image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates. 

EMR2

Family: Class B Orphans

Contents:
Gene and Protein Information
Previous and Unofficial Names
Database Links
Agonists
Tissue Distribution
General Comments
References
Gene and Protein Information
class B G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 823 19p13.1 EMR2 egf-like module containing, mucin-like, hormone receptor-like 2 1-2,4
Previous and Unofficial Names
egf-like module containing, mucin-like, hormone receptor-like 2
CD312
EGF-like module-containing mucin-like hormone receptor-like 2
EGF-like module EMR2
CD312 antigen
egf-like module containing, mucin-like, hormone receptor-like sequence 2
Database Links
Ensembl ENSG00000127507 (Hs)
Entrez Gene 30817 (Hs)
GeneCards EMR2 (Hs)
HomoloGene 69138 (Hs)
Human Protein Reference Database 07308 (Hs)
InterPro Q9UHX3 (Hs)
KEGG Gene hsa:30817 (Hs)
OMIM 606100 (Hs)
PharmGKB Gene PA27774 (Hs)
PhosphoSitePlus Q9UHX3 (Hs)
Protein Ontology (PRO) PRO:000007065 (Hs)
RefSeq Nucleotide NM_013447 (Hs)
RefSeq Protein NP_038475 (Hs)
TreeFam ENSG00000127507 (Hs)
UniGene Hs. 531619 (Hs)
UniProt Q9UHX3 (Hs)
Wikipedia EMR2
Orphan and other 7TM receptors
Agonist Comments
No ligands identified: orphan receptor.
Tissue Distribution
Highest expression was found in peripheral blood leukocytes, followed by spleen and lymph nodes, with intermediate to low levels in thymus, bone marrow, fetal liver, placenta and lung.
No expression in heart, brain, skeletal muscle, kidney or pancreas.
Species:  Human
Technique:  Northern blotting.
References:  4
General Comments
There are three well characterized amino acid-changing SNPs.

Full coding sequence human cDNA is publicly available, IMAGE:8317326 [3] in mammalian expression vector pCDNA3.1. This clone differs from the RefSeq and human reference genomic sequence at a know SNP. It has the less common Phe614 allele.

REFERENCES

Show »

1. Kwakkenbos, M. J., Chang, G. W., Lin, H. H., Pouwels, W., de Jong, E. C., van Lier, R. A., Gordon, S. and Hamann, J. (2002) The human EGF-TM7 family member EMR2 is a heterodimeric receptor expressed on myeloid cells. J Leukoc Biol, 71: 854-862. [PMID:11994511]

2. Kwakkenbos, M. J., Matmati, M., Madsen, O., Pouwels, W., Wang, Y., Bontrop, R. E., Heidt, P. J., Hoek, R. M. and Hamann, J. (2006) An unusual mode of concerted evolution of the EGF-TM7 receptor chimera EMR2. FASEB J, 20: 2582-2584. [PMID:17068111]

3. Lennon, G., Auffray, C., Polymeropoulos, M. and Soares, M. B. (1996) The I.M.A.G.E. Consortium: an integrated molecular analysis of genomes and their expression. Genomics, 33: 151-152. [PMID:8617505]

4. Lin, H. H., Stacey, M., Hamann, J., Gordon, S. and McKnight, A. J. (2000) Human EMR2, a novel EGF-TM7 molecule on chromosome 19p13.1, is closely related to CD97. Genomics, 67: 188-200. [PMID:10903844]

To cite this database page, please use the following:

Tom I. Bonner.
Class B Orphans: EMR2. Last modified on 13/02/2013. Accessed on 24/05/2013. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=183.


Contact us | Print | Back to top | Help