Ligand Id: 1223
Ligand name clobenpropit

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 7
Topological polar surface area 92.36
Molecular weight 308.09
XLogP 3.01
No. Lipinski's rules broken 0

Molecular properties generated using the CDK


Summary Biological activity References Structure Similar ligands
Selectivity at human GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
H3 receptor Antagonist Antagonist 8.4 – 9.4 pKi - 2-4,6,8,11-12
pKi 8.4 – 9.4 [2-4,6,8,11-12]
H4 receptor Agonist Partial agonist 7.4 – 8.3 pKi - 3,5-7,10
pKi 7.4 – 8.3 [3,5-7,10]
H1 receptor Antagonist Antagonist 5.6 pKi - 3
pKi 5.6 [3]
H2 receptor Antagonist Antagonist 5.2 pKi - 3
pKi 5.2 [3]
Selectivity at mouse GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
H3 receptor Antagonist Antagonist 9.5 pKi - 1
pKi 9.5 [1]
H4 receptor Agonist Partial agonist 7.8 pKi - 7
pKi 7.8 [7]
Selectivity at rat GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
H3 receptor Antagonist Antagonist 8.9 – 9.8 pKi - 3-4,8-9,11-12
pKi 8.9 – 9.8 [3-4,8-9,11-12]
H4 receptor Agonist Partial agonist 7.2 pKi - 7
pKi 7.2 [7]
Ligand mentioned in the following text fields in the Guide to PHARMACOLOGY

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