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LPA5 receptor

Family: Lysophospholipid (LPA) receptors

Contents:
Gene and Protein Information
Previous and Unofficial Names
Database Links
Agonists
Antagonists
Transduction Mechanisms
Expression Datasets
References
Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 372 12p13.31 LPAR5 lysophosphatidic acid receptor 5
Mouse 7 372 6 F2 Lpar5 lysophosphatidic acid receptor 5
Rat 7 372 4q42 Lpar5 lysophosphatidic acid receptor 5
Previous and Unofficial Names
GPR93
LPAR5
KPG_010
LPA5
lysophosphatidic acid receptor 5
GPR92
G-protein coupled receptor 92
LPAR5 lysophosphatidic acid receptor 5
G protein-coupled receptor 92
LOC500317
RGD1562580
RGD1562580_predicted
similar to Probable G-protein coupled receptor 92
similar to Probable G-protein coupled receptor 92 (predicted)
LOC381810
Gm1072
Database Links
ChEMBL Target 101505 (Hs)
Ensembl ENSG00000184574 (Hs), ENSMUSG00000067714 (Mm), ENSRNOG00000021401 (Rn)
Entrez Gene 57121 (Hs), 381810 (Mm), 500317 (Rn)
GeneCards LPAR5 (Hs)
GenitoUrinary Development Molecular Anatomy Project Lpar5 (Mm)
HomoloGene 10696 (Hs)
Human Protein Reference Database 09495 (Hs)
InterPro Q9H1C0 (Hs), Q149R9 (Mm)
KEGG Gene hsa:57121 (Hs), mmu:381810 (Mm), rno:500317 (Rn)
OMIM 606926 (Hs)
PharmGKB Gene PA162394223 (Hs), PA28935 (Hs)
PhosphoSitePlus Q9H1C0 (Hs), Q149R9 (Mm)
Protein Ontology (PRO) PRO:000001486 (Hs)
RefSeq Nucleotide NM_020400 (Hs), NM_001163268 (Mm), XM_575667 (Rn)
RefSeq Protein NP_065133 (Hs), NP_001156740 (Mm), XP_575667 (Rn)
TreeFam ENSG00000184574 (Hs), ENSMUSG00000067714 (Mm), ENSRNOG00000021401 (Rn)
UniGene Hs. 155538 (Hs)
UniProt Q9H1C0 (Hs), Q149R9 (Mm)
Wikipedia LPA5 receptor
Lysophospholipid (LPA) receptors
Search for 3D structures on the PDB
Search by keyword: Lysophospholipid (LPA) receptors LPA5 receptor Search by accession number: Q9H1C0, Q149R9
Natural/Endogenous Ligand(s)
LPA
Comments: Proposed ligand, two publications
Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
LPA Hs Agonist 7.92 pEC50 2
farnesyl diphosphate Hs Agonist 7.4 pEC50 4
farnesyl monophosphate Hs Agonist 7.31 pEC50 4
Antagonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
AM966 Hs Antagonist 5.1 pIC50 3
AM966 Mm Antagonist 4.6 pIC50 3
View species-specific antagonist tables
Primary Transduction Mechanisms
Transducer Effector/Response
Gq/G11 family
G12/G13 family 		Phospholipase C stimulation
Comments:  Others include: Rho. For a detailed review please see [1]
References: 
Expression Datasets

Click here to show/hide data

Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Available Assays
DiscoveRx PathHunter® CHO-K1 GPR92 (Orphan) High Expression β-Arrestin Cell Line Human Cat No. 93-0372C2
DiscoveRx PathHunter® eXpress GPR92 CHO-K1 β-Arrestin (Orphan) GPCR Assay Human Cat No. 93-0372E2C6

REFERENCES

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1. Choi, JW; Herr, DR; Noguchi, K; Yung, YC; Lee, CW; Mutoh, T; Lin, ME; Teo, ST; Park, KE; Mosley, AN; Chun, J. (2010) LPA receptors: subtypes and biological actions. Annu. Rev. Pharmacol. Toxicol., 50: 157-86. [PMID:20055701]

2. Lu, Y; Wang, Z; Li, CM; Chen, J; Dalton, JT; Li, W; Miller, DD. (2010) Synthesis, in vitro structure-activity relationship, and in vivo studies of 2-arylthiazolidine-4-carboxylic acid amides as anticancer agents. Bioorg. Med. Chem., 18 (2): 477-95. [PMID:20056548]

3. Swaney, JS; Chapman, C; Correa, LD; Stebbins, KJ; Bundey, RA; Prodanovich, PC; Fagan, P; Baccei, CS; Santini, AM; Hutchinson, JH; et al.. (2010) A novel, orally active LPA(1) receptor antagonist inhibits lung fibrosis in the mouse bleomycin model. Br. J. Pharmacol., 160 (7): 1699-713. [PMID:20649573]

4. Williams, JR; Khandoga, AL; Goyal, P; Fells, JI; Perygin, DH; Siess, W; Parrill, AL; Tigyi, G; Fujiwara, Y. (2009) Unique ligand selectivity of the GPR92/LPA5 lysophosphatidate receptor indicates role in human platelet activation. J. Biol. Chem., 284 (25): 17304-19. [PMID:19366702]

To cite this database page, please use the following:

Chido Mpamhanga.
Lysophospholipid (LPA) receptors: LPA5 receptor. Last modified on 31/01/2013. Accessed on 21/05/2013. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=124.


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