image of an orange circle Annotated and awaiting review. Please contact us if you can help with reviewing. 

TAAR8

Family: Class A Orphans

Contents:
Gene and Protein Information
Previous and Unofficial Names
Database Links
Tissue Distribution
Expression Datasets
Biologically Significant Variants
References
Gene and Protein Information
class A G protein-coupled receptor: probable pseudogene
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 342 6q23.2 TAAR8 trace amine associated receptor 8 3
Mouse 7 344 10 A4 Taar8a trace amine-associated receptor 8A
Rat 7 344 1p12 Taar8a trace amine-associated receptor 8a
Previous and Unofficial Names
trace amine associated receptor 8
trace amine receptor 5
TA5
TAR5
GPR102
TRAR5
TA11
TAR11
TRAR11
Gm1149
taR-11
taR-8a
trace amine receptor 11
trace amine receptor 8a
trace amine-associated receptor 8a
trace-amine-associated receptor 8a
LOC215859
Gm230
Database Links
Ensembl ENSG00000146385 (Hs), ENSMUSG00000050804 (Mm), ENSRNOG00000030414 (Rn)
Entrez Gene 83551 (Hs), 382348 (Mm), 319104 (Rn)
GeneCards TAAR8 (Hs)
GenitoUrinary Development Molecular Anatomy Project Taar8a (Mm)
HomoloGene 14242 (Hs)
Human Protein Reference Database 09496 (Hs)
InterPro Q969N4 (Hs), Q5QD06 (Mm), Q923X9 (Rn)
KEGG Gene hsa:83551 (Hs), mmu:382348 (Mm), rno:319104 (Rn)
OMIM 606927 (Hs)
PharmGKB Gene PA28850 (Hs)
PhosphoSitePlus Q969N4 (Hs)
Protein Ontology (PRO) PRO:000001717 (Hs)
RefSeq Nucleotide NM_053278 (Hs), NM_001010837 (Mm), NM_175599 (Rn)
RefSeq Protein NP_444508 (Hs), NP_001010837 (Mm), NP_783189 (Rn)
TreeFam ENSG00000146385 (Hs), ENSMUSG00000050804 (Mm), ENSRNOG00000030414 (Rn)
UniGene Hs. 350571 (Hs)
UniProt Q969N4 (Hs), Q5QD06 (Mm), Q923X9 (Rn)
Wikipedia TAAR8
Orphan and other 7TM receptors
Tissue Distribution
Kidney and amygdala
Species:  Human
Technique:  RT-PCR
References:  1
Olfactory epithelium
Species:  Mouse
Technique:  RT-PCR and in situ hybridisation
References:  4
Intestine, spleen, testis
Species:  Mouse
Technique:  RT-PCR
References:  2
Expression Datasets

Click here to show/hide data

Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

There should be a chart of expression data here, you may need to enable JavaScript!
Biologically Significant Variants
D328A, low frequency (<10% in tested population)
SNP accession:  rs8192627 
Type:  Naturally occurring SNPs.
Species:  Human
References: 
G48ter, is a pseudogene with 8% allele frequency
SNP accession:  rs8192627 
Type:  Naturally occurring SNPs.
Species:  Human
References: 
S153N
SNP accession:  rs8192626 
Type:  Naturally occurring SNPs.
Species:  Human
References: 

REFERENCES

Show »

1. Borowsky, B., Adham, N., Jones, K. A., Raddatz, R., Artymyshyn, R., Ogozalek, K. L., Durkin, M. M., Lakhlani, P. P., Bonini, J. A., Pathirana, S., Boyle, N., Pu, X., Kouranova, E., Lichtblau, H., Ochoa, F. Y., Branchek, T. A. and Gerald, C. (2001) Trace amines: identification of a family of mammalian G protein-coupled receptors. Proc Natl Acad Sci U S A, 98: 8966-8971. [PMID:11459929]

2. Chiellini, G; Erba, P; Carnicelli, V; Manfredi, C; Frascarelli, S; Ghelardoni, S; Mariani, G; Zucchi, R. (2012) Distribution of exogenous [125I]-3-iodothyronamine in mouse in vivo: relationship with trace amine-associated receptors. J. Endocrinol., 213 (3): 223-30. [PMID:22442117]

3. Lee, D. K., Nguyen, T., Lynch, K. R., Cheng, R., Vanti, W. B., Arkhitko, O., Lewis, T., Evans, J. F., George, S. R. and O'Dowd, B. F. (2001) Discovery and mapping of ten novel G protein-coupled receptor genes. Gene, 275: 83-91. [PMID:11574155]

4. Liberles, S. D. and Buck, L. B. (2006) A second class of chemosensory receptors in the olfactory epithelium. Nature, 442: 645-650. [PMID:16878137]

To cite this database page, please use the following:

Wen Chiy Liew.
Class A Orphans: TAAR8. Last modified on 05/11/2012. Accessed on 22/05/2013. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=172.


Contact us | Print | Back to top | Help