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α9

Family: Nicotinic acetylcholine receptors

Contents:
Gene and Protein Information
Previous and Unofficial Names
Database Links
Tissue Distribution
Physiological Consequences of Altering Gene Expression
References
Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 4 479 4p14 CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal) 5
Mouse 4 479 5 C3.1 Chrna9 cholinergic receptor, nicotinic, alpha polypeptide 9
Rat 4 479 14p11 Chrna9 cholinergic receptor, nicotinic, alpha 9 (neuronal) 1
Previous and Unofficial Names
NACHRA9
cholinergic receptor, nicotinic, alpha polypeptide 9
acetylcholine receptor, nicotinic, alpha 9 (neuronal)
NACHR alpha 9
NACHR alpha-9
acetylcholine receptor alpha 9 subunit (nAChR)
cholinergic receptor, nicotinic, alpha 9
neuronal acetylcholine receptor subunit alpha-9
nicotinic acetylcholine receptor subunit alpha 9
nicotinic acetylcholine receptor subunit alpha-9
Acra9
Gm8311
2410015I05Rik
EG666827
Database Links
ChEMBL Target 10636 (Hs), 10024 (Rn)
DrugBank Target 4097 (Hs)
Ensembl ENSG00000174343 (Hs), ENSMUSG00000029205 (Mm), ENSRNOG00000002484 (Rn)
Entrez Gene 55584 (Hs), 231252 (Mm), 65024 (Rn)
GeneCards CHRNA9 (Hs)
GenitoUrinary Development Molecular Anatomy Project Chrna9 (Mm)
HomoloGene 9729
Human Protein Reference Database 16092 (Hs)
InterPro Q9UGM1 (Hs), P43144 (Rn)
KEGG Gene hsa:55584 (Hs), mmu:231252 (Mm), rno:65024 (Rn)
OMIM 605116 (Hs)
PharmGKB Gene PA26493 (Hs)
PhosphoSitePlus Q9UGM1 (Hs), P43144 (Rn)
Protein Ontology (PRO) PRO:000005461 (Hs)
RefSeq Nucleotide NM_017581 (Hs), NM_001081104 (Mm), NM_022930 (Rn)
RefSeq Protein NP_060051 (Hs), NP_001074573 (Mm), NP_075219 (Rn)
TreeFam ENSG00000174343 (Hs), ENSMUSG00000029205 (Mm), ENSRNOG00000002484 (Rn)
UniGene Hs. 272278 (Hs)
UniProt Q9UGM1 (Hs), P43144 (Rn)
Wikipedia α9
Nicotinic acetylcholine receptors
Search for 3D structures on the PDB
Search by keyword: Nicotinic acetylcholine receptors α9 Search by accession number: Q9UGM1, P43144
Natural/Endogenous Ligand(s)
acetylcholine
Commonly used antagonists (Human)
(α9)5: α-bungarotoxin > methyllycaconitine > strychnine ~ tropisetron > (+)-tubocurarine; α9α10: α-bungarotoxin > tropisetron = strychnine > (+)-tubocurarine
Tissue Distribution
pituitary gland, keratinocytes
Species:  Human
Technique:  RT-PCR
References:  6
olfactory epithelia
Species:  Mouse
Technique:  RT-PCR
References:  7
Pituitary gland, nasal epithelium, tongue, cochlea:-
mRNA has been detected by in situ hybridization in the pars tiberalis region of the pituitary gland, the nasal epithelium and tongue. In contrast, no evidence for expression in the central nervous system was detected. By means of of RT-PCR and, subsequently, by in situ hybridization, expression has been confirmed in the cochlea.
Species:  Rat
Technique:  In situ hybridisation, RT-PCR
References:  1,3
dorsal root ganglion neurons
Species:  Rat
Technique:  In situ hybridisation, RT-PCR
References:  2
Physiological Consequences of Altering Gene Expression
Knockout mice have altered development and function of efferent innervation in the outer hair cells of the cochlear.
Species:  Mouse
Tissue:  Vetter et al. 1999; Murthy et al. 2009
Technique:  Knockout
References:  4,7

REFERENCES

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1. Elgoyhen, AB; Johnson, DS; Boulter, J; Vetter, DE; Heinemann, S. (1994) Alpha 9: an acetylcholine receptor with novel pharmacological properties expressed in rat cochlear hair cells. Cell, 79 (4): 705-15. [PMID:7954834]

2. Lips, KS; Pfeil, U; Kummer, W. (2002) Coexpression of alpha 9 and alpha 10 nicotinic acetylcholine receptors in rat dorsal root ganglion neurons. Neuroscience, 115 (1): 1-5. [PMID:12401316]

3. Morley, BJ; Li, HS; Hiel, H; Drescher, DG; Elgoyhen, AB. (1998) Identification of the subunits of the nicotinic cholinergic receptors in the rat cochlea using RT-PCR and in situ hybridization. Brain Res. Mol. Brain Res., 53 (1-2): 78-87. [PMID:9473597]

4. Murthy, V; Taranda, J; Elgoyhen, AB; Vetter, DE. (2009) Activity of nAChRs containing alpha9 subunits modulates synapse stabilization via bidirectional signaling programs. Dev Neurobiol, 69 (14): 931-49. [PMID:19790106]

5. Nguyen, VT; Ndoye, A; Grando, SA. (2000) Novel human alpha9 acetylcholine receptor regulating keratinocyte adhesion is targeted by Pemphigus vulgaris autoimmunity. Am. J. Pathol., 157 (4): 1377-91. [PMID:11021840]

6. Sgard, F; Charpantier, E; Bertrand, S; Walker, N; Caput, D; Graham, D; Bertrand, D; Besnard, F. (2002) A novel human nicotinic receptor subunit, alpha10, that confers functionality to the alpha9-subunit. Mol. Pharmacol., 61 (1): 150-9. [PMID:11752216]

7. Vetter, DE; Liberman, MC; Mann, J; Barhanin, J; Boulter, J; Brown, MC; Saffiote-Kolman, J; Heinemann, SF; Elgoyhen, AB. (1999) Role of alpha9 nicotinic ACh receptor subunits in the development and function of cochlear efferent innervation. Neuron, 23 (1): 93-103. [PMID:10402196]

To cite this database page, please use the following:

Cecilia Gotti, Michael. J. Marks, Neil S. Millar, Susan Wonnacott.
Nicotinic acetylcholine receptors: α9. Last modified on 16/11/2011. Accessed on 22/05/2013. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=469.


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