Nomenclature: TAAR8

Family: Class A Orphans

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates. 

Contents

Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 342 6q23.2 TAAR8 trace amine associated receptor 8 3
Mouse 7 344 10 A4 Taar8a trace amine-associated receptor 8A
Rat 7 344 1p12 Taar8a trace amine-associated receptor 8a
Previous and Unofficial Names
trace amine associated receptor 8
trace amine receptor 5
TA5
TAR5
GPR102
TRAR5
TA11
TAR11
TRAR11
Gm1149
taR-11
taR-8a
trace amine receptor 11
trace amine receptor 8a
trace amine-associated receptor 8a
trace-amine-associated receptor 8a
LOC215859
Gm230
Database Links
Ensembl Gene
Entrez Gene
GPCRDB
GeneCards
GenitoUrinary Development Molecular Anatomy Project
HomoloGene
Human Protein Reference Database
InterPro
KEGG Gene
OMIM
PharmGKB Gene
PhosphoSitePlus
Protein Ontology (PRO)
RefSeq Nucleotide
RefSeq Protein
TreeFam
UniGene Hs.
UniProtKB
Wikipedia
Tissue Distribution
Kidney and amygdala
Species:  Human
Technique:  RT-PCR
References:  1
Olfactory epithelium
Species:  Mouse
Technique:  RT-PCR and in situ hybridisation
References:  4
Intestine, spleen, testis
Species:  Mouse
Technique:  RT-PCR
References:  2
Expression Datasets

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Biologically Significant Variants
Type:  SNP
Species:  Human
Change:  D328A
Global MAF (%):  5
Subpopulation MAF (%):  AFR|AMR|ASN|EUR: 5|4|2|7
Minor allele count:  C=0.049/106
Comment on frequency:  Low frequency (<10% in all tested populations)
SNP accession: 
Validation:  1000 Genomes, HapMap, Frequency
Type:  SNP
Species:  Human
Change:  S153N
Global MAF (%):  2
Subpopulation MAF (%):  AFR: 9
Minor allele count:  A=0.020/44
Comment on frequency:  Low frequency (<10% in all tested populations)
SNP accession: 
Validation:  1000 Genomes, HapMap, Frequency

REFERENCES

1. Borowsky B, Adham N, Jones KA, Raddatz R, Artymyshyn R, Ogozalek KL, Durkin MM, Lakhlani PP, Bonini JA, Pathirana S, Boyle N, Pu X, Kouranova E, Lichtblau H, Ochoa FY, Branchek TA, Gerald C. (2001) Trace amines: identification of a family of mammalian G protein-coupled receptors. Proc Natl Acad Sci U S A98: 8966-8971. [PMID:11459929]

2. Chiellini G, Erba P, Carnicelli V, Manfredi C, Frascarelli S, Ghelardoni S, Mariani G, Zucchi R. (2012) Distribution of exogenous [125I]-3-iodothyronamine in mouse in vivo: relationship with trace amine-associated receptors. J. Endocrinol.213 (3): 223-30. [PMID:22442117]

3. Lee DK, Nguyen T, Lynch KR, Cheng R, Vanti WB, Arkhitko O, Lewis T, Evans JF, George SR, O'Dowd BF. (2001) Discovery and mapping of ten novel G protein-coupled receptor genes. Gene275: 83-91. [PMID:11574155]

4. Liberles SD, Buck LB. (2006) A second class of chemosensory receptors in the olfactory epithelium. Nature442: 645-650. [PMID:16878137]

To cite this database page, please use the following:

Anthony P. Davenport, Stephen Alexander, Joanna L. Sharman, Adam J. Pawson, Helen E. Benson, Amy E. Monaghan, Wen Chiy Liew, Chido Mpamhanga, Jim Battey, Richard V. Benya, Robert T. Jensen, Sadashiva Karnik, Evi Kostenis, Eliot Spindel, Laura Storjohann, Kalyan Tirupula, Tom I. Bonner, Richard Neubig, Jean-Philippe Pin, Michael Spedding, Anthony Harmar.
Class A Orphans: TAAR8. Last modified on 09/08/2013. Accessed on 16/09/2014. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=172.

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