Ligand Id: 308
Ligand name p-F-HHSiD

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 23.47
Molecular weight 349.22
XLogP 5.54
No. Lipinski's rules broken 1

Molecular properties generated using the CDK


Summary Biological activity References Structure Similar ligands
Selectivity at human GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
M3 receptor Antagonist Antagonist 7.3 – 7.9 pKi - 1-2
pKi 7.3 – 7.9 [1-2]
M1 receptor Antagonist Antagonist 7.1 – 7.8 pKi - 1-2
pKi 7.1 – 7.8 [1-2]
M4 receptor Antagonist Antagonist 7.1 – 7.5 pKi - 1-2
pKi 7.1 – 7.5 [1-2]
M2 receptor Antagonist Antagonist 6.1 – 6.6 pKi - 1-2
pKi 6.1 – 6.6 [1-2]
M5 receptor Antagonist Antagonist 6.3 pKi - 1
pKi 6.3 [1]
Selectivity at rat GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
M3 receptor Antagonist Antagonist 8.0 pKi - 3
pKi 8.0 [3]

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