Nomenclature: ρ3

Family: GABAA receptors

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation. 

Contents

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 4 467 3q11.2 GABRR3 gamma-aminobutyric acid (GABA) A receptor, rho 3 1
Mouse 4 464 16 C1.3 Gabrr3 gamma-aminobutyric acid (GABA) receptor, rho 3 3
Rat 4 464 11q12 Gabrr3 gamma-aminobutyric acid (GABA) A receptor, rho 3 2
Previous and Unofficial Names
gamma-aminobutyric acid (GABA) receptor, rho 3
GABA(A) receptor, rho 3
Loc192258
GABA receptor rho-3 subunit
GABA(A) receptor subunit rho-3
GABA(C) receptor
gamma-aminobutyric acid receptor subunit rho-3
Database Links
ChEMBL Target
Ensembl Gene
Entrez Gene
GeneCards
GenitoUrinary Development Molecular Anatomy Project
HomoloGene
InterPro
KEGG Gene
PharmGKB Gene
PhosphoSitePlus
Protein Ontology (PRO)
RefSeq Nucleotide
RefSeq Protein
TreeFam
UniGene Hs.
UniProtKB
Wikipedia
Natural/Endogenous Ligands
GABA
Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
5-Me-IAA Hs Full agonist - -
[Binds to: GABA site]
(±)-cis-2-CAMP Hs Full agonist - -
[Binds to: GABA site]
isoguvacine Hs Partial agonist - -
[Binds to: GABA site]
muscimol Hs Partial agonist - -
[Binds to: GABA site]
Antagonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
trans-3-ACPBPA Hs Antagonist - -
[Binds to: GABA site]
piperidine-4-sulphonic acid Hs Antagonist - -
[Binds to: GABA site]
cis-3-ACPBPA Hs Antagonist - -
[Binds to: GABA site]
TPMPA Hs Antagonist - -
[Binds to: GABA site]
aza-THIP Hs Antagonist - -
[Binds to: GABA site]
isonipecotic acid Hs Antagonist - -
[Binds to: GABA site]
gaboxadol Hs Antagonist - -
[Binds to: GABA site]
Channel Blockers
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Use-dependent Affinity Units Concentration range (M) Voltage-dependent (mV) Reference
TBPS Hs - no - - - no

Not voltage dependent
picrotoxin Hs - no - - - no

Not voltage dependent

REFERENCES

1. Bailey ME, Albrecht BE, Johnson KJ, Darlison MG. (1999) Genetic linkage and radiation hybrid mapping of the three human GABA(C) receptor rho subunit genes: GABRR1, GABRR2 and GABRR3. Biochim. Biophys. Acta1447 (2-3): 307-12. [PMID:10542332]

2. Ogurusu T, Shingai R. (1996) Cloning of a putative gamma-aminobutyric acid (GABA) receptor subunit rho 3 cDNA. Biochim. Biophys. Acta1305 (1-2): 15-8. [PMID:8605242]

3. Rose M, Dütting E, Schröder N, Sticht H, Brandstätter JH, Enz R. (2008) PNUTS forms a trimeric protein complex with GABA(C) receptors and protein phosphatase 1. Mol. Cell. Neurosci.37 (4): 808-19. [PMID:18325784]

To cite this database page, please use the following:

Richard Olsen, John A. Peters, Tim G. Hales, Werner Sieghart, Uwe Rudolph, Jeremy J. Lambert, Delia Belelli, Bernhard Luscher.
GABAA receptors: ρ3. Last modified on 14/03/2014. Accessed on 23/10/2014. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=422.

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