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5-HT7 receptor

Family: 5-Hydroxytryptamine receptors

Contents:
Gene and Protein Information
Previous and Unofficial Names
Database Links
Agonists
Antagonists
Allosteric Regulators
Transduction Mechanisms
Tissue Distribution
Expression Datasets
Functional Assays
Physiological Functions
Physiological Consequences of Altering Gene Expression
Phenotypes, Alleles and Disease Models
Biologically Significant Variants
References
Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 479 10q21-q24 HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled 41
Mouse 7 448 19 C2 Htr7 5-hydroxytryptamine (serotonin) receptor 7 33
Rat 7 448 1q53 Htr7 5-hydroxytryptamine (serotonin) receptor 7 25,37-38
Previous and Unofficial Names
5-HTx
5-HT1-like
5-HT1Y
5-HT7
5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled)
5Ht7
5-HT-7
5-HT-X
5-hydroxytryptamine receptor 7
GPRFO
high affinity serotonin receptor (5HT7)
high affinity serotonin receptor (5HT7) gene
serotonin receptor 7
Database Links
ChEMBL Target 10209 (Hs), 10022 (Mm), 11923 (Rn)
DrugBank Target 716 (Hs)
Ensembl ENSG00000148680 (Hs), ENSMUSG00000024798 (Mm), ENSRNOG00000018827 (Rn)
Entrez Gene 3363 (Hs), 15566 (Mm), 65032 (Rn)
GeneCards HTR7 (Hs)
GenitoUrinary Development Molecular Anatomy Project Htr7 (Mm)
HomoloGene 20244 (Hs)
Human Protein Reference Database 01639 (Hs)
InterPro P34969 (Hs), P32304 (Mm), P32305 (Rn)
KEGG Gene hsa:3363 (Hs), mmu:15566 (Mm), rno:65032 (Rn)
OMIM 182137 (Hs)
PharmGKB Gene PA29561 (Hs)
PhosphoSitePlus P34969 (Hs), P32304 (Mm), P32305 (Rn)
Protein Ontology (PRO) PRO:000001103 (Hs)
RefSeq Nucleotide NM_000872 (Hs), NM_008315 (Mm), NM_022938 (Rn)
RefSeq Protein NP_000863 (Hs), NP_032341 (Mm), NP_075227 (Rn)
TreeFam ENSG00000148680 (Hs), ENSMUSG00000024798 (Mm), ENSRNOG00000018827 (Rn)
UniGene Hs. 73739 (Hs)
UniProt P34969 (Hs), P32304 (Mm), P32305 (Rn)
Wikipedia 5-HT7 receptor
5-Hydroxytryptamine receptors
Search for 3D structures on the PDB
Search by keyword: 5-Hydroxytryptamine receptors 5-HT7 receptor Search by accession number: P32305, P34969, P32304
Natural/Endogenous Ligand(s)
5-HT
Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
[3H]5-CT Hs Agonist 9.4 pKd 48
[125I]LSD Rn Full agonist 8.9 pKd 25
[3H]5-HT Hs Full agonist 8.1 – 9.0 pKd 3,41
[3H]LSD Hs Full agonist 8.5 – 8.6 pKd 41
[3H]LSD Rn Full agonist 8.2 pKd 24
5-CT Rn Full agonist 9.5 – 9.9 pKi 37-38
5-CT Hs Full agonist 9.0 – 10.0 pKi 3,18,23,46
5-CT Mm Full agonist 9.0 pKi 33
5-MeOT Rn Full agonist 8.8 – 9.2 pKi 37-38
5-HT Rn Full agonist 8.7 – 9.2 pKi 37-38
5-MeOT Hs Full agonist 8.3 – 9.5 pKi 3,18,23
5-HT Hs Full agonist 8.1 – 9.6 pKi 3,13,18,23,46
lisuride Rn Full agonist 8.2 – 9.3 pKi 37-38
pergolide Rn Full agonist 8.3 – 9.0 pKi 38
E55888 Hs Full agonist 8.6 pKi 5
5-HT Mm Full agonist 8.3 pKi 33
dipropyl-5-CT Hs Full agonist 8.2 – 8.4 pKi 18
5-MeOT Mm Full agonist 8.2 pKi 33
(+)-LSD Hs Full agonist 8.0 pKi 37
aripiprazole Rn Full agonist 7.8 pKi 24
OPC 4392 Rn Full agonist 7.7 pKi 24
bromocriptine Rn Full agonist 7.3 – 8.0 pKi 38
tryptamine Rn Full agonist 7.5 – 7.8 pKi 38
1-naphthylpiperazine Rn Full agonist 7.5 – 7.7 pKi 38
5-MeO-DMT Rn Full agonist 7.4 – 7.7 pKi 38
8-OH-DPAT Rn Full agonist 7.3 – 7.5 pKi 37-38
1-naphthylpiperazine Hs Full agonist 7.1 pKi 3
bufotenine Mm Full agonist 7.0 pKi 33
8-OH-DPAT Hs Full agonist 6.3 – 7.6 pKi 3,18,23,46
RU 24969 Mm Full agonist 6.9 pKi 33
xanomeline Hs Full agonist 6.9 pKi 49
tryptamine Hs Full agonist 6.8 pKi 3
2-MPP Rn Full agonist 6.6 – 6.9 pKi 38
DM 1451 Rn Full agonist 6.7 pKi 24
8-OH-DPAT Mm Full agonist 6.6 pKi 33
EMDT Hs Full agonist 6.5 pKi 10
m-CPP Rn Full agonist 6.4 – 6.6 pKi 38
TFMPP Rn Full agonist 6.3 – 6.6 pKi 38
buspirone Rn Partial agonist 6.4 pKi 37
cisapride Mm Full agonist 5.8 pKi 33
SL65.0155 Hs Partial agonist 5.5 pKi 27
LY344864 Hs Full agonist 5.3 pKi 31
View species-specific agonist tables
Antagonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
risperidone Rn Inverse agonist 8.9 – 9.0 pKd 21,36
[3H]SB269970 Hs Antagonist 8.92 pKd 48
pimozide Rn Antagonist 9.3 pKi 36
methiothepin Rn Antagonist 9.0 – 9.4 pKi 38
tiospirone Rn Antagonist 9.2 pKi 36
methiothepin Hs Antagonist 8.4 – 9.4 pKi 3,18,23,46
zotepine Rn Inverse agonist 8.8 pKi 36
SB269970 Hs Antagonist 8.6 – 8.9 pKi 48
SB656104 Hs Antagonist 8.7 pKi 9
metergoline Hs Antagonist 8.2 – 8.9 pKi 3,18,23
risperidone Hs Inverse agonist 8.3 – 8.7 pKi 34,46
ziprasidone Hs Inverse agonist 8.4 pKi 34
zotepine Hs Inverse agonist 8.4 pKi 34
pirenperone Hs Antagonist 8.2 – 8.5 pKi 18
fluperlapine Rn Inverse agonist 8.3 pKi 36
methiothepin Mm Antagonist 8.2 pKi 33
fluphenazine Rn Inverse agonist 8.1 pKi 36
2-Br-LSD Mm Antagonist 8.0 pKi 33
dihydroergotamine Hs Antagonist 8.0 pKi 3
mesulergine Rn Antagonist 7.7 – 8.2 pKi 38
metergoline Rn Antagonist 7.2 – 8.7 pKi 37-38
fluphenazine Hs Inverse agonist 7.9 pKi 34
methysergide Mm Antagonist 7.9 pKi 33
methysergide Rn Antagonist 7.9 pKi 38
mesulergine Hs Antagonist 7.5 – 8.2 pKi 3,18,23,46
spiperone Rn Antagonist 7.7 – 8.0 pKi 36-37
ritanserin Rn Antagonist 7.7 – 7.8 pKi 38
clozapine Rn Inverse agonist 7.2 – 8.2 pKi 21,36-38
iloperidone Rn Antagonist 7.7 pKi 21
chlorpromazine Rn Inverse agonist 7.6 pKi 36
chlorpromazine Hs Inverse agonist 7.6 pKi 34
mesulergine Mm Antagonist 7.6 pKi 33
perphenazine Rn Inverse agonist 7.6 pKi 36
2-Br-LSD Hs Antagonist 7.5 pKi 3
(+)-butaclamol Mm Antagonist 7.5 pKi 33
clozapine Hs Inverse agonist 7.2 – 7.8 pKi 23,34,46
fluperlapine Hs Inverse agonist 7.5 pKi 34
metergoline Mm Antagonist 7.5 pKi 33
SB 258719 Hs Inverse agonist 7.5 pKi 46
spiperone Hs Antagonist 7.0 – 8.0 pKi 3,18,23
methysergide Hs Antagonist 7.1 – 7.8 pKi 3,18,23
mianserin Hs Antagonist 7.3 – 7.6 pKi 18
amoxapine Rn Antagonist 7.4 pKi 36
clozapine Mm Inverse agonist 7.4 pKi 33
cyproheptadine Rn Antagonist 7.1 – 7.5 pKi 37-38
ergotamine Mm Antagonist 7.3 pKi 33
cyamemazine Hs Antagonist 7.2 pKi 13
mianserin Rn Antagonist 7.0 – 7.4 pKi 37-38
perphenazine Hs Inverse agonist 7.2 pKi 34
spiperone Mm Antagonist 7.2 pKi 33
thioridazine Rn Inverse agonist 7.2 pKi 36
loxapine Rn Antagonist 6.8 – 7.4 pKi 36,38
ritanserin Hs Antagonist 6.8 – 7.4 pKi 3,23
thioridazine Hs Inverse agonist 7.1 pKi 34
(+)-butaclamol Rn Antagonist 7.0 pKi 37
dihydroergocryptine Mm Antagonist 7.0 pKi 33
iloperidone Hs Antagonist 7.0 pKi 19
mianserin Mm Antagonist 7.0 pKi 33
amitriptyline Rn Antagonist 6.9 – 7.0 pKi 38
cyproheptadine Hs Antagonist 6.9 pKi 3
olanzapine Rn Antagonist 6.8 – 7.0 pKi 21,36
dihydroergotamine Rn Antagonist 6.8 pKi 37
MPDT Hs Antagonist 6.8 pKi 10
ketanserin Rn Antagonist 6.6 – 6.7 pKi 38
dihydroergocryptine Rn Antagonist 6.5 pKi 37
olanzapine Hs Antagonist 6.5 pKi 46
haloperidol Hs Antagonist 6.3 – 6.6 pKi 18
haloperidol Rn Antagonist 6.3 – 6.6 pKi 21,36-37
amitriptyline Mm Antagonist 6.4 pKi 33
buspirone Mm Antagonist 6.4 pKi 33
ketanserin Mm Antagonist 6.4 pKi 33
sumatriptan Rn Antagonist 6.2 – 6.6 pKi 37-38
haloperidol Mm Antagonist 6.3 pKi 33
TFMPP Mm Antagonist 6.3 pKi 33
ketanserin Hs Antagonist 5.9 – 6.5 pKi 3,18,23,46
sumatriptan Hs Antagonist 5.7 – 6.0 pKi 3,18
yohimbine Hs Antagonist 5.6 pKi 3
SB 207710 Hs Antagonist 5.3 – 5.5 pKi 23
chlorpromazine Mm Inverse agonist 5.3 pKi 33
View species-specific antagonist tables
Allosteric Regulators
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
oleamide Hs Negative 8.6 pKd 15

Explore drug-target interactions for this set of compounds using iPHACE

Primary Transduction Mechanisms
Transducer Effector/Response
Gs family Adenylate cyclase stimulation
References:  2
Tissue Distribution
Amygdala, aorta, cerebral cortex, hippocampus, thalamus, small intestine >> spleen, pancreas, stomach, kidney.
Species:  Human
Technique:  RT-PCR.
References:  18
CNS: trigeminal ganglia.
Species:  Human
Technique:  RT-PCR.
References:  45
CNS: suprachiasmatic nucleus.
Species:  Human
Technique:  Electron microscopic immunocytochemistry.
References:  4
Coronary artery > brain > descending colon, ileum.
Species:  Human
Technique:  RT-PCR.
References:  3
Heart: ventricle wall > epicardium > atrium, coronary artery.
Species:  Human
Technique:  RT-PCR.
References:  28
Thymus, peripheral blood lymphocytes, spleen, mitogen-activated spleen cells.
Species:  Rat
Technique:  RT-PCR.
References:  42
CNS: lumbar dorsal root ganglia, superior cervical ganglia, lumbar sympathetic ganglia.
Species:  Rat
Technique:  RT-PCR.
References:  32
Expression Datasets

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Functional Assays
Measurement of cAMP levels in rat hippocampal homogenates endogenously expressing the rat 5-HT7 receptor.
Species:  Rat
Tissue:  Hippocampal cells.
Response measured:  Stimulation of cAMP accumulation.
References:  26
Measurement of cAMP levels in LM(tk-) cells transfected with the human 5-HT7(a) receptor.
Species:  Human
Tissue:  LM(tk-) cells.
Response measured:  Stimulation of cAMP accumulation.
References:  1
Measurement of cAMP levels in COS-7 cells transfected with the human 5-HT7 receptor.
Species:  Human
Tissue:  COS-7 cells.
Response measured:  Stimulation of cAMP accumulation.
References:  3
Measurement of cAMP levels in HeLa cells transfected with the rat 5-HT7 receptor.
Species:  Rat
Tissue:  HeLa cells.
Response measured:  Stimulation of cAMP accumulation.
References:  25
Measurement of ERK1/2 activity in HEK 293 cells transfected with the human 5-HT7 receptor.
Species:  Human
Tissue:  HEK 293 cells.
Response measured:  ERK1/2 activation via a pathway involving PKA and Ras.
References:  29
Measurement of ERK1/2 activity in HEK 293 cells transfected with the human 5-HT7 receptor.
Species:  Human
Tissue:  HEK 293 cells.
Response measured:  ERK1/2 activation via a pathway involving PKA and Ras.
References:  29
Physiological Functions
Nociception.
Species:  Rat
Tissue:  In vivo.
References:  35
Antinociception.
Species:  Rat
Tissue:  In vivo (parafascicular nucleus).
References:  14
Hypotension.
Species:  Rat
Tissue:  In vivo.
References:  7,44
Depolarisation via an increase in hyperpolarisation-activated conductance.
Species:  Rat
Tissue:  Anterodorsal nucleus of the thalamus.
References:  8
Hypothermia.
Species:  Mouse
Tissue:  In vivo.
References:  11,16
Modulation of REM sleep.
Species:  Rat
Tissue:  In vivo.
References:  47
Regulation of suprachiasmatic nuclei neuronal firing (potential role in the control of circadian rhythms).
Species:  Rat
Tissue:  Hypothalamic slices.
References:  40
Regulation of LH release.
Species:  Rat
Tissue:  In vivo (zona incerta of dorsal hypothalamus).
References:  39
Regulation of vagal outflow to the heart.
Species:  Rat
Tissue:  In vivo.
References:  20
Role in learning and memory.
Species:  Rat
Tissue:  In vivo.
References:  30
Regulation of locomotor activity.
Species:  Mouse
Tissue:  In vivo.
References:  43
Physiological Consequences of Altering Gene Expression
5-HT7 receptor knockout mice have an abolished hypothermic response upon agonist administration.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  11,16
Hypothalamic slices from 5-HT7 receptor knockout mice suggest a reduced circadian rhythm phase shift in response to agonist stimulation.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  12
Phenotypes, Alleles and Disease Models Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Htr7tm1Sut Htr7tm1Sut/Htr7tm1Sut
B6.129X1-Htr7		 MGI:99841  MP:0001777 abnormal body temperature regulation PMID: 12529502 
Htr7tm1Mrg Htr7tm1Mrg/Htr7tm1Mrg
involves: 129S/SvEv * C57BL/6		 MGI:99841  MP:0001777 abnormal body temperature regulation PMID: 12763096 
Htr7tm1Wtkn Htr7tm1Wtkn/Htr7tm1Wtkn
involves: 129S1/Sv * 129X1/SvJ * CD-1		 MGI:99841  MP:0001650 abnormal seizure response to electrical stimulation PMID: 17485199 
Htr7tm1Dgen Htr7tm1Dgen/Htr7tm1Dgen
involves: 129P2/OlaHsd * C57BL/6		 MGI:99841  MP:0003858 enhanced coordination
Htr7tm1Wtkn Htr7tm1Wtkn/Htr7tm1Wtkn
involves: 129S1/Sv * 129X1/SvJ * CD-1		 MGI:99841  MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality PMID: 17485199 
Htr7tm1Wtkn Htr7tm1Wtkn/Htr7tm1Wtkn
involves: 129S1/Sv * 129X1/SvJ * CD-1		 MGI:99841  MP:0002906 increased susceptibility to pharmacologically induced seizures PMID: 17485199 
Htr7tm1Dgen Htr7tm1Dgen/Htr7tm1Dgen
involves: 129P2/OlaHsd * C57BL/6		 MGI:99841  MP:0001973 increased thermal nociceptive threshold
Biologically Significant Variants
Splice variants of the 5-HT7 receptor have been found in the human brain, 5-HT7(a), 5-HT7(b) and 5-HT7(d). Differing only in the lengths of their carboxy terminal, these variants are all functional receptors.
Type:  Splice variants.
Species:  Human
References:  18,22-23,41
Splice variants of the 5-HT7 receptor have been found in rat tissues, 5-HT7(a), 5-HT7(b) and 5-HT7(c). Differing only in the lengths of their carboxy terminal, these variants are all functional receptors.
Type:  Splice variants.
Species:  Rat
References:  17
The human 5-HT7(a) receptor polymorphism Thr92 -> Lys exhibits reduced agonist binding affinities.
Type:  Single nucleotide polymorphism.
Species:  Human
References:  6

REFERENCES

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1. Adham, N., Zgombick, J. M., Bard, J. and Branchek, T. A. (1998) Functional characterization of the recombinant human 5-hydroxytryptamine7(a) receptor isoform coupled to adenylate cyclase stimulation. J Pharmacol Exp Ther, 287: 508-514. [PMID:9808674]

2. Baker, L. P., Nielsen, M. D., Impey, S., Metcalf, M. A., Poser, S. W., Chan, G., Obrietan, K., Hamblin, M. W. and Storm, D. R. (1998) Stimulation of type 1 and type 8 Ca2+/calmodulin-sensitive adenylyl cyclases by the Gs-coupled 5-hydroxytryptamine subtype 5-HT7A receptor. J Biol Chem, 273: 17469-17476. [PMID:9651336]

3. Bard, J. A., Zgombick, J., Adham, N., Vaysse, P., Branchek, T. A. and Weinshank, R. L. (1993) Cloning of a novel human serotonin receptor (5-HT7) positively linked to adenylate cyclase. J Biol Chem, 268: 23422-23426. [PMID:8226867]

4. Belenky, M. A. and Pickard, G. E. (2001) Subcellular distribution of 5-HT(1B) and 5-HT(7) receptors in the mouse suprachiasmatic nucleus. J Comp Neurol, 432: 371-388. [PMID:11246214]

5. Brenchat, A; Romero, L; García, M; Pujol, M; Burgueño, J; Torrens, A; Hamon, M; Baeyens, JM; Buschmann, H; Zamanillo, D; et al.. (2009) 5-HT7 receptor activation inhibits mechanical hypersensitivity secondary to capsaicin sensitization in mice. Pain, 141 (3): 239-47. [PMID:19118950]

6. Bruss, M., Kiel, S., Bonisch, H., Kostanian, A. and Gothert, M. (2005) Decreased agonist, but not antagonist, binding to the naturally occurring Thr92Lys variant of the h5-HT7(a) receptor. Neurochem Int, 47: 196-203. [PMID:15896881]

7. Centurion, D., Glusa, E., Sanchez-Lopez, A., Valdivia, L. F., Saxena, P. R. and Villalon, C. M. (2004) 5-HT7, but not 5-HT2B, receptors mediate hypotension in vagosympathectomized rats. Eur J Pharmacol, 502: 239-242. [PMID:15476750]

8. Chapin, E. M. and Andrade, R. (2001) A 5-HT(7) receptor-mediated depolarization in the anterodorsal thalamus. II. Involvement of the hyperpolarization-activated current I(h). J Pharmacol Exp Ther, 297: 403-409. [PMID:11259569]

9. Forbes, IT; Douglas, S; Gribble, AD; Ife, RJ; Lightfoot, AP; Garner, AE; Riley, GJ; Jeffrey, P; Stevens, AJ; Stean, TO; et al.. (2002) SB-656104-A: a novel 5-HT(7) receptor antagonist with improved in vivo properties. Bioorg. Med. Chem. Lett., 12 (22): 3341-4. [PMID:12392747]

10. Glennon, R. A., Lee, M., Rangisetty, J. B., Dukat, M., Roth, B. L., Savage, J. E., McBride, A., Rauser, L., Hufeisen, S. and Lee, D. K. (2000) 2-Substituted tryptamines: agents with selectivity for 5-HT(6) serotonin receptors. J Med Chem, 43: 1011-1018. [PMID:10715164]

11. Guscott, M. R., Egan, E., Cook, G. P., Stanton, J. A., Beer, M. S., Rosahl, T. W., Hartmann, S., Kulagowski, J., McAllister, G., Fone, K. C. and Hutson, P. H. (2003) The hypothermic effect of 5-CT in mice is mediated through the 5-HT7 receptor. Neuropharmacology, 44: 1031-1037. [PMID:12763096]

12. Guscott, M., Bristow, L. J., Hadingham, K., Rosahl, T. W., Beer, M. S., Stanton, J. A., Bromidge, F., Owens, A. P., Huscroft, I., Myers, J., Rupniak, N. M., Patel, S., Whiting, P. J., Hutson, P. H., Fone, K. C., Biello, S. M., Kulagowski, J. J. and McAllister, G. (2005) Genetic knockout and pharmacological blockade studies of the 5-HT7 receptor suggest therapeutic potential in depression. Neuropharmacology, 48: 492-502. [PMID:15755477]

13. Hameg, A., Bayle, F., Nuss, P., Dupuis, P., Garay, R. P. and Dib, M. (2003) Affinity of cyamemazine, an anxiolytic antipsychotic drug, for human recombinant dopamine vs. serotonin receptor subtypes. Biochem Pharmacol, 65: 435-440. [PMID:12527336]

14. Harte, S. E., Kender, R. G. and Borszcz, G. S. (2005) Activation of 5-HT1A and 5-HT7 receptors in the parafascicular nucleus suppresses the affective reaction of rats to noxious stimulation. Pain, 113: 405-415. [PMID:15661450]

15. Hedlund, P. B., Carson, M. J., Sutcliffe, J. G. and Thomas, E. A. (1999) Allosteric regulation by oleamide of the binding properties of 5-hydroxytryptamine7 receptors. Biochem Pharmacol, 58: 1807-1813. [PMID:10571256]

16. Hedlund, P. B., Kelly, L., Mazur, C., Lovenberg, T., Sutcliffe, J. G. and Bonaventure, P. (2004) 8-OH-DPAT acts on both 5-HT1A and 5-HT7 receptors to induce hypothermia in rodents. Eur J Pharmacol, 487: 125-132. [PMID:15033384]

17. Heidmann, D. E., Szot, P., Kohen, R. and Hamblin, M. W. (1998) Function and distribution of three rat 5-hydroxytryptamine7 (5-HT7) receptor isoforms produced by alternative splicing. Neuropharmacology, 37: 1621-1632. [PMID:9886685]

18. Jasper, J. R., Kosaka, A., To, Z. P., Chang, D. J. and Eglen, R. M. (1997) Cloning, expression and pharmacology of a truncated splice variant of the human 5-HT7 receptor (h5-HT7b). Br J Pharmacol, 122: 126-132. [PMID:9298538]

19. Kalkman, H. O., Subramanian, N. and Hoyer, D. (2001) Extended radioligand binding profile of iloperidone: a broad spectrum dopamine/serotonin/norepinephrine receptor antagonist for the management of psychotic disorders. Neuropsychopharmacology, 25: 904-914. [PMID:11750183]

20. Kellett, D. O., Ramage, A. G. and Jordan, D. (2005) Central 5-HT7 receptors are critical for reflex activation of cardiac vagal drive in anaesthetized rats. J Physiol, 563: 319-331. [PMID:15611034]

21. Kongsamut, S., Roehr, J. E., Cai, J., Hartman, H. B., Weissensee, P., Kerman, L. L., Tang, L. and Sandrasagra, A. (1996) Iloperidone binding to human and rat dopamine and 5-HT receptors. Eur J Pharmacol, 317: 417-423. [PMID:8997630]

22. Krobert, K. A. and Levy, F. O. (2002) The human 5-HT7 serotonin receptor splice variants: constitutive activity and inverse agonist effects. Br J Pharmacol, 135: 1563-1571. [PMID:11906971]

23. Krobert, K. A., Bach, T., Syversveen, T., Kvingedal, A. M. and Levy, F. O. (2001) The cloned human 5-HT7 receptor splice variants: a comparative characterization of their pharmacology, function and distribution. Naunyn Schmiedebergs Arch Pharmacol, 363: 620-632. [PMID:11414657]

24. Lawler, C. P., Prioleau, C., Lewis, M. M., Mak, C., Jiang, D., Schetz, J. A., Gonzalez, A. M., Sibley, D. R. and Mailman, R. B. (1999) Interactions of the novel antipsychotic aripiprazole (OPC-14597) with dopamine and serotonin receptor subtypes. Neuropsychopharmacology, 20: 612-627. [PMID:10327430]

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26. Markstein, R., Matsumoto, M., Kohler, C., Togashi, H., Yoshioka, M. and Hoyer, D. (1999) Pharmacological characterisation of 5-HT receptors positively coupled to adenylyl cyclase in the rat hippocampus. Naunyn Schmiedebergs Arch Pharmacol, 359: 454-459. [PMID:10431755]

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To cite this database page, please use the following:

Rodrigo Andrade, Nicholas M. Barnes, Gordon Baxter, Joel Bockaert, Theresa Branchek, Marlene L. Cohen, Aline Dumuis, Richard M. Eglen, Manfred Göthert, Mark Hamblin, Michel Hamon, Paul R. Hartig, René Hen, Katharine Herrick-Davis, Rebecca Hills, Daniel Hoyer, Patrick P. A. Humphrey, Klaus Peter Latté, Luc Maroteaux, Graeme R. Martin, Derek N. Middlemiss, Ewan Mylecharane, Stephen J. Peroutka, Pramod R. Saxena, Andrew Sleight, Carlos M. Villalon, Frank Yocca.
5-Hydroxytryptamine receptors: 5-HT7 receptor. Last modified on 26/11/2012. Accessed on 18/05/2013. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=12.


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