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GPR128

Family: Class B Orphans

Contents:
Gene and Protein Information
Previous and Unofficial Names
Database Links
Agonists
Tissue Distribution
Expression Datasets
General Comments
References
Gene and Protein Information
class B G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 797 3q12.3 GPR128 G protein-coupled receptor 128 1
Mouse 7 785 16 C1.1 Gpr128 G protein-coupled receptor 128
Rat 7 785 11q12 Gpr128 G protein-coupled receptor 128
Previous and Unofficial Names
FLJ14454
FLJ16382
FLJ29035
MGC142011
MGC163260
Gpr128_predicted
LOC304014
G protein-coupled receptor 128
G protein-coupled receptor 128 (predicted)
probable G-protein coupled receptor 128
9130020O16Rik
Database Links
Ensembl ENSG00000144820 (Hs), ENSMUSG00000022755 (Mm), ENSRNOG00000001634 (Rn)
Entrez Gene 84873 (Hs), 239853 (Mm), 304014 (Rn)
GeneCards GPR128 (Hs)
GenitoUrinary Development Molecular Anatomy Project Gpr128 (Mm)
HomoloGene 1311 (Hs)
Human Protein Reference Database 17060 (Hs)
InterPro Q14D94 (Hs), Q8BM96 (Mm)
KEGG Gene hsa:84873 (Hs), mmu:239853 (Mm), rno:304014 (Rn)
PharmGKB Gene PA134982718 (Hs)
PhosphoSitePlus Q96K78 (Hs), Q8BM96 (Mm)
RefSeq Nucleotide NM_032787 (Hs), NM_172825 (Mm), NM_001107098 (Rn)
RefSeq Protein NP_116176 (Hs), NP_766413 (Mm), NP_001100568 (Rn)
TreeFam ENSG00000144820 (Hs), ENSMUSG00000022755 (Mm), ENSRNOG00000001634 (Rn)
UniGene Hs. 334511 (Hs)
UniProt Q14D94 (Hs), Q8BM96 (Mm)
Wikipedia GPR128
Orphan and other 7TM receptors
Agonist Comments
No ligands identified: orphan receptor.
Tissue Distribution
Liver, small intestine.
Species:  Human
Technique:  Microarray analysis.
References:  2
Expression Datasets

Click here to show/hide data

Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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General Comments
Full coding sequence human cDNA is publicly available, IMAGE:7447864 [3] in the mammalian expression vector pCDNA3.1. It has two silent changes compared to the RefSeq and reference human genomic sequence and has the more common (K151) allele of known SNP rs1144122. Also IMAGE:8322503 [3] in pCR4-TOPO with reversed insert has the same K151 allele but without the two silent changes.

REFERENCES

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1. Fredriksson, R., Lagerström, M. C., Höglund, P. J. and Schiöth, H. B. (2002) Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions. FEBS Lett, 531: 407-414. [PMID:12435584]

2. Lee, J., Hever, A., Willhite, D., Zlotnik, A. and Hevezi, P. (2005) Effects of RNA degradation on gene expression analysis of human postmortem tissues. FASEB J, 19: 1356-1358. [PMID:15955843]

3. Lennon, G., Auffray, C., Polymeropoulos, M. and Soares, M. B. (1996) The I.M.A.G.E. Consortium: an integrated molecular analysis of genomes and their expression. Genomics, 33: 151-152. [PMID:8617505]

To cite this database page, please use the following:

Tom I. Bonner.
Class B Orphans: GPR128. Last modified on 13/02/2013. Accessed on 20/05/2013. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=201.


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