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GPR116

Family: Class B Orphans

Contents:
Gene and Protein Information
Previous and Unofficial Names
Database Links
Agonists
Tissue Distribution
Expression Datasets
General Comments
References
Gene and Protein Information
class B G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 1346 6p12.3 GPR116 G protein-coupled receptor 116 3
Mouse 7 1348 17 B3 Gpr116 G protein-coupled receptor 116 4
Rat 7 1349 9q12 Gpr116 G protein-coupled receptor 116 1
Previous and Unofficial Names
DKFZp564O1923
FLJ90640
KIAA0758
KPG_001
Ig-Hepta homolog
Gprhep
Ig-Hepta
G protein-coupled hepta-helical receptor Ig-Hepta
G protein-coupled receptor 116
G-protein coupled hepta-helical receptor Ig-hepta
probable G-protein coupled receptor 116
8430401C09Rik
AI528491
Database Links
Ensembl ENSG00000069122 (Hs), ENSMUSG00000056492 (Mm), ENSRNOG00000011154 (Rn)
Entrez Gene 221395 (Hs), 224792 (Mm), 245977 (Rn)
GeneCards GPR116 (Hs)
GenitoUrinary Development Molecular Anatomy Project Gpr116 (Mm)
HomoloGene 9065 (Hs)
Human Protein Reference Database 11010 (Hs)
InterPro Q5TF06 (Hs), Q9WVT0 (Rn)
KEGG Gene hsa:221395 (Hs), mmu:224792 (Mm), rno:245977 (Rn)
PharmGKB Gene PA134886165 (Hs)
PhosphoSitePlus Q8IZF2 (Hs), Q69ZZ8 (Mm), Q9WVT0 (Rn)
RefSeq Nucleotide NM_015234 (Hs), NM_001081178 (Mm), NM_139110 (Rn)
RefSeq Protein NP_056049 (Hs), NP_001074647 (Mm), NP_620810 (Rn)
TreeFam ENSG00000069122 (Hs), ENSMUSG00000056492 (Mm), ENSRNOG00000011154 (Rn)
UniGene Hs. 362806 (Hs)
UniProt Q5TF06 (Hs), Q9WVT0 (Rn)
Wikipedia GPR116
Orphan and other 7TM receptors
Agonist Comments
No ligands identified: orphan receptor.
Tissue Distribution
Unigene expression profile gives high normalized expression and multiple ESTs in thyroid, placenta, uterus, spleen, stomach, lung, kidney, brain, connective tissue, heart, eye, liver, muscle, pancreas, pharynx, testis.
Species:  Human
Technique: 
References: 
KIAA0758 highest in lung and kidney, then heart ovary, brain and skeletal muscle
Species:  Human
Technique:  RT-PCR.
References:  3
Very high expression in lung, weak but detectable levels in kidney and heart.
Species:  Rat
Technique:  Northern blotting.
References:  1
Expression Datasets

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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General Comments
Full coding sequence human cDNA is publicly available, IMAGE:5298732 [2] in pBluescript vector. This clone has two known amino acid changing polymorphisms, rs586024 and rs547499. The Met604 and Thr856 alleles in this clone are both the more common allele in Europeans and Asians but the less common allele in sub-Saharan Africans.

REFERENCES

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1. Abe, J., Suzuki, H., Notoya, M., Yamamoto, T. and Hirose, S. (1999) Ig-hepta, a novel member of the G protein-coupled hepta-helical receptor (GPCR) family that has immunoglobulin-like repeats in a long N-terminal extracellular domain and defines a new subfamily of GPCRs. J Biol Chem, 274: 19957-19964. [PMID:10391944]

2. Lennon, G., Auffray, C., Polymeropoulos, M. and Soares, M. B. (1996) The I.M.A.G.E. Consortium: an integrated molecular analysis of genomes and their expression. Genomics, 33: 151-152. [PMID:8617505]

3. Nagase, T., Ishikawa, K., Suyama, M., Kikuno, R., Miyajima, N., Tanaka, A., Kotani, H., Nomura, N. and Ohara, O. (1998) Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res, 5: 277-286. [PMID:9872452]

4. Okazaki, N., F-Kikuno, R., Ohara, R., Inamoto, S., Koseki, H., Hiraoka, S., Saga, Y., Seino, S., Nishimura, M., Kaisho, T., Hoshino, K., Kitamura, H., Nagase, T., Ohara, O. and Koga, H. (2004) Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res, 11: 205-218. [PMID:15368895]

To cite this database page, please use the following:

Tom I. Bonner.
Class B Orphans: GPR116. Last modified on 13/02/2013. Accessed on 19/05/2013. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=196.


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