IUPHAR DATABASE OF RECEPTORS AND ION CHANNELS

The IUPHAR-DB and Guide to Pharmacology sites will be offline for a 2 hour period between 9am and 11am (UK time) on Saturday 28th January

Welcome to the official database of the IUPHAR Committee on Receptor Nomenclature and Drug Classification.

Incorporating detailed pharmacological, functional and pathophysiological information on G Protein-Coupled Receptors, Voltage-Gated Ion Channels, Ligand-Gated Ion Channels and Nuclear Hormone Receptors.

Database content:

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* Orphans are defined as proteins having similarity to receptors but whose endogenous ligands have not yet been conclusively identified.

[Cite the database] [About]

Latest news:

IUPHAR-DB and Guide to Pharmacology downtime on Saturday 28th January
- The IUPHAR-DB and Guide to Pharmacology sites will be offline for a 2 hour period between 9am and 11am (UK time) on Saturday 28th January.
NC-IUPHAR and BPS announce the launch of a new online portal, the Guide to Pharmacology
- NC-IUPHAR and the British Pharmacological Society (BPS) announce the launch of a new web site, the Guide to Pharmacology, developed as a joint initiative to provide a one-stop shop for quantitative information on drug targets and the prescription medicines and experimental dugs that act on them. It provides a single entry point to IUPHAR-DB and an online database of information from the Guide to Receptors and Channels (GRAC) 5th (2011) edition. GRAC provides a succinct overview of the key properties of over 1600 established or potential pharmacological targets. This resource should be of interest to researchers and students in pharmacology and drug discovery as well as the interested public.
NC-IUPHAR and DiscoveRx form an alliance to accelerate GPCR deorphanization efforts
- NC-IUPHAR and DiscoveRx have announced that they will form an alliance to accelerate progress on understanding the functions of orphan G Protein-coupled receptors (GPCRs) and their signalling mechanisms, which will be communicated through the IUPHAR Database. Read more about the goals of this unprecedented industry-academia alliance.

Recent database updates (December 2011) include:

New database links:
- Links from ligand pages to Zinc - a free database of commercially-available compounds for virtual screening;
- Links from receptor and ligand pages to the Guide to Receptors and Channels (GRAC) database;
- IUPHAR-DB search tools now search across both the IUPHAR and GRAC data;

Useful links:

BPS/IUPHAR Guide to Pharmacology
A FREE online portal to quantitative information on drug targets and the prescription medicines and experimental dugs that act on them from the BJP Guide to Receptors and Channels (GRAC) and IUPHAR-DB.

HUGO Gene Nomenclature committee

Pharmacological reviews

IUPHAR Career Centre

We welcome all questions, comments and suggestions - Email us: curators@iuphar-db.org

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Page last updated 5th December 2011