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GPR45

Family: Class A Orphans

Contents:
Gene and Protein Information
Previous and Unofficial Names
Database Links
Tissue Distribution
Expression Datasets
Biologically Significant Variants
References
Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 372 2q11.1-q12 GPR45 G protein-coupled receptor 45 2
Mouse 7 373 1 C1 Gpr45 G protein-coupled receptor 45
Rat 7 373 9q22 Gpr45 G protein-coupled receptor 45
Previous and Unofficial Names
PSP24
PSP24-1
PSP24-alpha
PSP24A
GPR45
G-protein coupled receptor 45
high-affinity lysophosphatidic acid receptor
probable G-protein coupled receptor 45
PSP24(ALPHA)
Gpr45_predicted
LOC301372
G protein-coupled receptor 45
G protein-coupled receptor 45 (predicted)
PSP24alpha
9230112G11Rik
AW046772
Database Links
Ensembl ENSG00000135973 (Hs), ENSMUSG00000041907 (Mm), ENSRNOG00000016446 (Rn)
Entrez Gene 11250 (Hs), 93690 (Mm), 301372 (Rn)
GeneCards GPR45 (Hs)
GenitoUrinary Development Molecular Anatomy Project Gpr45 (Mm)
HomoloGene 5228 (Hs)
Human Protein Reference Database 05325 (Hs)
InterPro Q9Y5Y3 (Hs), Q9EQQ4 (Mm)
KEGG Gene hsa:11250 (Hs), mmu:93690 (Mm), rno:301372 (Rn)
OMIM 604838 (Hs)
PharmGKB Gene PA28892 (Hs)
PhosphoSitePlus Q9Y5Y3 (Hs), Q9EQQ4 (Mm)
Protein Ontology (PRO) PRO:000001645 (Hs)
RefSeq Nucleotide NM_007227 (Hs), NM_053107 (Mm), NM_001106906 (Rn)
RefSeq Protein NP_009158 (Hs), NP_444337 (Mm), NP_001100376 (Rn)
TreeFam ENSG00000135973 (Hs), ENSMUSG00000041907 (Mm), ENSRNOG00000016446 (Rn)
UniGene Hs. 590903 (Hs)
UniProt Q9Y5Y3 (Hs), Q9EQQ4 (Mm)
Wikipedia GPR45
Orphan and other 7TM receptors
Tissue Distribution
Basal forebrain, frontal cortex, caudate, liver
Species:  Human
Technique:  Northern blot
References:  2
Neuronal cells, such as olfactory mitral cells, cortical neurons, hippocampal pyramidal cells, purkinje cells in the cerebellum
Species:  Mouse
Technique:  in situ hybridisation
References:  1
Brain
Species:  Mouse
Technique:  Northern blot
References:  1
Tissue Distribution Comments
No transcripts of GPR45 were detected in thalamus, hippocampus or putamen [2]. The expression of GPR45 in mouse brain starts from E13 and remains constant throughout adulthood [1].
Expression Datasets

Click here to show/hide data

Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Biologically Significant Variants
L312F
SNP accession:  rs35946826 
Type:  Naturally occurring SNPs.
Species:  Human
References: 
Available Assays
DiscoveRx PathHunter® HEK 293 GPR45 (Orphan) High Expression β-Arrestin Cell Line Human Cat No. 93-0374C1A
DiscoveRx PathHunter® CHO-K1 GPR45 (Orphan) High Expression β-Arrestin Cell Line Human Cat No. 93-0374C2A
DiscoveRx PathHunter® eXpress GPR45 CHO-K1 β-Arrestin (Orphan) GPCR Assay Human Cat No. 93-0374E2ACP1

REFERENCES

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1. Kawasawa, Y; Kume, K; Nakade, S; Haga, H; Izumi, T; Shimizu, T. (2000) Brain-specific expression of novel G-protein-coupled receptors, with homologies to Xenopus PSP24 and human GPR45. Biochem. Biophys. Res. Commun., 276 (3): 952-6. [PMID:11027574]

2. Marchese, A; Sawzdargo, M; Nguyen, T; Cheng, R; Heng, HH; Nowak, T; Im, DS; Lynch, KR; George, SR; O'dowd, BF. (1999) Discovery of three novel orphan G-protein-coupled receptors. Genomics, 56 (1): 12-21. [PMID:10036181]

To cite this database page, please use the following:

Wen Chiy Liew.
Class A Orphans: GPR45. Last modified on 02/11/2012. Accessed on 22/05/2013. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=106.


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