Nomenclature: GPR128

Family: Adhesion Class GPCRs

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates. 

Contents

Gene and Protein Information
Adhesion G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 797 3q12.3 GPR128 G protein-coupled receptor 128 5
Mouse 7 785 16 C1.1 Gpr128 G protein-coupled receptor 128
Rat 7 785 11q12 Gpr128 G protein-coupled receptor 128
Previous and Unofficial Names
FLJ16382
FLJ29035
MGC142011
MGC163260
FLJ14454
Gpr128_predicted
LOC304014
G protein-coupled receptor 128
G protein-coupled receptor 128 (predicted)
probable G-protein coupled receptor 128
9130020O16Rik
Database Links
Ensembl Gene
Entrez Gene
GPCRDB
GeneCards
GenitoUrinary Development Molecular Anatomy Project
HomoloGene
Human Protein Reference Database
InterPro
KEGG Gene
OMIM
PharmGKB Gene
PhosphoSitePlus
RefSeq Nucleotide
RefSeq Protein
TreeFam
UniGene Hs.
UniProtKB
Wikipedia
Agonist Comments
No ligands identified: orphan receptor.
Tissue Distribution
Liver, small intestine.
Species:  Human
Technique:  Microarray analysis.
References:  6
Cervix, skin, liver and small intestine
Species:  Human
Technique:  Microarray analysis and EST
References:  1,6
Expression Datasets

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Gene Expression and Pathophysiology Comments
Fusion to TFG, a target of chromosome translocations in lymphoma and soft tissue tumors in healthy donors [2-3].
General Comments
GPR128 is an orphan receptor belonging to Family VIII Adhesion-GPCRs together with GPR56, GPR64, GPR97, GPR112, GPR114 and GPR126 [4]. Full coding sequence human cDNA is publicly available, IMAGE:7447864 [7] in the mammalian expression vector pCDNA3.1. It has two silent changes compared to the RefSeq and reference human genomic sequence and has the more common (K151) allele of known SNP rs1144122. Also IMAGE:8322503 [7] in pCR4-TOPO with reversed insert has the same K151 allele but without the two silent changes.

In lymphoma and soft tissue tumors, TFG fuses to GPR128. The downstream mechanism is not yet known [2].

REFERENCES

1. Bjarnadóttir TK, Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB. (2004) The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. Genomics84: 23-33. [PMID:15203201]

2. Chase A, Ernst T, Fiebig A, Collins A, Grand F, Erben P, Reiter A, Schreiber S, Cross NC. (2010) TFG, a target of chromosome translocations in lymphoma and soft tissue tumors, fuses to GPR128 in healthy individuals. Haematologica95 (1): 20-6. [PMID:19797732]

3. Ernst T, Chase A, Zoi K, Waghorn K, Hidalgo-Curtis C, Score J, Jones A, Grand F, Reiter A, Hochhaus A et al.. (2010) Transcription factor mutations in myelodysplastic/myeloproliferative neoplasms. Haematologica95 (9): 1473-80. [PMID:20421268]

4. Fredriksson R, Gloriam DE, Höglund PJ, Lagerström MC, Schiöth HB. (2003) There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini. Biochem. Biophys. Res. Commun.301 (3): 725-34. [PMID:12565841]

5. Fredriksson R, Lagerström MC, Höglund PJ, Schiöth HB. (2002) Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions. FEBS Lett531: 407-414. [PMID:12435584]

6. Lee J, Hever A, Willhite D, Zlotnik A, Hevezi P. (2005) Effects of RNA degradation on gene expression analysis of human postmortem tissues. FASEB J19: 1356-1358. [PMID:15955843]

7. Lennon G, Auffray C, Polymeropoulos M, Soares MB. (1996) The I.M.A.G.E. Consortium: an integrated molecular analysis of genomes and their expression. Genomics33: 151-152. [PMID:8617505]

To cite this database page, please use the following:

Xianhua Piao, Kathleen Singer, Kelly Monk, Tom I. Bonner.
Adhesion Class GPCRs: GPR128. Last modified on 13/03/2014. Accessed on 01/09/2014. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=201.

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