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GPR126
Family: Class B Orphans
| Gene and Protein Information |
|
class B G protein-coupled receptor |
| Species |
TM |
AA |
Chromosomal Location |
Gene Symbol |
Gene Name |
Reference |
| Human |
7 |
1250 |
6q24.1 |
GPR126
|
G protein-coupled receptor 126
|
1-2 |
| Mouse |
7 |
1165 |
10 A2 |
Gpr126
|
G protein-coupled receptor 126
|
|
| Rat |
7 |
1217 |
1p13 |
Gpr126
|
G protein-coupled receptor 126
|
|
| Previous and Unofficial Names |
| FLJ14937 |
| DREG |
| OTTHUMP00000040178 |
| PS1TP2 |
| VIGR |
| HBV PreS1-transactivated protein 2 |
| Gpr126_predicted |
| LOC308376 |
| G protein-coupled receptor 126 |
| G protein-coupled receptor 126 (predicted) |
| G-protein coupled receptor 126 |
| LOC215798 |
| 1190004A11Rik |
| AI449247 |
| AW045736 |
| Gm222 |
| Database Links |
|
Ensembl
|
ENSG00000112414 (Hs), ENSMUSG00000039116 (Mm)
|
|
Entrez Gene
|
57211 (Hs), 215798 (Mm), 308376 (Rn)
|
|
GeneCards
|
GPR126 (Hs)
|
|
GenitoUrinary Development Molecular Anatomy Project
|
Gpr126 (Mm)
|
|
HomoloGene
|
10724 (Hs)
|
|
Human Protein Reference Database
|
17059 (Hs)
|
|
InterPro
|
Q86SQ4 (Hs), Q6F3F9 (Mm)
|
|
KEGG Gene
|
hsa:57211 (Hs), mmu:215798 (Mm), rno:308376 (Rn)
|
|
PharmGKB Gene
|
PA134878328 (Hs)
|
|
PhosphoSitePlus
|
Q86SQ4 (Hs), Q6F3F9 (Mm)
|
|
RefSeq Nucleotide
|
NM_020455 (Hs), NM_001032394 (Hs), NM_001032395 (Hs), NM_198569 (Hs), NM_001002268 (Mm)
|
|
RefSeq Protein
|
NP_001027567 (Hs), NP_065188 (Hs), NP_940971 (Hs), NP_001027566 (Hs), NP_001002268 (Mm)
|
|
TreeFam
|
ENSG00000112414 (Hs), ENSMUSG00000039116 (Mm)
|
|
UniGene Hs.
|
318894 (Hs)
|
|
UniProt
|
Q86SQ4 (Hs), Q6F3F9 (Mm)
|
|
Wikipedia
|
GPR126
|
|
Orphan and other 7TM receptors
|
| Agonist Comments |
| No ligands identified: orphan receptor. |
| Tissue Distribution
|
| Transcripts of approximately 7.7 and 4.7kb in placenta and to a lower extent in pancreas and liver and maybe brain. Not detected in lung, skeletal muscle or kidney. |
| Species: |
Human |
| Technique: |
Northern blotting. |
| References: |
2 |
|
|
| Lung, spleen, 11-, 15- and 17-day embryo > 7-day embryo, heart, brain, skeletal muscle, kidney, testis. Not detected in liver. |
| Species: |
Mouse |
| Technique: |
RT-PCR. |
| References: |
1 |
|
|
| Expression Datasets |
|
Click here to show/hide data
Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]
There should be a chart of expression data here, you may need to enable JavaScript!
|
|
| Biologically Significant Variants
|
| Four splice variants were described with all possible combinations of including or excluding exons 6 and 25. |
| Type: |
Splice variants. |
| Species: |
Human |
| References: |
1 |
|
|
REFERENCES
Show »« Hide
1. Moriguchi, T., Haraguchi, K., Ueda, N., Okada, M., Furuya, T. and Akiyama, T. (2004) DREG, a developmentally regulated G protein-coupled receptor containing two conserved proteolytic cleavage sites.
Genes Cells, 9: 549-560.
[PMID:15189448]
2. Stehlik, C., Kroismayr, R., Dorfleutner, A., Binder, B. R. and Lipp, J. (2004) VIGR--a novel inducible adhesion family G-protein coupled receptor in endothelial cells.
FEBS Lett, 569: 149-155.
[PMID:15225624]
To cite this database page, please use the following:
Tom I. Bonner.
Class B Orphans: GPR126. Last modified on 13/02/2013. Accessed on 25/05/2013. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=200.
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