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GPR82

Family: Class A Orphans

Contents:
Gene and Protein Information
Database Links
Tissue Distribution
Expression Datasets
Physiological Consequences of Altering Gene Expression
Phenotypes, Alleles and Disease Models
General Comments
References
Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 336 Xp11.4 GPR82 G protein-coupled receptor 82
Mouse 7 328 X A1.1 Gpr82 G protein-coupled receptor 82
Structural Information Comments
There is no evidence for Gpr82 in rats
Database Links
Ensembl ENSG00000171657 (Hs), ENSMUSG00000047678 (Mm)
Entrez Gene 27197 (Hs), 319200 (Mm)
GeneCards GPR82 (Hs)
GenitoUrinary Development Molecular Anatomy Project Gpr82 (Mm)
HomoloGene 36824 (Hs)
Human Protein Reference Database 06084 (Hs)
InterPro Q96P67 (Hs), Q8BZR0 (Mm)
KEGG Gene hsa:27197 (Hs), mmu:319200 (Mm)
OMIM 606924 (Hs)
PharmGKB Gene PA28926 (Hs)
PhosphoSitePlus Q96P67 (Hs), Q8BZR0 (Mm)
Protein Ontology (PRO) PRO:000001538 (Hs)
RefSeq Nucleotide NM_080817 (Hs), NM_175669 (Mm)
RefSeq Protein NP_543007 (Hs), NP_783600 (Mm)
TreeFam ENSG00000171657 (Hs), ENSMUSG00000047678 (Mm)
UniGene Hs. 664795 (Hs)
UniProt Q96P67 (Hs), Q8BZR0 (Mm)
Wikipedia GPR82
Orphan and other 7TM receptors
Tissue Distribution
Ubiquitously expressed in the brain, microglia, spleen and bone-marrow-derived dendritic cells. Highly expressed in the epididymis, testis and hypothalamus.
Species:  Mouse
Technique:  RT-PCR
References:  1
Tissue Distribution Comments
Lee et al. reported that no transcripts of GPR82 were detected by Northern blot analysis in the human frontal cortex, caudate putamen, thalamus, hypothalamus, hippocampus, pons and liver tissue [2].
Expression Datasets

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Physiological Consequences of Altering Gene Expression
Mice with Gpr82 knockout have a lower body weight and body fat content associated with a reduced food intake. In addition, mice with Gpr82 knockout show decreased serum triacyglyceride levels, higher insulin sensitivity and glucose tolerance.
Species:  Mouse
Tissue: 
Technique:  Knock-out by homologous recombination in embryonic stem cells
References:  1
Phenotypes, Alleles and Disease Models Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Gpr82tm1Lex Gpr82tm1Lex/Gpr82tm1Lex
involves: 129S5/SvEvBrd * C57BL/6J		 MGI:2441734  MP:0002169 no abnormal phenotype detected
General Comments
GPR82 belongs to the group of P2Y12-like receptors [1].

REFERENCES

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1. Engel, KM; Schröck, K; Teupser, D; Holdt, LM; Tönjes, A; Kern, M; Dietrich, K; Kovacs, P; Krügel, U; Scheidt, HA; et al.. (2011) Reduced food intake and body weight in mice deficient for the G protein-coupled receptor GPR82. PLoS ONE, 6 (12): e29400. [PMID:22216272]

2. Lee, D. K., Nguyen, T., Lynch, K. R., Cheng, R., Vanti, W. B., Arkhitko, O., Lewis, T., Evans, J. F., George, S. R. and O'Dowd, B. F. (2001) Discovery and mapping of ten novel G protein-coupled receptor genes. Gene, 275: 83-91. [PMID:11574155]

To cite this database page, please use the following:

Wen Chiy Liew.
Class A Orphans: GPR82. Last modified on 26/07/2012. Accessed on 19/05/2013. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=118.


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