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TAAR9

Family: Class A Orphans

Contents:
Gene and Protein Information
Previous and Unofficial Names
Database Links
Tissue Distribution
Expression Datasets
Biologically Significant Variants
References
Gene and Protein Information
class A G protein-coupled receptor: probable pseudogene
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 348 6q23.2 TAAR9 trace amine associated receptor 9 (gene/pseudogene)
Mouse 7 348 10 A4 Taar9 trace amine-associated receptor 9
Rat 7 338 1p12 Taar9 trace amine-associated receptor 9
Previous and Unofficial Names
trace amine-associated receptor 9
TA3
TAR3
TRAR3
trace amine receptor 3
trace amine associated receptor 9
taR-3
taR-9
trace amine receptor 9
trace-amine-associated receptor 9
Gm231
Database Links
Ensembl ENSG00000237110 (Hs), ENSMUSG00000037424 (Mm), ENSRNOG00000026096 (Rn)
Entrez Gene 134860 (Hs), 503558 (Mm), 319107 (Rn)
GeneCards TAAR9 (Hs)
GenitoUrinary Development Molecular Anatomy Project Taar9 (Mm)
HomoloGene 65286 (Hs)
Human Protein Reference Database 16308 (Hs)
InterPro Q96RI9 (Hs), Q5QD04 (Mm), Q923Y6 (Rn)
KEGG Gene hsa:134860 (Hs), mmu:503558 (Mm), rno:319107 (Rn)
OMIM 608282 (Hs)
PharmGKB Gene PA134931528 (Hs)
PhosphoSitePlus Q96RI9 (Hs), Q5QD04 (Mm), Q923Y6 (Rn)
Protein Ontology (PRO) PRO:000001718 (Hs)
RefSeq Nucleotide NM_175057 (Hs), NM_001010831 (Mm), NM_175602 (Rn)
RefSeq Protein NP_778227 (Hs), NP_001010831 (Mm), NP_783192 (Rn)
TreeFam ENSG00000237110 (Hs), ENSMUSG00000037424 (Mm), ENSRNOG00000026096 (Rn)
UniGene Hs. 434116 (Hs)
UniProt Q96RI9 (Hs), Q5QD04 (Mm), Q923Y6 (Rn)
Wikipedia TAAR9
Orphan and other 7TM receptors
Natural/Endogenous Ligand(s)
Comments: A polymorphism introduces a stop codons in some individuals.
Tissue Distribution
Pituitary gland, skeletal muscle
Species:  Human
Technique:  Northern blot
References:  4
Kidney
Species:  Human
Technique:  RT-PCR
References:  1
Olfactory epithelium
Species:  Mouse
Technique:  RT-PCR and in situ hybridisation.
References:  3
Tissue Distribution Comments
No expression of TAAR9 was detected by RT-PCR in the Grueneberg ganglion [2]. TAAR9 expression was not detected by Northern blot analysis in thalamus, amygdala, midbrain, hippocampus, putamen, caudate, frontal cortex, pons, prostate, stomach, heart, bladder, small intestine, colon or uterus [4].
Expression Datasets

Click here to show/hide data

Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Biologically Significant Variants
K61Ter, is a pseudogene with 10-20% allele frequency
SNP accession:  rs2842899 
Type:  Naturally occurring SNPs.
Species:  Human
References: 
A278T, low frequency (<10% in all tested population)
SNP accession:  rs9389004 
Type:  Naturally occurring SNPs.
Species:  Human
References: 

REFERENCES

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1. Borowsky, B., Adham, N., Jones, K. A., Raddatz, R., Artymyshyn, R., Ogozalek, K. L., Durkin, M. M., Lakhlani, P. P., Bonini, J. A., Pathirana, S., Boyle, N., Pu, X., Kouranova, E., Lichtblau, H., Ochoa, F. Y., Branchek, T. A. and Gerald, C. (2001) Trace amines: identification of a family of mammalian G protein-coupled receptors. Proc Natl Acad Sci U S A, 98: 8966-8971. [PMID:11459929]

2. Fleischer, J; Schwarzenbacher, K; Breer, H. (2007) Expression of trace amine-associated receptors in the Grueneberg ganglion. Chem. Senses, 32 (6): 623-31. [PMID:17556730]

3. Liberles, S. D. and Buck, L. B. (2006) A second class of chemosensory receptors in the olfactory epithelium. Nature, 442: 645-650. [PMID:16878137]

4. Vanti, W. B., Muglia, P., Nguyen, T., Cheng, R., Kennedy, J. L., George, S. R. and O'Dowd, B. F. (2003) Discovery of a null mutation in a human trace amine receptor gene. Genomics, 82: 531-536. [PMID:14559210]

To cite this database page, please use the following:

Wen Chiy Liew.
Class A Orphans: TAAR9. Last modified on 05/11/2012. Accessed on 23/05/2013. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=173.


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