs-2MLPl Ednrbs-2MLPl/Ednrb+
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0001265 decreased body size
Ednrb+|Ednrbs-15DttMb Ednrbs-15DttMb/Ednrb+
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0001265 decreased body size
Ednrbs-15DttMb|Ednrbs Ednrbs-15DttMb/Ednrbs
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0001265 decreased body size
Ednrb+|Ednrbs-4Chlc Ednrbs-4Chlc/Ednrb+
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0001265 decreased body size
Ednrbs-4Chlc|Ednrbs Ednrbs/Ednrbs-4Chlc
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0001265 decreased body size
Ednrb+|Ednrbs-4Pub Ednrbs-4Pub/Ednrb+
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0001265 decreased body size
Ednrbs-4Pub|Ednrbs Ednrbs/Ednrbs-4Pub
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0001265 decreased body size
Ednrb+|Ednrbs-36Pub Ednrbs-36Pub/Ednrb+
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0001265 decreased body size
Ednrbs-36Pub|Ednrbs Ednrbs/Ednrbs-36Pub
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0001265 decreased body size
Ednrb+|Ednrbs-31Pub Ednrbs-31Pub/Ednrb+
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0001265 decreased body size
Ednrbs-31Pub|Ednrbs Ednrbs/Ednrbs-31Pub
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0001265 decreased body size
Ednrb+|Ednrbs-3Etopf Ednrbs-3Etopf/Ednrb+
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0001265 decreased body size
Ednrbs-3Etopf|Ednrbs Ednrbs/Ednrbs-3Etopf
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0001265 decreased body size
Ednrbs-48UThc|Ednrbs Ednrbs/Ednrbs-48UThc
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0001265 decreased body size
Ednrb+|Ednrbs-48UThc Ednrbs-48UThc/Ednrb+
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0001265 decreased body size
Ednrbs-4Blec|Ednrbs Ednrbs/Ednrbs-4Blec
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0001265 decreased body size
Ednrb+|Ednrbs-4Blec Ednrbs-4Blec/Ednrb+
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0001265 decreased body size
Ednrbs-52Pub|Ednrbs Ednrbs/Ednrbs-52Pub
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0001265 decreased body size
Ednrb+|Ednrbs-52Pub Ednrbs-52Pub/Ednrb+
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0001265 decreased body size
Ednrbs-9ThW|Ednrbs Ednrbs/Ednrbs-9ThW
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0001265 decreased body size
Ednrb+|Ednrbs-9ThW Ednrbs-9ThW/Ednrb+
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0001265 decreased body size
Ednrbtm1Yko|Tg(AQP2-cre)2Dek Ednrbtm1Yko/Ednrbtm1Yko,Tg(AQP2-cre)2Dek/0
involves: C57BL/6 * CBA
MGI:102720  MGI:3054060  MP:0005583 decreased renin activity PMID: 16868309 
Ednrbtm1Yko|Tg(AQP2-cre)2Dek Ednrbtm1Yko/Ednrbtm1Yko,Tg(AQP2-cre)2Dek/0
involves: C57BL/6 * CBA
MGI:102720  MGI:3054060  MP:0003620 decreased urine output PMID: 16868309 
Ednrbtm1Yko|Tg(Tek-cre)1Ywa Ednrbtm1Yko/Ednrbtm1Yko,Tg(Tek-cre)1Ywa/0
involves: 129P2/OlaHsd * Bkl:BKW * C57BL/6 * SJL
MGI:102720  MGI:2450309  MP:0005591 decreased vasodilation PMID: 16801484 
Ednrbtm1.1Yko Ednrbtm1.1Yko/Ednrbtm1.1Yko
involves: 129P2/OlaHsd * Bkl:BKW * C57BL/6 * SJL
MGI:102720  MP:0005591 decreased vasodilation PMID: 16801484 
Ednrbtm1Nrd|Gt(ROSA)26Sor+|Gt(ROSA)26Sortm1(EYFP)Cos|Tg(Wnt1-cre)11Rth Ednrbtm1Nrd/Ednrbtm1Nrd,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Tg(Wnt1-cre)11Rth/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA/J
MGI:102720  MGI:104735  MGI:2447280  MP:0001270 distended abdomen PMID: 18693272 
Ednrb+|Ednrbs-24Pub|m183-15Tpo|m183-15Tpo+ Ednrbs-24Pub/Ednrb+,m183-15Tpo/m183-15Tpo+
involves: 101/Rl * C3H/Rl * C57BL/6J * SSL/LeJ
MGI:102720  MGI:3849691  MP:0006205 embryonic lethality before somite formation PMID: 19391113 
Ednrb+|Ednrbs-24Pub|m128-7Tpo|m128-7Tpo+ Ednrbs-24Pub/Ednrb+,m128-7Tpo/m128-7Tpo+
involves: 101/Rl * C3H/Rl * C57BL/6J * SSL/LeJ
MGI:102720  MGI:3849690  MP:0006207 embryonic lethality during organogenesis PMID: 19391113 
Ednrb+|Ednrbs-24Pub|m128-7Tpo|m128-7Tpo+ Ednrbs-24Pub/Ednrb+,m128-7Tpo/m128-7Tpo+
involves: 101/Rl * C3H/Rl * C57BL/6J * SSL/LeJ
MGI:102720  MGI:3849690  MP:0000291 enlarged pericardium PMID: 19391113 
Ednrbs-36Pub Ednrbs-36Pub/Ednrbs-36Pub
B6.Cg-Ednrb
MGI:102720  MP:0009886 failure of palatal shelf elevation PMID: 17693063 
Ednrb+|Ednrbs-24Pub|m128-7Tpo|m128-7Tpo+ Ednrbs-24Pub/Ednrb+,m128-7Tpo/m128-7Tpo+
involves: 101/Rl * C3H/Rl * C57BL/6J * SSL/LeJ
MGI:102720  MGI:3849690  MP:0005244 hemopericardium PMID: 19391113 
Ednrbs|Ednrbtm1Ywa Ednrbtm1Ywa/Ednrbs
involves: 129S/SvEv
MGI:102720  MP:0002318 hypercapnia PMID: 10626068 
Ednrbtm1Ywa Ednrbtm1Ywa/Ednrbtm1Ywa
involves: 129S5/SvEvBrd
MGI:102720  MP:0003043 hypoalgesia PMID: 10496965 
Ednrb+|Ednrbtm1Ywa Ednrbtm1Ywa/Ednrb+
involves: 129S/SvEvBrd
MGI:102720  MP:0003043 hypoalgesia PMID: 10496965 
Ednrbs|Ednrbtm1Ywa Ednrbtm1Ywa/Ednrbs
involves: 129S/SvEv
MGI:102720  MP:0005039 hypoxia PMID: 10626068 
Ednrb+|Ednrbs-24Pub|m128-7Tpo|m128-7Tpo+ Ednrbs-24Pub/Ednrb+,m128-7Tpo/m128-7Tpo+
involves: 101/Rl * C3H/Rl * C57BL/6J * SSL/LeJ
MGI:102720  MGI:3849690  MP:0001701 incomplete embryo turning PMID: 19391113 
Ednrbs-36Pub Ednrbs-36Pub/Ednrbs-36Pub
B6.Cg-Ednrb
MGI:102720  MP:0000351 increased cell proliferation PMID: 17693063 
Ednrbs|Ednrbtm1Ywa Ednrbtm1Ywa/Ednrbs
involves: 129S/SvEv
MGI:102720  MP:0004875 increased mean systemic arterial blood pressure PMID: 10626068 
Ednrbs-36Pub Ednrbs-36Pub/Ednrbs-36Pub
B6.Cg-Ednrb
MGI:102720  MP:0004760 increased mitotic index PMID: 17693063 
Ednrbtm1Yko|Tg(AQP2-cre)2Dek Ednrbtm1Yko/Ednrbtm1Yko,Tg(AQP2-cre)2Dek/0
involves: C57BL/6 * CBA
MGI:102720  MGI:3054060  MP:0002842 increased systemic arterial blood pressure PMID: 16868309 
Ednrbtm1Yko|Tg(AQP2-cre)2Dek Ednrbtm1Yko/Ednrbtm1Yko,Tg(AQP2-cre)2Dek/0
involves: C57BL/6 * CBA
MGI:102720  MGI:3054060  MP:0006143 increased systemic arterial diastolic blood pressure PMID: 16868309 
Ednrbtm1Yko|Tg(AQP2-cre)2Dek Ednrbtm1Yko/Ednrbtm1Yko,Tg(AQP2-cre)2Dek/0
involves: C57BL/6 * CBA
MGI:102720  MGI:3054060  MP:0006144 increased systemic arterial systolic blood pressure PMID: 16868309 
Ednrbtm1Ywa Ednrbtm1Ywa/Ednrbtm1Ywa
involves: 129S5/SvEvBrd
MGI:102720  MP:0003270 intestinal obstruction PMID: 8001159 
Ednrbtm1.1Yko Ednrbtm1.1Yko/Ednrbtm1.1Yko
involves: 129P2/OlaHsd * Bkl:BKW * C57BL/6 * SJL
MGI:102720  MP:0003270 intestinal obstruction PMID: 16801484 
Ednrb+|Ednrbs-24Pub|m174-16Tpo|m174-16Tpo+ Ednrbs-24Pub/Ednrb+,m174-16Tpo/m174-16Tpo+
involves: 101/Rl * C3H/Rl * C57BL/6J * SSL/LeJ
MGI:102720  MGI:3849687  MP:0006208 lethality throughout fetal growth and development PMID: 19391113 
Ednrbs-36Pub Ednrbs-36Pub/Ednrbs-36Pub
B6.Cg-Ednrb
MGI:102720  MP:0009898 maxillary shelf hypoplasia PMID: 17693063 
Ednrbs-36Pub|Tg(Spry2)2Tpo Ednrbs-36Pub/Ednrbs-36Pub,Tg(Spry2)2Tpo/0
B6.Cg-Ednrb Tg(Spry2)2Tpo
MGI:102720  MGI:3759542  MP:0009898 maxillary shelf hypoplasia PMID: 17693063 
Ednrbs-36Pub|Tg(Spry2)69Tpo Ednrbs-36Pub/Ednrbs-36Pub,Tg(Spry2)69Tpo/0
B6.Cg-Ednrb Tg(Spry2)69Tpo
MGI:102720  MGI:3759543  MP:0009898 maxillary shelf hypoplasia PMID: 17693063 
EdnrbWS4 EdnrbWS4/EdnrbWS4
involves: BALB/c * MSM
MGI:102720  MP:0002731 megacolon PMID: 11773966 
Ednrbs-l Ednrbs-l/Ednrbs-l
involves: C3H/HeJ * C57BL/6
MGI:102720  MP:0002731 megacolon PMID: 5917257 
Ednrbtm2(rtTA)Tilg|Ednrbtm3(tetO)Tilg Ednrbtm2(rtTA)Tilg/Ednrbtm3(tetO)Tilg
involves: 129P2/OlaHsd * 129S1/Sv
MGI:102720  MP:0002731 megacolon PMID: 10591209 
Ednrbtm1(tTA)Tilg|Ednrbtm3(tetO)Tilg Ednrbtm1(tTA)Tilg/Ednrbtm3(tetO)Tilg
involves: 129P2/OlaHsd * 129S1/Sv
MGI:102720  MP:0002731 megacolon PMID: 10591209 
Ednrbtm1Myks Ednrbtm1Myks/Ednrbtm1Myks
involves: 129P2/OlaHsd
MGI:102720  MP:0002731 megacolon PMID: 12812796 
Ednrbs-17FrS Ednrbs-17FrS/Ednrbs-17FrS
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0002731 megacolon PMID: 9371807 
Ednrbs-1Chlc Ednrbs-1Chlc/Ednrbs-1Chlc
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0002731 megacolon PMID: 2304907  9371807 
Ednrbs-27Pub Ednrbs-27Pub/Ednrbs-27Pub
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0002731 megacolon PMID: 9371807 
Ednrbs-3CHLo Ednrbs-3CHLo/Ednrbs-3CHLo
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0002731 megacolon PMID: 9371807 
Ednrbs Ednrbs/Ednrbs
Not Specified
MGI:102720  MP:0002731 megacolon PMID: 13800713 
Ednrbs-15DttMb Ednrbs-15DttMb/Ednrbs-15DttMb
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0002058 neonatal lethality PMID: 8138159 
Ednrb+|Ednrbs-24Pub|Mycbp2+|Mycbp2m274-4Tpo Ednrbs-24Pub/Ednrb+,Mycbp2m274-4Tpo/Mycbp2+
involves: 101/Rl * C3H/Rl * C57BL/6J * SSL/LeJ
MGI:102720  MGI:2179432  MP:0002058 neonatal lethality PMID: 19391113 
Ednrbs-36Pub Ednrbs-36Pub/Ednrbs-36Pub
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0002058 neonatal lethality PMID: 8138159 
EdnrbWS4 EdnrbWS4/EdnrbWS4
involves: BALB/c * MSM
MGI:102720  MP:0000043 organ of Corti degeneration PMID: 11773966 
Ednratm1Ywa|Ednrbtm1Ywa Ednratm1Ywa/Ednratm1Ywa,Ednrbtm1Ywa/Ednrbtm1Ywa
involves: 129S/SvEv
MGI:102720  MGI:105923  MP:0005312 pericardial effusion PMID: 9449665 
Ednrbtm1Ywa Ednrbtm1Ywa/Ednrbtm1Ywa
involves: 129S5/SvEvBrd
MGI:102720  MP:0001732 postnatal growth retardation PMID: 8001159 
EdnrbWS4 EdnrbWS4/EdnrbWS4
involves: BALB/c * MSM
MGI:102720  MP:0002082 postnatal lethality PMID: 11773966 
Ednrbs-l Ednrbs-l/Ednrbs-l
involves: C3H/HeJ * C57BL/6
MGI:102720  MP:0002082 postnatal lethality PMID: 5917257 
Ednrbs-17FrS Ednrbs-17FrS/Ednrbs-17FrS
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0002082 postnatal lethality PMID: 9371807 
Ednrbs-1Chlc Ednrbs-1Chlc/Ednrbs-1Chlc
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0002082 postnatal lethality PMID: 2304907  8138159  9371807 
Ednrbs-27Pub Ednrbs-27Pub/Ednrbs-27Pub
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0002082 postnatal lethality PMID: 8138159  9371807 
Ednrbtm1.1Yko Ednrbtm1.1Yko/Ednrbtm1.1Yko
involves: 129P2/OlaHsd * Bkl:BKW * C57BL/6 * SJL
MGI:102720  MP:0002082 postnatal lethality PMID: 16801484 
Ednrb+|Ednrbs-24Pub|m251-2Tpo|m251-2Tpo+ Ednrbs-24Pub/Ednrb+,m251-2Tpo/m251-2Tpo+
involves: 101/Rl * C3H/Rl * C57BL/6J * SSL/LeJ
MGI:102720  MGI:3849694  MP:0002082 postnatal lethality PMID: 19391113 
Ednrb+|Ednrbs-24Pub|m283-1Tpo|m283-1Tpo+ Ednrbs-24Pub/Ednrb+,m283-1Tpo/m283-1Tpo+
involves: 101/Rl * C3H/Rl * C57BL/6J * SSL/LeJ
MGI:102720  MGI:3849697  MP:0002082 postnatal lethality PMID: 19391113 
Ednrbs-24Pub|m289-5Tpo|m289-5Tpo+ Ednrbs-24Pub/Ednrbs-24Pub,m289-5Tpo/m289-5Tpo+
involves: 101/Rl * C3H/Rl * C57BL/6J * SSL/LeJ
MGI:102720  MGI:3849700  MP:0002082 postnatal lethality PMID: 19391113 
Ednrbs-12MNURn Ednrbs-12MNURn/Ednrbs-12MNURn
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0002082 postnatal lethality
Ednrbs-3CHLo Ednrbs-3CHLo/Ednrbs-3CHLo
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0002082 postnatal lethality PMID: 9371807 
Ednrbtm1Nrd|Gt(ROSA)26Sor+|Gt(ROSA)26Sortm1(EYFP)Cos|Tg(Wnt1-cre)11Rth Ednrbtm1Nrd/Ednrbtm1Nrd,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Tg(Wnt1-cre)11Rth/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA/J
MGI:102720  MGI:104735  MGI:2447280  MP:0008489 postnatal slow weight gain PMID: 18693272 
Ednrbtm1Ywa Ednrbtm1Ywa/Ednrbtm1Ywa
involves: 129S5/SvEvBrd
MGI:102720  MP:0002083 premature death PMID: 8001159 
Ednrbtm2(rtTA)Tilg|Ednrbtm3(tetO)Tilg Ednrbtm2(rtTA)Tilg/Ednrbtm3(tetO)Tilg
involves: 129P2/OlaHsd * 129S1/Sv
MGI:102720  MP:0002083 premature death PMID: 10591209 
Ednrbtm1Myks Ednrbtm1Myks/Ednrbtm1Myks
involves: 129P2/OlaHsd
MGI:102720  MP:0002083 premature death PMID: 12812796 
Ednrbtm1Nrd|Gt(ROSA)26Sor+|Gt(ROSA)26Sortm1(EYFP)Cos|Tg(Wnt1-cre)11Rth Ednrbtm1Nrd/Ednrbtm1Nrd,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Tg(Wnt1-cre)11Rth/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA/J
MGI:102720  MGI:104735  MGI:2447280  MP:0002083 premature death PMID: 18693272 
Ednratm1Ywa|Ednrbtm1Ywa Ednratm1Ywa/Ednratm1Ywa,Ednrbtm1Ywa/Ednrbtm1Ywa
involves: 129S/SvEv
MGI:102720  MGI:105923  MP:0002080 prenatal lethality PMID: 9449665 
Ednrbs-13Pub Ednrbs-13Pub/Ednrbs-13Pub
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0002080 prenatal lethality
Ednrbs-17Pub Ednrbs-17Pub/Ednrbs-17Pub
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0002080 prenatal lethality PMID: 8138159 
Ednrbs-1Acrg Ednrbs-1Acrg/Ednrbs-1Acrg
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0002080 prenatal lethality PMID: 8138159 
Ednrbs-1MLPf Ednrbs-1MLPf/Ednrbs-1MLPf
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0002080 prenatal lethality PMID: 1352884 
Ednrbs-1Pu Ednrbs-1Pu/Ednrbs-1Pu
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0002080 prenatal lethality
Ednrbs-1XMLP Ednrbs-1XMLP/Ednrbs-1XMLP
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0002080 prenatal lethality
Ednrbs-1XMLPc Ednrbs-1XMLPc/Ednrbs-1XMLPc
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0002080 prenatal lethality
Ednrbs-24Pub Ednrbs-24Pub/Ednrbs-24Pub
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0002080 prenatal lethality PMID: 8138159 
Ednrbs-27Pu Ednrbs-27Pu/Ednrbs-27Pu
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0002080 prenatal lethality
Ednrbs-29Pub Ednrbs-29Pub/Ednrbs-29Pub
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0002080 prenatal lethality
Ednrbs-2CHLd Ednrbs-2CHLd/Ednrbs-2CHLd
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0002080 prenatal lethality PMID: 2304907 
Ednrbs-2Etopc Ednrbs-2Etopc/Ednrbs-2Etopc
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0002080 prenatal lethality
Ednrbs-2MLPl Ednrbs-2MLPl/Ednrbs-2MLPl
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0002080 prenatal lethality
Ednrbs-4Chlc Ednrbs-4Chlc/Ednrbs-4Chlc
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0002080 prenatal lethality PMID: 2304907  8138159 
Ednrbs-4Pub Ednrbs-4Pub/Ednrbs-4Pub
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0002080 prenatal lethality PMID: 8138159 
Ednrbs-31Pub Ednrbs-31Pub/Ednrbs-31Pub
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0002080 prenatal lethality
Ednrbs-3Etopf Ednrbs-3Etopf/Ednrbs-3Etopf
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0002080 prenatal lethality
Ednrbs-48UThc Ednrbs-48UThc/Ednrbs-48UThc
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0002080 prenatal lethality
Ednrbs-4Blec Ednrbs-4Blec/Ednrbs-4Blec
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0002080 prenatal lethality
Ednrbs-52Pub Ednrbs-52Pub/Ednrbs-52Pub
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0002080 prenatal lethality
Ednrbs-9ThW Ednrbs-9ThW/Ednrbs-9ThW
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0002080 prenatal lethality
Ednrbs-1Acrg|Ednrbs-9ThW Ednrbs-1Acrg/Ednrbs-9ThW
involves: 101/Rl * C3H/Rl * C57BL/6J
MGI:102720  MP:0001954 respiratory distress PMID: 14729956 
Ednrb+|Ednrbs-24Pub|Mycbp2+|Mycbp2m274-4Tpo Ednrbs-24Pub/Ednrb+,Mycbp2m274-4Tpo/Mycbp2+
involves: 101/Rl * C3H/Rl * C57BL/6J * SSL/LeJ
MGI:102720  MGI:2179432  MP:0001954 respiratory distress PMID: 19391113 
EdnrbWS4 EdnrbWS4/EdnrbWS4
involves: BALB/c * MSM
MGI:102720  MP:0004364 thin stria vascularis PMID: 11773966 
EdnrbWS4 EdnrbWS4/EdnrbWS4
involves: BALB/c * MSM
MGI:102720  MP:0002940 variable body spotting PMID: 11773966 
Ednrbs Ednrbs/Ednrbs
Not Specified
MGI:102720  MP:0002940 variable body spotting PMID: 17246828 
Ednrbtm1Ywa Ednrbtm1Ywa/Ednrbtm1Ywa
involves: 129S5/SvEvBrd
MGI:102720  MP:0010016 variable depigmentation PMID: 8001159 
Ednrbs Ednrbs/Ednrbs
Not Specified
MGI:102720  MP:0010016 variable depigmentation
Ednrbtm1Ywa Ednrbtm1Ywa/Ednrbtm1Ywa
involves: 129S5/SvEvBrd
MGI:102720  MP:0002938 white spotting PMID: 8001159 
Ednrbs|Mc1re Ednrbs/Ednrbs,Mc1re/Mc1re
Not Specified
MGI:102720  MGI:99456  MP:0002938 white spotting PMID: 5713933 
Ednrbs-13Pub|Ednrbs Ednrbs/Ednrbs-13Pub
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0002938 white spotting
Ednrbs-17FrS Ednrbs-17FrS/Ednrbs-17FrS
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0002938 white spotting PMID: 9371807 
Ednrbs-17FrS|Ednrbs Ednrbs/Ednrbs-17FrS
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0002938 white spotting
Ednrbs-17Pub|Ednrbs Ednrbs/Ednrbs-17Pub
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0002938 white spotting
Ednrbs-1Acrg|Ednrbs Ednrbs/Ednrbs-1Acrg
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0002938 white spotting
Ednrbs-1Chlc|Ednrbs Ednrbs/Ednrbs-1Chlc
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0002938 white spotting
Ednrbs-1Chlc Ednrbs-1Chlc/Ednrbs-1Chlc
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0002938 white spotting PMID: 2304907  8138159  9371807 
Ednrbs-1MLPf|Ednrbs Ednrbs/Ednrbs-1MLPf
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0002938 white spotting
Ednrbs-1Pu|Ednrbs Ednrbs/Ednrbs-1Pu
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0002938 white spotting
Ednrbs-1XMLP|Ednrbs Ednrbs/Ednrbs-1XMLP
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0002938 white spotting
Ednrbs-1XMLPc|Ednrbs Ednrbs/Ednrbs-1XMLPc
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0002938 white spotting
Ednrbs-24Pub|Ednrbs Ednrbs/Ednrbs-24Pub
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0002938 white spotting
Ednrbs-27Pu|Ednrbs Ednrbs/Ednrbs-27Pu
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0002938 white spotting
Ednrbs-27Pub Ednrbs-27Pub/Ednrbs-27Pub
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0002938 white spotting PMID: 8138159  9371807 
Ednrbs-27Pub|Ednrbs Ednrbs/Ednrbs-27Pub
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0002938 white spotting
Ednrbs-29Pub|Ednrbs Ednrbs/Ednrbs-29Pub
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0002938 white spotting
Ednrbs-2CHLd|Ednrbs Ednrbs/Ednrbs-2CHLd
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0002938 white spotting
Ednrbs-2Etopc|Ednrbs Ednrbs/Ednrbs-2Etopc
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0002938 white spotting
Ednrbs-2MLPl|Ednrbs Ednrbs/Ednrbs-2MLPl
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0002938 white spotting
Ednrbtm1.1Yko Ednrbtm1.1Yko/Ednrbtm1.1Yko
involves: 129P2/OlaHsd * Bkl:BKW * C57BL/6 * SJL
MGI:102720  MP:0002938 white spotting PMID: 16801484 
Ednrbtm1Nrd|Gt(ROSA)26Sor+|Gt(ROSA)26Sortm1(EYFP)Cos|Tg(Wnt1-cre)11Rth Ednrbtm1Nrd/Ednrbtm1Nrd,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Tg(Wnt1-cre)11Rth/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA/J
MGI:102720  MGI:104735  MGI:2447280  MP:0002938 white spotting PMID: 18693272 
Ednrbs-12MNURn Ednrbs-12MNURn/Ednrbs-12MNURn
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0002938 white spotting
Ednrbs-12MNURn|Ednrbs Ednrbs/Ednrbs-12MNURn
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0002938 white spotting
Ednrbs-15DttMb|Ednrbs Ednrbs-15DttMb/Ednrbs
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0002938 white spotting
Ednrbs-3CHLo|Ednrbs Ednrbs/Ednrbs-3CHLo
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0002938 white spotting
Ednrbs-3CHLo Ednrbs-3CHLo/Ednrbs-3CHLo
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0002938 white spotting PMID: 9371807 
Ednrbs-4Chlc|Ednrbs Ednrbs/Ednrbs-4Chlc
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0002938 white spotting
Ednrbs-4Pub|Ednrbs Ednrbs/Ednrbs-4Pub
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0002938 white spotting
Ednrbs-36Pub|Ednrbs Ednrbs/Ednrbs-36Pub
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0002938 white spotting
Ednrbs-31Pub|Ednrbs Ednrbs/Ednrbs-31Pub
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0002938 white spotting
Ednrbs-3Etopf|Ednrbs Ednrbs/Ednrbs-3Etopf
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0002938 white spotting
Ednrbs-48UThc|Ednrbs Ednrbs/Ednrbs-48UThc
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0002938 white spotting
Ednrbs-4Blec|Ednrbs Ednrbs/Ednrbs-4Blec
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0002938 white spotting
Ednrbs-52Pub|Ednrbs Ednrbs/Ednrbs-52Pub
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0002938 white spotting
Ednrbs-9ThW|Ednrbs Ednrbs/Ednrbs-9ThW
involves: 101/Rl * C3H/Rl
MGI:102720  MP:0002938 white spotting
Ednrbs Ednrbs/Ednrbs
Not Specified
MGI:102720  MP:0002938 white spotting PMID: 17246828 
Ednrbs|Mc1re Ednrbs/Ednrbs,Mc1re/Mc1re
Not Specified
MGI:102720  MGI:99456  MP:0003136 yellow coat color PMID: 5713933 
Clinically-Relevant Mutations and Pathophysiology
Disease:  Waardenburg-Shah syndrome, type 4A
OMIM:  277580
Orphanet:  897
References: 
Mutations not determined
Disease:  ABCD syndrome
OMIM:  600501
Orphanet:  918
References: 
Mutations not determined
Disease:  Hirschsprung disease
OMIM:  600155, 142623
Orphanet:  388
Comments: 
References:  42,51
Click column headers to sort
Type Species Molecular location Description Reference
single nucleotide polymorphism Human S390R 51
single nucleotide polymorphism Human C109R 51
single nucleotide polymorphism Human W276C 42
General Comments
Antagonists that block both ETA and ETB receptors (also called mixed or balanced) include peptides such as TAK044. Non-peptide compounds included bosentan (RO470203, Tracleer [8]) the first antagonist in clinical use [12] SB209670 [17], SB217242 (enrasentan, [39]) and RO610612 (tezosentan, [9]). The distinction between antagonists that are ETA selective and those that block both ETA and ETB receptors is not precise but generally the former display greater than 100-fold selectivity for the ETA subtype and the latter less than 100-fold.

For reviews on endothelin receptors see [3,13,47].
Available Assays
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To cite this database page, please use the following:

Anthony P. Davenport, Pedro D'Orléans-Juste, Théophile Godfraind, Janet J. Maguire, Eliot H. Ohlstein, Robert R. Ruffolo.
Endothelin receptors: ETB receptor. Last modified on 23/05/2014. Accessed on 02/09/2014. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=220.

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