G PROTEIN-COUPLED RECEPTORS

CLASS A

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5-Hydroxytryptamine receptors
Family name Ligand Official IUPHAR receptor name Human gene name Rat gene name Mouse gene name Comment
5-Hydroxytryptamine receptors 5-hydroxytryptamine 5-HT1A HTR1A
Htr1a
Htr1a
5-Hydroxytryptamine receptors 5-hydroxytryptamine 5-HT1B HTR1B
Htr1b
Htr1b
5-Hydroxytryptamine receptors 5-hydroxytryptamine 5-HT1D HTR1D
Htr1d
Htr1d
5-Hydroxytryptamine receptors 5-hydroxytryptamine 5-ht1e HTR1E
5-Hydroxytryptamine receptors 5-hydroxytryptamine 5-HT1F HTR1F
Htr1f
Htr1f
5-Hydroxytryptamine receptors 5-hydroxytryptamine 5-HT2A HTR2A
Htr2a
Htr2a
5-Hydroxytryptamine receptors 5-hydroxytryptamine 5-HT2B HTR2B
Htr2b
Htr2b
5-Hydroxytryptamine receptors 5-hydroxytryptamine 5-HT2C HTR2C
Htr2c
Htr2c
5-Hydroxytryptamine receptors 5-hydroxytryptamine 5-HT4 HTR4
Htr4
Htr4
5-Hydroxytryptamine receptors 5-hydroxytryptamine 5-ht5a HTR5A
Htr5a
Htr5a
5-Hydroxytryptamine receptors 5-hydroxytryptamine 5-ht5b HTR5BP
Htr5b
Htr5b
5-Hydroxytryptamine receptors 5-hydroxytryptamine 5-HT6 HTR6
Htr6
Htr6
5-Hydroxytryptamine receptors 5-hydroxytryptamine 5-HT7 HTR7
Htr7
Htr7
Acetylcholine receptors (muscarinic)
Family name Ligand Official IUPHAR receptor name Human gene name Rat gene name Mouse gene name Comment
Acetylcholine receptors (muscarinic) acetylcholine M1 CHRM1
Chrm1
Chrm1
Acetylcholine receptors (muscarinic) acetylcholine M2 CHRM2
Chrm2
Chrm2
Acetylcholine receptors (muscarinic) acetylcholine M3 CHRM3
Chrm3
Chrm3
Acetylcholine receptors (muscarinic) acetylcholine M4 CHRM4
Chrm4
Chrm4
Acetylcholine receptors (muscarinic) acetylcholine M5 CHRM5
Chrm5
Chrm5
Adenosine receptors
Family name Ligand Official IUPHAR receptor name Human gene name Rat gene name Mouse gene name Comment
Adenosine receptors adenosine A1 ADORA1
Adora1
Adora1
Adenosine receptors adenosine A2A ADORA2A
Adora2a
Adora2a
Adenosine receptors adenosine A2B ADORA2B
Adora2b
Adora2b
Adenosine receptors adenosine A3 ADORA3
Adora3
Adora3
Adrenoceptors
Family name Ligand Official IUPHAR receptor name Human gene name Rat gene name Mouse gene name Comment
Adrenoceptors noradrenaline α1A-adrenoceptor ADRA1A
Adra1a
Adra1a
Adrenoceptors adrenaline α1B-adrenoceptor ADRA1B
Adra1b
Adra1b
Adrenoceptors adrenaline α1D-adrenoceptor ADRA1D
Adra1d
Adra1d
Adrenoceptors adrenaline α2A-adrenoceptor ADRA2A
Adra2a
Adra2a
Adrenoceptors adrenaline α2B-adrenoceptor ADRA2B
Adra2b
Adra2b
Adrenoceptors adrenaline α2C-adrenoceptor ADRA2C
Adra2c
Adra2c
Adrenoceptors noradrenaline β1-adrenoceptor ADRB1
Adrb1
Adrb1
Adrenoceptors adrenaline β2-adrenoceptor ADRB2
Adrb2
Adrb2
Adrenoceptors adrenaline β3-adrenoceptor ADRB3
Adrb3
Adrb3
Anaphylatoxin receptors
Family name Ligand Official IUPHAR receptor name Human gene name Rat gene name Mouse gene name Comment
Anaphylatoxin receptors anaphylatoxin C3a C3a receptor C3AR1
C3ar1
C3ar1
Anaphylatoxin receptors anaphylatoxin C5a C5a receptor C5AR1
C5ar1
C5ar1
Anaphylatoxin receptors anaphylatoxin C5a, C5a des Arg74 C5L2 GPR77
Gpr77
Gpr77
Angiotensin receptors
Family name Ligand Official IUPHAR receptor name Human gene name Rat gene name Mouse gene name Comment
Angiotensin receptors angiotensin AT1 AGTR1
Agtr1b
Agtr1a
Agtr1b
Agtr1a
Angiotensin receptors angiotensin AT2 AGTR2
Agtr2
Agtr2
Apelin receptor
Family name Ligand Official IUPHAR receptor name Human gene name Rat gene name Mouse gene name Comment
Apelin receptor apelin apelin receptor APLNR
Aplnr
Aplnr
Bile acid receptor
Family name Ligand Official IUPHAR receptor name Human gene name Rat gene name Mouse gene name Comment
Bile acid receptor bile acids GPBA GPBAR1
Gpbar1
Gpbar1
Bombesin receptors
Family name Ligand Official IUPHAR receptor name Human gene name Rat gene name Mouse gene name Comment
Bombesin receptors neuromedin B BB1 NMBR
Nmbr
Nmbr
Bombesin receptors gastrin-releasing peptide BB2 GRPR
Grpr
Grpr
Bombesin receptors BB3 BRS3
Brs3
Brs3
Bradykinin receptors
Family name Ligand Official IUPHAR receptor name Human gene name Rat gene name Mouse gene name Comment
Bradykinin receptors bradykinin B1 BDKRB1
Bdkrb1
Bdkrb1
Bradykinin receptors bradykinin B2 BDKRB2
Bdkrb2
Bdkrb2
Cannabinoid receptors
Family name Ligand Official IUPHAR receptor name Human gene name Rat gene name Mouse gene name Comment
Cannabinoid receptors cannabinoid CB1 CNR1
Cnr1
Cnr1
Cannabinoid receptors cannabinoid CB2 CNR2
Cnr2
Cnr2
Chemokine receptors
Family name Ligand Official IUPHAR receptor name Human gene name Rat gene name Mouse gene name Comment
Chemokine receptors CCL3, CCL5, CCL7, CCL8, CCL13-16, CCL23 CCR1 CCR1
Ccr1
Ccr1
Chemokine receptors CCL2, CCL7, CCL8, CCL13 CCR2 CCR2
Ccr2
Ccr2
Chemokine receptors CCL11 (eotaxin); CCL5, CCL7, CCL8, CCL13, CCL15, CCL24, CCL26 CCR3 CCR3
Ccr3
Ccr3
Chemokine receptors CCL17, CCL22 CCR4 CCR4
Ccr4
Ccr4
Chemokine receptors CCL3, CCL4, CCL5, CCL8, CCL14 CCR5 CCR5
Ccr5
Ccr5
Chemokine receptors CCL20 CCR6 CCR6
Ccr6
Ccr6
Chemokine receptors CCL19, CCL21 CCR7 CCR7
Ccr7
Ccr7
Chemokine receptors CCL1, CCL4, CCL17 CCR8 CCR8
Ccr8
Ccr8
Chemokine receptors CCL25 CCR9 CCR9
Ccr9
Ccr9
Chemokine receptors CCL26-28 CCR10 CCR10
Ccr10
Ccr10
Chemokine receptors CXCL8 CXCR1 CXCR1
Il8ra
Cxcr1
Chemokine receptors CXCL1-3, CXCL5-8, macrophage derived lectin CXCR2 CXCR2
Il8rb
Cxcr2
macrophage derived lectin is a proposed ligand, single publication
Chemokine receptors CXCL9-11 CXCR3 CXCR3
Cxcr3
Cxcr3
Chemokine receptors CXCL12 CXCR4 CXCR4
Cxcr4
Cxcr4
Chemokine receptors CXCL13 CXCR5 CXCR5
Cxcr5
Cxcr5
Chemokine receptors CXCL16 CXCR6 CXCR6
Cxcr6
Cxcr6
Chemokine receptors CXCR7 CXCR7
Cxcr7
Cxcr7
aka RDC1
Chemokine receptors CX3CL1 CX3CR1 CX3CR1
Cx3cr1
Cx3cr1
Chemokine receptors XCL1, XCL2 XCR1 XCR1
Xcr1
Xcr1
Cholecystokinin receptors
Family name Ligand Official IUPHAR receptor name Human gene name Rat gene name Mouse gene name Comment
Cholecystokinin receptors cholecystokinin CCK1 CCKAR
Cckar
Cckar
Cholecystokinin receptors cholecystokinin, gastrin CCK2 CCKBR
Cckbr
Cckbr
Dopamine receptors
Family name Ligand Official IUPHAR receptor name Human gene name Rat gene name Mouse gene name Comment
Dopamine receptors dopamine D1 DRD1
Drd1a
Drd1a
Dopamine receptors dopamine D2 DRD2
Drd2
Drd2
Dopamine receptors dopamine D3 DRD3
Drd3
Drd3
Dopamine receptors dopamine D4 DRD4
Drd4
Drd4
Dopamine receptors dopamine D5 DRD5
Drd5
Drd5
Endothelin receptors
Family name Ligand Official IUPHAR receptor name Human gene name Rat gene name Mouse gene name Comment
Endothelin receptors endothelin 1, endothelin 2 ETA EDNRA
Ednra
Ednra
Endothelin receptors endothelins 1, 2 and 3 ETB EDNRB
Ednrb
Ednrb
Estrogen (G protein coupled) receptor
Family name Ligand Official IUPHAR receptor name Human gene name Rat gene name Mouse gene name Comment
Estrogen (G protein coupled) receptor GPER GPER
Gper
Gpr30
Formylpeptide receptors
Family name Ligand Official IUPHAR receptor name Human gene name Rat gene name Mouse gene name Comment
Formylpeptide receptors FPR1 FPR1
Fpr1
Fpr1
Formylpeptide receptors FPR2/ALX FPR2
Fpr2
Fpr2
Formylpeptide receptors FPR3 FPR3
Fpr3
Fpr3
Free fatty acid receptors
Family name Ligand Official IUPHAR receptor name Human gene name Rat gene name Mouse gene name Comment
Free fatty acid receptors long chain carboxylic acids FFA1 FFAR1
Ffar1
Ffar1
Free fatty acid receptors FFA2 FFAR2
Ffar2
Ffar2
Free fatty acid receptors FFA3 FFAR3
Ffar3
Ffar3
Free fatty acid receptors GPR42 GPR42
Very closely related to GPR41. Might be pseudogene.
Galanin receptors
Family name Ligand Official IUPHAR receptor name Human gene name Rat gene name Mouse gene name Comment
Galanin receptors galanin GAL1 GALR1
Galr1
Galr1
Galanin receptors galanin GAL2 GALR2
Galr2
Galr2
Galanin receptors galanin GAL3 GALR3
Galr3
Galr3
Ghrelin receptor
Family name Ligand Official IUPHAR receptor name Human gene name Rat gene name Mouse gene name Comment
Ghrelin receptor ghrelin ghrelin receptor GHSR
Ghsr
Ghsr
Glycoprotein hormone receptors
Family name Ligand Official IUPHAR receptor name Human gene name Rat gene name Mouse gene name Comment
Glycoprotein hormone receptors follicle-stimulating hormone FSH receptor FSHR
Fshr
Fshr
Glycoprotein hormone receptors luteinizing hormone, chorionic gonadotropin LH receptor LHCGR
Lhcgr
Lhcgr
Glycoprotein hormone receptors thyroid-stimulating hormone TSH receptor TSHR
Tshr
Tshr
Gonadotrophin-releasing hormone receptors
Family name Ligand Official IUPHAR receptor name Human gene name Rat gene name Mouse gene name Comment
Gonadotrophin-releasing hormone receptors gonadotrophin-releasing hormone GnRH receptor GNRHR
Gnrhr
Gnrhr
Gonadotrophin-releasing hormone receptors gonadotrophin-releasing hormone GnRH2 receptor GNRHR2
probable transcribed pseudogene
Histamine receptors
Family name Ligand Official IUPHAR receptor name Human gene name Rat gene name Mouse gene name Comment
Histamine receptors histamine H1 HRH1
Hrh1
Hrh1
Histamine receptors histamine H2 HRH2
Hrh2
Hrh2
Histamine receptors histamine H3 HRH3
Hrh3
Hrh3
Histamine receptors histamine H4 HRH4
Hrh4
Hrh4
Hydroxycarboxylic acid receptors
Family name Ligand Official IUPHAR receptor name Human gene name Rat gene name Mouse gene name Comment
Hydroxycarboxylic acid receptors lactate HCA1 HCAR1
Gpr81
Gpr81
Proposed ligand, two publications
Hydroxycarboxylic acid receptors nicotinic acid (high affinity) HCA2 HCAR2
Gpr109a
Niacr1
Hydroxycarboxylic acid receptors nicotinic acid (low affinity) HCA3 HCAR3
Kisspeptin receptor
Family name Ligand Official IUPHAR receptor name Human gene name Rat gene name Mouse gene name Comment
Kisspeptin receptor kisspeptin receptor KISS1R
Kiss1r
Kiss1r
Leukotriene receptors
Family name Ligand Official IUPHAR receptor name Human gene name Rat gene name Mouse gene name Comment
Leukotriene receptors leukotriene B4 BLT1 LTB4R
Ltb4r
Ltb4r1
Leukotriene receptors leukotriene B4 BLT2 LTB4R2
Ltb4r2
Ltb4r2
Leukotriene receptors leukotriene D4 CysLT1 CYSLTR1
Cysltr1
Cysltr1
Leukotriene receptors leukotriene C4 CysLT2 CYSLTR2
Cysltr2
Cysltr2
Leukotriene receptors 5-oxo-ETE OXE OXER1
Leukotriene receptors FPR2/ALX FPR2
Fpr2
Fpr2
Lysophospholipid receptors
Family name Ligand Official IUPHAR receptor name Human gene name Rat gene name Mouse gene name Comment
Lysophospholipid receptors lysophosphatidic acid (LPA) LPA1 LPAR1
Lpar1
Lpar1
Lysophospholipid receptors lysophosphatidic acid LPA2 LPAR2
Lpar2
Lpar2
Lysophospholipid receptors lysophosphatidic acid LPA3 LPAR3
Lpar3
Lpar3
Lysophospholipid receptors lysophosphatidic acid LPA4 LPAR4
Lpar4
Lpar4
Proposed ligand, single publication
Lysophospholipid receptors lysophosphatidic acid LPA5 LPAR5
Lpar5
Lpar5
Proposed ligand, two publications
Lysophospholipid receptors sphingosine 1-phosphate S1P1 S1PR1
S1pr1
S1pr1
Lysophospholipid receptors sphingosine 1-phosphate S1P2 S1PR2
S1pr2
S1pr2
Lysophospholipid receptors sphingosine 1-phosphate S1P3 S1PR3
S1pr3
S1pr3
Lysophospholipid receptors sphingosine 1-phosphate S1P4 S1PR4
S1pr4
S1pr4
Lysophospholipid receptors sphingosine 1-phosphate S1P5 S1PR5
S1pr5
S1pr5
Melanin-concentrating hormone receptors
Family name Ligand Official IUPHAR receptor name Human gene name Rat gene name Mouse gene name Comment
Melanin-concentrating hormone receptors MCH1 MCHR1
Mchr1
Mchr1
Melanin-concentrating hormone receptors MCH2 MCHR2
Melanocortin receptors
Family name Ligand Official IUPHAR receptor name Human gene name Rat gene name Mouse gene name Comment
Melanocortin receptors α-melanocyte stimulating hormone MC1 MC1R
Mc1r
Mc1r
Melanocortin receptors adrenocorticotropic hormone MC2 MC2R
Mc2r
Mc2r
Melanocortin receptors γ-melanocyte stimulating hormone MC3 MC3R
Mc3r
Mc3r
Melanocortin receptors β-melanocyte stimulating hormone MC4 MC4R
Mc4r
Mc4r
Melanocortin receptors α-melanocyte stimulating hormone MC5 MC5R
Mc5r
Mc5r
Melatonin receptors
Family name Ligand Official IUPHAR receptor name Human gene name Rat gene name Mouse gene name Comment
Melatonin receptors melatonin MT1 MTNR1A
Mtnr1a
Mtnr1a
Melatonin receptors melatonin MT2 MTNR1B
Mtnr1b
Mtnr1b
Motilin receptor
Family name Ligand Official IUPHAR receptor name Human gene name Rat gene name Mouse gene name Comment
Motilin receptor motilin motilin receptor MLNR
aka GPR38
Neuromedin U receptors
Family name Ligand Official IUPHAR receptor name Human gene name Rat gene name Mouse gene name Comment
Neuromedin U receptors neuromedin U NMU1 NMUR1
Nmur1
Nmur1
Neuromedin U receptors neuromedin U NMU2 NMUR2
Nmur2
Nmur2
Neuropeptide FF/neuropeptide AF receptors
Family name Ligand Official IUPHAR receptor name Human gene name Rat gene name Mouse gene name Comment
Neuropeptide FF/neuropeptide AF receptors NPFF1 NPFFR1
Npffr1
Neuropeptide FF/neuropeptide AF receptors NPFF2 NPFFR2
Npffr2
Npffr2
Neuropeptide S receptor
Family name Ligand Official IUPHAR receptor name Human gene name Rat gene name Mouse gene name Comment
Neuropeptide S receptor NPS receptor NPSR1
Npsr1
Npsr1
Neuropeptide W/neuropeptide B receptors
Family name Ligand Official IUPHAR receptor name Human gene name Rat gene name Mouse gene name Comment
Neuropeptide W/neuropeptide B receptors NPBW1 NPBWR1
Npbwr1
Npbwr1
Neuropeptide W/neuropeptide B receptors NPBW2 NPBWR2
Neuropeptide Y receptors
Family name Ligand Official IUPHAR receptor name Human gene name Rat gene name Mouse gene name Comment
Neuropeptide Y receptors neuropeptide Y Y1 NPY1R
Npy1r
Npy1r
Neuropeptide Y receptors neuropeptide Y Y2 NPY2R
Npy2r
Npy2r
Neuropeptide Y receptors pancreatic polypeptide Y4 PPYR1
Ppyr1
Ppyr1
Neuropeptide Y receptors neuropeptide Y Y5 NPY5R
Npy5r
Npy5r
Neuropeptide Y receptors y6 NPY6R
Npy6r
Neurotensin receptors
Family name Ligand Official IUPHAR receptor name Human gene name Rat gene name Mouse gene name Comment
Neurotensin receptors neurotensin NTS1 NTSR1
Ntsr1
Ntsr1
Neurotensin receptors neurotensin NTS2 NTSR2
Ntsr2
Ntsr2
Opioid receptors
Family name Ligand Official IUPHAR receptor name Human gene name Rat gene name Mouse gene name Comment
Opioid receptors β-endorphin δ OPRD1
Oprd1
Oprd1
Opioid receptors dynorphin A κ OPRK1
Oprk1
Oprk1
Opioid receptors β-endorphin μ OPRM1
Oprm1
Oprm1
Opioid receptors nociceptin/orphanin FQ NOP OPRL1
Oprl1
Oprl1
Orexin receptors
Family name Ligand Official IUPHAR receptor name Human gene name Rat gene name Mouse gene name Comment
Orexin receptors orexin A, orexin B OX1 HCRTR1
Hcrtr1
Hcrtr1
Orexin receptors orexin A, orexin B OX2 HCRTR2
Hcrtr2
Hcrtr2
P2Y receptors
Family name Ligand Official IUPHAR receptor name Human gene name Rat gene name Mouse gene name Comment
P2Y receptors ADP P2Y1 P2RY1
P2ry1
P2ry1
P2Y receptors UTP, ATP P2Y2 P2RY2
P2ry2
P2ry2
P2Y receptors UTP P2Y4 P2RY4
P2ry4
P2ry4
P2Y receptors UDP P2Y6 P2RY6
P2ry6
P2ry6
P2Y receptors ATP P2Y11 P2RY11
P2Y receptors ADP P2Y12 P2RY12
P2ry12
P2ry12
P2Y receptors ADP P2Y13 P2RY13
P2ry13
P2ry13
P2Y receptors UDP-glucose P2Y14 P2RY14
P2ry14
P2ry14
Peptide P518 receptor
Family name Ligand Official IUPHAR receptor name Human gene name Rat gene name Mouse gene name Comment
Peptide P518 receptor RF-amide P518 gene product QRFP QRFPR
Qrfpr
Qrfpr
Platelet-activating factor receptor
Family name Ligand Official IUPHAR receptor name Human gene name Rat gene name Mouse gene name Comment
Platelet-activating factor receptor platelet-activating factor PAF receptor PTAFR
Ptafr
Ptafr
Prokineticin receptors
Family name Ligand Official IUPHAR receptor name Human gene name Rat gene name Mouse gene name Comment
Prokineticin receptors PKR1 PROKR1
Prokr1
Prokr1
Prokineticin receptors PKR2 PROKR2
Prokr2
Prokr2
Prolactin-releasing peptide receptor
Family name Ligand Official IUPHAR receptor name Human gene name Rat gene name Mouse gene name Comment
Prolactin-releasing peptide receptor PRRP receptor PRLHR
Prlhr
Prlhr
Prostanoid receptors
Family name Ligand Official IUPHAR receptor name Human gene name Rat gene name Mouse gene name Comment
Prostanoid receptors prostaglandin D2 DP1 PTGDR
Ptgdr
Ptgdr
Prostanoid receptors 11-dehydro-thromboxane B2 DP2 PTGDR2
Gpr44
Gpr44
Prostanoid receptors prostaglandin E2 EP1 PTGER1
Ptger1
Ptger1
Prostanoid receptors prostaglandin E2 EP2 PTGER2
Ptger2
Ptger2
Prostanoid receptors prostaglandin E2 EP3 PTGER3
Ptger3
Ptger3
Prostanoid receptors prostaglandin E2 EP4 PTGER4
Ptger4
Ptger4
Prostanoid receptors prostaglandin F2a FP PTGFR
Ptgfr
Ptgfr
Prostanoid receptors prostacyclin IP1 PTGIR
Ptgir
Ptgir
Prostanoid receptors thromboxane A2 TP TBXA2R
Tbxa2r
Tbxa2r
Protease-activated receptors
Family name Ligand Official IUPHAR receptor name Human gene name Rat gene name Mouse gene name Comment
Protease-activated receptors thrombin PAR1 F2R
F2r
F2r
Protease-activated receptors serine proteases PAR2 F2RL1
F2rl1
F2rl1
Protease-activated receptors thrombin PAR3 F2RL2
F2rl2
F2rl2
Protease-activated receptors serine proteases PAR4 F2RL3
F2rl3
F2rl3
Relaxin family peptide receptors
Family name Ligand Official IUPHAR receptor name Human gene name Rat gene name Mouse gene name Comment
Relaxin family peptide receptors RXFP1 RXFP1
Rxfp1
Rxfp1
Relaxin family peptide receptors RXFP2 RXFP2
Rxfp2
Rxfp2
Relaxin family peptide receptors RXFP3 RXFP3
Rxfp3
Rxfp3
Relaxin family peptide receptors