Ligand Id: 2478
Ligand name citric acid

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 4
Rotatable bonds 5
Topological polar surface area 132.13
Molecular weight 192.03
XLogP -2.25
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Summary Biological activity References Structure Similar ligands
Transporters
Transporter DB page EC number Reaction Reference
Na+/dicarboxylate cotransporter 1 View in GRAC
Na+/dicarboxylate cotransporter 3 View in GRAC
Na+/citrate cotransporter View in GRAC
Mitochondrial citrate transporter View in GRAC

Selectivity data from IUPHAR-DB

Selectivity at human ion channels
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
TRPP2 Activator Agonist 1.7 pEC50 1.5x10-2 - 3x10-2 1
Selectivity at mouse ion channels
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
TRPV4 Activator Agonist 5.6 pEC50 - 2

Please note: The activity data given on this ligand page represents selected literature values and may not include all reported data.
For more details please contact: curators@iuphar-db.org

Contact us | Print | Back to top | Help