Ligand Id: 2478
Ligand name citric acid

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 4
Rotatable bonds 5
Topological polar surface area 132.13
Molecular weight 192.03
XLogP -2.25
No. Lipinski's rules broken 0

Molecular properties generated using the CDK


Summary Biological activity References Structure Similar ligands
Transporters Moving this Compound Across a Lipid Membrane
Transporter DB page EC number Reaction Reference
Na+/dicarboxylate cotransporter 1
Na+/dicarboxylate cotransporter 3
Na+/citrate cotransporter
Mitochondrial citrate transporter
Selectivity at human ion channels
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
TRPP2 Activator Agonist 1.7 pEC50 1.5x10-2 - 3x10-2 1
pEC50 1.7 Conc range: 1.5x10-2 - 3x10-2 M [1]
Voltage: Physiological
Selectivity at mouse ion channels
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
TRPV4 Activator Agonist 5.6 pEC50 - 2
pEC50 5.6 [2]
Voltage: 0.0 mV
Ligand mentioned in the following text fields in the Guide to PHARMACOLOGY

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