Nomenclature: GPR45

Family: Class A Orphans

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates. 

Contents

Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 372 2q11.1-q12 GPR45 G protein-coupled receptor 45 2
Mouse 7 373 1 C1 Gpr45 G protein-coupled receptor 45
Rat 7 373 9q22 Gpr45 G protein-coupled receptor 45
Previous and Unofficial Names
PSP24-1
PSP24-alpha
PSP24A
PSP24
GPR45
G-protein coupled receptor 45
high-affinity lysophosphatidic acid receptor
probable G-protein coupled receptor 45
PSP24(ALPHA)
Gpr45_predicted
LOC301372
G protein-coupled receptor 45
G protein-coupled receptor 45 (predicted)
PSP24alpha
9230112G11Rik
AW046772
Database Links
Ensembl Gene
Entrez Gene
GPCRDB
GeneCards
GenitoUrinary Development Molecular Anatomy Project
HomoloGene
Human Protein Reference Database
InterPro
KEGG Gene
OMIM
PharmGKB Gene
PhosphoSitePlus
Protein Ontology (PRO)
RefSeq Nucleotide
RefSeq Protein
TreeFam
UniGene Hs.
UniProtKB
Wikipedia
Tissue Distribution
Basal forebrain, frontal cortex, caudate, liver
Species:  Human
Technique:  Northern blot
References:  2
Neuronal cells, such as olfactory mitral cells, cortical neurons, hippocampal pyramidal cells, purkinje cells in the cerebellum
Species:  Mouse
Technique:  in situ hybridisation
References:  1
Brain
Species:  Mouse
Technique:  Northern blot
References:  1
Tissue Distribution Comments
No transcripts of GPR45 were detected in thalamus, hippocampus or putamen [2]. The expression of GPR45 in mouse brain starts from E13 and remains constant throughout adulthood [1].
Expression Datasets

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Biologically Significant Variants
Type:  SNP
Species:  Human
Change:  L312F
Global MAF (%):  10
Subpopulation MAF (%):  AFR|AMR|ASN|EUR: 5|12|2|16
Minor allele count:  T=0.096/209
SNP accession: 
Validation:  1000 Genomes, HapMap
Available Assays
DiscoveRx PathHunter® CHO-K1 GPR45 β-Arrestin Orphan GPCR Cell Line (Cat no. 93-0374C2A)
PathHunter® eXpress GPR45 CHO-K1 β-Arrestin Orphan GPCR Assay (Cat no. 93-0374E2ACP1M)
PathHunter® HEK 293 GPR45 β-Arrestin Orphan GPCR Cell Line (Cat no. 93-0374C1A)
more info

REFERENCES

1. Kawasawa Y, Kume K, Nakade S, Haga H, Izumi T, Shimizu T. (2000) Brain-specific expression of novel G-protein-coupled receptors, with homologies to Xenopus PSP24 and human GPR45. Biochem. Biophys. Res. Commun.276 (3): 952-6. [PMID:11027574]

2. Marchese A, Sawzdargo M, Nguyen T, Cheng R, Heng HH, Nowak T, Im DS, Lynch KR, George SR, O'dowd BF. (1999) Discovery of three novel orphan G-protein-coupled receptors. Genomics56 (1): 12-21. [PMID:10036181]

To cite this database page, please use the following:

Anthony P. Davenport, Stephen Alexander, Joanna L. Sharman, Adam J. Pawson, Helen E. Benson, Amy E. Monaghan, Wen Chiy Liew, Chido Mpamhanga, Jim Battey, Richard V. Benya, Robert T. Jensen, Sadashiva Karnik, Evi Kostenis, Eliot Spindel, Laura Storjohann, Kalyan Tirupula, Tom I. Bonner, Richard Neubig, Jean-Philippe Pin, Michael Spedding, Anthony Harmar.
Class A Orphans: GPR45. Last modified on 09/08/2013. Accessed on 20/10/2014. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=106.

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