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MRGPRX4

Family: Class A Orphans

Contents:
Gene and Protein Information
Previous and Unofficial Names
Database Links
Transduction Mechanisms
Tissue Distribution
Biologically Significant Variants
General Comments
References
Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 322 11p15.1 MRGPRX4 MAS-related GPR, member X4
Previous and Unofficial Names
MGC129753
MGC129754
MAS-related GPR, member X4
SNSR5
SNSR6
MRGX4
Sensory neuron-specific G protein-coupled receptor 5/6
Sensory neuron-specific G-protein coupled receptor 5/6
G protein-coupled receptor SNSR5
G protein-coupled receptor SNSR6
G protein-coupled receptor MRGX4
MRGPRX4
Database Links
Ensembl ENSG00000179817 (Hs)
Entrez Gene 117196 (Hs)
GeneCards MRGPRX4 (Hs)
HomoloGene 86184 (Hs)
Human Protein Reference Database 06249 (Hs)
InterPro Q96LA9 (Hs)
KEGG Gene hsa:117196 (Hs)
OMIM 607230 (Hs)
PharmGKB Gene PA142671337 (Hs)
Protein Ontology (PRO) PRO:000001705 (Hs)
RefSeq Nucleotide NM_054032 (Hs)
RefSeq Protein NP_473373 (Hs)
TreeFam ENSG00000179817 (Hs)
UniGene Hs. 632138 (Hs)
UniProt Q96LA9 (Hs)
Wikipedia MRGPRX4
Orphan and other 7TM receptors
Primary Transduction Mechanisms
Transducer Effector/Response
Gq/G11 family Phospholipase C stimulation
References:  2
Tissue Distribution
Dorsal root ganglion
Species:  Human
Technique:  RT-PCR
References:  6
Biologically Significant Variants
S83L
SNP accession:  rs2445179 
Type:  Naturally occurring SNPs.
Species:  Human
References: 
S150F, low frequency (<10% in all tested populations)
SNP accession:  rs73434269 
Type:  Naturally occurring SNPs.
Species:  Human
References: 
N25K
SNP accession:  rs2445180 
Type:  Naturally occurring SNPs.
Species:  Human
References: 
F8L
SNP accession:  rs2468774 
Type:  Naturally occurring SNPs.
Species:  Human
References: 
Y54C
SNP accession:  rs1869788 
Type:  Naturally occurring SNPs.
Species:  Human
References: 
A182V
SNP accession:  rs11024532 
Type:  Naturally occurring SNPs.
Species:  Human
References: 
N245S
SNP accession:  rs7102322 
Type:  Naturally occurring SNPs.
Species:  Human
References: 
General Comments
MRGPRX4 is a member of the sensory neuron-specific G protein-coupled receptors, which are uniquely expressed in small nociceptive sensory neurons [6].

Of the eight human Mas-related GPCRs (MRGs), four (MRGPRD, MRGPRE, MRGPRF and MRGPRG) have clear orthologues in rodents, whereas the cluster of genes including human MRGPRX1, MRGPRX2, MRGPRX3 and MRGPRX4 is found only in primates and is replaced in rodents with a family of genes (>25 in mice, ~10 in rats) which have no obvious human counterparts [3]. Certain rodent MRGs have been reported to respond to adenine [1] and to RF-amide peptides including neuropeptide FF [4-5] but the relevance of these findings to man is unclear. MRGs are expressed predominantly in small diameter sensory neurons of the dorsal root ganglia, where there is emerging evidence that they may be mediators of histamine-independent itch [7-8].
Available Assays
DiscoveRx PathHunter® CHO-K1 MRGPRX4 (Orphan) High Expression β-Arrestin Cell Line Human Cat No. 93-0541C2A
DiscoveRx PathHunter® eXpress MRGPRX4 CHO-K1 β-Arrestin (Orphan) GPCR Assay Human Cat No. 93-0541E2ACP1

REFERENCES

Show »

1. Bender, E; Buist, A; Jurzak, M; Langlois, X; Baggerman, G; Verhasselt, P; Ercken, M; Guo, HQ; Wintmolders, C; Van den Wyngaert, I; et al.. (2002) Characterization of an orphan G protein-coupled receptor localized in the dorsal root ganglia reveals adenine as a signaling molecule. Proc. Natl. Acad. Sci. U.S.A., 99 (13): 8573-8. [PMID:12084918]

2. Burstein, ES; Ott, TR; Feddock, M; Ma, JN; Fuhs, S; Wong, S; Schiffer, HH; Brann, MR; Nash, NR. (2006) Characterization of the Mas-related gene family: structural and functional conservation of human and rhesus MrgX receptors. Br. J. Pharmacol., 147 (1): 73-82. [PMID:16284629]

3. Dong, X; Han, S; Zylka, MJ; Simon, MI; Anderson, DJ. (2001) A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. Cell, 106 (5): 619-32. [PMID:11551509]

4. Han, SK; Dong, X; Hwang, JI; Zylka, MJ; Anderson, DJ; Simon, MI. (2002) Orphan G protein-coupled receptors MrgA1 and MrgC11 are distinctively activated by RF-amide-related peptides through the Galpha q/11 pathway. Proc. Natl. Acad. Sci. U.S.A., 99 (23): 14740-5. [PMID:12397184]

5. Lee, MG; Dong, X; Liu, Q; Patel, KN; Choi, OH; Vonakis, B; Undem, BJ. (2008) Agonists of the MAS-related gene (Mrgs) orphan receptors as novel mediators of mast cell-sensory nerve interactions. J. Immunol., 180 (4): 2251-5. [PMID:18250432]

6. Lembo, PM; Grazzini, E; Groblewski, T; O'Donnell, D; Roy, MO; Zhang, J; Hoffert, C; Cao, J; Schmidt, R; Pelletier, M; et al.. (2002) Proenkephalin A gene products activate a new family of sensory neuron--specific GPCRs. Nat. Neurosci., 5 (3): 201-9. [PMID:11850634]

7. Liu, Q; Tang, Z; Surdenikova, L; Kim, S; Patel, KN; Kim, A; Ru, F; Guan, Y; Weng, HJ; Geng, Y; Undem, BJ; Kollarik, M; Chen, ZF; Anderson, DJ; Dong, X. (2009) Sensory neuron-specific GPCR Mrgprs are itch receptors mediating chloroquine-induced pruritus. Cell, 139 (7): 1353-65. [PMID:20004959]

8. Wilson, SR; Gerhold, KA; Bifolck-Fisher, A; Liu, Q; Patel, KN; Dong, X; Bautista, DM. (2011) TRPA1 is required for histamine-independent, Mas-related G protein-coupled receptor-mediated itch. Nat. Neurosci., 14 (5): 595-602. [PMID:21460831]

To cite this database page, please use the following:

Wen Chiy Liew.
Class A Orphans: MRGPRX4. Last modified on 05/11/2012. Accessed on 23/05/2013. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=159.


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