Nomenclature: P2X5

Family: P2X receptors

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation. 

Contents

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 2 422 17p13.3 P2RX5 purinergic receptor P2X, ligand-gated ion channel, 5 3
Mouse 2 455 11 B5 P2rx5 purinergic receptor P2X, ligand-gated ion channel, 5 2
Rat 2 455 10q24 P2rx5 purinergic receptor P2X, ligand-gated ion channel, 5 1
Previous and Unofficial Names
P2X5
ATP receptor
P2X purinoceptor 5
purinergic receptor P2X, ligand-gated ion channel, 5
Database Links
ChEMBL Target
Ensembl Gene
Entrez Gene
GeneCards
GenitoUrinary Development Molecular Anatomy Project
HomoloGene
Human Protein Reference Database
InterPro
KEGG Gene
OMIM
PharmGKB Gene
PhosphoSitePlus
Protein Ontology (PRO)
RefSeq Nucleotide
RefSeq Protein
TreeFam
UniGene Hs.
UniProtKB
Wikipedia
Natural/Endogenous Ligand(s)
ATP
General Comments
The human P2X5 subunit exists as 3 alternatively spliced isoforms (A, which is tabulated above; B, NP_778255 - 397 aa and C, NP_778256 - 178 aa).

REFERENCES

1. Collo G, North RA, Kawashima E, Merlo-Pich E, Neidhart S, Surprenant A, Buell G. (1996) Cloning OF P2X5 and P2X6 receptors and the distribution and properties of an extended family of ATP-gated ion channels. J. Neurosci.16 (8): 2495-507. [PMID:8786426]

2. Cox JA, Barmina O, Voigt MM. (2001) Gene structure, chromosomal localization, cDNA cloning and expression of the mouse ATP-gated ionotropic receptor P2X5 subunit. Gene270 (1-2): 145-52. [PMID:11404011]

3. Lê KT, Paquet M, Nouel D, Babinski K, Séguéla P. (1997) Primary structure and expression of a naturally truncated human P2X ATP receptor subunit from brain and immune system. FEBS Lett.418 (1-2): 195-9. [PMID:9414125]

To cite this database page, please use the following:

Francesco Di Virgilio, Richard J Evans, Michael F Jarvis, Charles Kennedy, Baljit S. Khakh, Patrizia Pellegatti, John A. Peters.
P2X receptors: P2X5. Last modified on 14/03/2014. Accessed on 19/04/2014. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=482.

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