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GPR111

Family: Class B Orphans

Contents:
Gene and Protein Information
Previous and Unofficial Names
Database Links
Agonists
Expression Datasets
General Comments
References
Gene and Protein Information
class B G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 642 6p12.3 GPR111 G protein-coupled receptor 111
Mouse 7 644 17 B3 Gpr111 G protein-coupled receptor 111
Rat 7 650 9q12 Gpr111 G protein-coupled receptor 111
Previous and Unofficial Names
PGR20
hGPCR35
FLJ44729
Gpr115_predicted
Gpr115
LOC301269
G protein-coupled receptor 111
G protein-coupled receptor 115
G protein-coupled receptor 115 (predicted)
probable G-protein coupled receptor 111
Database Links
Ensembl ENSG00000164393 (Hs), ENSMUSG00000057899 (Mm), ENSRNOG00000025603 (Rn)
Entrez Gene 222611 (Hs), 435529 (Mm), 301269 (Rn)
GeneCards GPR111 (Hs)
GenitoUrinary Development Molecular Anatomy Project Gpr111 (Mm)
HomoloGene 45213 (Hs)
Human Protein Reference Database 17055 (Hs)
InterPro Q2PNZ1 (Hs)
KEGG Gene hsa:222611 (Hs), mmu:435529 (Mm), rno:301269 (Rn)
PharmGKB Gene PA134984088 (Hs)
PhosphoSitePlus Q8IZF7 (Hs), Q3UQ38 (Mm)
RefSeq Nucleotide NM_153839 (Hs), NM_001033493 (Mm)
RefSeq Protein NP_722581 (Hs), NP_001028665 (Mm)
TreeFam ENSG00000164393 (Hs), ENSMUSG00000057899 (Mm), ENSRNOG00000025603 (Rn)
UniGene Hs. 136350 (Hs)
UniProt Q2PNZ1 (Hs)
Wikipedia GPR111
Orphan and other 7TM receptors
Agonist Comments
No ligands identified: orphan receptor.
Expression Datasets

Click here to show/hide data

Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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General Comments
Original gene prediction [1] failed to predict several exons at both the 5' and 3' ends and included one exon of GPR111 in the prediction of GPR115 which is the adjacent gene.

A rat cDNA similar to the mouse cDNA AK142836 can be predicted with an open reading frame of 650 amino acids.

REFERENCES

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1. Fredriksson, R., Lagerström, M. C., Höglund, P. J. and Schiöth, H. B. (2002) Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions. FEBS Lett, 531: 407-414. [PMID:12435584]

To cite this database page, please use the following:

Tom I. Bonner.
Class B Orphans: GPR111. Last modified on 13/02/2013. Accessed on 22/05/2013. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=191.


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