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P2X5

Family: P2X receptors

Contents:
Gene and Protein Information
Previous and Unofficial Names
Database Links
General Comments
References
Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 2 422 17p13.3 P2RX5 purinergic receptor P2X, ligand-gated ion channel, 5 3
Mouse 2 455 11 B5 P2rx5 purinergic receptor P2X, ligand-gated ion channel, 5 2
Rat 2 455 10q24 P2rx5 purinergic receptor P2X, ligand-gated ion channel, 5 1
Previous and Unofficial Names
P2X5
ATP receptor
P2X purinoceptor 5
purinergic receptor P2X, ligand-gated ion channel, 5
Database Links
ChEMBL Target 10205 (Hs), 10538 (Rn)
Ensembl ENSG00000083454 (Hs), ENSMUSG00000005950 (Mm), ENSRNOG00000019208 (Rn)
Entrez Gene 5026 (Hs), 94045 (Mm), 113995 (Rn)
GeneCards P2RX5 (Hs)
GenitoUrinary Development Molecular Anatomy Project P2rx5 (Mm)
HomoloGene 1924 (Hs)
Human Protein Reference Database 09110 (Hs)
InterPro Q93086 (Hs), P51578 (Rn)
KEGG Gene hsa:5026 (Hs), mmu:94045 (Mm), rno:113995 (Rn)
OMIM 602836 (Hs)
PharmGKB Gene PA32865 (Hs)
PhosphoSitePlus Q93086 (Hs)
Protein Ontology (PRO) PRO:000012192 (Hs)
RefSeq Nucleotide NM_002561 (Hs), NM_033321 (Mm), NM_080780 (Rn)
RefSeq Protein NP_002552 (Hs), NP_201578 (Mm), NP_542958 (Rn)
TreeFam ENSG00000083454 (Hs), ENSMUSG00000005950 (Mm), ENSRNOG00000019208 (Rn)
UniGene Hs. 408615 (Hs)
UniProt Q93086 (Hs), P51578 (Rn)
Wikipedia P2X5
P2X receptors
Search for 3D structures on the PDB
Search by keyword: P2X receptors P2X5 Search by accession number: Q93086, P51578
Natural/Endogenous Ligand(s)
ATP
General Comments
The human P2X5 subunit exists as 3 alternatively spliced isoforms (A, which is tabulated above; B, NP_778255 - 397 aa and C, NP_778256 - 178 aa).

REFERENCES

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1. Collo, G; North, RA; Kawashima, E; Merlo-Pich, E; Neidhart, S; Surprenant, A; Buell, G. (1996) Cloning OF P2X5 and P2X6 receptors and the distribution and properties of an extended family of ATP-gated ion channels. J. Neurosci., 16 (8): 2495-507. [PMID:8786426]

2. Cox, JA; Barmina, O; Voigt, MM. (2001) Gene structure, chromosomal localization, cDNA cloning and expression of the mouse ATP-gated ionotropic receptor P2X5 subunit. Gene, 270 (1-2): 145-52. [PMID:11404011]

3. Lê, KT; Paquet, M; Nouel, D; Babinski, K; Séguéla, P. (1997) Primary structure and expression of a naturally truncated human P2X ATP receptor subunit from brain and immune system. FEBS Lett., 418 (1-2): 195-9. [PMID:9414125]

To cite this database page, please use the following:

Francesco Di Virgilio, Richard J Evans, Michael F Jarvis, Charles Kennedy, Baljit S. Khakh, Patrizia Pellegatti, John A. Peters.
P2X receptors: P2X5. Accessed on 18/05/2013. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=482.


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