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GPR143

Family: Other 7TM proteins

Contents:
Gene and Protein Information
Previous and Unofficial Names
Database Links
Expression Datasets
Phenotypes, Alleles and Disease Models
Clinically-Relevant Mutations and Pathophysiology
Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 404 Xp22.3 GPR143 G protein-coupled receptor 143
Mouse 7 405 X F2-F3 Gpr143 G protein-coupled receptor 143
Rat 7 405 Xq21 Gpr143 G protein-coupled receptor 143
Previous and Unofficial Names
MOA1
OA1
ocular albinism 1 (Nettleship-Falls)
GPR143
G-protein coupled receptor 143
G protein-coupled receptor 143
Ocular albinism type 1 protein
NYS6
Gpr143_predicted
LOC302619
RGD1565799
RGD1565799_predicted
G protein-coupled receptor 143 (predicted)
similar to Oa1
similar to Oa1 (predicted)
Database Links
Ensembl ENSG00000101850 (Hs), ENSMUSG00000025333 (Mm), ENSRNOG00000003543 (Rn)
Entrez Gene 4935 (Hs), 18241 (Mm), 302619 (Rn)
GeneCards GPR143 (Hs)
GenitoUrinary Development Molecular Anatomy Project Gpr143 (Mm)
HomoloGene 230 (Hs)
Human Protein Reference Database 02355 (Hs)
InterPro P51810 (Hs), P70259 (Mm)
KEGG Gene hsa:4935 (Hs), mmu:18241 (Mm), rno:302619 (Rn)
OMIM 300500 (Hs)
Orphanet Gene ORPHA122263 (Hs)
PhosphoSitePlus P51810 (Hs), P70259 (Mm)
Protein Ontology (PRO) PRO:000008186 (Hs)
RefSeq Nucleotide NM_000273 (Hs), NM_010951 (Mm), NM_001103958 (Rn)
RefSeq Protein NP_000264 (Hs), NP_035081 (Mm), NP_001100428 (Rn)
TreeFam ENSG00000101850 (Hs), ENSMUSG00000025333 (Mm), ENSRNOG00000003543 (Rn)
UniGene Hs. 74124 (Hs)
UniProt P51810 (Hs), P70259 (Mm)
Wikipedia GPR143
Orphan and other 7TM receptors
Expression Datasets

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Phenotypes, Alleles and Disease Models Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Gpr143tm1Inc Gpr143tm1Inc/Y
either: (involves: 129/Sv * 129S7/SvEvBrd * C57BL/6) or (involves: 129S7/SvEvBrd * C57BL/6)		 MGI:107193  MP:0005101 abnormal ciliary body pigmentation PMID: 11092754 
Gpr143tm1Inc Gpr143tm1Inc/Y
either: (involves: 129/Sv * 129S7/SvEvBrd * C57BL/6) or (involves: 129S7/SvEvBrd * C57BL/6)		 MGI:107193  MP:0005199 abnormal iris pigment epithelium PMID: 11092754 
Gpr143tm1Inc Gpr143tm1Inc/Y
either: (involves: 129/Sv * 129S7/SvEvBrd * C57BL/6) or (involves: 129S7/SvEvBrd * C57BL/6)		 MGI:107193  MP:0005075 abnormal melanosome morphology PMID: 11092754 
Gpr143tm1Inc Gpr143tm1Inc/Y
either: (involves: 129/Sv * 129S7/SvEvBrd * C57BL/6) or (involves: 129S7/SvEvBrd * C57BL/6)		 MGI:107193  MP:0002864 abnormal ocular fundus morphology PMID: 11092754 
Gpr143tm1Inc Gpr143tm1Inc/Y
either: (involves: 129/Sv * 129S7/SvEvBrd * C57BL/6) or (involves: 129S7/SvEvBrd * C57BL/6)		 MGI:107193  MP:0001332 abnormal optic nerve innervation PMID: 11092754 
Gpr143tm1Inc Gpr143tm1Inc/Y
either: (involves: 129/Sv * 129S7/SvEvBrd * C57BL/6) or (involves: 129S7/SvEvBrd * C57BL/6)		 MGI:107193  MP:0005200 abnormal pigment epithelium of the eye PMID: 11092754 
Gpr143tm1Inc Gpr143tm1Inc/Y
either: (involves: 129/Sv * 129S7/SvEvBrd * C57BL/6) or (involves: 129S7/SvEvBrd * C57BL/6)		 MGI:107193  MP:0005103 abnormal retinal pigmentation PMID: 11092754 
Gpr143tm1Inc Gpr143tm1Inc/Y
either: (involves: 129/Sv * 129S7/SvEvBrd * C57BL/6) or (involves: 129S7/SvEvBrd * C57BL/6)		 MGI:107193  MP:0005201 abnormal retinal pigment epithelium morphology PMID: 11092754 
Clinically-Relevant Mutations and Pathophysiology
Disease:  X-linked recessive ocular albinism
OMIM:  300500
Orphanet:  54
References: 
Mutations not determined
Disease:  Congenital idiopathic nystagmus
OMIM:  300814
Orphanet:  651
References: 
Mutations not determined
Available Assays
DiscoveRx PathHunter® CHO-K1 GPR143 (Orphan) High Expression β-Arrestin Cell Line Human Cat No. 93-0362C2A
DiscoveRx PathHunter® eXpress GPR143 CHO-K1 β-Arrestin (Orphan) GPCR Assay Human Cat No. 93-0362E2ACP1

To cite this database page, please use the following:

Tom I. Bonner.
Other 7TM proteins: GPR143. Last modified on 23/02/2012. Accessed on 22/05/2013. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=203.


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