Ligand Id: 1606
Ligand name (-)-pentazocine

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 1
Rotatable bonds 2
Topological polar surface area 23.47
Molecular weight 285.21
XLogP 4.09
No. Lipinski's rules broken 0

Molecular properties generated using the CDK


Summary Biological activity Clinical data References Structure Similar ligands (Un)labelled forms
Classification
Compound class Synthetic organic
DrugBank groups approved
International Nonproprietary Names
INN number INN
1674 pentazocine
Synonyms
pentazocine
WIN-20228
Database Links
BindingDB Ligand 50001028
CAS Registry No. 359-83-1 (source: Scifinder)
ChEMBL Ligand CHEMBL560
DrugBank Ligand DB00652
PharmGKB Drug PA450852
PubChem CID 441278
Search Google for chemical match using the InChIKey VOKSWYLNZZRQPF-GDIGMMSISA-N
Search Google for chemicals with the same backbone VOKSWYLNZZRQPF
Search PubMed clinical trials pentazocine
Search PubMed titles pentazocine
Search PubMed titles/abstracts pentazocine
Wikipedia Pentazocine
ZINC ZINC00000596
Comments
(-)-pentazocine is one of the two enantiomers in the approved drug pentazocine. (-)-pentazocine is a κ-opioid receptor agonist, while (+)-pentazocine exhibits ten-fold greater affinity for the σ receptor. Pentazocine is a mixed agonist-antagonist opioid pain medication. It is postulated that pentazocine behaves as an agonist at the κ and σ opioid receptors and has weak antagonistic action at the μ receptor.

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