IUPHAR DATABASE OF RECEPTORS AND ION CHANNELS

Welcome to the official database of the IUPHAR Committee on Receptor Nomenclature and Drug Classification.

Incorporating detailed pharmacological, functional and pathophysiological information on G Protein-Coupled Receptors, Voltage-Gated Ion Channels, Ligand-Gated Ion Channels and Nuclear Hormone Receptors.

Database content:

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* Orphans are defined as proteins having similarity to receptors but whose endogenous ligands have not yet been conclusively identified.

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Latest news:

IUPHAR-DB and Orphanet collaborate to share information on the molecular basis of rare diseases
- IUPHAR-DB and Orphanet, the Portal for Rare Diseases and Orphan Drugs, have begun a collaboration to share knowledge and links on the genetic and molecular bases of rare diseases and the actions of orphan drugs. Database links have been established between GPCRs, ion channels and NHRs in IUPHAR-DB and their respective Orphanet gene pages. Information about the rare diseases to which they are linked has been added to the database and links are provided to expert-curated disease summaries in Orphanet.
NC-IUPHAR and BPS announce the launch of a new online portal, the Guide to Pharmacology
- NC-IUPHAR and the British Pharmacological Society (BPS) announce the launch of a new web site, the Guide to Pharmacology, developed as a joint initiative to provide a one-stop shop for quantitative information on drug targets and the prescription medicines and experimental dugs that act on them. It provides a single entry point to IUPHAR-DB and an online database of information from the Guide to Receptors and Channels (GRAC) 5th (2011) edition. GRAC provides a succinct overview of the key properties of over 1600 established or potential pharmacological targets. This resource should be of interest to researchers and students in pharmacology and drug discovery as well as the interested public.

Recent database updates (February/March 2012) include:

GPCR updates:
- GPCR pages that have been recently updated include: β-Adrenoceptors and Adrenoceptor introduction, Calcitonin receptors, Cannabinoid receptor introduction and Orexin receptors;
- The curation of sequence, structure and precursor data for all the endogenous peptide ligands of human, rat and mouse GPCRs has been completed. Endogenous ligands for each receptor are listed on their database pages. For a representative endogenous peptide ligand page see human ghrelin;
- The Lysophospholipid receptors have been split into two families: Lysophospholipid (LPA) receptors and Lysophospholipid (S1P) receptors.
New annotation for LGICs:
- The GABA_A subunits α3, α4, α5, β2, β3, γ1, γ2 and γ3 now have full annotation.
New enzyme database:
- A pilot project to investigate the inclusion of enzymes in the IUPHAR database has been completed by database curators, covering the enzymes of the lanosterol biosynthesis pathway, including HMG CoA reductase, the target of statin drugs. The database pages can be accessed here.
New database links:
- Links from receptor/channel pages to DrugBank target pages, giving information on approved drugs which act on them;
- Links from ligand pages to the Human Metabolome Database - a public database containing detailed information about small molecule metabolites found in the human body;
- Where available, links have been provided from GPCR, ion channel and NHR pages to genes in Orphanet, the Portal for Rare Diseases and Orphan Drugs. Receptor and ion channel pathophysiologies have been linked up to expert-curated disease information available in Orphanet;
- Links from ligand pages to BindingDB - a public database of measured binding affinities, focusing mainly on proteins considered to be drug-targets and small, drug-like molecules;
- The enzyme pages link to BRENDA, the Comprehensive Enzyme Information System, KEGG, the Kyoto Encyclopedia of Genes and Genomes, which contains pathway, gene and chemical information, and the IUBMB Enzyme Nomenclature database.

Useful links:

BPS/IUPHAR Guide to Pharmacology
A FREE online portal to quantitative information on drug targets and the prescription medicines and experimental dugs that act on them from the BJP Guide to Receptors and Channels (GRAC) and IUPHAR-DB.

HUGO Gene Nomenclature committee

Pharmacological reviews

IUPHAR Career Centre

We welcome all questions, comments and suggestions - Email us: curators@iuphar-db.org

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Page last updated 1st March 2012