IUPHAR DATABASE | LIGAND SUMMARY

Ligand Id: 649
Ligand name	bradykinin
Species	Human, Mouse, Rat

2D Structure

Summary Biological activity References Structure Similar ligands Radio analogues

Classification
Compound class	Endogenous peptide in human, mouse or rat

IUPAC Name

2-[[2-[[1-[2-[[2-[[2-[[1-[1-[2-amino-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbonyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid

Gene/Precursor

Gene symbol	Gene name	Species	Protein name	Synonyms
Kng1	kininogen 1	Mouse	kininogen-1 precursor	H-kininigen, L-kininogen
Kng1	kininogen 1	Rat	kininogen-1 precursor	alpha-1-MAP, kininogen, kininogen 1, kininogen 1, variant 1, KINKG, KINKH, KINT1G, K-kininogen, differential splicing leads to HMW Kngk, Kng, Kng1_v1, Kngk, Kngt, Kngt1, Kng_v1, LMW T-kininogen I, major acute phase protein, Map1, MGC93589, RATKINKG, RATKINKH, RATKINT1G, RATTKG6, thiostatin, Tkg, TKG6, T-kininogen, T-kininogen 1, T-kininogen I, T-kininogen see also D11Elh1 and D11Mit8
KNG1	kininogen 1	Human	kininogen-1 precursor	alpha-2-thiol proteinase inhibitor, BDK, bradykinin, kininogen, KNG

Synonyms

kallidin I

kinin 9

Database Links
CAS Registry No.	1806553 (Hs), 1806553 (Mm), 1805457 (Rn)
ChEBI	CHEBI:143708
ChEMBL Ligand	143708, 225208, 395092
PubChem CID	6026
Search on ChemSpider	QXZGBUJJYSLZLT-UHFFFAOYSA-N
UniProt	P01042 (Hs), O08677 (Mm), P08934 (Rn)
Wikipedia	Bradykinin
iPHACE	E5752NEF

Please note: some links may refer to related isomers. For more details please contact: curators@iuphar-db.org

Comments

The rat, mouse and human sequences are identical.

Disclaimer: Peptide pages are currently under development, please exercise caution over the use of sequence and structural information provided here. Please send notification of errors to curators@iuphar-db.org.