Nomenclature: β1

Family: GABAA receptors

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation. 

Contents

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 4 474 4p12 GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1 2-3
Mouse 4 474 5 C3.2 Gabrb1 gamma-aminobutyric acid (GABA) A receptor, subunit beta 1 1
Rat 4 474 14p11 Gabrb1 gamma-aminobutyric acid (GABA) A receptor, beta 1 4
Previous and Unofficial Names
GABA(A) receptor, beta 1
GARB1
GABA(A) receptor subunit beta-1
Gamma-aminobutyric acid receptor beta 1
gamma-aminobutyric acid (GABA-A) receptor, subunit beta 1
gamma-aminobutyric acid receptor subunit beta-1
gamma-aminobutyric acid receptor, subunit beta 1
Gabrb-1
AW061132
B230208N19Rik
Database Links
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
GeneCards
GenitoUrinary Development Molecular Anatomy Project
HomoloGene
Human Protein Reference Database
InterPro
KEGG Gene
OMIM
PharmGKB Gene
PhosphoSitePlus
Protein Ontology (PRO)
RefSeq Nucleotide
RefSeq Protein
TreeFam
UniGene Hs.
UniProtKB
Wikipedia
Natural/Endogenous Ligands
GABA
Channel Blockers
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Use-dependent Affinity Units Concentration range (M) Voltage-dependent (mV) Reference
TBPS Hs - no - - - no

Not voltage dependent
picrotoxin Hs - no - - - no

Not voltage dependent

REFERENCES

1. Kamatchi GL, Kofuji P, Wang JB, Fernando JC, Liu Z, Mathura JR, Burt DR. (1995) GABAA receptor beta 1, beta 2, and beta 3 subunits: comparisons in DBA/2J and C57BL/6J mice. Biochim. Biophys. Acta1261 (1): 134-42. [PMID:7893750]

2. Kirkness EF, Kusiak JW, Fleming JT, Menninger J, Gocayne JD, Ward DC, Venter JC. (1991) Isolation, characterization, and localization of human genomic DNA encoding the beta 1 subunit of the GABAA receptor (GABRB1). Genomics10 (4): 985-95. [PMID:1655634]

3. Schofield PR, Pritchett DB, Sontheimer H, Kettenmann H, Seeburg PH. (1989) Sequence and expression of human GABAA receptor alpha 1 and beta 1 subunits. FEBS Lett.244 (2): 361-4. [PMID:2465923]

4. Ymer S, Schofield PR, Draguhn A, Werner P, Köhler M, Seeburg PH. (1989) GABAA receptor beta subunit heterogeneity: functional expression of cloned cDNAs. EMBO J.8 (6): 1665-70. [PMID:2548852]

To cite this database page, please use the following:

Richard Olsen, John A. Peters, Tim G. Hales, Werner Sieghart, Uwe Rudolph, Jeremy J. Lambert, Delia Belelli, Bernhard Luscher.
GABAA receptors: β1. Last modified on 14/03/2014. Accessed on 17/09/2014. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=410.

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