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MRGPRG

Family: Class A Orphans

Contents:
Gene and Protein Information
Previous and Unofficial Names
Database Links
Tissue Distribution
Biologically Significant Variants
General Comments
References
Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 289 11p15.4 MRGPRG MAS-related GPR, member G
Mouse 7 289 7 F5 Mrgprg MAS-related GPR, member G
Rat 7 289 1q41 Mrgprg MAS-related GPR, member G
Previous and Unofficial Names
MAS-related GPR, member G
GPR169
mrgG
MRGG
EBRT2
MRGPRG
G protein-coupled receptor 169
G protein-coupled receptor Mrgg
MAS-related G-protein coupled receptor, member G
MAS-related gene G
mas-related G-protein coupled receptor member G
LOC381974
Gm1098
Database Links
Ensembl ENSG00000182170 (Hs), ENSMUSG00000050276 (Mm), ENSRNOG00000020734 (Rn)
Entrez Gene 386746 (Hs), 381974 (Mm), 309133 (Rn)
GeneCards MRGPRG (Hs)
GenitoUrinary Development Molecular Anatomy Project Mrgprg (Mm)
HomoloGene 28580 (Hs)
InterPro Q86SM5 (Hs), Q91ZB5 (Mm), Q7TN39 (Rn)
KEGG Gene hsa:386746 (Hs), mmu:381974 (Mm), rno:309133 (Rn)
OMIM 607234 (Hs)
PharmGKB Gene PA134953683 (Hs)
Protein Ontology (PRO) PRO:000001605 (Hs)
RefSeq Nucleotide NM_001164377 (Hs), NM_203492 (Mm), NM_203470 (Rn)
RefSeq Protein NP_001157849 (Hs), NP_987077 (Mm), NP_982296 (Rn)
TreeFam ENSG00000182170 (Hs), ENSMUSG00000050276 (Mm), ENSRNOG00000020734 (Rn)
UniGene Hs. 647287 (Hs)
UniProt Q86SM5 (Hs), Q91ZB5 (Mm), Q7TN39 (Rn)
Wikipedia MRGPRG
Orphan and other 7TM receptors
Tissue Distribution Comments
MRGPRG was not detectable by in situ hybridisation in dorsal root ganglia [2].
Biologically Significant Variants
G287V
SNP accession:  rs75066302 
Type:  Naturally occurring SNPs.
Species:  Human
References: 
T19R
SNP accession:  rs74049082 
Type:  Naturally occurring SNPs.
Species:  Human
References: 
A162V, low frequency (<10% in all tested populations)
SNP accession:  rs75003193 
Type:  Naturally occurring SNPs.
Species:  Human
References: 
General Comments
Of the eight human Mas-related GPCRs (MRGs), four (MRGPRD, MRGPRE, MRGPRF and MRGPRG) have clear orthologues in rodents, whereas the cluster of genes including human MRGPRX1, MRGPRX2, MRGPRX3 and MRGPRX4 is found only in primates and is replaced in rodents with a family of genes (>25 in mice, ~10 in rats) which have no obvious human counterparts [2]. Certain rodent MRGs have been reported to respond to adenine [1] and to RF-amide peptides including neuropeptide FF [3-4] but the relevance of these findings to man is unclear. MRGs are expressed predominantly in small diameter sensory neurons of the dorsal root ganglia, where there is emerging evidence that they may be mediators of histamine-independent itch [5-6].

REFERENCES

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1. Bender, E; Buist, A; Jurzak, M; Langlois, X; Baggerman, G; Verhasselt, P; Ercken, M; Guo, HQ; Wintmolders, C; Van den Wyngaert, I; et al.. (2002) Characterization of an orphan G protein-coupled receptor localized in the dorsal root ganglia reveals adenine as a signaling molecule. Proc. Natl. Acad. Sci. U.S.A., 99 (13): 8573-8. [PMID:12084918]

2. Dong, X; Han, S; Zylka, MJ; Simon, MI; Anderson, DJ. (2001) A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. Cell, 106 (5): 619-32. [PMID:11551509]

3. Han, SK; Dong, X; Hwang, JI; Zylka, MJ; Anderson, DJ; Simon, MI. (2002) Orphan G protein-coupled receptors MrgA1 and MrgC11 are distinctively activated by RF-amide-related peptides through the Galpha q/11 pathway. Proc. Natl. Acad. Sci. U.S.A., 99 (23): 14740-5. [PMID:12397184]

4. Lee, MG; Dong, X; Liu, Q; Patel, KN; Choi, OH; Vonakis, B; Undem, BJ. (2008) Agonists of the MAS-related gene (Mrgs) orphan receptors as novel mediators of mast cell-sensory nerve interactions. J. Immunol., 180 (4): 2251-5. [PMID:18250432]

5. Liu, Q; Tang, Z; Surdenikova, L; Kim, S; Patel, KN; Kim, A; Ru, F; Guan, Y; Weng, HJ; Geng, Y; Undem, BJ; Kollarik, M; Chen, ZF; Anderson, DJ; Dong, X. (2009) Sensory neuron-specific GPCR Mrgprs are itch receptors mediating chloroquine-induced pruritus. Cell, 139 (7): 1353-65. [PMID:20004959]

6. Wilson, SR; Gerhold, KA; Bifolck-Fisher, A; Liu, Q; Patel, KN; Dong, X; Bautista, DM. (2011) TRPA1 is required for histamine-independent, Mas-related G protein-coupled receptor-mediated itch. Nat. Neurosci., 14 (5): 595-602. [PMID:21460831]

To cite this database page, please use the following:

Wen Chiy Liew.
Class A Orphans: MRGPRG. Last modified on 05/11/2012. Accessed on 24/05/2013. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=155.


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