Nomenclature: GPR62

Family: Class A Orphans

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates. 

Contents

Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 368 3p21.1-p21.9 GPR62 G protein-coupled receptor 62 1
Mouse 7 358 9 F1 Gpr62 G protein-coupled receptor 62
Rat 7 358 8q32 Gpr62 G protein-coupled receptor 62
Previous and Unofficial Names
KPG_005
MGC26943
GPCR8
LOC501049
RGD1560166_predicted
similar to Probable G-protein coupled receptor 62 (hGPCR8)
similar to Probable G-protein coupled receptor 62 (hGPCR8) (predicted)
4933402E03Rik
Database Links
Ensembl Gene
Entrez Gene
GPCRDB
GeneCards
GenitoUrinary Development Molecular Anatomy Project
HomoloGene
Human Protein Reference Database
InterPro
KEGG Gene
OMIM
PharmGKB Gene
Protein Ontology (PRO)
RefSeq Nucleotide
RefSeq Protein
TreeFam
UniGene Hs.
UniProtKB
Wikipedia
Tissue Distribution
Brain regions (basal forebrain, frontal cortex, thalamus, hippocampus, caudate and putamen)
Species:  Human
Technique:  Northern blot
References:  1
Tissue Distribution Comments
Transcripts of GPR62 were not detected in the liver when examined by Northern blot analysis [1].
Biologically Significant Variants
Type:  SNP
Species:  Human
Change:  S365R
Global MAF (%):  1
Subpopulation MAF (%):  AFR: 5
Minor allele count:  G=0.011/24
Comment on frequency:  Low frequency (<10% in all tested populations)
SNP accession: 
Validation:  1000 Genomes, Frequency
Type:  SNP
Species:  Human
Change:  V313L
Global MAF (%):  11
Subpopulation MAF (%):  AFR|AMR|ASN|EUR: 36|3|8|2
Minor allele count:  C=0.113/247
SNP accession: 
Validation:  1000 Genomes, HapMap, Frequency
General Comments
GPR62 has higher expression in the brain, indicating its cognate ligand may be a neurotransmitter [1].

REFERENCES

1. Lee DK, George SR, Cheng R, Nguyen T, Liu Y, Brown M, Lynch KR, O'Dowd BF. (2001) Identification of four novel human G protein-coupled receptors expressed in the brain. Brain Res. Mol. Brain Res.86 (1-2): 13-22. [PMID:11165367]

To cite this database page, please use the following:

Anthony P. Davenport, Stephen Alexander, Joanna L. Sharman, Adam J. Pawson, Helen E. Benson, Amy E. Monaghan, Wen Chiy Liew, Chido Mpamhanga, Jim Battey, Richard V. Benya, Robert T. Jensen, Sadashiva Karnik, Evi Kostenis, Eliot Spindel, Laura Storjohann, Kalyan Tirupula, Tom I. Bonner, Richard Neubig, Jean-Philippe Pin, Michael Spedding, Anthony Harmar.
Class A Orphans: GPR62. Last modified on 09/07/2013. Accessed on 19/04/2014. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=111.

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