Nomenclature: GPR111

Family: Adhesion Class GPCRs

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates. 


Gene and Protein Information
Adhesion G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 642 6p12.3 GPR111 G protein-coupled receptor 111
Mouse 7 644 17 B3 Gpr111 G protein-coupled receptor 111
Rat 7 650 9q12 Gpr111 G protein-coupled receptor 111
Previous and Unofficial Names
G protein-coupled receptor 111
G protein-coupled receptor 115
G protein-coupled receptor 115 (predicted)
probable G-protein coupled receptor 111
Database Links
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Reference Database
PharmGKB Gene
RefSeq Nucleotide
RefSeq Protein
UniGene Hs.
Agonist Comments
No ligands identified: orphan receptor.
Tissue Distribution
Heart, skin, spleen, testis, brain, tongue, esophagus, forestomach
Species:  Mouse
Technique:  RT-PCR and LacZ insertion
References:  3
Expression Datasets

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Physiological Functions
Skin barrier assay
Species:  Mouse
Tissue:  Skin
References:  3
Physiological Consequences of Altering Gene Expression Comments
Gpr111 knockout mice do not show defects in development or fertility [3].
General Comments
GPR111 is an orphan receptor that belongs to Family VI Adhesion-GPCRs together with GPR110, GPR113, GPR115 and GPR116 [1]. The genes of Family VI Adhesion-GPCRs except GPR113 are syntenically clustered on human chromosome 6 and mouse chromosome 17 suggesting the evolution from an ancestral gene through gene duplication and exon shuffling [3].

Original gene prediction [2] failed to predict several exons at both the 5' and 3' ends and included one exon of GPR111 in the prediction of GPR115 which is the adjacent gene.

A rat cDNA similar to the mouse cDNA AK142836 can be predicted with an open reading frame of 650 amino acids.


1. Fredriksson R, Gloriam DE, Höglund PJ, Lagerström MC, Schiöth HB. (2003) There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini. Biochem. Biophys. Res. Commun.301 (3): 725-34. [PMID:12565841]

2. Fredriksson R, Lagerström MC, Höglund PJ, Schiöth HB. (2002) Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions. FEBS Lett531: 407-414. [PMID:12435584]

3. Prömel S, Waller-Evans H, Dixon J, Zahn D, Colledge WH, Doran J, Carlton MB, Grosse J, Schöneberg T, Russ AP et al.. (2012) Characterization and functional study of a cluster of four highly conserved orphan adhesion-GPCR in mouse. Dev. Dyn.241 (10): 1591-602. [PMID:22837050]

To cite this database page, please use the following:

Tobias Langenhan, Simone Prömel, Tom I. Bonner.
Adhesion Class GPCRs: GPR111. Last modified on 23/07/2013. Accessed on 22/10/2014. IUPHAR database (IUPHAR-DB),

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