Nomenclature: LPHN2

Family: Adhesion Class GPCRs

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates. 


Gene and Protein Information
Adhesion G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 1459 1p31.1 LPHN2 latrophilin 2
Mouse 7 891 3 H3 Lphn2 latrophilin 2
Rat 7 1487 2q45 Lphn2 latrophilin 2
Previous and Unofficial Names
latrophilin 2
calcium-independent α-latrotoxin receptor 2
latrophilin homologue 1
latrophilin 1
calcium-independent alpha-latrotoxin receptor 2
calcium-independent alpha-latrotoxin receptor homolog 2
calcium-independent receptor of α-latrotoxin 2
Database Links
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Reference Database
PharmGKB Gene
Protein Ontology (PRO)
RefSeq Nucleotide
RefSeq Protein
UniGene Hs.
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Affinity Units Reference
α-latrotoxin Rn Full agonist 8.85 pKd 8
pKd 8.85 (Kd 1.4x10-9 M) [8]
Tissue Distribution
Expressed in all tissues tested. High expression in placenta, lung and heart. Not detected in blood cells
Species:  Human
Technique:  Northern blot
References:  8,12-13
Expressed in all tissues tested. Highest expression in lung and hypothalamus. Low expression in liver
Species:  Mouse
Technique:  RT-PCR
References:  7,11
Expressed in all tissues tested. Highest expression in liver
Species:  Rat
Technique:  Northern blot and RT-PCR
References:  7,9
Detectable in all tissues tested. High expression in brain
Species:  Rat
Technique:  Western blot
References:  8
Expression Datasets

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Xenobiotics Influencing Gene Expression
Acetaminophen alters LPHN2 mRNA expression
Species:  Mouse
Tissue:  Liver
Technique:  Toxicogenetics
References:  1
Bisphenol A increases the expression of LPHN2 mRNA
Species:  Rat
Tissue:  Uterus and ovary
Technique:  Microarray
References:  10
Dietary fats increase the expression of LPHN2 mRNA
Species:  Mouse
Tissue:  Skeletal muscle
Technique:  Transcriptomics combined with protein and lipid analysis
References:  3
Intragastric infusion with ethanol decreases the expression of LPHN2 mRNA
Species:  Rat
Tissue:  Liver
Technique:  cDNA microarray
References:  4
Expression of LPHN2 mRNA correlates with cancer cells' resistance to anticancer drugs 5-fluorouracil and methotrexate
Species:  Human
Tissue:  Cancer cell lines
Technique:  Microarray
References:  6
Bis-(2-chloroethyl) sulfide (mustard gas) decreases the expression of LPHN2 mRNA
Species:  Human
Tissue:  Lung
Technique:  Microarray
References:  5
Gene Expression and Pathophysiology Comments
LPHN2 mRNA is dysregulated (up or down) in various cancers [13]. More information on the dysregulation of LPHN2 in cancer can be found on the NCBI Geoprofiles database (
General Comments
LPHN2 (latrophilin 2) is an orphan receptor that belongs to Family I Adhesion-GPCRs along with latrophilin 1, latrophilin 3 and ELTD1 [2]. Family I Adhesion-GPCRs have orthologs in vertebrate and invertebrate species.


1. Beyer RP, Fry RC, Lasarev MR, McConnachie LA, Meira LB, Palmer VS, Powell CL, Ross PK, Bammler TK, Bradford BU et al.. (2007) Multicenter study of acetaminophen hepatotoxicity reveals the importance of biological endpoints in genomic analyses. Toxicol. Sci.99 (1): 326-37. [PMID:17562736]

2. Bjarnadóttir TK, Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB. (2004) The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. Genomics84: 23-33. [PMID:15203201]

3. de Wilde J, Mohren R, van den Berg S, Boekschoten M, Dijk KW, de Groot P, Müller M, Mariman E, Smit E. (2008) Short-term high fat-feeding results in morphological and metabolic adaptations in the skeletal muscle of C57BL/6J mice. Physiol. Genomics32 (3): 360-9. [PMID:18042831]

4. Deaciuc IV, Arteel GE, Peng X, Hill DB, McClain CJ. (2004) Gene expression in the liver of rats fed alcohol by means of intragastric infusion. Alcohol33 (1): 17-30. [PMID:15353170]

5. Dillman 3rd JF, Phillips CS, Dorsch LM, Croxton MD, Hege AI, Sylvester AJ, Moran TS, Sciuto AM. (2005) Genomic analysis of rodent pulmonary tissue following bis-(2-chloroethyl) sulfide exposure. Chem. Res. Toxicol.18 (1): 28-34. [PMID:15651846]

6. Györffy B, Surowiak P, Kiesslich O, Denkert C, Schäfer R, Dietel M, Lage H. (2006) Gene expression profiling of 30 cancer cell lines predicts resistance towards 11 anticancer drugs at clinically achieved concentrations. Int. J. Cancer118 (7): 1699-712. [PMID:16217747]

7. Haitina T, Olsson F, Stephansson O, Alsiö J, Roman E, Ebendal T, Schiöth HB, Fredriksson R. (2008) Expression profile of the entire family of Adhesion G protein-coupled receptors in mouse and rat. BMC Neurosci9: 43. [PMID:18445277]

8. Ichtchenko K, Bittner MA, Krasnoperov V, Little AR, Chepurny O, Holz RW, Petrenko AG. (1999) A novel ubiquitously expressed alpha-latrotoxin receptor is a member of the CIRL family of G-protein-coupled receptors. J. Biol. Chem.274 (9): 5491-8. [PMID:10026162]

9. Matsushita H, Lelianova VG, Ushkaryov YA. (1999) The latrophilin family: multiply spliced G protein-coupled receptors with differential tissue distribution. FEBS Lett.443 (3): 348-52. [PMID:10025961]

10. Naciff JM, Jump ML, Torontali SM, Carr GJ, Tiesman JP, Overmann GJ, Daston GP. (2002) Gene expression profile induced by 17alpha-ethynyl estradiol, bisphenol A, and genistein in the developing female reproductive system of the rat. Toxicol. Sci.68 (1): 184-99. [PMID:12075121]

11. Regard JB, Sato IT, Coughlin SR. (2008) Anatomical profiling of G protein-coupled receptor expression. Cell135: 561-571. [PMID:18984166]

12. Sugita S, Ichtchenko K, Khvotchev M, Südhof TC. (1998) alpha-Latrotoxin receptor CIRL/latrophilin 1 (CL1) defines an unusual family of ubiquitous G-protein-linked receptors. G-protein coupling not required for triggering exocytosis. J. Biol. Chem.273 (49): 32715-24. [PMID:9830014]

13. White GR, Varley JM, Heighway J. (1998) Isolation and characterization of a human homologue of the latrophilin gene from a region of 1p31.1 implicated in breast cancer. Oncogene17 (26): 3513-9. [PMID:10030676]

To cite this database page, please use the following:

Yuri Ushkaryov, Tobias Langenhan, Tom I. Bonner.
Adhesion Class GPCRs: LPHN2. Last modified on 23/07/2013. Accessed on 31/10/2014. IUPHAR database (IUPHAR-DB),

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