Nomenclature: GPR82

Family: Class A Orphans

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates. 

Contents

Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 336 Xp11.4 GPR82 G protein-coupled receptor 82
Mouse 7 328 X A1.1 Gpr82 G protein-coupled receptor 82
Gene and Protein Information Comments
There is no evidence for Gpr82 in rats
Database Links
Ensembl Gene
Entrez Gene
GPCRDB
GeneCards
GenitoUrinary Development Molecular Anatomy Project
HomoloGene
Human Protein Reference Database
InterPro
KEGG Gene
OMIM
PharmGKB Gene
PhosphoSitePlus
Protein Ontology (PRO)
RefSeq Nucleotide
RefSeq Protein
TreeFam
UniGene Hs.
UniProtKB
Wikipedia
Tissue Distribution
Ubiquitously expressed in the brain, microglia, spleen and bone-marrow-derived dendritic cells. Highly expressed in the epididymis, testis and hypothalamus.
Species:  Mouse
Technique:  RT-PCR
References:  1
Tissue Distribution Comments
Lee et al. reported that no transcripts of GPR82 were detected by Northern blot analysis in the human frontal cortex, caudate putamen, thalamus, hypothalamus, hippocampus, pons and liver tissue [2].
Expression Datasets

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Physiological Consequences of Altering Gene Expression
Mice with Gpr82 knockout have a lower body weight and body fat content associated with a reduced food intake. In addition, mice with Gpr82 knockout show decreased serum triglyceride levels, higher insulin sensitivity and glucose tolerance.
Species:  Mouse
Tissue: 
Technique:  Knock-out by homologous recombination in embryonic stem cells
References:  1
Phenotypes, Alleles and Disease Models Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Gpr82tm1Lex Gpr82tm1Lex/Gpr82tm1Lex
involves: 129S5/SvEvBrd * C57BL/6J
MGI:2441734  MP:0002169 no abnormal phenotype detected
General Comments
GPR82 belongs to the group of P2Y12-like receptors [1].

REFERENCES

1. Engel KM, Schröck K, Teupser D, Holdt LM, Tönjes A, Kern M, Dietrich K, Kovacs P, Krügel U, Scheidt HA et al.. (2011) Reduced food intake and body weight in mice deficient for the G protein-coupled receptor GPR82. PLoS ONE6 (12): e29400. [PMID:22216272]

2. Lee DK, Nguyen T, Lynch KR, Cheng R, Vanti WB, Arkhitko O, Lewis T, Evans JF, George SR, O'Dowd BF. (2001) Discovery and mapping of ten novel G protein-coupled receptor genes. Gene275: 83-91. [PMID:11574155]

To cite this database page, please use the following:

Anthony P. Davenport, Stephen Alexander, Joanna L. Sharman, Adam J. Pawson, Helen E. Benson, Amy E. Monaghan, Wen Chiy Liew, Chido Mpamhanga, Jim Battey, Richard V. Benya, Robert T. Jensen, Sadashiva Karnik, Evi Kostenis, Eliot Spindel, Laura Storjohann, Kalyan Tirupula, Tom I. Bonner, Richard Neubig, Jean-Philippe Pin, Michael Spedding, Anthony Harmar.
Class A Orphans: GPR82. Last modified on 24/07/2013. Accessed on 31/07/2014. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=118.

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