Ligand Id: 2844
Ligand name adenosine

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 9
Hydrogen bond donors 4
Rotatable bonds 2
Topological polar surface area 139.54
Molecular weight 267.1
XLogP -1.81
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Summary Biological activity References Structure Similar ligands Radio analogues
Natural/Endogenous Targets
Target DB page
A1 receptor View in IUPHAR-DB
View in GRAC
A2A receptor View in IUPHAR-DB
View in GRAC
A2B receptor View in IUPHAR-DB
View in GRAC
A3 receptor View in IUPHAR-DB
View in GRAC
Enzyme Reactions
Enzyme DB page EC number Reaction Reference
Adenosine deaminase View in GRAC
Adenosine kinase View in GRAC
Transporters
Transporter DB page EC number Reaction Reference
Equilibrative nucleoside transporter 3 View in GRAC 1
CNT3 View in GRAC
Equilibrative nucleoside transporter 1 View in GRAC 2
CNT1 View in GRAC
Equilibrative nucleoside transporter 2 View in GRAC
CNT2 View in GRAC

Selectivity data from IUPHAR-DB

Selectivity at human GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
A1 receptor Agonist Agonist ~7.0 pKi - 5
A3 receptor Agonist Agonist 6.54 pKi - 3-5
A2A receptor Agonist Agonist 6.51 pKi - 3-5
A2B receptor Agonist Agonist 4.82 pKi - 3-5
Selectivity at rat GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
A1 receptor Agonist Agonist 7.14 pKi - 5
A2A receptor Agonist Agonist 6.82 pKi - 5
A2B receptor Agonist Agonist 5.29 pKi - 5
A3 receptor Agonist Agonist 5.19 pKi - 5

Selectivity data from the Guide to Receptors and Channels (GRAC), 5th Edition.

Selectivity at human targets (unless otherwise stated)
Key to terms and symbols Click column headers to sort
Receptor Type Action Affinity Units Concentration range (M) Reference
TRPM4 Channel blocker - 3.2 pIC50 -
Rank order of potency at human receptors (unless otherwise stated)
Description Rank order of potency Reference
Rank order of affinity at Adenosine deaminase 2'-deoxyadenosine > adenosine
Rank order of affinity at Adenosine kinase adenosine

Please note: The activity data given on this ligand page represents selected literature values and may not include all reported data.
For more details please contact: curators@iuphar-db.org

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