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CD97

Family: Class B Orphans

Contents:
Gene and Protein Information
Previous and Unofficial Names
Database Links
Expression Datasets
Phenotypes, Alleles and Disease Models
Gene and Protein Information
class B G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 835 19p13 CD97 CD97 molecule
Mouse 7 818 8 C2 Cd97 CD97 antigen
Rat 7 825 19q11 Cd97 CD97 molecule
Previous and Unofficial Names
CD97 molecule
CD97 antigen
EGF-TM7 receptor
TM7LN1
Leukocyte antigen CD97
seven-span transmembrane protein
seven-transmembrane, heterodimeric receptor associated with inflammation
seven transmembrane helix receptor
Cd97_predicted
LOC361383
CD97 antigen (predicted)
AA409984
Database Links
Ensembl ENSG00000123146 (Hs), ENSMUSG00000002885 (Mm), ENSRNOG00000004489 (Rn)
Entrez Gene 976 (Hs), 26364 (Mm), 361383 (Rn)
GeneCards CD97 (Hs)
GenitoUrinary Development Molecular Anatomy Project Cd97 (Mm)
HomoloGene 8050 (Hs)
Human Protein Reference Database 03130 (Hs)
InterPro P48960 (Hs), Q9Z0M6 (Mm), Q5XI36 (Rn)
KEGG Gene hsa:976 (Hs), mmu:26364 (Mm), rno:361383 (Rn)
OMIM 601211 (Hs)
PharmGKB Gene PA26248 (Hs)
PhosphoSitePlus P48960 (Hs), Q9Z0M6 (Mm)
Protein Ontology (PRO) PRO:000001311 (Hs)
RefSeq Nucleotide NM_078481 (Hs), NM_011925 (Mm), NM_001012164 (Rn)
RefSeq Protein NP_510966 (Hs), NP_036055 (Mm), NP_001012164 (Rn)
TreeFam ENSG00000123146 (Hs), ENSMUSG00000002885 (Mm), ENSRNOG00000004489 (Rn)
UniGene Hs. 466039 (Hs)
UniProt P48960 (Hs), Q9Z0M6 (Mm), Q5XI36 (Rn)
Wikipedia CD97
Orphan and other 7TM receptors
Expression Datasets

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Phenotypes, Alleles and Disease Models Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Cd97tm1Kake Cd97tm1Kake/Cd97tm1Kake
B6.129S6-Cd97		 MGI:1347095  MP:0002411 decreased susceptibility to bacterial infection PMID: 17158902 
Cd97tm1Kake Cd97tm1Kake/Cd97tm1Kake
B6.129S6-Cd97		 MGI:1347095  MP:0009789 decreased susceptibility to bacterial infection induced morbidity/mortality PMID: 17158902 
Cd97tm1Kake Cd97tm1Kake/Cd97tm1Kake
B6.129S6-Cd97		 MGI:1347095  MP:0000322 increased granulocyte number PMID: 17158902 
Cd97tm1.1Joha Cd97tm1.1Joha/Cd97tm1.1Joha
involves: 129P2/OlaHsd * C57BL/6J * FVB/N		 MGI:1347095  MP:0000322 increased granulocyte number PMID: 18941248 
Cd97tm1Dgen Cd97tm1Dgen/Cd97tm1Dgen
involves: 129P2/OlaHsd * C57BL/6		 MGI:1347095  MP:0002169 no abnormal phenotype detected

To cite this database page, please use the following:

Tom I. Bonner.
Class B Orphans: CD97. Last modified on 13/02/2013. Accessed on 21/05/2013. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=177.


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