Ligand Id: 1606
Ligand name (-)-pentazocine

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 1
Rotatable bonds 2
Topological polar surface area 23.47
Molecular weight 285.21
XLogP 4.09
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Summary Biological activity Clinical data References Structure Similar ligands Radio analogues
Compound class Synthetic organic
Approved drug? Yes (source: FDA (1967))
DrugBank groups approved
International Nonproprietary Names
INN number INN
1674 pentazocine
Database Links
BindingDB Ligand 50001028
CAS Registry No. 359-83-1 (source: DrugBank)
ChEBI CHEBI:116117
DrugBank Ligand DB00652
PharmGKB Drug PA450852
PubChem CID 441278
Search Google for chemical match using the InChIKey VOKSWYLNZZRQPF-GDIGMMSISA-N
Search Google for chemicals with the same backbone VOKSWYLNZZRQPF
Search PubMed clinical trials pentazocine
Search PubMed titles pentazocine
Search PubMed titles/abstracts pentazocine
Wikipedia Pentazocine
ZINC ZINC00000596
(-)-pentazocine is one of the two enantiomers in the approved drug pentazocine. (-)-pentazocine is a κ-opioid receptor agonist, while (+)-pentazocine exhibits ten-fold greater affinity for the σ receptor. Pentazocine is a mixed agonist-antagonist opioid pain medication. It is postulated that pentazocine behaves as an agonist at the κ and σ opioid receptors and has weak antagonistic action at the μ receptor.

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