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BAI2

Family: Class B Orphans

Contents:
Gene and Protein Information
Previous and Unofficial Names
Database Links
Agonists
Tissue Distribution
Expression Datasets
Phenotypes, Alleles and Disease Models
References
Gene and Protein Information
class B G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 1572 1p35 BAI2 brain-specific angiogenesis inhibitor 2 2
Mouse 7 1561 4D2.2 Bai2 brain-specific angiogenesis inhibitor 2 1
Rat 7 1548 5q36 Bai2 brain-specific angiogenesis inhibitor 2
Previous and Unofficial Names
brain-specific angiogenesis inhibitor 2
BAI2
Bai2_predicted
LOC313058
brain-specific angiogenesis inhibitor 2 (predicted)
Database Links
Ensembl ENSG00000121753 (Hs), ENSMUSG00000028782 (Mm), ENSRNOG00000014375 (Rn)
Entrez Gene 576 (Hs), 230775 (Mm), 313058 (Rn)
GeneCards BAI2 (Hs)
GenitoUrinary Development Molecular Anatomy Project Bai2 (Mm)
HomoloGene 1128 (Hs)
Human Protein Reference Database 04063 (Hs)
InterPro O60241 (Hs), Q8CGM1 (Mm)
KEGG Gene hsa:576 (Hs), mmu:230775 (Mm), rno:313058 (Rn)
OMIM 602683 (Hs)
PharmGKB Gene PA25248 (Hs)
PhosphoSitePlus O60241 (Hs), Q8CGM1 (Mm)
Protein Ontology (PRO) PRO:000004630 (Hs)
RefSeq Nucleotide NM_001703 (Hs), NM_173071 (Mm), NM_001107914 (Rn)
RefSeq Protein NP_001694 (Hs), NP_775094 (Mm), NP_001101384 (Rn)
TreeFam ENSG00000121753 (Hs), ENSMUSG00000028782 (Mm), ENSRNOG00000014375 (Rn)
UniGene Hs. 524138 (Hs)
UniProt O60241 (Hs), Q8CGM1 (Mm)
Wikipedia BAI2
Orphan and other 7TM receptors
Agonist Comments
No ligands identified: orphan receptor.
Tissue Distribution
Brain but not gut, heart, kidney, liver, lung, skeletal muscle, spleen, thymus in adult and newborn.
Brain and possible weak signals in other tissues in embryo.
Species:  Mouse
Technique:  Northern blotting.
References:  2
Expression in most neurons of the cerebral cortex but highest in layers II to III (as was BAI1). High levels also in pyramidal neurons of all fields of the hippocampus, in the granule cell and polymorphic layers of dentate gyrus, medial and lateral, and medial and lateral habenular nucleus.
Species:  Rat
Technique:  in situ hybridisation.
References:  2
Expression Datasets

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Phenotypes, Alleles and Disease Models Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Bai2tm1Dgen Bai2tm1Dgen/Bai2tm1Dgen
involves: 129P2/OlaHsd * C57BL/6		 MGI:2451244  MP:0003063 increased coping response
Available Assays
DiscoveRx PathHunter® CHO-K1 BAI2 (Orphan) High Expression β-Arrestin Cell Line Human Cat No. 93-0546C2
DiscoveRx PathHunter® eXpress BAI2 CHO-K1 β-Arrestin (Orphan) GPCR Assay Human Cat No. 93-0546E2ACP1

REFERENCES

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1. Kee, H. J., Koh, J. T., Kim, M. Y., Ahn, K. Y., Kim, J. K., Bae, C. S., Park, S. S. and Kim, K. K. (2002) Expression of brain-specific angiogenesis inhibitor 2 (BAI2) in normal and ischemic brain: involvement of BAI2 in the ischemia-induced brain angiogenesis. J Cereb Blood Flow Metab, 22: 1054-1067. [PMID:12218411]

2. Shiratsuchi, T., Nishimori, H., Ichise, H., Nakamura, Y. and Tokino, T. (1997) Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1). Cytogenet Cell Genet, 79: 103-108. [PMID:9533023]

To cite this database page, please use the following:

Tom I. Bonner.
Class B Orphans: BAI2. Last modified on 13/02/2013. Accessed on 22/05/2013. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=175.


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