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D1 receptor

Family: Dopamine receptors

Contents:
Gene and Protein Information
Previous and Unofficial Names
Database Links
Agonists
Antagonists
Transduction Mechanisms
Tissue Distribution
Expression Datasets
Functional Assays
Physiological Functions
Physiological Consequences of Altering Gene Expression
Phenotypes, Alleles and Disease Models
Biologically Significant Variants
General Comments
References
Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 446 5q35.1 DRD1 dopamine receptor D1 15,42,49
Mouse 7 446 13 B1 Drd1a dopamine receptor D1A 40
Rat 7 446 17p14 Drd1a dopamine receptor D1A 32,49
Previous and Unofficial Names
D1A
DADR
DRD1A
Gpcr15
D1A
Drd-1
Drd1
D(1A) dopamine receptor
Dopamine-1A receptor
dopamine D1 receptor
dopamine receptor 1A
dopamine receptor D1A
D1 receptor
C030036C15Rik
Database Links
ChEMBL Target
DrugBank Target
Ensembl
Entrez Gene
GeneCards
GenitoUrinary Development Molecular Anatomy Project
HomoloGene
Human Protein Reference Database
InterPro
KEGG Gene
OMIM
PharmGKB Gene
PhosphoSitePlus
Protein Ontology (PRO)
RefSeq Nucleotide
RefSeq Protein
TreeFam
UniGene Hs.
UniProt
Wikipedia
Search for 3D structures on the PDB
Search by keyword: Dopamine receptors D1 receptor
Natural/Endogenous Ligand(s)
dopamine
Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
SKF-75670 Rn Full agonist 8.7 pKi 5
SKF-81297 Rn Full agonist 8.7 pKi 5
NPA Hs Full agonist 7.4 pKi 41
lisuride Hs Partial agonist 7.2 pKi 30
SKF-82526 Hs Full agonist 6.5 – 7.9 pKi 43
cabergoline Hs Full agonist 6.7 pKi 30
(+)-SKF-82526 Hs Full agonist 5.7 – 7.6 pKi 41
SKF-38393 Hs Full agonist 6.2 – 6.8 pKi 41,43
bromocriptine Hs Partial agonist 6.2 pKi 30,41
pergolide Hs Full agonist 5.9 – 6.5 pKi 30,41
SKF-76783 Hs Full agonist 6.2 pKi 41
(+)-ADTN Hs Full agonist 5.3 – 6.4 pKi 30,41
apomorphine Hs Full agonist 5.3 – 6.2 pKi 41,43
rotigotine Hs Full agonist 5.6 pKi 41
5-HT Hs Full agonist 5.0 pKi 41
dopamine Hs Full agonist 4.3 – 5.6 pKi 41,43
noradrenaline Hs Full agonist 4.3 pKi 41
View species-specific agonist tables
Agonist Comments
Reference [5] uses rat striatal homogenate to obtain pKi values.
Antagonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
[125I]SCH23982 Hs Antagonist 9.5 pKd 15
[3H]SCH-23390 Hs Antagonist 9.5 pKd 49
SKF-83556 Hs Antagonist 9.5 pKi 41
SCH-23390 Hs Antagonist 7.4 – 9.5 pKi 41,43
ecopipam Hs Antagonist 8.3 pKi 44
cis flupentixol Hs Antagonist 7.0 – 8.4 pKi 41,43
fluphenazine Hs Antagonist 7.7 pKi 41
haloperidol Hs Antagonist 7.6 pKi 41
(+)-butaclamol Hs Antagonist 6.5 – 8.5 pKi 41,43
chlorpromazine Hs Antagonist 7.1 pKi 41
thioridazine Hs Antagonist 7.0 pKi 41
clozapine Hs Antagonist 6.9 pKi 41
ketanserin Hs Antagonist 6.7 pKi 41
spiperone Hs Antagonist 6.7 pKi 41

Explore drug-target interactions for this set of compounds using iPHACE

Primary Transduction Mechanisms
Transducer Effector/Response
Gs family Adenylate cyclase stimulation
References:  12
Secondary Transduction Mechanisms
Transducer Effector/Response
Gs family Calcium channel
References:  7,21
Tissue Distribution
Heart, kidney.
Species:  Human
Technique:  Western Blot and Immunohistochemistry.
References:  34
Seminal vesicles.
Species:  Human
Technique:  RT-PCR and Western blot.
References:  23
Adrenal cortex.
Species:  Human
Technique:  Radioligand binding.
References:  2
Brain: Striatum, substantia nigra pars reticulata, globus pallidus, olfactory bulb, amygdala, cerebellar granule cell layer.
Species:  Rat
Technique:  immunocytochemistry.
References:  25
Kidney: Juxtaglomerular apparatus, proximal tubule, distal tubule, cortical collecting duct.
Species:  Rat
Technique:  Immunohistochemistry and immunocytochemistry.
References:  33
Retina.
Species:  Rat
Technique:  Immunohistochemistry.
References:  45
Seminal vesicles.
Species:  Rat
Technique:  RT-PCR and Western blot.
References:  23
Cerebral, mesenteric and renal arteries.
Species:  Rat
Technique:  Radioligand binding.
References:  1,3
Heart.
Species:  Rat
Technique:  RT-PCR.
References:  29,47
Expression Datasets

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Functional Assays
Measurement of cAMP accumulation in HEK 293 cells transfected with the human D1 receptor.
Species:  Human
Tissue:  HEK 293 cells.
Response measured:  Stimulation of cAMP accumulation.
References:  27,40,49
Measurement of cAMP levels in COS-7 cells transfected with the rat D1 receptor.
Species:  Rat
Tissue:  COS-7 cells.
Response measured:  Stimulation of cAMP accumulation.
References:  32
Measurement of Ca2+ levels in HEK 293 cells transfected with the human D1 receptor.
Species:  Human
Tissue:  HEK 293 cells.
Response measured:  Stimulation of calcium mobilisation.
References:  27,40
Measurement of cAMP levels in CHO cells transfected with the human D1 receptor, using a cAMP response element (CRE)-coupled luciferase construct as the reporter.
Species:  Human
Tissue:  CHO cells.
Response measured:  Stimulation of cAMP accumulation.
References:  22
Measurement of cAMP levels in CHO cells transfected with the human D1 receptor.
Species:  Human
Tissue:  CHO cells.
Response measured:  Stimulation of cAMP accumulation.
References:  35
Measurement of IP3 and Ca2+ levels in Xenopus oocytes transfected with the rat D1 receptor.
Species:  Rat
Tissue:  Xenopus oocytes.
Response measured:  Stimulation of IP3 formation and Ca2+ mobilsation.
References:  28
Measurement of PLC activity in Ltk- cells transfected with the rat D1 receptor.
Species:  Rat
Tissue:  LTK- cells.
Response measured:  Stimulation of PLC activity.
References:  46
Measurement of p38 MAPK and JNK levels in SK-N-MC human neuroblastoma cells endogenously expressing the D1 receptor.
Species:  Human
Tissue:  SK-N-MC cells.
Response measured:  Activation of p38 MAPK and JNK signalling pathways.
References:  48
Measurement of [3H]arachidonic acid release from rat striatal neurons endogenously expressing the D1 receptors.
Species:  Rat
Tissue:  Striatal neurons.
Response measured:  Inhibition of [3H]arachidonic acid release.
References:  37
Physiological Functions
Stimulation of accumulation of cAMP in membrane particles of the rat kidney medulla.
Species:  Rat
Tissue:  Membrane particles of the rat kidney medulla.
References:  4
Modulation of renin release.
Species:  Rat
Tissue:  Renal cortical slices.
References:  6
Induction of circling behaviour.
Species:  Rat
Tissue:  In vivo.
References:  8
Induction of gnawing behaviour and hypermotility.
Species:  Mouse
Tissue:  In vivo.
References:  8
Inhibits Na+-K+-adenosinetriphosphatase (ATPase) activity when a D1 agonist is co-administered with a D2 agonist.
Species:  Rat
Tissue:  Proximal tubule.
References:  9,14
Inhibition of (Na++K+)ATPase activity via synergism with the D2 receptor.
Species:  Rat
Tissue:  Isolated striatal neurons.
References:  10
Modulation of locomotor activity.
Species:  Rat
Tissue:  In vivo.
References:  11
Contribution to pathophysiology and/or maintenance of increased blood pressure in essential hypertension.
Species:  Human
Tissue:  In vivo.
References:  13
Physiological Consequences of Altering Gene Expression
D1 receptor knockout mice exhibit abnormal spatial learning.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  17
D1 receptor knockout mice exhibit abnormal contextual conditioning.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  19
D1 receptor knockout mice suffer premature death.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  16
D1 receptor knockout mice exhibit dishevelled coats.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  16
D1 receptor knockout mice exhibit hunched posture.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  16
D1 receptor knockout mice exhibit significantly fewer rearing events.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  16
D1 receptor knockout mice exhibit decreased body weight and post-natal growth retardation compared with wild-type.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  16-17,19
D1 receptor knockout mice exhibit abnormal passive avoidance behaviour.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  19
D1 receptor knockout mice exhibit abnormal dendritic morphology in projection neurones within the anterior cingulate cortex and the pre-frontal cortex.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  39
D1 receptor knockout mice exhibit attenuation of sucrose reinforcement.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  20
D1 receptor knockout mice exhibit reduced motivation for alcohol consumption.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  18
Phenotypes, Alleles and Disease Models Mouse data from MGI

Click here to show/hide data

Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Drd1atm1(cre)Rpa Drd1atm1(cre)Rpa/Drd1atm1(cre)Rpa
involves: 129S4/SvJaeSor * C57BL/6
MGI:99578  MP:0004924 abnormal behavior PMID: 18615733 
Drd1atm1Jcd Drd1atm1Jcd/Drd1atm1Jcd
B6.129S4-Drd1a/J
MGI:99578  MP:0005535 abnormal body temperature PMID: 18486343 
Drd1a+|Drd1atm2Jcd|Tg(Camk2a-cre)2Gsc Drd1atm2Jcd/Drd1a+,Tg(Camk2a-cre)2Gsc/0
involves: 129S4/SvJae * FVB/N
MGI:2181425  MGI:99578  MP:0000822 abnormal brain ventricle morphology PMID: 17360497 
Drd1a+|Drd1atm2Jcd|Tg(Camk2a-cre)2Gsc Drd1atm2Jcd/Drd1a+,Tg(Camk2a-cre)2Gsc/0
involves: 129S4/SvJae * FVB/N
MGI:2181425  MGI:99578  MP:0004994 abnormal brain wave pattern PMID: 17360497 
Drd1a+|Drd1atm2Jcd|Tg(Camk2a-cre)2Gsc Drd1atm2Jcd/Drd1a+,Tg(Camk2a-cre)2Gsc/0
involves: 129S4/SvJae * FVB/N
MGI:2181425  MGI:99578  MP:0000788 abnormal cerebral cortex morphology PMID: 17360497 
Drd1atm1Jcd Drd1atm1Jcd/Drd1atm1Jcd
involves: 129S4/SvJae
MGI:99578  MP:0001469 abnormal contextual conditioning behavior PMID: 11172752 
Drd1a+|Drd1atm1Jcd Drd1atm1Jcd/Drd1a+
involves: 129S4/SvJae
MGI:99578  MP:0001469 abnormal contextual conditioning behavior PMID: 11172752 
Drd1a+|Drd1atm2Jcd|Tg(Camk2a-cre)2Gsc Drd1atm2Jcd/Drd1a+,Tg(Camk2a-cre)2Gsc/0
involves: 129S4/SvJae * FVB/N
MGI:2181425  MGI:99578  MP:0000812 abnormal dentate gyrus morphology PMID: 17360497 
Drd1atm1Jcd|Drd2tm1Ebo Drd1atm1Jcd/Drd1atm1Jcd,Drd2tm1Ebo/Drd2tm1Ebo
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6
MGI:94924  MGI:99578  MP:0003119 abnormal digestive system development PMID: 15272078 
Drd1atm1Jcd|Drd2tm1Ebo Drd1atm1Jcd/Drd1atm1Jcd,Drd2tm1Ebo/Drd2tm1Ebo
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6
MGI:94924  MGI:99578  MP:0001663 abnormal digestive system physiology PMID: 15272078 
Drd1atm1Jcd|Drd2+|Drd2tm1Ebo Drd1atm1Jcd/Drd1atm1Jcd,Drd2tm1Ebo/Drd2+
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6
MGI:94924  MGI:99578  MP:0003271 abnormal duodenum morphology PMID: 15272078 
Drd1a+|Drd1atm2Jcd|Tg(EIIa-cre)C5379Lmgd Drd1atm2Jcd/Drd1a+,Tg(EIIa-cre)C5379Lmgd/0
involves: 129S4/SvJae * BALB/c * CD-1 * FVB/N
MGI:2137685  MGI:99578  MP:0000783 abnormal forebrain morphology PMID: 9822743 
Drd1a+|Drd1atm2Jcd|Tg(Camk2a-cre)2Gsc Drd1atm2Jcd/Drd1a+,Tg(Camk2a-cre)2Gsc/0
involves: 129S4/SvJae * FVB/N
MGI:2181425  MGI:99578  MP:0000783 abnormal forebrain morphology PMID: 17360497 
Drd1a+|Drd1atm2Jcd|Tg(EIIa-cre)C5379Lmgd Drd1atm2Jcd/Drd1a+,Tg(EIIa-cre)C5379Lmgd/0
involves: 129S4/SvJae * BALB/c * CD-1 * FVB/N
MGI:2137685  MGI:99578  MP:0000807 abnormal hippocampus morphology PMID: 9822743 
Drd1a+|Drd1atm2Jcd|Tg(Camk2a-cre)2Gsc Drd1atm2Jcd/Drd1a+,Tg(Camk2a-cre)2Gsc/0
involves: 129S4/SvJae * FVB/N
MGI:2181425  MGI:99578  MP:0000807 abnormal hippocampus morphology PMID: 17360497 
Drd1atm1Jcd|Drd2tm1Ebo Drd1atm1Jcd/Drd1atm1Jcd,Drd2tm1Ebo/Drd2tm1Ebo
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6
MGI:94924  MGI:99578  MP:0005645 abnormal hypothalamus physiology PMID: 15272078 
Drd1atm1Jcd|Drd2tm1Ebo Drd1atm1Jcd/Drd1atm1Jcd,Drd2tm1Ebo/Drd2tm1Ebo
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6
MGI:94924  MGI:99578  MP:0008802 abnormal intestinal smooth muscle morphology PMID: 15272078 
Drd1atm1Jcd|Drd2tm1Ebo Drd1atm1Jcd/Drd1atm1Jcd,Drd2tm1Ebo/Drd2tm1Ebo
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6
MGI:94924  MGI:99578  MP:0000477 abnormal intestine morphology PMID: 15272078 
Drd1a+|Drd1atm2Jcd|Tg(Camk2a-cre)2Gsc Drd1atm2Jcd/Drd1a+,Tg(Camk2a-cre)2Gsc/0
involves: 129S4/SvJae * FVB/N
MGI:2181425  MGI:99578  MP:0003691 abnormal microglial cell physiology PMID: 17360497 
Drd1a+|Drd1atm1(cre)Rpa|Gad1tm1.1Rpa|Gad1tm1Rpa Drd1atm1(cre)Rpa/Drd1a+,Gad1tm1Rpa/Gad1tm1.1Rpa
involves: 129S4/SvJaeSor * C57BL/6
MGI:95632  MGI:99578  MP:0001516 abnormal motor coordination/ balance PMID: 18615733 
Drd1a+|Drd1atm2Jcd|Tg(Camk2a-cre)2Gsc Drd1atm2Jcd/Drd1a+,Tg(Camk2a-cre)2Gsc/0
involves: 129S4/SvJae * FVB/N
MGI:2181425  MGI:99578  MP:0003632 abnormal nervous system morphology PMID: 17360497 
Drd1a+|Drd1atm2Jcd|Tg(EIIa-cre)C5379Lmgd Drd1atm2Jcd/Drd1a+,Tg(EIIa-cre)C5379Lmgd/0
involves: 129S4/SvJae * BALB/c * CD-1 * FVB/N
MGI:2137685  MGI:99578  MP:0003633 abnormal nervous system physiology PMID: 9822743 
Drd1a+|Drd1atm2Jcd|Tg(Camk2a-cre)2Gsc Drd1atm2Jcd/Drd1a+,Tg(Camk2a-cre)2Gsc/0
involves: 129S4/SvJae * FVB/N
MGI:2181425  MGI:99578  MP:0003633 abnormal nervous system physiology PMID: 17360497 
Drd1atm1Jcd Drd1atm1Jcd/Drd1atm1Jcd
involves: 129S4/SvJae
MGI:99578  MP:0006009 abnormal neuronal migration PMID: 17409246 
Drd1atm1Jcd Drd1atm1Jcd/Drd1atm1Jcd
involves: 129S4/SvJae
MGI:99578  MP:0002799 abnormal passive avoidance behavior PMID: 11172752 
Drd1a+|Drd1atm1Jcd Drd1atm1Jcd/Drd1a+
involves: 129S4/SvJae
MGI:99578  MP:0002799 abnormal passive avoidance behavior PMID: 11172752 
Drd1a+|Drd1atm2Jcd|Tg(EIIa-cre)C5379Lmgd Drd1atm2Jcd/Drd1a+,Tg(EIIa-cre)C5379Lmgd/0
involves: 129S4/SvJae * BALB/c * CD-1 * FVB/N
MGI:2137685  MGI:99578  MP:0001504 abnormal posture PMID: 9822743 
Drd1atm1Stl Drd1atm1Stl/Drd1atm1Stl
involves: 129P2/OlaHsd
MGI:99578  MP:0003638 abnormal response/metabolism to endogenous compounds PMID: 8001143 
Drd1atm1Jcd Drd1atm1Jcd/Drd1atm1Jcd
involves: 129S4/SvJae
MGI:99578  MP:0001463 abnormal spatial learning PMID: 10585522 
Drd1atm1Jcd|Drd2+|Drd2tm1Ebo Drd1atm1Jcd/Drd1atm1Jcd,Drd2tm1Ebo/Drd2+
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6
MGI:94924  MGI:99578  MP:0000470 abnormal stomach morphology PMID: 15272078 
Drd1a+|Drd1atm2Jcd|Tg(EIIa-cre)C5379Lmgd Drd1atm2Jcd/Drd1a+,Tg(EIIa-cre)C5379Lmgd/0
involves: 129S4/SvJae * BALB/c * CD-1 * FVB/N
MGI:2137685  MGI:99578  MP:0004077 abnormal striatum morphology PMID: 9822743 
Drd1a+|Drd1atm2Jcd|Tg(Camk2a-cre)2Gsc Drd1atm2Jcd/Drd1a+,Tg(Camk2a-cre)2Gsc/0
involves: 129S4/SvJae * FVB/N
MGI:2181425  MGI:99578  MP:0004077 abnormal striatum morphology PMID: 17360497 
Drd1atm1Stl Drd1atm1Stl/Drd1atm1Stl
involves: 129P2/OlaHsd * C57BL/6
MGI:99578  MP:0004077 abnormal striatum morphology PMID: 7954836 
Drd1atm1Tono Drd1atm1Tono/Drd1atm1Tono
B6.129P2-Drd1a
MGI:99578  MP:0004859 abnormal synaptic plasticity PMID: 19074012 
Drd1atm1Jcd|Drd2tm1Ebo Drd1atm1Jcd/Drd1atm1Jcd,Drd2tm1Ebo/Drd2tm1Ebo
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6
MGI:94924  MGI:99578  MP:0009546 absent gastric milk in neonates PMID: 15272078 
Drd1atm1Jcd|Drd2tm1Ebo Drd1atm1Jcd/Drd1atm1Jcd,Drd2tm1Ebo/Drd2tm1Ebo
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6
MGI:94924  MGI:99578  MP:0001438 aphagia PMID: 15272078 
Drd1a+|Drd1atm2Jcd|Tg(Camk2a-cre)2Gsc Drd1atm2Jcd/Drd1a+,Tg(Camk2a-cre)2Gsc/0
involves: 129S4/SvJae * FVB/N
MGI:2181425  MGI:99578  MP:0003354 astrocytosis PMID: 17360497 
Drd1a+|Drd1atm2Jcd|Tg(EIIa-cre)C5379Lmgd Drd1atm2Jcd/Drd1a+,Tg(EIIa-cre)C5379Lmgd/0
involves: 129S4/SvJae * BALB/c * CD-1 * FVB/N
MGI:2137685  MGI:99578  MP:0005156 bradykinesia PMID: 9822743 
Drd1atm1Jcd Drd1atm1Jcd/Drd1atm1Jcd
involves: 129S4/SvJae
MGI:99578  MP:0001265 decreased body size PMID: 10585522  11172752 
Drd1atm1(cre)Rpa Drd1atm1(cre)Rpa/Drd1atm1(cre)Rpa
involves: 129S4/SvJaeSor * C57BL/6
MGI:99578  MP:0001265 decreased body size PMID: 18615733 
Drd1atm1Stl Drd1atm1Stl/Drd1atm1Stl
involves: 129P2/OlaHsd * C57BL/6
MGI:99578  MP:0001265 decreased body size PMID: 7954836 
Drd1atm1Jcd|Drd2tm1Ebo Drd1atm1Jcd/Drd1atm1Jcd,Drd2tm1Ebo/Drd2tm1Ebo
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6
MGI:94924  MGI:99578  MP:0001265 decreased body size PMID: 15272078 
Drd1atm1Jcd Drd1atm1Jcd/Drd1atm1Jcd
involves: 129S4/SvJae * C57BL/6
MGI:99578  MP:0001262 decreased body weight PMID: 7809078 
Drd1a+|Drd1atm2Jcd|Tg(Camk2a-cre)2Gsc Drd1atm2Jcd/Drd1a+,Tg(Camk2a-cre)2Gsc/0
involves: 129S4/SvJae * FVB/N
MGI:2181425  MGI:99578  MP:0001262 decreased body weight PMID: 17360497 
Drd1atm1Stl Drd1atm1Stl/Drd1atm1Stl
involves: 129P2/OlaHsd * C57BL/6
MGI:99578  MP:0001262 decreased body weight PMID: 7954836 
Drd1a+|Drd1atm2Jcd|Tg(EIIa-cre)C5379Lmgd Drd1atm2Jcd/Drd1a+,Tg(EIIa-cre)C5379Lmgd/0
involves: 129S4/SvJae * BALB/c * CD-1 * FVB/N
MGI:2137685  MGI:99578  MP:0000774 decreased brain size PMID: 9822743 
Drd1a+|Drd1atm2Jcd|Tg(Camk2a-cre)2Gsc Drd1atm2Jcd/Drd1a+,Tg(Camk2a-cre)2Gsc/0
involves: 129S4/SvJae * FVB/N
MGI:2181425  MGI:99578  MP:0000774 decreased brain size PMID: 17360497 
Drd1atm1Stl Drd1atm1Stl/Drd1atm1Stl
involves: 129P2/OlaHsd * C57BL/6
MGI:99578  MP:0000774 decreased brain size PMID: 7954836 
Drd1a+|Drd1atm2Jcd|Tg(EIIa-cre)C5379Lmgd Drd1atm2Jcd/Drd1a+,Tg(EIIa-cre)C5379Lmgd/0
involves: 129S4/SvJae * BALB/c * CD-1 * FVB/N
MGI:2137685  MGI:99578  MP:0002175 decreased brain weight PMID: 9822743 
Drd1a+|Drd1atm2Jcd|Tg(Camk2a-cre)2Gsc Drd1atm2Jcd/Drd1a+,Tg(Camk2a-cre)2Gsc/0
involves: 129S4/SvJae * FVB/N
MGI:2181425  MGI:99578  MP:0002175 decreased brain weight PMID: 17360497 
Drd1a+|Drd1atm2Jcd|Tg(EIIa-cre)C5379Lmgd Drd1atm2Jcd/Drd1a+,Tg(EIIa-cre)C5379Lmgd/0
involves: 129S4/SvJae * BALB/c * CD-1 * FVB/N
MGI:2137685  MGI:99578  MP:0005574 decreased breathing frequency PMID: 9822743 
Drd1atm1Jcd|Drd2+|Drd2tm1Ebo Drd1atm1Jcd/Drd1atm1Jcd,Drd2tm1Ebo/Drd2+
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6
MGI:94924  MGI:99578  MP:0003910 decreased eating behavior PMID: 15272078 
Drd1a+|Drd1atm1(cre)Rpa|Gad1tm1.1Rpa|Gad1tm1Rpa Drd1atm1(cre)Rpa/Drd1a+,Gad1tm1Rpa/Gad1tm1.1Rpa
involves: 129S4/SvJaeSor * C57BL/6
MGI:95632  MGI:99578  MP:0010053 decreased grip strength PMID: 18615733 
Drd1atm1Stl Drd1atm1Stl/Drd1atm1Stl
involves: 129P2/OlaHsd
MGI:99578  MP:0008874 decreased physiological sensitivity to xenobiotic PMID: 8001143 
Drd1atm1Jcd Drd1atm1Jcd/Drd1atm1Jcd
B6.129S4-Drd1a/J
MGI:99578  MP:0008874 decreased physiological sensitivity to xenobiotic PMID: 18486343 
Drd1atm1Jcd Drd1atm1Jcd/Drd1atm1Jcd
B6.129S4-Drd1a/J
MGI:99578  MP:0009767 decreased sensitivity to xenobiotic induced morbidity/mortality PMID: 18486343 
Drd1atm1Jcd Drd1atm1Jcd/Drd1atm1Jcd
involves: 129S4/SvJae * C57BL/6
MGI:99578  MP:0002757 decreased vertical activity PMID: 7809078 
Drd1atm1Jcd Drd1atm1Jcd/Drd1atm1Jcd
involves: 129S4/SvJae * C57BL/6
MGI:99578  MP:0001511 disheveled coat PMID: 7809078 
Drd1a+|Drd1atm2Jcd|Tg(EIIa-cre)C5379Lmgd Drd1atm2Jcd/Drd1a+,Tg(EIIa-cre)C5379Lmgd/0
involves: 129S4/SvJae * BALB/c * CD-1 * FVB/N
MGI:2137685  MGI:99578  MP:0005323 dystonia PMID: 9822743 
Drd1a+|Drd1atm2Jcd|Tg(Camk2a-cre)2Gsc Drd1atm2Jcd/Drd1a+,Tg(Camk2a-cre)2Gsc/0
involves: 129S4/SvJae * FVB/N
MGI:2181425  MGI:99578  MP:0005323 dystonia PMID: 17360497 
Drd1atm1Jcd|Drd2tm1Ebo Drd1atm1Jcd/Drd1atm1Jcd,Drd2tm1Ebo/Drd2tm1Ebo
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6
MGI:94924  MGI:99578  MP:0000465 gastrointestinal hemorrhage PMID: 15272078 
Drd1atm1Jcd|Drd2+|Drd2tm1Ebo Drd1atm1Jcd/Drd1atm1Jcd,Drd2tm1Ebo/Drd2+
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6
MGI:94924  MGI:99578  MP:0000465 gastrointestinal hemorrhage PMID: 15272078 
Drd1a+|Drd1atm2Jcd|Tg(EIIa-cre)C5379Lmgd Drd1atm2Jcd/Drd1a+,Tg(EIIa-cre)C5379Lmgd/0
involves: 129S4/SvJae * BALB/c * CD-1 * FVB/N
MGI:2137685  MGI:99578  MP:0002183 gliosis PMID: 9822743 
Drd1atm1Jcd Drd1atm1Jcd/Drd1atm1Jcd
involves: 129S4/SvJae * C57BL/6
MGI:99578  MP:0001505 hunched posture PMID: 7809078 
Drd1a+|Drd1atm2Jcd|Tg(Camk2a-cre)2Gsc Drd1atm2Jcd/Drd1a+,Tg(Camk2a-cre)2Gsc/0
involves: 129S4/SvJae * FVB/N
MGI:2181425  MGI:99578  MP:0001399 hyperactivity PMID: 17360497 
Drd1atm1Stl Drd1atm1Stl/Drd1atm1Stl
involves: 129P2/OlaHsd * C57BL/6
MGI:99578  MP:0001399 hyperactivity PMID: 7954836 
Drd1atm1Stl Drd1atm1Stl/Drd1atm1Stl
involves: 129P2/OlaHsd
MGI:99578  MP:0001399 hyperactivity PMID: 8001143 
Drd1atm1Jcd|Drd2tm1Ebo Drd1atm1Jcd/Drd1atm1Jcd,Drd2tm1Ebo/Drd2tm1Ebo
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6
MGI:94924  MGI:99578  MP:0001402 hypoactivity PMID: 15272078 
Drd1a+|Drd1atm2Jcd|Tg(EIIa-cre)C5379Lmgd Drd1atm2Jcd/Drd1a+,Tg(EIIa-cre)C5379Lmgd/0
involves: 129S4/SvJae * BALB/c * CD-1 * FVB/N
MGI:2137685  MGI:99578  MP:0001525 impaired balance PMID: 9822743 
Drd1atm2Rpa Drd1atm2Rpa/Drd1atm2Rpa
involves: 129S4/SvJae * C57BL/6 * C57BL/6J
MGI:99578  MP:0009758 impaired behavioral response to cocaine PMID: 16014726 
Drd1atm1Stl Drd1atm1Stl/Drd1atm1Stl
involves: 129P2/OlaHsd
MGI:99578  MP:0009758 impaired behavioral response to cocaine PMID: 8001143 
Drd1atm1Stl Drd1atm1Stl/Drd1atm1Stl
involves: 129P2/OlaHsd * C57BL/6J
MGI:99578  MP:0009758 impaired behavioral response to cocaine PMID: 18045908 
Drd1atm1Stl Drd1atm1Stl/Drd1atm1Stl
involves: 129P2/OlaHsd * C57BL/6
MGI:99578  MP:0009747 impaired behavioral response to xenobiotic PMID: 7954836 
Drd1atm1Stl Drd1atm1Stl/Drd1atm1Stl
involves: 129P2/OlaHsd * C57BL/6J
MGI:99578  MP:0009747 impaired behavioral response to xenobiotic PMID: 18045908 
Drd1atm2Rpa Drd1atm2Rpa/Drd1atm2Rpa
involves: 129S4/SvJae * C57BL/6 * C57BL/6J
MGI:99578  MP:0009712 impaired conditioned place preference behavior PMID: 16014726 
Drd1a+|Drd1atm2Jcd|Tg(EIIa-cre)C5379Lmgd Drd1atm2Jcd/Drd1a+,Tg(EIIa-cre)C5379Lmgd/0
involves: 129S4/SvJae * BALB/c * CD-1 * FVB/N
MGI:2137685  MGI:99578  MP:0001523 impaired righting response PMID: 9822743 
Drd1a+|Drd1atm2Jcd|Tg(Camk2a-cre)2Gsc Drd1atm2Jcd/Drd1a+,Tg(Camk2a-cre)2Gsc/0
involves: 129S4/SvJae * FVB/N
MGI:2181425  MGI:99578  MP:0002574 increased vertical activity PMID: 17360497 
Drd1atm1Jcd|Drd2+|Drd2tm1Ebo Drd1atm1Jcd/Drd1atm1Jcd,Drd2tm1Ebo/Drd2+
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6
MGI:94924  MGI:99578  MP:0000512 intestinal ulcer PMID: 15272078 
Drd1a+|Drd1atm2Jcd|Tg(Camk2a-cre)2Gsc Drd1atm2Jcd/Drd1a+,Tg(Camk2a-cre)2Gsc/0
involves: 129S4/SvJae * FVB/N
MGI:2181425  MGI:99578  MP:0001513 limb grasping PMID: 17360497 
Drd1a+|Drd1atm1(cre)Rpa|Gad1tm1.1Rpa|Gad1tm1Rpa Drd1atm1(cre)Rpa/Drd1a+,Gad1tm1Rpa/Gad1tm1.1Rpa
involves: 129S4/SvJaeSor * C57BL/6
MGI:95632  MGI:99578  MP:0001513 limb grasping PMID: 18615733 
Drd1atm1Jcd Drd1atm1Jcd/Drd1atm1Jcd
involves: 129S4/SvJae
MGI:99578  MP:0003246 loss of GABAergic neurons PMID: 17409246 
Drd1a+|Drd1atm2Jcd|Tg(EIIa-cre)C5379Lmgd Drd1atm2Jcd/Drd1a+,Tg(EIIa-cre)C5379Lmgd/0
involves: 129S4/SvJae * BALB/c * CD-1 * FVB/N
MGI:2137685  MGI:99578  MP:0000243 myoclonus PMID: 9822743 
Drd1a+|Drd1atm2Jcd Drd1atm2Jcd/Drd1a+
either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * CD-1)
MGI:99578  MP:0002169 no abnormal phenotype detected PMID: 9822743 
Drd1atm1Jcd Drd1atm1Jcd/Drd1atm1Jcd
involves: 129S4/SvJae * C57BL/6
MGI:99578  MP:0001732 postnatal growth retardation PMID: 7809078 
Drd1atm1Jcd|Drd2tm1Ebo Drd1atm1Jcd/Drd1atm1Jcd,Drd2tm1Ebo/Drd2tm1Ebo
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6
MGI:94924  MGI:99578  MP:0001732 postnatal growth retardation PMID: 15272078 
Drd1atm1Jcd|Drd2+|Drd2tm1Ebo Drd1atm1Jcd/Drd1atm1Jcd,Drd2tm1Ebo/Drd2+
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6
MGI:94924  MGI:99578  MP:0001732 postnatal growth retardation PMID: 15272078 
Drd1a+|Drd1atm2Jcd|Tg(EIIa-cre)C5379Lmgd Drd1atm2Jcd/Drd1a+,Tg(EIIa-cre)C5379Lmgd/0
involves: 129S4/SvJae * BALB/c * CD-1 * FVB/N
MGI:2137685  MGI:99578  MP:0002082 postnatal lethality PMID: 9822743 
Drd1atm1Stl Drd1atm1Stl/Drd1atm1Stl
involves: 129P2/OlaHsd * C57BL/6
MGI:99578  MP:0002082 postnatal lethality PMID: 7954836 
Drd1atm1Jcd|Drd2tm1Ebo Drd1atm1Jcd/Drd1atm1Jcd,Drd2tm1Ebo/Drd2tm1Ebo
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6
MGI:94924  MGI:99578  MP:0002082 postnatal lethality PMID: 15272078 
Drd1atm1Jcd Drd1atm1Jcd/Drd1atm1Jcd
involves: 129S4/SvJae * C57BL/6
MGI:99578  MP:0002083 premature death PMID: 7809078 
Drd1atm1Jcd|Drd2+|Drd2tm1Ebo Drd1atm1Jcd/Drd1atm1Jcd,Drd2tm1Ebo/Drd2+
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6
MGI:94924  MGI:99578  MP:0002083 premature death PMID: 15272078 
Drd1a+|Drd1atm2Jcd|Tg(Camk2a-cre)2Gsc Drd1atm2Jcd/Drd1a+,Tg(Camk2a-cre)2Gsc/0
involves: 129S4/SvJae * FVB/N
MGI:2181425  MGI:99578  MP:0002064 seizures PMID: 17360497 
Drd1atm1Jcd|Drd2+|Drd2tm1Ebo Drd1atm1Jcd/Drd1atm1Jcd,Drd2tm1Ebo/Drd2+
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6
MGI:94924  MGI:99578  MP:0003306 small intestinal inflammation PMID: 15272078 
Drd1a+|Drd1atm2Jcd|Tg(Camk2a-cre)2Gsc Drd1atm2Jcd/Drd1a+,Tg(Camk2a-cre)2Gsc/0
involves: 129S4/SvJae * FVB/N
MGI:2181425  MGI:99578  MP:0001512 trunk curl PMID: 17360497 
Biologically Significant Variants
Ala48 -> Gly48 polymorphism associated with hypertension.
Type:  Single nucleotide polymorphism.
Species:  Human
References:  36
5' UTR substitution Ala48 -> Gly48 increases severity of alcohol dependence and promotes sensation-seeking behaviour in alcoholic males.
Type:  Single nucleotide polymorphism.
Species:  Human
References:  24,26
Ala48 -> Gly48 polymorphism associated with bipolar disorder.
Type:  Single nucleotide polymorphism.
Species:  Human
References:  38
General Comments
The gene organisation was established in rat [49] and human [31] and is intronless in the coding region but presents a small intron in the 5'-untranslated region. The promoter region lacks TATA and CAAT boxes and has a high G+C content and consensus sequences for cAMP response element, AP1, AP2 and Sp1 binding sites [31].

REFERENCES

To cite this database page, please use the following:

Arvid Carlsson, Marc Caron, Olivier Civelli, John W. Kebabian, Saloman Z. Langer, Bernard Scatton, Jean-Charles Schwartz, Goran Sedvall, Philip Seeman, Pierre Sokoloff, Pierre F. Spano, Hubert H. M. Van Tol.
Dopamine receptors: D1 receptor. Last modified on 05/03/2013. Accessed on 24/05/2013. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=214.


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