Nomenclature: Retinoid X receptor-β

Systematic Nomenclature: NR2B2

Family: 2B. Retinoid X receptors

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates. 

Contents

Gene and Protein Information
Species AA Chromosomal Location Gene Symbol Gene Name Reference
Human 533 6p21.3 RXRB retinoid X receptor, beta 2,18
Mouse 520 17 18.49 cM Rxrb retinoid X receptor beta 12,14,17-18,20
Rat 518 20p12 Rxrb retinoid X receptor beta 33
Previous and Unofficial Names
H-2RIIBP
RCoR-1
RXRβ
NR2B2
nuclear receptor subfamily 2 group B member 2
RXR-beta
Retinoic acid receptor beta
nuclear receptor co-regulator 1
nuclear receptor coregulator 1
retinoic acid receptor RXR-beta
retinoic acid receptor, beta
Rub
AL023085
Database Links
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
GeneCards
GenitoUrinary Development Molecular Anatomy Project
HomoloGene
Human Protein Reference Database
InterPro
KEGG Gene
NURSA Receptor
OMIM
PharmGKB Gene
PhosphoSitePlus
RefSeq Nucleotide
RefSeq Protein
TreeFam
UniProtKB
Wikipedia
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  Heterodimeric complex of LXRalpha and RXRbeta ligand-binding domains in a fully agonistic conformation
PDB Id:  1UHL
Ligand:  T0901317
Resolution:  2.9Å
Species:  Human
References:  28
Natural/Endogenous Ligands
alitretinoin
Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
AGN194204 Mm Agonist 8.44 pIC50 32
pIC50 8.44 [32]
LG100268 N/A Agonist 8.1 – 8.5 pIC50 3,15,29
pIC50 8.1 – 8.5 [3,15,29]
bexarotene Hs Agonist 7.7 pIC50 4-5,29
pIC50 7.7 [4-5,29]
alitretinoin N/A Agonist 6.9 – 8.2 pIC50 1,13,15,19-20,26
pIC50 6.9 – 8.2 [1,13,15,19-20,26]
View species-specific agonist tables
Antagonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
LG100754 Hs Antagonist 8.0 pIC50 6,11,15
pIC50 8.0 [6,11,15]
DNA Binding
Structure:  Homodimer, Heterodimer, RXR partner
HRE core sequence:  5’-AGGTCA
Response element:  DR1, DR2, DR3, DR4, DR5
DNA Binding Comments
RXR can bind to several DR elements as common heterodimerization partners for members of the subfamily 1 of nuclear receptors. In direct repeats, RXR generally occupies the 5’-element. RXR can also form RXR-RXR homodimers that bind to DR1.
Name Interaction Effect Reference
Co-binding Partners Comments
Binding partners are the same as RXRα
Main Co-regulators
Name Activity Specific Ligand dependent AF-2 dependent Comments References
NCOA1 Co-activator No Yes Yes 16,24,27
NCOA2 Co-activator No Yes Yes 16,30-31
NCOA3 Co-activator No Yes Yes 9,16,24
Tissue Distribution
Ubiquitous
Species:  Human
Technique:  Northern, in situ, Western, other
References:  10,12,20,33
Tissue Distribution Comments
Similar expression patterns are observed in rodents and other mammals.
Functional Assays
Induction of apoptosis (associated to RARa activation)
Species:  Human
Tissue:  Leukemia cell lines (HL60 or PLB-985)
Response measured:  Apoptosis (typical apoptotic morphological features, genomic DNA laddering, TUNEL assay).
References:  25-26
Cellular differentiation
Species:  Mouse
Tissue:  Fibroblasts - embryo - (3T3-L1 pre-adipocytes)
Response measured:  3T3-L1 cells are differentiated to adipocytes. The extend of the differentiation is quantitated by measuring the accumulation of triglyceride produce within the cytoplasm of the adipocyte.
References:  5,7-8
Physiological Consequences of Altering Gene Expression
RXR-β null mice:- display male sterility due to a defective spermatogenesis, show abnormal lipid metabolism in Sertoli cells and behavorial defects.
Species:  Mouse
Tissue: 
Technique:  Knock-out by homologous recombination in embryonic stem cells
References:  21-23
Phenotypes, Alleles and Disease Models Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Rxrbtm1Ipc Rxrbtm1Ipc/Rxrbtm1Ipc
involves: 129S2/SvPas
MGI:98215  MP:0008898 abnormal acrosome morphology PMID: 8557197 
Rxratm1Ipc|Rxrbtm1Mma Rxratm1Ipc/Rxratm1Ipc,Rxrbtm1Mma/Rxrbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:98214  MGI:98215  MP:0010584 abnormal conotruncus septation PMID: 19255444 
Rxratm1Ipc|Rxrbtm1Mma Rxratm1Ipc/Rxratm1Ipc,Rxrbtm1Mma/Rxrbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:98214  MGI:98215  MP:0005300 abnormal corneal stroma morphology PMID: 19255444 
Rxratm1Ipc|Rxratm4Ipc|Rxrbtm1Mma|Rxrbtm1Pcn|Tg(KRT14-cre/ERT2)1Ipc Rxratm1Ipc/Rxratm4Ipc,Rxrbtm1Mma/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
involves: 129S2/SvPas
MGI:2177423  MGI:98214  MGI:98215  MP:0001240 abnormal epidermis stratum corneum morphology PMID: 16751185 
Rxratm4Ipc|Rxrbtm1Pcn|Tg(KRT14-cre)1Ipc Rxratm4Ipc/Rxratm4Ipc,Rxrbtm1Pcn/Rxrbtm1Pcn,Tg(KRT14-cre)1Ipc/0
involves: 129S2/SvPas * C57BL/6 * SJL
MGI:2177412  MGI:98214  MGI:98215  MP:0001240 abnormal epidermis stratum corneum morphology PMID: 16751185 
Rxratm1Ipc|Rxratm4Ipc|Rxrbtm1Mma|Rxrbtm1Pcn|Tg(KRT14-cre)1Ipc Rxratm1Ipc/Rxratm4Ipc,Rxrbtm1Mma/Rxrbtm1Pcn,Tg(KRT14-cre)1Ipc/0
involves: 129S2/SvPas * C57BL/6 * SJL
MGI:2177412  MGI:98214  MGI:98215  MP:0001240 abnormal epidermis stratum corneum morphology PMID: 16751185 
Rarbtm1Vgi|Rxrbtm1Rev Rarbtm1Vgi/Rarbtm1Vgi,Rxrbtm1Rev/Rxrbtm1Rev
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
MGI:97857  MGI:98215  MP:0002912 abnormal excitatory postsynaptic potential PMID: 9883728 
Rxratm1Ipc|Rxrbtm1Mma Rxratm1Ipc/Rxratm1Ipc,Rxrbtm1Mma/Rxrbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:98214  MGI:98215  MP:0001286 abnormal eye development PMID: 19255444 
Rxratm1Ipc|Rxrbtm1Mma Rxratm1Ipc/Rxratm1Ipc,Rxrbtm1Mma/Rxrbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:98214  MGI:98215  MP:0001340 abnormal eyelid morphology PMID: 19255444 
Rxratm1Ipc|Rxratm4Ipc|Rxrbtm1Mma|Rxrbtm1Pcn|Tg(KRT14-cre/ERT2)1Ipc Rxratm1Ipc/Rxratm4Ipc,Rxrbtm1Mma/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
involves: 129S2/SvPas
MGI:2177423  MGI:98214  MGI:98215  MP:0002655 abnormal keratinocyte morphology PMID: 16751185 
Rxratm4Ipc|Rxrbtm1Pcn|Tg(KRT14-cre)1Ipc Rxratm4Ipc/Rxratm4Ipc,Rxrbtm1Pcn/Rxrbtm1Pcn,Tg(KRT14-cre)1Ipc/0
involves: 129S2/SvPas * C57BL/6 * SJL
MGI:2177412  MGI:98214  MGI:98215  MP:0002655 abnormal keratinocyte morphology PMID: 16751185 
Rxratm1Ipc|Rxratm4Ipc|Rxrbtm1Mma|Rxrbtm1Pcn|Tg(KRT14-cre)1Ipc Rxratm1Ipc/Rxratm4Ipc,Rxrbtm1Mma/Rxrbtm1Pcn,Tg(KRT14-cre)1Ipc/0
involves: 129S2/SvPas * C57BL/6 * SJL
MGI:2177412  MGI:98214  MGI:98215  MP:0002655 abnormal keratinocyte morphology PMID: 16751185 
Rxratm1Ipc|Rxrbtm1Mma Rxratm1Ipc/Rxratm1Ipc,Rxrbtm1Mma/Rxrbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:98214  MGI:98215  MP:0001303 abnormal lens morphology PMID: 19255444 
Rxratm4Ipc|Rxrbtm1Pcn|Tg(KRT14-cre/ERT2)1Ipc Rxratm4Ipc/Rxratm4Ipc,Rxrbtm1Pcn/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
involves: 129S2/SvPas
MGI:2177423  MGI:98214  MGI:98215  MP:0002339 abnormal lymph node morphology PMID: 16199515 
Rxratm1Ipc|Rxrbtm1Mma Rxratm1Ipc/Rxratm1Ipc,Rxrbtm1Mma/Rxrbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:98214  MGI:98215  MP:0004056 abnormal myocardium compact layer morphology PMID: 19255444 
Rxratm1Ipc|Rxrbtm1Mma Rxratm1Ipc/Rxratm1Ipc,Rxrbtm1Mma/Rxrbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:98214  MGI:98215  MP:0002864 abnormal ocular fundus morphology PMID: 19255444 
Rxratm1Ipc|Rxrbtm1Mma Rxratm1Ipc/Rxratm1Ipc,Rxrbtm1Mma/Rxrbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:98214  MGI:98215  MP:0008259 abnormal optic disc morphology PMID: 19255444 
Rxratm2Ipc|Rxrbtm1Mma Rxratm2Ipc/Rxratm2Ipc,Rxrbtm1Mma/Rxrbtm1Mma
involves: 129/Sv * C57BL/6
MGI:98214  MGI:98215  MP:0006030 abnormal otic vesicle development PMID: 19255444 
Rxratm1Ipc|Rxrbtm1Mma Rxratm1Ipc/Rxratm1Ipc,Rxrbtm1Mma/Rxrbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:98214  MGI:98215  MP:0001325 abnormal retina morphology PMID: 19255444 
Rxratm2Ipc|Rxrbtm1Mma Rxratm2Ipc/Rxratm2Ipc,Rxrbtm1Mma/Rxrbtm1Mma
involves: 129/Sv * C57BL/6
MGI:98214  MGI:98215  MP:0000933 abnormal rhombomere morphology PMID: 19255444 
Rxrbtm1Ipc Rxrbtm1Ipc/Rxrbtm1Ipc
involves: 129S2/SvPas
MGI:98215  MP:0002216 abnormal seminiferous tubule morphology PMID: 8557197 
Rxrbtm1Mma Rxrbtm1Mma/Rxrbtm1Mma
involves: 129 * C57BL/6
MGI:98215  MP:0002784 abnormal Sertoli cell morphology PMID: 14993927 
Nr1h2+|Nr1h2tm1.1Gstr|Rxrb+|Rxrbtm1Mma Nr1h2tm1.1Gstr/Nr1h2+,Rxrbtm1Mma/Rxrb+
involves: 129 * C57BL/6
MGI:1352463  MGI:98215  MP:0002784 abnormal Sertoli cell morphology PMID: 14993927 
Rxratm1Ipc|Rxratm4Ipc|Rxrbtm1Mma|Rxrbtm1Pcn|Tg(KRT14-cre)1Ipc Rxratm1Ipc/Rxratm4Ipc,Rxrbtm1Mma/Rxrbtm1Pcn,Tg(KRT14-cre)1Ipc/0
involves: 129S2/SvPas * C57BL/6 * SJL
MGI:2177412  MGI:98214  MGI:98215  MP:0001191 abnormal skin condition PMID: 16751185 
Rxratm1Ipc|Rxratm4Ipc|Rxrbtm1Mma|Rxrbtm1Pcn|Tg(KRT14-cre/ERT2)1Ipc Rxratm1Ipc/Rxratm4Ipc,Rxrbtm1Mma/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
involves: 129S2/SvPas
MGI:2177423  MGI:98214  MGI:98215  MP:0002060 abnormal skin morphology PMID: 16751185 
Rxratm1Ipc|Rxratm4Ipc|Rxrbtm1Mma|Rxrbtm1Pcn|Tg(KRT14-cre)1Ipc Rxratm1Ipc/Rxratm4Ipc,Rxrbtm1Mma/Rxrbtm1Pcn,Tg(KRT14-cre)1Ipc/0
involves: 129S2/SvPas * C57BL/6 * SJL
MGI:2177412  MGI:98214  MGI:98215  MP:0002060 abnormal skin morphology PMID: 16751185 
Rarbtm1Vgi|Rxrbtm1Rev Rarbtm1Vgi/Rarbtm1Vgi,Rxrbtm1Rev/Rxrbtm1Rev
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
MGI:97857  MGI:98215  MP:0001463 abnormal spatial learning PMID: 9883728 
Rxrbtm1Ipc Rxrbtm1Ipc/Rxrbtm1Ipc
involves: 129S2/SvPas
MGI:98215  MP:0009832 abnormal sperm mitochondrial sheath morphology PMID: 8557197 
Rxratm2Ipc|Rxrbtm1Mma Rxratm2Ipc/Rxratm2Ipc,Rxrbtm1Mma/Rxrbtm1Mma
involves: 129/Sv * C57BL/6
MGI:98214  MGI:98215  MP:0006356 abnormal third branchial arch artery morphology PMID: 19255444 
Rxratm2Ipc|Rxrbtm1Mma Rxratm2Ipc/Rxratm2Ipc,Rxrbtm1Mma/Rxrbtm1Mma
involves: 129/Sv * C57BL/6
MGI:98214  MGI:98215  MP:0006339 abnormal third branchial arch morphology PMID: 19255444 
Rxrbtm1Ipc Rxrbtm1Ipc/Rxrbtm1Ipc
involves: 129S2/SvPas
MGI:98215  MP:0008839 absent acrosome PMID: 8557197 
Rarbtm1Vgi|Rxrbtm1Rev Rarbtm1Vgi/Rarbtm1Vgi,Rxrbtm1Rev/Rxrbtm1Rev
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
MGI:97857  MGI:98215  MP:0001899 absent long term depression PMID: 9883728 
Rxratm4Ipc|Rxrbtm1Pcn|Tg(KRT14-cre/ERT2)1Ipc Rxratm4Ipc/Rxratm4Ipc,Rxrbtm1Pcn/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
involves: 129S2/SvPas
MGI:2177423  MGI:98214  MGI:98215  MP:0000414 alopecia PMID: 16199515 
Rxratm1Ipc|Rxratm4Ipc|Rxrbtm1Mma|Rxrbtm1Pcn|Tg(KRT14-cre/ERT2)1Ipc Rxratm1Ipc/Rxratm4Ipc,Rxrbtm1Mma/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
involves: 129S2/SvPas
MGI:2177423  MGI:98214  MGI:98215  MP:0000414 alopecia PMID: 16199515 
Rxrbtm1Ipc Rxrbtm1Ipc/Rxrbtm1Ipc
involves: 129S2/SvPas
MGI:98215  MP:0001155 arrest of spermatogenesis PMID: 8557197 
Rxrbtm1Ipc Rxrbtm1Ipc/Rxrbtm1Ipc
involves: 129S2/SvPas
MGI:98215  MP:0002675 asthenozoospermia PMID: 8557197 
Rxrbtm1Ipc Rxrbtm1Ipc/Rxrbtm1Ipc
involves: 129S2/SvPas
MGI:98215  MP:0009238 coiled sperm flagellum PMID: 8557197 
Rxrbtm1Mma Rxrbtm1Mma/Rxrbtm1Mma
involves: 129 * C57BL/6
MGI:98215  MP:0003193 decreased cholesterol efflux PMID: 14993927 
Rxratm4Ipc|Rxrbtm1Pcn|Tg(KRT14-cre)1Ipc Rxratm4Ipc/Rxratm4Ipc,Rxrbtm1Pcn/Rxrbtm1Pcn,Tg(KRT14-cre)1Ipc/0
involves: 129S2/SvPas * C57BL/6 * SJL
MGI:2177412  MGI:98214  MGI:98215  MP:0003983 decreased cholesterol level PMID: 16751185 
Rxrbtm1Ipc Rxrbtm1Ipc/Rxrbtm1Ipc
involves: 129S2/SvPas
MGI:98215  MP:0002209 decreased germ cell number PMID: 8557197 
Rxratm4Ipc|Rxrbtm1Pcn|Tg(KRT14-cre/ERT2)1Ipc Rxratm4Ipc/Rxratm4Ipc,Rxrbtm1Pcn/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
involves: 129S2/SvPas
MGI:2177423  MGI:98214  MGI:98215  MP:0001247 dermal cysts PMID: 16199515 
Rxratm1Ipc|Rxratm4Ipc|Rxrbtm1Mma|Rxrbtm1Pcn|Tg(KRT14-cre/ERT2)1Ipc Rxratm1Ipc/Rxratm4Ipc,Rxrbtm1Mma/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
involves: 129S2/SvPas
MGI:2177423  MGI:98214  MGI:98215  MP:0004971 dermal hyperplasia PMID: 16199515 
Rxratm4Ipc|Rxrbtm1Pcn|Tg(KRT14-cre/ERT2)1Ipc Rxratm4Ipc/Rxratm4Ipc,Rxrbtm1Pcn/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
involves: 129S2/SvPas
MGI:2177423  MGI:98214  MGI:98215  MP:0001194 dermatitis PMID: 16199515 
Rxrbtm1Ipc Rxrbtm1Ipc/Rxrbtm1Ipc
involves: 129S2/SvPas
MGI:98215  MP:0009231 detached acrosome PMID: 8557197 
Rxratm4Ipc|Rxrbtm1Pcn|Tg(KRT14-cre/ERT2)1Ipc Rxratm4Ipc/Rxratm4Ipc,Rxrbtm1Pcn/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
involves: 129S2/SvPas
MGI:2177423  MGI:98214  MGI:98215  MP:0003853 dry skin PMID: 16199515 
Rxratm4Ipc|Rxrbtm1Pcn|Tg(KRT14-cre/ERT2)1Ipc Rxratm4Ipc/Rxratm4Ipc,Rxrbtm1Pcn/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
involves: 129S2/SvPas
MGI:2177423  MGI:98214  MGI:98215  MP:0001849 ear inflammation PMID: 16199515 
Rxratm1.1Pcn|Rxrbtm1Ipc Rxratm1.1Pcn/Rxratm1.1Pcn,Rxrbtm1Ipc/Rxrbtm1Ipc
involves: 129S2/SvPas * C57BL/6 * SJL
MGI:98214  MGI:98215  MP:0003984 embryonic growth retardation PMID: 19255444 
Rxratm4Ipc|Rxrbtm1Pcn|Tg(KRT14-cre/ERT2)1Ipc Rxratm4Ipc/Rxratm4Ipc,Rxrbtm1Pcn/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
involves: 129S2/SvPas
MGI:2177423  MGI:98214  MGI:98215  MP:0000599 enlarged liver PMID: 16199515 
Rxratm4Ipc|Rxrbtm1Pcn|Tg(KRT14-cre/ERT2)1Ipc Rxratm4Ipc/Rxratm4Ipc,Rxrbtm1Pcn/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
involves: 129S2/SvPas
MGI:2177423  MGI:98214  MGI:98215  MP:0000702 enlarged lymph nodes PMID: 16199515 
Rxratm4Ipc|Rxrbtm1Pcn|Tg(KRT14-cre/ERT2)1Ipc Rxratm4Ipc/Rxratm4Ipc,Rxrbtm1Pcn/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
involves: 129S2/SvPas
MGI:2177423  MGI:98214  MGI:98215  MP:0000691 enlarged spleen PMID: 16199515 
Rxratm4Ipc|Rxrbtm1Pcn|Tg(KRT14-cre/ERT2)1Ipc Rxratm4Ipc/Rxratm4Ipc,Rxrbtm1Pcn/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
involves: 129S2/SvPas
MGI:2177423  MGI:98214  MGI:98215  MP:0001222 epidermal hyperplasia PMID: 16199515 
Rxratm1Ipc|Rxratm4Ipc|Rxrbtm1Mma|Rxrbtm1Pcn|Tg(KRT14-cre/ERT2)1Ipc Rxratm1Ipc/Rxratm4Ipc,Rxrbtm1Mma/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
involves: 129S2/SvPas
MGI:2177423  MGI:98214  MGI:98215  MP:0001222 epidermal hyperplasia PMID: 16199515 
Rxratm4Ipc|Rxrbtm1Pcn|Tg(KRT14-cre/ERT2)1Ipc Rxratm4Ipc/Rxratm4Ipc,Rxrbtm1Pcn/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
involves: 129S2/SvPas
MGI:2177423  MGI:98214  MGI:98215  MP:0003413 hair follicle degeneration PMID: 16199515 
Rxratm1Ipc|Rxratm4Ipc|Rxrbtm1Mma|Rxrbtm1Pcn|Tg(KRT14-cre/ERT2)1Ipc Rxratm1Ipc/Rxratm4Ipc,Rxrbtm1Mma/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
involves: 129S2/SvPas
MGI:2177423  MGI:98214  MGI:98215  MP:0003413 hair follicle degeneration PMID: 16199515 
Rxratm1Ipc|Rxratm4Ipc|Rxrbtm1Mma|Rxrbtm1Pcn|Tg(KRT14-cre/ERT2)1Ipc Rxratm1Ipc/Rxratm4Ipc,Rxrbtm1Mma/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
involves: 129S2/SvPas
MGI:2177423  MGI:98214  MGI:98215  MP:0002461 increased immunoglobulin level PMID: 16199515 
Rxratm4Ipc|Rxrbtm1Pcn|Tg(KRT14-cre/ERT2)1Ipc Rxratm4Ipc/Rxratm4Ipc,Rxrbtm1Pcn/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
involves: 129S2/SvPas
MGI:2177423  MGI:98214  MGI:98215  MP:0000218 increased leukocyte cell number PMID: 16199515 
Rxrbtm1Ipc Rxrbtm1Ipc/Rxrbtm1Ipc
involves: 129S2/SvPas
MGI:98215  MP:0001925 male infertility PMID: 8557197 
Rxratm4Ipc|Rxrbtm1Pcn|Tg(KRT14-cre/ERT2)1Ipc Rxratm4Ipc/Rxratm4Ipc,Rxrbtm1Pcn/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
involves: 129S2/SvPas
MGI:2177423  MGI:98214  MGI:98215  MP:0001246 mixed cellular infiltration to dermis PMID: 16199515 
Rxratm1Ipc|Rxratm4Ipc|Rxrbtm1Mma|Rxrbtm1Pcn|Tg(KRT14-cre/ERT2)1Ipc Rxratm1Ipc/Rxratm4Ipc,Rxrbtm1Mma/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
involves: 129S2/SvPas
MGI:2177423  MGI:98214  MGI:98215  MP:0001246 mixed cellular infiltration to dermis PMID: 16199515 
Rxrbtm1Pcn|Tg(KRT14-cre)1Ipc Rxrbtm1Pcn/Rxrbtm1Pcn,Tg(KRT14-cre)1Ipc/0
involves: C57BL/6 * SJL
MGI:2177412  MGI:98215  MP:0002169 no abnormal phenotype detected PMID: 16751185 
Rxrbtm1Ipc Rxrbtm1Ipc/Rxrbtm1Ipc
involves: 129S2/SvPas
MGI:98215  MP:0002687 oligozoospermia PMID: 8557197 
Rxrbtm1Ipc Rxrbtm1Ipc/Rxrbtm1Ipc
involves: 129S2/SvPas
MGI:98215  MP:0002081 perinatal lethality PMID: 8557197 
Rxrbtm1Ipc Rxrbtm1Ipc/Rxrbtm1Ipc
involves: 129S2/SvPas
MGI:98215  MP:0002080 prenatal lethality PMID: 8557197 
Rarbtm1Vgi|Rxrbtm1Rev Rarbtm1Vgi/Rarbtm1Vgi,Rxrbtm1Rev/Rxrbtm1Rev
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
MGI:97857  MGI:98215  MP:0001473 reduced long term potentiation PMID: 9883728 
Rxratm4Ipc|Rxrbtm1Pcn|Tg(KRT14-cre/ERT2)1Ipc Rxratm4Ipc/Rxratm4Ipc,Rxrbtm1Pcn/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
involves: 129S2/SvPas
MGI:2177423  MGI:98214  MGI:98215  MP:0001192 scaly skin PMID: 16199515 
Rxrbtm1Ipc Rxrbtm1Ipc/Rxrbtm1Ipc
involves: 129S2/SvPas
MGI:98215  MP:0001154 seminiferous tubule degeneration PMID: 8557197 
Rxratm4Ipc|Rxrbtm1Pcn|Tg(KRT14-cre)1Ipc Rxratm4Ipc/Rxratm4Ipc,Rxrbtm1Pcn/Rxrbtm1Pcn,Tg(KRT14-cre)1Ipc/0
involves: 129S2/SvPas * C57BL/6 * SJL
MGI:2177412  MGI:98214  MGI:98215  MP:0001196 shiny skin PMID: 16751185 
Rxratm4Ipc|Rxrbtm1Pcn|Tg(KRT14-cre/ERT2)1Ipc Rxratm4Ipc/Rxratm4Ipc,Rxrbtm1Pcn/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
involves: 129S2/SvPas
MGI:2177423  MGI:98214  MGI:98215  MP:0001212 skin lesions PMID: 16199515 
Rxrbtm1Ipc Rxrbtm1Ipc/Rxrbtm1Ipc
involves: 129S2/SvPas
MGI:98215  MP:0005578 teratozoospermia PMID: 8557197 
General Comments
Through its heterodimeric interaction with many other nuclear receptors, RXRβ may play a role in a wide variety of diseases as well as in the control of multiple target genes.

REFERENCES

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To cite this database page, please use the following:

2B. Retinoid X receptors: Retinoid X receptor-β. Last modified on 01/05/2014. Accessed on 02/08/2014. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=611.

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