Nomenclature: MRGPRG

Family: Class A Orphans

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates. 


Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 289 11p15.4 MRGPRG MAS-related GPR, member G
Mouse 7 289 7 F5 Mrgprg MAS-related GPR, member G
Rat 7 289 1q41 Mrgprg MAS-related GPR, member G
Previous and Unofficial Names
MAS-related GPR, member G
G protein-coupled receptor 169
G protein-coupled receptor Mrgg
MAS-related G-protein coupled receptor, member G
MAS-related gene G
mas-related G-protein coupled receptor member G
Database Links
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
PharmGKB Gene
Protein Ontology (PRO)
RefSeq Nucleotide
RefSeq Protein
UniGene Hs.
Tissue Distribution Comments
MRGPRG was not detectable by in situ hybridisation in dorsal root ganglia [2].
Biologically Significant Variants
Type:  SNP
Species:  Human
Change:  A162V
Global MAF (%):  1
Subpopulation MAF (%):  AFR|AMR|EUR: 1|3|2
Minor allele count:  A=0.014/31
Comment on frequency:  Low frequency (<10% in all tested populations)
SNP accession: 
Validation:  1000 Genomes
Type:  SNP
Species:  Human
Change:  A76T
Global MAF (%):  4
Subpopulation MAF (%):  AFR|AMR|ASN|EUR: 11|3|2|3
Minor allele count:  T=0.044/96
SNP accession: 
Validation:  1000 Genomes, Frequency, Cluster
Type:  SNP
Species:  Human
Change:  T19R
Global MAF (%):  3
Subpopulation MAF (%):  AFR|AMR: 12|1
Minor allele count:  C=0.029/63
SNP accession: 
Validation:  1000 Genomes
Type:  SNP
Species:  Human
Change:  G287V
Global MAF (%):  4
Subpopulation MAF (%):  AFR|AMR: 18|2
Minor allele count:  A=0.044/96
SNP accession: 
Validation:  1000 Genomes, Frequency
General Comments
Of the eight human Mas-related GPCRs (MRGs), four (MRGPRD, MRGPRE, MRGPRF and MRGPRG) have clear orthologues in rodents, whereas the cluster of genes including human MRGPRX1, MRGPRX2, MRGPRX3 and MRGPRX4 is found only in primates and is replaced in rodents with a family of genes (>25 in mice, ~10 in rats) which have no obvious human counterparts [2]. Certain rodent MRGs have been reported to respond to adenine [1] and to RF-amide peptides including neuropeptide FF [3-4] but the relevance of these findings to man is unclear. MRGs are expressed predominantly in small diameter sensory neurons of the dorsal root ganglia, where there is emerging evidence that they may be mediators of histamine-independent itch [5-6].


1. Bender E, Buist A, Jurzak M, Langlois X, Baggerman G, Verhasselt P, Ercken M, Guo HQ, Wintmolders C, Van den Wyngaert I et al.. (2002) Characterization of an orphan G protein-coupled receptor localized in the dorsal root ganglia reveals adenine as a signaling molecule. Proc. Natl. Acad. Sci. U.S.A.99 (13): 8573-8. [PMID:12084918]

2. Dong X, Han S, Zylka MJ, Simon MI, Anderson DJ. (2001) A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. Cell106 (5): 619-32. [PMID:11551509]

3. Han SK, Dong X, Hwang JI, Zylka MJ, Anderson DJ, Simon MI. (2002) Orphan G protein-coupled receptors MrgA1 and MrgC11 are distinctively activated by RF-amide-related peptides through the Galpha q/11 pathway. Proc. Natl. Acad. Sci. U.S.A.99 (23): 14740-5. [PMID:12397184]

4. Lee MG, Dong X, Liu Q, Patel KN, Choi OH, Vonakis B, Undem BJ. (2008) Agonists of the MAS-related gene (Mrgs) orphan receptors as novel mediators of mast cell-sensory nerve interactions. J. Immunol.180 (4): 2251-5. [PMID:18250432]

5. Liu Q, Tang Z, Surdenikova L, Kim S, Patel KN, Kim A, Ru F, Guan Y, Weng HJ, Geng Y, Undem BJ, Kollarik M, Chen ZF, Anderson DJ, Dong X. (2009) Sensory neuron-specific GPCR Mrgprs are itch receptors mediating chloroquine-induced pruritus. Cell139 (7): 1353-65. [PMID:20004959]

6. Wilson SR, Gerhold KA, Bifolck-Fisher A, Liu Q, Patel KN, Dong X, Bautista DM. (2011) TRPA1 is required for histamine-independent, Mas-related G protein-coupled receptor-mediated itch. Nat. Neurosci.14 (5): 595-602. [PMID:21460831]

To cite this database page, please use the following:

Anthony P. Davenport, Stephen Alexander, Joanna L. Sharman, Adam J. Pawson, Helen E. Benson, Amy E. Monaghan, Wen Chiy Liew, Chido Mpamhanga, Jim Battey, Richard V. Benya, Robert T. Jensen, Sadashiva Karnik, Evi Kostenis, Eliot Spindel, Laura Storjohann, Kalyan Tirupula, Tom I. Bonner, Richard Neubig, Jean-Philippe Pin, Michael Spedding, Anthony Harmar.
Class A Orphans: MRGPRG. Last modified on 09/08/2013. Accessed on 25/10/2014. IUPHAR database (IUPHAR-DB),

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