Nomenclature: GPR144

Family: Adhesion Class GPCRs

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates. 

Contents

Gene and Protein Information
Adhesion G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 963 9q34.11 GPR144 G protein-coupled receptor 144
Mouse 7 - 2 B Gpr144 G protein-coupled receptor 144
Previous and Unofficial Names
PGR24
EG666416
Gm13585
Gm999
OTTMUSG00000012858
Database Links
Ensembl Gene
Entrez Gene
GPCRDB
GeneCards
GenitoUrinary Development Molecular Anatomy Project
HomoloGene
Human Protein Reference Database
InterPro
KEGG Gene
PharmGKB Gene
PhosphoSitePlus
RefSeq Nucleotide
RefSeq Protein
TreeFam
UniGene Hs.
UniProtKB
Wikipedia
Primary Transduction Mechanisms
Transducer Effector/Response
G protein (identity unknown)
Comments:  Predicted to transduce signal through G proteins based on sequence signatures [3]. However, studies on several different adhesion GPCRs have provided evidence that these receptors are in fact authentic G protein-coupled receptors. Adhesion GPCRs with experimentally verified G-protein coupling includes GPR56 [5], GPR133 [2] and GPR126 [7]. Recent reviews [9] and adhesion GPCR consortium meeting report [1] addressed the issues to unravel the signal transduction of adhesion GPCRs and provided further preliminary evidences [4] for other adhesion GPCRs to transduce singnal through G proteins.
References: 
Secondary Transduction Mechanisms
Transducer Effector/Response
G protein (identity unknown)
References: 
General Comments
GPR144 is an orphan receptor belonging to Family V Adhesion-GPCRs together with GPR133 [3]. GPR133 and GPR144 are the Adhesion-GPCRs most closely related to the Secretin class of GPCRs [8]. A search for homologs in the invertebrates like ciona and amphioxus revealed that GPR133 and GPR144 are well conserved in pre-vertebrate genomes [6,8]. Unlike the close paralog GPR133, which only contains a GPCR proteolysis site (GPS) motif in its rather short N terminus, GPR144 was found to contain a pentraxin (PTX) domain along with the GPS motif. The PTX domain has previously been found in one other Adhesion-GPCR (GPR112). GPR112 is, together with CELSR1-3 and VLGR1, one the largest Adhesion-GPCRs. The PTX domain in GPR144 is only 33% similar to the PTX domain in GPR112. GPR112 belongs to a different phylogenetic cluster as GPR144 and these receptors are not particularly similar, sharing about 36–40% amino acid identity in the TM regions. The PTX domains are found in a number of other proteins and consist of up to five non-covalently bound identical subunits that are arranged in a flat pentameric disk.

REFERENCES

1. Araç D, Aust G, Calebiro D, Engel FB, Formstone C, Goffinet A, Hamann J, Kittel RJ, Liebscher I, Lin HH et al.. (2012) Dissecting signaling and functions of adhesion G protein-coupled receptors. Ann. N. Y. Acad. Sci.1276: 1-25. [PMID:23215895]

2. Bohnekamp J, Schöneberg T. (2011) Cell adhesion receptor GPR133 couples to Gs protein. J. Biol. Chem.286 (49): 41912-6. [PMID:22025619]

3. Fredriksson R, Gloriam DE, Höglund PJ, Lagerström MC, Schiöth HB. (2003) There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini. Biochem. Biophys. Res. Commun.301 (3): 725-34. [PMID:12565841]

4. Gupte J, Swaminath G, Danao J, Tian H, Li Y, Wu X. (2012) Signaling property study of adhesion G-protein-coupled receptors. FEBS Lett.586 (8): 1214-9. [PMID:22575658]

5. Iguchi T, Sakata K, Yoshizaki K, Tago K, Mizuno N, Itoh H. (2008) Orphan G protein-coupled receptor GPR56 regulates neural progenitor cell migration via a G alpha 12/13 and Rho pathway. J. Biol. Chem.283 (21): 14469-78. [PMID:18378689]

6. Kamesh N, Aradhyam GK, Manoj N. (2008) The repertoire of G protein-coupled receptors in the sea squirt Ciona intestinalis. BMC Evol. Biol.8: 129. [PMID:18452600]

7. Monk KR, Naylor SG, Glenn TD, Mercurio S, Perlin JR, Dominguez C, Moens CB, Talbot WS. (2009) A G protein-coupled receptor is essential for Schwann cells to initiate myelination. Science325 (5946): 1402-5. [PMID:19745155]

8. Nordström KJ, Fredriksson R, Schiöth HB. (2008) The amphioxus (Branchiostoma floridae) genome contains a highly diversified set of G protein-coupled receptors. BMC Evol. Biol.8: 9. [PMID:18199322]

9. Paavola KJ, Hall RA. (2012) Adhesion G protein-coupled receptors: signaling, pharmacology, and mechanisms of activation. Mol. Pharmacol.82 (5): 777-83. [PMID:22821233]

To cite this database page, please use the following:

Helgi Schiöth, Arunkumar Krishnan, Torsten Schöneberg, Tom I. Bonner.
Adhesion Class GPCRs: GPR144. Last modified on 23/07/2013. Accessed on 30/09/2014. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=204.

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