Ligand Id: 2844
Ligand name adenosine

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 9
Hydrogen bond donors 4
Rotatable bonds 2
Topological polar surface area 139.54
Molecular weight 267.1
XLogP -1.81
No. Lipinski's rules broken 0

Molecular properties generated using the CDK


Summary Biological activity References Structure Similar ligands Radio analogues
References
1. Baldwin, SA; Yao, SY; Hyde, RJ; Ng, AM; Foppolo, S; Barnes, K; Ritzel, MW; Cass, CE; Young, JD. (2005)
Functional characterization of novel human and mouse equilibrative nucleoside transporters (hENT3 and mENT3) located in intracellular membranes.
J. Biol. Chem.280 (16): 15880-7. [PMID:15701636]
2. Yao, SY; Ng, AM; Cass, CE; Baldwin, SA; Young, JD. (2011)
Nucleobase transport by human equilibrative nucleoside transporter 1 (hENT1).
J. Biol. Chem.286 (37): 32552-62. [PMID:21795683]
3. Fredholm, B. B., Chen, J. F., Masino, S. A. and Vaugeois, J. M. (2005)
Actions of adenosine at its receptors in the CNS: insights from knockouts and drugs.
Annu Rev Pharmacol Toxicol45: 385-412. [PMID:15822182]
4. Fredholm, B. B. (1995)
Adenosine, adenosine receptors and the actions of caffeine.
Pharmacol. Toxicol.76: 93-101. [PMID:7746802]
5. Yan, L; Burbiel, JC; Maass, A; Müller, CE. (2003)
Adenosine receptor agonists: from basic medicinal chemistry to clinical development.
Expert Opin Emerg Drugs8 (2): 537-76. [PMID:14662005]

Contact us | Print | Back to top | Help