Nomenclature: P2X5

Family: P2X receptors

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation. 


Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 2 422 17p13.3 P2RX5 purinergic receptor P2X, ligand-gated ion channel, 5 3
Mouse 2 455 11 B5 P2rx5 purinergic receptor P2X, ligand-gated ion channel, 5 2
Rat 2 455 10q24 P2rx5 purinergic receptor P2X, ligand-gated ion channel, 5 1
Previous and Unofficial Names
ATP receptor
P2X purinoceptor 5
purinergic receptor P2X, ligand-gated ion channel, 5
Database Links
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Reference Database
PharmGKB Gene
Protein Ontology (PRO)
RefSeq Nucleotide
RefSeq Protein
UniGene Hs.
Natural/Endogenous Ligands
General Comments
The human P2X5 subunit exists as 3 alternatively spliced isoforms (A, which is tabulated above; B, NP_778255 - 397 aa and C, NP_778256 - 178 aa).


1. Collo G, North RA, Kawashima E, Merlo-Pich E, Neidhart S, Surprenant A, Buell G. (1996) Cloning OF P2X5 and P2X6 receptors and the distribution and properties of an extended family of ATP-gated ion channels. J. Neurosci.16 (8): 2495-507. [PMID:8786426]

2. Cox JA, Barmina O, Voigt MM. (2001) Gene structure, chromosomal localization, cDNA cloning and expression of the mouse ATP-gated ionotropic receptor P2X5 subunit. Gene270 (1-2): 145-52. [PMID:11404011]

3. Lê KT, Paquet M, Nouel D, Babinski K, Séguéla P. (1997) Primary structure and expression of a naturally truncated human P2X ATP receptor subunit from brain and immune system. FEBS Lett.418 (1-2): 195-9. [PMID:9414125]

To cite this database page, please use the following:

Francesco Di Virgilio, Richard J Evans, Michael F Jarvis, Charles Kennedy, Baljit S. Khakh, Patrizia Pellegatti, John A. Peters.
P2X receptors: P2X5. Last modified on 14/03/2014. Accessed on 31/10/2014. IUPHAR database (IUPHAR-DB),

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