Nomenclature: GPR143

Family: Other 7TM proteins

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation. 

Contents

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 404 Xp22.3 GPR143 G protein-coupled receptor 143
Mouse 7 405 X F2-F3 Gpr143 G protein-coupled receptor 143
Rat 7 405 Xq21 Gpr143 G protein-coupled receptor 143
Previous and Unofficial Names
MOA1
ocular albinism 1 (Nettleship-Falls)
OA1
GPR143
G-protein coupled receptor 143
G protein-coupled receptor 143
Ocular albinism type 1 protein
NYS6
Gpr143_predicted
LOC302619
RGD1565799
RGD1565799_predicted
G protein-coupled receptor 143 (predicted)
similar to Oa1
similar to Oa1 (predicted)
Database Links
Ensembl Gene
Entrez Gene
GeneCards
GenitoUrinary Development Molecular Anatomy Project
HomoloGene
Human Protein Reference Database
InterPro
KEGG Gene
OMIM
Orphanet Gene
PhosphoSitePlus
Protein Ontology (PRO)
RefSeq Nucleotide
RefSeq Protein
TreeFam
UniGene Hs.
UniProtKB
Wikipedia
Expression Datasets

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Phenotypes, Alleles and Disease Models Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Gpr143tm1Inc Gpr143tm1Inc/Y
either: (involves: 129/Sv * 129S7/SvEvBrd * C57BL/6) or (involves: 129S7/SvEvBrd * C57BL/6)
MGI:107193  MP:0005101 abnormal ciliary body pigmentation PMID: 11092754 
Gpr143tm1Inc Gpr143tm1Inc/Y
either: (involves: 129/Sv * 129S7/SvEvBrd * C57BL/6) or (involves: 129S7/SvEvBrd * C57BL/6)
MGI:107193  MP:0005199 abnormal iris pigment epithelium PMID: 11092754 
Gpr143tm1Inc Gpr143tm1Inc/Y
either: (involves: 129/Sv * 129S7/SvEvBrd * C57BL/6) or (involves: 129S7/SvEvBrd * C57BL/6)
MGI:107193  MP:0005075 abnormal melanosome morphology PMID: 11092754 
Gpr143tm1Inc Gpr143tm1Inc/Y
either: (involves: 129/Sv * 129S7/SvEvBrd * C57BL/6) or (involves: 129S7/SvEvBrd * C57BL/6)
MGI:107193  MP:0002864 abnormal ocular fundus morphology PMID: 11092754 
Gpr143tm1Inc Gpr143tm1Inc/Y
either: (involves: 129/Sv * 129S7/SvEvBrd * C57BL/6) or (involves: 129S7/SvEvBrd * C57BL/6)
MGI:107193  MP:0001332 abnormal optic nerve innervation PMID: 11092754 
Gpr143tm1Inc Gpr143tm1Inc/Y
either: (involves: 129/Sv * 129S7/SvEvBrd * C57BL/6) or (involves: 129S7/SvEvBrd * C57BL/6)
MGI:107193  MP:0005200 abnormal pigment epithelium of the eye PMID: 11092754 
Gpr143tm1Inc Gpr143tm1Inc/Y
either: (involves: 129/Sv * 129S7/SvEvBrd * C57BL/6) or (involves: 129S7/SvEvBrd * C57BL/6)
MGI:107193  MP:0005103 abnormal retinal pigmentation PMID: 11092754 
Gpr143tm1Inc Gpr143tm1Inc/Y
either: (involves: 129/Sv * 129S7/SvEvBrd * C57BL/6) or (involves: 129S7/SvEvBrd * C57BL/6)
MGI:107193  MP:0005201 abnormal retinal pigment epithelium morphology PMID: 11092754 
Clinically-Relevant Mutations and Pathophysiology
Disease:  X-linked recessive ocular albinism
OMIM:  300500
Orphanet:  54
References: 
Mutations not determined
Disease:  Congenital idiopathic nystagmus
OMIM:  300814
Orphanet:  651
References: 
Mutations not determined
General Comments
GPR143 shows no homology to known G protein-coupled receptors.
Available Assays
DiscoveRx PathHunter® CHO-K1 GPR143 β-Arrestin Orphan GPCR Cell Line (Cat no. 93-0362C2A)
PathHunter® eXpress GPR143 CHO-K1 β-Arrestin Orphan GPCR Assay (Cat no. 93-0362E2ACP1M)
more info

To cite this database page, please use the following:

Tom I. Bonner.
Other 7TM proteins: GPR143. Last modified on 06/08/2013. Accessed on 18/09/2014. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=203.

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