Ligand Id: 308
Ligand name p-F-HHSiD

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 23.47
Molecular weight 349.22
XLogP 5.54
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Summary Biological activity References Structure Similar ligands

Selectivity data from IUPHAR-DB

Selectivity at human GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
M3 receptor Antagonist Antagonist 7.3 – 7.9 pKi - 2-3
M1 receptor Antagonist Antagonist 7.1 – 7.8 pKi - 2-3
M4 receptor Antagonist Antagonist 7.1 – 7.5 pKi - 2-3
M2 receptor Antagonist Antagonist 6.1 – 6.6 pKi - 2-3
M5 receptor Antagonist Antagonist 6.3 pKi - 3
Selectivity at rat GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
M3 receptor Antagonist Antagonist 8.0 pKi - 1

Please note: The activity data given on this ligand page represents selected literature values and may not include all reported data.
For more details please contact: curators@iuphar-db.org

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