image of an orange circle Annotated and awaiting review. Please contact us if you can help with reviewing. 

LPA6 receptor

Family: Lysophospholipid (LPA) receptors

Contents:
Gene and Protein Information
Previous and Unofficial Names
Database Links
Agonists
Transduction Mechanisms
Tissue Distribution
Expression Datasets
Physiological Functions
Clinically-Relevant Mutations and Pathophysiology
References
Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 344 13q14 LPAR6 lysophosphatidic acid receptor 6
Mouse 7 344 14 D3 Lpar6 lysophosphatidic acid receptor 6
Rat 7 344 15p11 Lpar6 lysophosphatidic acid receptor 6
Previous and Unofficial Names
P2Y5
MGC120358
P2RY5
LPAR6
purinergic receptor P2Y, G-protein coupled, 5
MGC112684
LPA receptor 6
LPA-6
P2Y purinoceptor 5
lysophosphatidic acid receptor 6
oleoyl-L-alpha-lysophosphatidic acid receptor
purinergic receptor 5
similar to purinergic receptor P2Y, G-protein coupled, 5
2610302I02Rik
Database Links
Ensembl ENSG00000139679 (Hs), ENSMUSG00000033446 (Mm), ENSRNOG00000015577 (Rn)
Entrez Gene 10161 (Hs), 67168 (Mm), 691774 (Rn)
GeneCards LPAR6 (Hs)
GenitoUrinary Development Molecular Anatomy Project Lpar6 (Mm)
HomoloGene 55925 (Hs)
Human Protein Reference Database 16465 (Hs)
InterPro P43657 (Hs), Q8BMC0 (Mm), Q4G072 (Rn)
KEGG Gene hsa:10161 (Hs), mmu:67168 (Mm), rno:691774 (Rn)
OMIM 609239 (Hs)
Orphanet Gene ORPHA159166 (Hs)
PharmGKB Gene PA134864949 (Hs)
PhosphoSitePlus P43657 (Hs), Q8BMC0 (Mm), Q4G072 (Rn)
Protein Ontology (PRO) PRO:000001632 (Hs)
RefSeq Nucleotide NM_005767 (Hs), NM_175116 (Mm), NM_001045843 (Rn)
RefSeq Protein NP_005758 (Hs), NP_780325 (Mm), NP_001039308 (Rn)
TreeFam ENSG00000139679 (Hs), ENSMUSG00000033446 (Mm), ENSRNOG00000015577 (Rn)
UniGene Hs. 123464 (Hs)
UniProt P43657 (Hs), Q8BMC0 (Mm), Q4G072 (Rn)
Wikipedia LPA6 receptor
Lysophospholipid (LPA) receptors
Search for 3D structures on the PDB
Search by keyword: Lysophospholipid (LPA) receptors LPA6 receptor Search by accession number: P43657, Q8BMC0, Q4G072
Natural/Endogenous Ligand(s)
LPA
Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
LPA Hs Agonist 6.0 pEC50 6,10
Agonist Comments
LPA6 was originally reported to bind extracellular nucleotides as ligands [9], although this was not substantiated by additional experiments [3,8]
Primary Transduction Mechanisms
Transducer Effector/Response
Gs family
Gi/Go family
G12/G13 family 		Adenylate cyclase stimulation
Phospholipase C stimulation
Other - See Comments
Comments:  G13-Rho pathway [10], and Gα12/13-Rho, PLC, PKC, ROCK, p38, PI3K pathway stimulation [2]
References:  2,6
Tissue Distribution
leukocytes
Expression level:  High
Species:  Human
Technique:  protein blot, PCR, immunofluorescence
References:  6
Hair cells (follicles: skin, scalp, eyebrow)
Expression level:  High
Species:  Human
Technique:  protein blot, PCR, immunofluorescence
References:  5-6
duodenum mucosa; jejunum mucosa; ileum mucosa; colon mucosa.
Expression level:  High
Species:  Mouse
Technique:  Semiquantitative RT-PCR, Western immunoblotting
References:  2
Expression Datasets

Click here to show/hide data

Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

There should be a chart of expression data here, you may need to enable JavaScript!
Physiological Functions
LPA6 was identified as critical mediator for hair growth
Species:  Human
Tissue:  Hair follicles (skin, scalp, eyebrow)
References:  1,5-6
Clinically-Relevant Mutations and Pathophysiology
Disease:  Familial hair loss: hypotrichosis
OMIM:  278150
Orphanet:  170
Role:  LPA6/p2y5 is an LPA receptor essential for human hair growth
Comments:  HYPOTRICHOSIS, LOCALIZED, AUTOSOMAL RECESSIVE 3; LAH3, however a case of congenital woolly with no associated P2RY5 mutation has also been reported.
References:  1,4-7
Mutations not determined

REFERENCES

Show »

1. Horev, L; Saad-Edin, B; Ingber, A; Zlotogorski, A. (2010) A novel deletion mutation in P2RY5/LPA(6) gene cause autosomal recessive woolly hair with hypotrichosis. J Eur Acad Dermatol Venereol, 24 (7): 858-9. [PMID:20015179]

2. Lee, M; Choi, S; Halldén, G; Yo, SJ; Schichnes, D; Aponte, GW. (2009) P2Y5 is a G(alpha)i, G(alpha)12/13 G protein-coupled receptor activated by lysophosphatidic acid that reduces intestinal cell adhesion. Am. J. Physiol. Gastrointest. Liver Physiol., 297 (4): G641-54. [PMID:19679818]

3. Li, Q., Schachter, J. B., Harden, T. K. and Nicholas, R. A. (1997) The 6H1 orphan receptor, claimed to be the p2y5 receptor, does not mediate nucleotide-promoted second messenger responses. Biochem. Biophys. Res. Commun., 236: 455-460. [PMID:9240460]

4. Nakamura, M; Tokura, Y. (2009) Congenital woolly hair without P2RY5 mutation. Dermatoendocrinol, 1 (1): 58-9. [PMID:20046591]

5. Pasternack, SM; Murugusundram, S; Eigelshoven, S; Müller, M; Kruse, R; Lehmann, P; Betz, RC. (2009) Novel mutations in the P2RY5 gene in one Turkish and two Indian patients presenting with hypotrichosis and woolly hair. Arch. Dermatol. Res., 301 (8): 621-4. [PMID:19529952]

6. Pasternack, SM; von Kügelgen, I; Aboud, KA; Lee, YA; Rüschendorf, F; Voss, K; Hillmer, AM; Molderings, GJ; Franz, T; Ramirez, A; Nürnberg, P; Nöthen, MM; Betz, RC. (2008) G protein-coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth. Nat. Genet., 40 (3): 329-34. [PMID:18297070]

7. Shimomura, Y; Garzon, MC; Kristal, L; Shapiro, L; Christiano, AM. (2009) Autosomal recessive woolly hair with hypotrichosis caused by a novel homozygous mutation in the P2RY5 gene. Exp. Dermatol., 18 (3): 218-21. [PMID:18803659]

8. von Kügelgen, I. (2006) Pharmacological profiles of cloned mammalian P2Y-receptor subtypes. Pharmacol. Ther., 110 (3): 415-32. [PMID:16257449]

9. Webb, T. E., Kaplan, M. G. and Barnard, E. A. (1996) Identification of 6H1 as a P2Y purinoceptor: P2Y5. Biochem. Biophys. Res. Commun., 219: 105-110. [PMID:8619790]

10. Yanagida, K; Masago, K; Nakanishi, H; Kihara, Y; Hamano, F; Tajima, Y; Taguchi, R; Shimizu, T; Ishii, S. (2009) Identification and characterization of a novel lysophosphatidic acid receptor, p2y5/LPA6. J. Biol. Chem., 284 (26): 17731-41. [PMID:19386608]

To cite this database page, please use the following:

Chido Mpamhanga.
Lysophospholipid (LPA) receptors: LPA6 receptor. Last modified on 31/01/2013. Accessed on 21/05/2013. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=163.


Contact us | Print | Back to top | Help